{"id":"https://openalex.org/W4386981608","doi":"https://doi.org/10.1007/s00018-023-04957-8","title":"Stem cell antigen-1+cell-derived fibroblasts are crucial for cardiac fibrosis during heart failure","display_name":"Stem cell antigen-1+cell-derived fibroblasts are crucial for cardiac fibrosis during heart failure","publication_year":2023,"publication_date":"2023-09-23","ids":{"openalex":"https://openalex.org/W4386981608","doi":"https://doi.org/10.1007/s00018-023-04957-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37740736","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11073062"},"language":"en","primary_location":{"id":"doi:10.1007/s00018-023-04957-8","doi":"https://doi.org/10.1007/s00018-023-04957-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00018-023-04957-8","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3087476/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080145938","display_name":"Tingting Tao","orcid":"https://orcid.org/0000-0002-2350-6683","observed_orcids":["https://orcid.org/0000-0002-2350-6683"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Tao","raw_affiliation_strings":["Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Luping Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luping Du","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070253843","display_name":"Peng Teng","orcid":"https://orcid.org/0000-0002-7412-9646","observed_orcids":["https://orcid.org/0000-0002-7412-9646"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Teng","raw_affiliation_strings":["Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056796466","display_name":"Yan Ping Guo","orcid":"https://orcid.org/0000-0001-5252-3960","observed_orcids":["https://orcid.org/0000-0001-5252-3960"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Guo","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451334","display_name":"Xuyang Wang","orcid":"https://orcid.org/0000-0001-6942-7289","observed_orcids":["https://orcid.org/0000-0001-6942-7289"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuyang Wang","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036831600","display_name":"Yanhua Hu","orcid":"https://orcid.org/0000-0002-8149-5636","observed_orcids":["https://orcid.org/0000-0002-8149-5636"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanhua Hu","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076457381","display_name":"Haige Zhao","orcid":"https://orcid.org/0000-0003-1533-0304","observed_orcids":["https://orcid.org/0000-0003-1533-0304"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haige Zhao","raw_affiliation_strings":["Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022101190","display_name":"Qingbo Xu","orcid":"https://orcid.org/0000-0003-2474-8155","observed_orcids":["https://orcid.org/0000-0003-2474-8155","https://orcid.org/0000-0002-6414-2273"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingbo Xu","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China. qingbo_xu@zju.edu.cn","Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China"],"raw_orcid":"https://orcid.org/0000-0003-2474-8155","affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China. qingbo_xu@zju.edu.cn","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100637354","display_name":"Liang Ma","orcid":"https://orcid.org/0000-0001-8054-4582","observed_orcids":["https://orcid.org/0000-0001-8054-4582"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liang Ma","raw_affiliation_strings":["Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China. ml1402@zju.edu.cn","Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China. ml1402@zju.edu.cn","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Cardiovascular Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022101190","https://openalex.org/A5100637354"],"corresponding_institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.7418,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73903717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"80","issue":"10","first_page":"300","last_page":"300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.843999981880188},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.996999979019165},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/fibroblast-differentiation","display_name":"fibroblast differentiation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7350000143051147},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.6330000162124634},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6309038996696472},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5980299711227417},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5391991138458252},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5345368385314941},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.44531163573265076},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4363046884536743},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40331485867500305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38890787959098816},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3667430281639099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3577686548233032},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3554689288139343},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3405044674873352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3394511640071869},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3319332003593445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10547161102294922}],"mesh":[{"descriptor_ui":"D000067696","descriptor_name":"Ataxin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000067696","descriptor_name":"Ataxin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000950","descriptor_name":"Antigens, Ly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00018-023-04957-8","doi":"https://doi.org/10.1007/s00018-023-04957-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00018-023-04957-8","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-3087476/v1","doi":"https://doi.org/10.21203/rs.3.rs-3087476/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3087476/v1","pdf_url":"https://www.researchsquare.com/article/rs-3087476/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11073062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11073062","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11073062/pdf/18_2023_Article_4957.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},{"id":"pmid:37740736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37740736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular life sciences : CMLS","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3087476/v1","doi":"https://doi.org/10.21203/rs.3.rs-3087476/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3087476/v1","pdf_url":"https://www.researchsquare.com/article/rs-3087476/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1193134650","display_name":null,"funder_award_id":"2023C03087","funder_id":"https://openalex.org/F4320338469","funder_display_name":"Science and Technology Program of Zhejiang Province"},{"id":"https://openalex.org/G1868421709","display_name":"\u9ad8\u8840\u538b\u8bf1\u5bfc\u7684\u5fc3\u808c\u91cd\u5851\u4e2dCD34+\u7ec6\u80de\u5206\u5316\u4e0e\u4ee3\u8c22\u6539\u53d8\u7684\u5173\u7cfb\u53ca\u673a\u7406\u7814\u7a76","funder_award_id":"LQ23H020006","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G4917887423","display_name":null,"funder_award_id":"82030008","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5981661239","display_name":"\u4ee3\u8c22\u8c03\u63a7\u8840\u7ba1\u5916\u819c\u5e72/\u7956\u7ec6\u80de\u53c2\u4e0e\u8840\u7ba1\u91cd\u5851\u7684\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"31830039","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6752235078","display_name":null,"funder_award_id":"82270409","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8318855848","display_name":null,"funder_award_id":"82030008","funder_id":"https://openalex.org/F4320322927","funder_display_name":"Zhejiang University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338469","display_name":"Science and Technology Program of Zhejiang Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386981608.pdf","grobid_xml":"https://content.openalex.org/works/W4386981608.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W865397047","https://openalex.org/W1195941168","https://openalex.org/W1966177375","https://openalex.org/W1974848384","https://openalex.org/W1984883254","https://openalex.org/W1990163699","https://openalex.org/W2010368308","https://openalex.org/W2021467952","https://openalex.org/W2024174149","https://openalex.org/W2055875992","https://openalex.org/W2078281649","https://openalex.org/W2104931922","https://openalex.org/W2122744876","https://openalex.org/W2124857894","https://openalex.org/W2137522919","https://openalex.org/W2139522433","https://openalex.org/W2143940787","https://openalex.org/W2153616813","https://openalex.org/W2158285228","https://openalex.org/W2161918376","https://openalex.org/W2299099463","https://openalex.org/W2300734873","https://openalex.org/W2582033455","https://openalex.org/W2608644283","https://openalex.org/W2613671225","https://openalex.org/W2752610058","https://openalex.org/W2794521141","https://openalex.org/W2803376125","https://openalex.org/W2851393963","https://openalex.org/W2903754839","https://openalex.org/W2904689786","https://openalex.org/W2949177718","https://openalex.org/W2953151710","https://openalex.org/W2972517993","https://openalex.org/W2973703035","https://openalex.org/W2998055946","https://openalex.org/W3005621312","https://openalex.org/W3012389947","https://openalex.org/W3014730061","https://openalex.org/W3126754513","https://openalex.org/W3161845713","https://openalex.org/W3163348136","https://openalex.org/W3169066672","https://openalex.org/W3184368135","https://openalex.org/W3201735942","https://openalex.org/W3202385745","https://openalex.org/W3208281126","https://openalex.org/W4205166413","https://openalex.org/W4210607007","https://openalex.org/W4214672451","https://openalex.org/W4235484022","https://openalex.org/W4285274814","https://openalex.org/W4307911811","https://openalex.org/W4321370697","https://openalex.org/W4360612373","https://openalex.org/W4364321961"],"related_works":["https://openalex.org/W4321370697","https://openalex.org/W6939291247","https://openalex.org/W4224301931","https://openalex.org/W3109316107","https://openalex.org/W1981748685","https://openalex.org/W2088820548","https://openalex.org/W4214665861","https://openalex.org/W3098111955","https://openalex.org/W2040822095","https://openalex.org/W2745125081"],"abstract_inverted_index":{"Abstract":[0],"Aims":[1],"Mesenchymal":[2],"stem":[3,84,118],"cells":[4,89,108,119,158,190],"(MSCs)":[5],"present":[6],"in":[7,19,38,132,135,146],"the":[8,23,31,62,69,72,76,121,165,170,177,208],"heart":[9,41,79,150,219],"cannot":[10],"differentiate":[11],"into":[12,161,207],"cardiomyocytes,":[13],"but":[14],"may":[15],"play":[16],"a":[17,129,192],"role":[18,32],"pathological":[20],"conditions.":[21],"Therefore,":[22],"aim":[24],"of":[25,35,51,64,71,78,83,116,123,167,180,196,210],"this":[26],"study":[27,154,175],"was":[28],"to":[29,111,128],"scrutinise":[30],"and":[33,44,56,90,97,126,142,163,183,213],"mechanism":[34],"MSC":[36],"differentiation":[37],"vivo":[39],"during":[40,75],"failure.":[42,151,220],"Methods":[43],"Results":[45],"We":[46],"performed":[47],"single-cell":[48],"RNA":[49],"sequencing":[50],"total":[52],"non-cardiomyocytes":[53],"from":[54,188],"murine":[55],"adult":[57],"human":[58,147],"hearts.":[59],"By":[60,92],"analysing":[61],"transcriptomes":[63],"single":[65],"cells,":[66],"we":[67,102],"illustrated":[68],"dynamics":[70],"cell":[73,85,140],"landscape":[74,179],"progression":[77],"hypertrophy,":[80],"including":[81],"those":[82],"antigen-1":[86],"(Sca1)+":[87],"stem/progenitor":[88],"fibroblasts.":[91,112],"combining":[93],"genetic":[94],"lineage":[95],"tracing":[96],"bone":[98],"marrow":[99,194],"transplantation":[100],"models,":[101],"demonstrated":[103],"that":[104,156,185],"non-bone":[105,193],"marrow-derived":[106],"Sca1+":[107,117,157,189],"give":[109],"rise":[110],"Interestingly,":[113],"partial":[114],"depletion":[115],"alleviated":[120],"severity":[122,166],"myocardial":[124],"fibrosis":[125,168,212],"led":[127],"significant":[130],"improvement":[131],"cardiac":[133,200,211],"function":[134],"Sca1-CreERT2;Rosa26-eGFP-DTA":[136],"mice.":[137],"Similar":[138],"non-cardiomyocyte":[139],"composition":[141],"heterogeneity":[143],"were":[144],"observed":[145],"patients":[148],"with":[149,191],"Mechanistically,":[152],"our":[153],"revealed":[155],"can":[159],"transform":[160],"fibroblasts":[162,186],"affect":[164],"through":[169],"Wnt4-Pdgfra":[171],"pathway":[172],"Conclusions":[173],"Our":[174],"describes":[176],"cellular":[178],"hypertrophic":[181],"hearts":[182],"reveals":[184],"derived":[187],"source":[195],"largely":[197],"account":[198],"for":[199,218],"fibrosis.":[201],"These":[202],"findings":[203],"provide":[204],"novel":[205],"insights":[206],"pathogenesis":[209],"have":[214],"potential":[215],"therapeutic":[216],"implications":[217],"Graphical":[221],"abstract:":[222]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-24T00:00:00"}
