{"id":"https://openalex.org/W4386964913","doi":"https://doi.org/10.1166/jbn.2023.3653","title":"Analysis of the Pathogenesis of Gram-Negative Bacterial Sepsis in Rats Under Nano-Body","display_name":"Analysis of the Pathogenesis of Gram-Negative Bacterial Sepsis in Rats Under Nano-Body","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386964913","doi":"https://doi.org/10.1166/jbn.2023.3653"},"language":"en","primary_location":{"id":"doi:10.1166/jbn.2023.3653","doi":"https://doi.org/10.1166/jbn.2023.3653","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1166/jbn.2023.3653","pdf_url":null,"source":{"id":"https://openalex.org/S15497777","display_name":"Journal of Biomedical Nanotechnology","issn_l":"1550-7033","issn":["1550-7033","1550-7041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Nanotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100418679","display_name":"Xiaoli Li","orcid":"https://orcid.org/0000-0001-8106-2358","observed_orcids":["https://orcid.org/0000-0001-8106-2358"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoli Li","raw_affiliation_strings":["Department of Critical Care Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaogang Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaogang Wang","raw_affiliation_strings":["Intensive Care Unit (ICU), The People\u2019s Hospital of Zhaoyuan City, Zhaoyuan, 265400, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit (ICU), The People\u2019s Hospital of Zhaoyuan City, Zhaoyuan, 265400, Shandong Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053764898","display_name":"Weiye Liu","orcid":"https://orcid.org/0000-0001-9908-0407","observed_orcids":["https://orcid.org/0000-0001-9908-0407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiye Liu","raw_affiliation_strings":["Intensive Care Unit (ICU), The People\u2019s Hospital of Zhaoyuan City, Zhaoyuan, 265400, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit (ICU), The People\u2019s Hospital of Zhaoyuan City, Zhaoyuan, 265400, Shandong Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363900","display_name":"Wenqiang Li","orcid":"https://orcid.org/0000-0002-0833-246X","observed_orcids":["https://orcid.org/0000-0002-0833-246X","https://orcid.org/0009-0002-2593-0194"]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenqiang Li","raw_affiliation_strings":["Intensive Care Unit (ICU), Jining No.1 People\u2019s Hospital, Jining, 272011, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit (ICU), Jining No.1 People\u2019s Hospital, Jining, 272011, Shandong Province, China","institution_ids":["https://openalex.org/I4210136826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101544371","display_name":"Meifeng Li","orcid":"https://orcid.org/0000-0003-3161-3611","observed_orcids":["https://orcid.org/0000-0003-3161-3611"]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I3018397418","display_name":"Yuhuangding Hospital","ror":"https://ror.org/05vawe413","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3018397418"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meifeng Li","raw_affiliation_strings":["Department of Critical Care Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I3018397418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18001482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"9","first_page":"1611","last_page":"1618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5810999870300293,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.2833999991416931,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0649000033736229,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gram-negative-sepsis","display_name":"gram-negative sepsis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7009999752044678},{"id":"https://openalex.org/keywords/sepsis-survival","display_name":"sepsis survival","score":0.6309999823570251},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7699999809265137},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9440000057220459},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9890000224113464},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cleaved-caspase-3","display_name":"cleaved caspase-3","score":0.8939999938011169},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6653315424919128},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6358228325843811},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5690761208534241},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.5274377465248108},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4981377124786377},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.48288679122924805},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.4744190573692322},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4404394030570984},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4295518398284912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4119942784309387},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.34208372235298157},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3252224922180176},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3200419247150421},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31118929386138916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1853606402873993}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1166/jbn.2023.3653","doi":"https://doi.org/10.1166/jbn.2023.3653","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1166/jbn.2023.3653","pdf_url":null,"source":{"id":"https://openalex.org/S15497777","display_name":"Journal of Biomedical Nanotechnology","issn_l":"1550-7033","issn":["1550-7033","1550-7041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Nanotechnology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W7839082","https://openalex.org/W202323776","https://openalex.org/W2018207514","https://openalex.org/W2070283025","https://openalex.org/W2101004945","https://openalex.org/W2522054313","https://openalex.org/W2910028884","https://openalex.org/W2917653726","https://openalex.org/W2936191760","https://openalex.org/W2952125019","https://openalex.org/W2960786720","https://openalex.org/W2964354576","https://openalex.org/W2964930843","https://openalex.org/W2972054198","https://openalex.org/W2976204613","https://openalex.org/W2988113603","https://openalex.org/W2990143321","https://openalex.org/W2999542381","https://openalex.org/W3000349893","https://openalex.org/W3098953199","https://openalex.org/W3115154419","https://openalex.org/W3118504473","https://openalex.org/W3175248024","https://openalex.org/W3208247254","https://openalex.org/W4224325063","https://openalex.org/W4224443387","https://openalex.org/W4280602454","https://openalex.org/W4281550710","https://openalex.org/W4283019630","https://openalex.org/W4283744638","https://openalex.org/W4293029245","https://openalex.org/W4306411299","https://openalex.org/W4313463429","https://openalex.org/W4313561516","https://openalex.org/W4321786809","https://openalex.org/W4322621421","https://openalex.org/W6777522568"],"related_works":["https://openalex.org/W3098953199","https://openalex.org/W2007701914","https://openalex.org/W3098220870","https://openalex.org/W2101901856","https://openalex.org/W2098389295","https://openalex.org/W4361017346","https://openalex.org/W4282919027","https://openalex.org/W4298088974","https://openalex.org/W4236225064","https://openalex.org/W1984623022"],"abstract_inverted_index":{"This":[0,189],"work":[1],"aimed":[2],"to":[3,61,80],"evaluate":[4],"the":[5,47,57,63,82,92,117,154,168,178,192,200],"effectiveness":[6],"of":[7,39,65,84,171,181,202],"several":[8],"anti-TLR4":[9,28],"nanobody":[10],"administration":[11],"techniques":[12],"in":[13,46,71,109,149],"a":[14,128,143],"gram-negative":[15],"bacterial":[16],"sepsis":[17,203],"(GNBS)":[18],"rat":[19,93,110],"model.":[20],"The":[21,35,124,163],"targeting":[22],"proteins":[23],"for":[24],"TI-Nb2":[25,172],"and":[26,32,51,69,89,95,116,139,142,151,157,173,186,195,198],"TC-Nb6":[27,174],"nanobodies":[29],"were":[30,44,99],"TLR4203-348":[31],"TLR4349-582,":[33],"respectively.":[34],"survival":[36],"times":[37],"(STs)":[38],"44":[40],"Sprague-Dawley":[41],"(SD)":[42],"rats":[43],"tracked":[45],"TI-Nb2,":[48,155],"TC-Nb6,":[49,156],"TI-Nb2+TC-Nb6,":[50],"D0":[52,158],"groups":[53,159],"(saline":[54],"control).":[55],"Besides,":[56],"ELISA":[58],"was":[59,78,112,122],"utilized":[60],"measure":[62],"levels":[64,83,180],"TNF-,":[66],"IL-1,":[67],"IL-8,":[68,134],"IL-10":[70],"different":[72],"groups.":[73],"An":[74],"automatic":[75],"biochemical":[76,184],"analyzer":[77],"employed":[79],"determine":[81],"AST,":[85,136],"ALT,":[86,135],"AMS,":[87,137],"CRE,":[88,138],"Urea.":[90],"Furthermore,":[91],"liver":[94],"kidney":[96],"tissue":[97],"samples":[98],"stained":[100],"with":[101],"hematoxylin-eosin":[102],"(HE).":[103],"Cleaved-caspase-3":[104],"(CC3)":[105],"protein":[106,146],"expression":[107,179],"(PE)":[108],"tissues":[111],"discovered":[113],"using":[114],"immunohistochemistry,":[115],"positive":[118],"unit":[119],"(PU)":[120],"value":[121,148],"computed.":[123],"TI-Nb2+TC-Nb6":[125],"group":[126],"exhibited":[127],"longder":[129],"ST,":[130],"lower":[131],"TNF-\u03b1,":[132],"IL-1\u03b2,":[133],"Urea":[140],"levels,":[141],"smaller":[144],"CC3":[145,182],"PU":[147],"nucleus":[150],"cytoplasm":[152],"than":[153],"(all":[160],"P":[161],"<0.05).":[162],"above":[164],"findings":[165],"indicated":[166],"that":[167],"combined":[169],"usage":[170],"can":[175],"successfully":[176],"reduce":[177],"protein,":[183],"markers,":[185],"inflammatory":[187],"factors.":[188],"could":[190],"protect":[191],"liver,":[193],"kidneys,":[194],"other":[196],"organs":[197],"prolong":[199],"ST":[201],"rats.":[204]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-09-23T00:00:00"}