{"id":"https://openalex.org/W4386968541","doi":"https://doi.org/10.1166/jbn.2023.3634","title":"Zinc Oxide Nanoparticles Produced Sustainably Utilizing Solanum xanthocarpum Leaf Extracts and Their Anti-Neoplastic Effects on Colon Cancer Cells (HT-29)","display_name":"Zinc Oxide Nanoparticles Produced Sustainably Utilizing Solanum xanthocarpum Leaf Extracts and Their Anti-Neoplastic Effects on Colon Cancer Cells (HT-29)","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386968541","doi":"https://doi.org/10.1166/jbn.2023.3634"},"language":"en","primary_location":{"id":"doi:10.1166/jbn.2023.3634","doi":"https://doi.org/10.1166/jbn.2023.3634","is_oa":false,"landing_page_url":"https://doi.org/10.1166/jbn.2023.3634","pdf_url":null,"source":{"id":"https://openalex.org/S15497777","display_name":"Journal of Biomedical Nanotechnology","issn_l":"1550-7033","issn":["1550-7033","1550-7041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Nanotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045907730","display_name":"Jie Yang","orcid":"https://orcid.org/0000-0002-9152-308X","observed_orcids":["https://orcid.org/0000-0002-9152-308X","https://orcid.org/0009-0009-9161-7674"]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Yang","raw_affiliation_strings":["The Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China","institution_ids":["https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104172725","display_name":"Lu Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Yao","raw_affiliation_strings":["The Clinical Skills Center, Kunming Medical University, Kunming, 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Clinical Skills Center, Kunming Medical University, Kunming, 650000, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101074814","display_name":"Sai He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160452","display_name":"Third People's Hospital of Yunnan Province","ror":"https://ror.org/0555qme52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sai He","raw_affiliation_strings":["Department of Thyroid and Breast Surgery, The Third People\u2019s Hospital of Yunnan Province, Kunming, 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid and Breast Surgery, The Third People\u2019s Hospital of Yunnan Province, Kunming, 650000, China","institution_ids":["https://openalex.org/I4210160452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037571959","display_name":"Periyannan Velu","orcid":"https://orcid.org/0000-0003-3894-9556","observed_orcids":["https://orcid.org/0000-0003-3894-9556"]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Periyannan Velu","raw_affiliation_strings":["Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram 608002, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram 608002, Tamil Nadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030907691","display_name":"Annamalai Vijayalakshmi","orcid":"https://orcid.org/0000-0002-2436-8956","observed_orcids":["https://orcid.org/0000-0002-2436-8956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annamalai Vijayalakshmi","raw_affiliation_strings":["PG & Research Department of Biochemistry, Rabiammal Ahamed Maideen College for Women, Thiruvarur 610001, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PG & Research Department of Biochemistry, Rabiammal Ahamed Maideen College for Women, Thiruvarur 610001, Tamil Nadu, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050121662","display_name":"Runxu Yang","orcid":"https://orcid.org/0000-0002-0367-1139","observed_orcids":["https://orcid.org/0000-0002-0367-1139"]},"institutions":[{"id":"https://openalex.org/I4210114896","display_name":"The First Hospital of Kunming","ror":"https://ror.org/01hq7pd83","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114896"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Run-Xu Yang","raw_affiliation_strings":["Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, 650000, China","institution_ids":["https://openalex.org/I4210114896","https://openalex.org/I4210120169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015419400","display_name":"Hong-xuan Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-xuan Ren","raw_affiliation_strings":["Department of Internal Medicine-Oncology, Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine-Oncology, Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University), Kunming, 650000, China","institution_ids":["https://openalex.org/I26080491"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1348,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.23469817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"19","issue":"9","first_page":"1583","last_page":"1593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10090","display_name":"ZnO doping and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-oxide-nanoparticles","display_name":"zinc oxide nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/green-synthesis","display_name":"green synthesis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/solanum-xanthocarpum","display_name":"Solanum xanthocarpum","score":0.9810000061988831},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.8399999737739563},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9900000095367432},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.7941582202911377},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.7355895042419434},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.6186726689338684},{"id":"https://openalex.org/C2777527632","wikidata":"https://www.wikidata.org/wiki/Q238382","display_name":"DAPI","level":3,"score":0.6048031449317932},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5697846412658691},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.5565288066864014},{"id":"https://openalex.org/C2776907736","wikidata":"https://www.wikidata.org/wiki/Q408634","display_name":"Ethidium bromide","level":3,"score":0.5391362905502319},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49862146377563477},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.410602331161499},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34797191619873047},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2596730589866638},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2484278678894043},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.09845107793807983},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1166/jbn.2023.3634","doi":"https://doi.org/10.1166/jbn.2023.3634","is_oa":false,"landing_page_url":"https://doi.org/10.1166/jbn.2023.3634","pdf_url":null,"source":{"id":"https://openalex.org/S15497777","display_name":"Journal of Biomedical Nanotechnology","issn_l":"1550-7033","issn":["1550-7033","1550-7041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Nanotechnology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1984588396","https://openalex.org/W2062059117","https://openalex.org/W2129555794","https://openalex.org/W2199944392","https://openalex.org/W2272984102","https://openalex.org/W2302003756","https://openalex.org/W2344644350","https://openalex.org/W2747001756","https://openalex.org/W2889646458","https://openalex.org/W2938476080","https://openalex.org/W2944404949","https://openalex.org/W2947235784","https://openalex.org/W2947578925","https://openalex.org/W2947752040","https://openalex.org/W2954678774","https://openalex.org/W2965611334","https://openalex.org/W2970045605","https://openalex.org/W2988782087","https://openalex.org/W2989766421","https://openalex.org/W3004769637","https://openalex.org/W3010878105","https://openalex.org/W3012638502","https://openalex.org/W3082462777","https://openalex.org/W3094998614","https://openalex.org/W3096514623","https://openalex.org/W3101629064","https://openalex.org/W3119544361","https://openalex.org/W3120329162","https://openalex.org/W3205141766","https://openalex.org/W3208985294","https://openalex.org/W4200051578","https://openalex.org/W6633658626","https://openalex.org/W6693972512","https://openalex.org/W6754669450"],"related_works":["https://openalex.org/W4280598060","https://openalex.org/W2973303066","https://openalex.org/W4205850996","https://openalex.org/W4405072636","https://openalex.org/W4410898550","https://openalex.org/W4385462651","https://openalex.org/W4214573328","https://openalex.org/W3195774950","https://openalex.org/W4412016227","https://openalex.org/W3165658263"],"abstract_inverted_index":{"Zinc":[0],"oxide":[1],"nanoparticles":[2],"(ZnO-NPs)":[3],"were":[4,38,72],"synthesized":[5],"in":[6,134,163],"this":[7],"study":[8],"using":[9,24,40,74],"Solanum":[10],"xanthocarpum":[11],"(Sx)":[12],"leaf":[13],"extracts":[14],"via":[15,81],"a":[16],"green":[17],"method.":[18],"The":[19,32,61,96],"nanomaterial,":[20],"ZnO-NPs-Sx,":[21],"was":[22,149],"prepared":[23],"zinc":[25],"acetate":[26],"dehydrate":[27],"solution":[28],"followed":[29],"by":[30,105],"purification.":[31],"nanofabricate":[33],"size":[34],"and":[35,48,77,91,103,112,125,148],"structural":[36],"properties":[37,63],"investigated":[39],"UV-V":[41],"Spectroscopy,":[42],"X-ray":[43],"diffraction,":[44],"energy":[45],"dispersive":[46],"X-ray,":[47],"Fourier":[49],"transform":[50],"infrared":[51],"spectroscopy":[52],"(FT-IR),":[53],"as":[54,56],"well":[55],"scanning":[57],"electron":[58],"microscopy":[59],"(SEM).":[60],"anti-neoplastic":[62],"of":[64,119],"nanomaterial":[65,97,131,141],"against":[66],"the":[67,78,130,140,156],"colon":[68],"cancer":[69,170],"cells":[70,121],"(HT-29)":[71],"measured":[73],"MTT":[75],"assay":[76],"apoptotic":[79],"biomarkers":[80],"staining":[82],"techniques":[83],"(i.e.,":[84],"acridine":[85],"orange/ethidium":[86],"bromide":[87],"(AO/EB),":[88],"4\u2032,6-diamidino-2-phenylindole":[89],"(DAPI)":[90],"Propidium":[92],"iodide":[93],"(PI":[94],"staining).":[95],"induced":[98,132],"reactive":[99],"oxygen":[100],"species":[101],"ROS":[102],"apoptosis":[104,133],"stimulating":[106],"cell":[107],"signaling":[108],"biomarkers:":[109],"caspase-3,":[110],"-8":[111],"-9.":[113],"Staining":[114],"showed":[115],"proportionately":[116],"higher":[117],"number":[118],"dead":[120],"with":[122],"nuclear":[123],"damage":[124],"chromatin":[126],"condensation":[127],"to":[128,165],"confirm":[129],"HT-29":[135,153],"cells.":[136,154,171],"At":[137],"low":[138],"concentrations,":[139],"did":[142],"not":[143],"elicit":[144],"adverse":[145],"cellular":[146],"changes,":[147],"less":[150],"toxic":[151],"towards":[152,169],"Thus,":[155],"bio-synthesized":[157],"nanofabricate,":[158],"can":[159],"be":[160],"used":[161],"ZnO-NPs-Sx":[162],"nanomedicine":[164],"improve":[166],"current":[167],"treatments":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-09-23T00:00:00"}
