{"id":"https://openalex.org/W4387001985","doi":"https://doi.org/10.4049/jimmunol.2300283","title":"IL-15 Priming Alters IFN-\u03b3 Regulation in Murine NK Cells","display_name":"IL-15 Priming Alters IFN-\u03b3 Regulation in Murine NK Cells","publication_year":2023,"publication_date":"2023-09-25","ids":{"openalex":"https://openalex.org/W4387001985","doi":"https://doi.org/10.4049/jimmunol.2300283","pmid":"https://pubmed.ncbi.nlm.nih.gov/37163083","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10168240"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.2300283","doi":"https://doi.org/10.4049/jimmunol.2300283","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.2300283","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/04/25/2023.04.23.537947.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010817079","display_name":"Maria Cimpean","orcid":"https://orcid.org/0000-0003-3735-2643","observed_orcids":["https://orcid.org/0000-0003-3735-2643"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Cimpean","raw_affiliation_strings":["*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0003-3735-2643","affiliations":[{"raw_affiliation_string":"*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066059553","display_name":"Molly P. Keppel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly P Keppel","raw_affiliation_strings":["*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066651028","display_name":"Anastasiia Gainullina","orcid":"https://orcid.org/0000-0003-3796-2337","observed_orcids":["https://orcid.org/0000-0003-3796-2337"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasiia Gainullina","raw_affiliation_strings":["\u2020Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0003-3796-2337","affiliations":[{"raw_affiliation_string":"\u2020Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013064161","display_name":"Changxu Fan","orcid":"https://orcid.org/0000-0002-4375-4019","observed_orcids":["https://orcid.org/0000-0002-4375-4019"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changxu Fan","raw_affiliation_strings":["\u2021Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-4375-4019","affiliations":[{"raw_affiliation_string":"\u2021Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075274633","display_name":"Hyogon Sohn","orcid":"https://orcid.org/0000-0001-8103-1551","observed_orcids":["https://orcid.org/0000-0001-8103-1551"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyogon Sohn","raw_affiliation_strings":["*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0001-8103-1551","affiliations":[{"raw_affiliation_string":"*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018915411","display_name":"Nathan C. Schedler","orcid":"https://orcid.org/0009-0008-2924-1189","observed_orcids":["https://orcid.org/0009-0008-2924-1189"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan C Schedler","raw_affiliation_strings":["*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084203836","display_name":"Amanda Swain","orcid":"https://orcid.org/0000-0003-0683-368X","observed_orcids":["https://orcid.org/0000-0003-0683-368X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Swain","raw_affiliation_strings":["\u2020Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001329171","display_name":"Ana Kolicheski","orcid":"https://orcid.org/0000-0002-7084-5119","observed_orcids":["https://orcid.org/0000-0002-7084-5119"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Kolicheski","raw_affiliation_strings":["*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-7084-5119","affiliations":[{"raw_affiliation_string":"*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002214933","display_name":"Hannah Shapiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Shapiro","raw_affiliation_strings":["*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090914300","display_name":"Howard A. Young","orcid":"https://orcid.org/0000-0002-3118-5111","observed_orcids":["https://orcid.org/0000-0002-3118-5111"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard A Young","raw_affiliation_strings":["\u00a7Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD"],"raw_orcid":"https://orcid.org/0000-0002-3118-5111","affiliations":[{"raw_affiliation_string":"\u00a7Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100427963","display_name":"Ting Wang","orcid":"https://orcid.org/0000-0002-6800-242X","observed_orcids":["https://orcid.org/0000-0002-6800-242X","https://orcid.org/0000-0003-4712-6658","https://orcid.org/0000-0001-9357-4238","https://orcid.org/0000-0002-3344-6231"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting Wang","raw_affiliation_strings":["\u2021Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-6800-242X","affiliations":[{"raw_affiliation_string":"\u2021Department of Genetics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086311928","display_name":"Maxim N. Artyomov","orcid":"https://orcid.org/0000-0002-1133-4212","observed_orcids":["https://orcid.org/0000-0002-1133-4212"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxim N Artyomov","raw_affiliation_strings":["\u2020Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-1133-4212","affiliations":[{"raw_affiliation_string":"\u2020Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059127312","display_name":"Megan A. Cooper","orcid":"https://orcid.org/0000-0002-5696-172X","observed_orcids":["https://orcid.org/0000-0002-5696-172X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan A Cooper","raw_affiliation_strings":["\u2020Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO","*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO"],"raw_orcid":"https://orcid.org/0000-0002-5696-172X","affiliations":[{"raw_affiliation_string":"\u2020Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"*Division of Rheumatology/Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":1.5384,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82150579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"211","issue":"10","first_page":"1481","last_page":"1493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/itam-signaling","display_name":"ITAM signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8539999723434448},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7429999709129333},{"id":"https://openalex.org/keywords/nk-cell-metabolism","display_name":"NK cell metabolism","score":0.6079999804496765},{"id":"https://openalex.org/keywords/murine-nk-cells","display_name":"murine NK cells","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.6401365995407104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5491750240325928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4036189913749695},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39485204219818115},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37188059091567993},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.4049/jimmunol.2300283","doi":"https://doi.org/10.4049/jimmunol.2300283","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.2300283","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"doi:10.1101/2023.04.23.537947","doi":"https://doi.org/10.1101/2023.04.23.537947","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.04.23.537947","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/04/25/2023.04.23.537947.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37163083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37163083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37747317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37747317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10873103","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10873103","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10873103/pdf/nihms-1929184.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Immunol","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10168240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10168240","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2023.04.23.537947","doi":"https://doi.org/10.1101/2023.04.23.537947","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.04.23.537947","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/04/25/2023.04.23.537947.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1114310655","display_name":null,"funder_award_id":"CA91842","funder_id":"https://openalex.org/F4320315130","funder_display_name":"Alvin J. Siteman Cancer Center"},{"id":"https://openalex.org/G1485266116","display_name":null,"funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320316438","funder_display_name":"Georgia Clinical and Translational Science Alliance"},{"id":"https://openalex.org/G2052854178","display_name":null,"funder_award_id":"TR000448","funder_id":"https://openalex.org/F4320316438","funder_display_name":"Georgia Clinical and Translational Science Alliance"},{"id":"https://openalex.org/G299873027","display_name":null,"funder_award_id":"#P30 CA91842","funder_id":"https://openalex.org/F4320315130","funder_display_name":"Alvin J. Siteman Cancer Center"},{"id":"https://openalex.org/G3052571696","display_name":"Metabolic Regulation of Natural Killer Cell Activation","funder_award_id":"R56AI127752","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3876247145","display_name":"METABOLIC REGULATION OF NATURAL KILLER CELL ACTIVATION","funder_award_id":"R01AI127752","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4241677154","display_name":null,"funder_award_id":"TR000448","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G725115302","display_name":"Washington University Institute of Clinical and Translational Sciences","funder_award_id":"UL1TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7647900390","display_name":null,"funder_award_id":"UL1 TR000448","funder_id":"https://openalex.org/F4320315130","funder_display_name":"Alvin J. Siteman Cancer Center"},{"id":"https://openalex.org/G9000115080","display_name":null,"funder_award_id":"TR000448","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000907135","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA091842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320315130","display_name":"Alvin J. Siteman Cancer Center","ror":"https://ror.org/03jrmgg47"},{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387001985.pdf","grobid_xml":"https://content.openalex.org/works/W4387001985.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W1491936665","https://openalex.org/W1519245034","https://openalex.org/W1546952436","https://openalex.org/W1663833839","https://openalex.org/W1904243869","https://openalex.org/W1932665887","https://openalex.org/W1953902819","https://openalex.org/W1968321644","https://openalex.org/W1969950463","https://openalex.org/W1970090817","https://openalex.org/W1970591872","https://openalex.org/W1975717760","https://openalex.org/W1979524871","https://openalex.org/W1993023349","https://openalex.org/W2003565653","https://openalex.org/W2004603629","https://openalex.org/W2006073656","https://openalex.org/W2014677321","https://openalex.org/W2020313517","https://openalex.org/W2024857291","https://openalex.org/W2025000087","https://openalex.org/W2030681935","https://openalex.org/W2031593086","https://openalex.org/W2037070751","https://openalex.org/W2037608249","https://openalex.org/W2040914801","https://openalex.org/W2043848225","https://openalex.org/W2049050680","https://openalex.org/W2058860008","https://openalex.org/W2063809122","https://openalex.org/W2064138946","https://openalex.org/W2069795464","https://openalex.org/W2084914434","https://openalex.org/W2089947832","https://openalex.org/W2100084936","https://openalex.org/W2104145276","https://openalex.org/W2104825199","https://openalex.org/W2107277218","https://openalex.org/W2114104545","https://openalex.org/W2114360920","https://openalex.org/W2117757143","https://openalex.org/W2120072658","https://openalex.org/W2121158936","https://openalex.org/W2127906377","https://openalex.org/W2130410032","https://openalex.org/W2137586531","https://openalex.org/W2138207763","https://openalex.org/W2139826995","https://openalex.org/W2146512944","https://openalex.org/W2146791037","https://openalex.org/W2147450297","https://openalex.org/W2148077170","https://openalex.org/W2151349447","https://openalex.org/W2164115182","https://openalex.org/W2166507670","https://openalex.org/W2169456326","https://openalex.org/W2171808845","https://openalex.org/W2175045656","https://openalex.org/W2179438025","https://openalex.org/W2183443721","https://openalex.org/W2557375540","https://openalex.org/W2703960277","https://openalex.org/W2763346562","https://openalex.org/W2772960486","https://openalex.org/W2775606072","https://openalex.org/W2785517216","https://openalex.org/W2788914092","https://openalex.org/W2799849968","https://openalex.org/W2805888917","https://openalex.org/W2887976969","https://openalex.org/W2903350032","https://openalex.org/W2941999083","https://openalex.org/W2944778679","https://openalex.org/W2945863457","https://openalex.org/W3004480366","https://openalex.org/W3005456357","https://openalex.org/W3029024642","https://openalex.org/W3042910263","https://openalex.org/W3131634425","https://openalex.org/W3165801055","https://openalex.org/W3178173272","https://openalex.org/W4226185665","https://openalex.org/W4237244682","https://openalex.org/W4294091472","https://openalex.org/W4307425817","https://openalex.org/W4318542938","https://openalex.org/W4322500256","https://openalex.org/W4323825331","https://openalex.org/W4367175830","https://openalex.org/W4396894255"],"related_works":["https://openalex.org/W6978089078","https://openalex.org/W4319432351","https://openalex.org/W2969903696","https://openalex.org/W1899804292","https://openalex.org/W4200355735","https://openalex.org/W2125550288","https://openalex.org/W2281453979","https://openalex.org/W4313354802","https://openalex.org/W1973852067","https://openalex.org/W2133588094"],"abstract_inverted_index":{"NK":[0,14,29,93,109,167,186],"effector":[1],"functions":[2],"can":[3],"be":[4],"triggered":[5],"by":[6,159],"inflammatory":[7],"cytokines":[8],"and":[9,51,222],"engagement":[10],"of":[11,17,91,107,162,175,189,204],"activating":[12,42,52,102,130,228],"receptors.":[13],"cell":[15],"production":[16,70],"IFN-\u03b3,":[18],"an":[19],"important":[20],"immunoregulatory":[21],"cytokine,":[22],"exhibits":[23],"activation-specific":[24,32],"IFN-\u03b3":[25,36,58,82,99,223],"regulation.":[26],"Resting":[27],"murine":[28,92],"cells":[30,94,110,114,116,124,187],"exhibit":[31],"metabolic":[33],"requirements":[34],"for":[35,41,197],"production,":[37,60],"which":[38],"are":[39],"reversed":[40],"receptor-mediated":[43],"stimulation":[44,54,63,161],"following":[45,129],"IL-15":[46,89,120],"priming.":[47],"Although":[48,183],"both":[49],"cytokine":[50,62],"receptor":[53,75,103,131,229],"leads":[55],"to":[56,98,137,227],"similar":[57],"protein":[59,69],"only":[61],"upregulates":[64],"Ifng":[65,127,143,181,190,198],"transcript,":[66],"suggesting":[67],"that":[68,86,122],"is":[71],"translationally":[72],"regulated":[73],"after":[74],"stimulation.":[76,132,230],"Based":[77],"on":[78],"these":[79],"differences":[80],"in":[81,141,147,213,217,225],"regulation,":[83],"we":[84],"hypothesized":[85],"ex":[87],"vivo":[88],"priming":[90],"allows":[95],"a":[96,154,172,201],"switch":[97],"transcription":[100,199],"upon":[101],"engagement.":[104],"Transcriptional":[105,169],"analysis":[106],"primed":[108,123,163],"compared":[111,164],"with":[112,118,153,165,180],"naive":[113,166],"or":[115,145],"cultured":[117],"low-dose":[119],"demonstrated":[121],"strongly":[125],"upregulated":[126],"transcript":[128],"This":[133,207],"was":[134,151,194],"not":[135,195],"due":[136],"chromatin":[138],"accessibility":[139],"changes":[140,146],"the":[142],"locus":[144],"ITAM":[148,160],"signaling,":[149],"but":[150],"associated":[152,179],"distinct":[155,218],"transcriptional":[156],"signature":[157,174],"induced":[158],"cells.":[168],"analyses":[170],"identified":[171],"common":[173],"c-Myc":[176],"(Myc)":[177],"targets":[178],"transcription.":[182],"Myc":[184,192,205],"marked":[185],"capable":[188],"transcription,":[191],"itself":[193],"required":[196],"using":[200],"genetic":[202],"model":[203],"deletion.":[206],"work":[208],"highlights":[209],"altered":[210],"regulatory":[211],"networks":[212],"IL-15-primed":[214],"cells,":[215],"resulting":[216],"gene":[219],"expression":[220],"patterns":[221],"regulation":[224],"response":[226]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-09-26T00:00:00"}