{"id":"https://openalex.org/W4386950344","doi":"https://doi.org/10.21203/rs.3.rs-3359390/v1","title":"A Systematic Review on NSAID and Tanezumab efficacy in Chronic Lower Back Pain","display_name":"A Systematic Review on NSAID and Tanezumab efficacy in Chronic Lower Back Pain","publication_year":2023,"publication_date":"2023-09-22","ids":{"openalex":"https://openalex.org/W4386950344","doi":"https://doi.org/10.21203/rs.3.rs-3359390/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-3359390/v1","doi":"https://doi.org/10.21203/rs.3.rs-3359390/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3359390/v1","pdf_url":"https://www.researchsquare.com/article/rs-3359390/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3359390/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047135695","display_name":"Smaran Kasireddy","orcid":"https://orcid.org/0009-0009-0842-0329","observed_orcids":["https://orcid.org/0009-0009-0842-0329"]},"institutions":[{"id":"https://openalex.org/I2802445252","display_name":"University Hospitals of Leicester NHS Trust","ror":"https://ror.org/02fha3693","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Smaran Kasireddy","raw_affiliation_strings":["University Hospital Leicester, Leicester, United Kingdom"],"raw_orcid":"https://orcid.org/0009-0009-0842-0329","affiliations":[{"raw_affiliation_string":"University Hospital Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I2802445252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030130191","display_name":"Sweta Sahu","orcid":"https://orcid.org/0000-0003-2555-2584","observed_orcids":["https://orcid.org/0000-0003-2555-2584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sweta Sahu","raw_affiliation_strings":["JJM Medical College, Davanagere, India"],"raw_orcid":"https://orcid.org/0000-0003-2555-2584","affiliations":[{"raw_affiliation_string":"JJM Medical College, Davanagere, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087585398","display_name":"Lyluma Ishfaq","orcid":"https://orcid.org/0009-0000-6879-6453","observed_orcids":["https://orcid.org/0009-0000-6879-6453"]},"institutions":[{"id":"https://openalex.org/I150956004","display_name":"Government Medical College","ror":"https://ror.org/00m4gxn44","country_code":"IN","type":"education","lineage":["https://openalex.org/I135388327","https://openalex.org/I150956004"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Lyluma Ishfaq","raw_affiliation_strings":["Government medical college, Srinagar, Directorate of health services Kashmir Srinagar, J&k , India"],"raw_orcid":"https://orcid.org/0009-0000-6879-6453","affiliations":[{"raw_affiliation_string":"Government medical college, Srinagar, Directorate of health services Kashmir Srinagar, J&k , India","institution_ids":["https://openalex.org/I150956004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092920806","display_name":"Berjis Rahmath","orcid":"https://orcid.org/0009-0007-9645-8516","observed_orcids":["https://orcid.org/0009-0007-9645-8516"]},"institutions":[{"id":"https://openalex.org/I99557698","display_name":"Osmania Medical College","ror":"https://ror.org/00hr54p22","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I99557698"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Berjis Rahmath","raw_affiliation_strings":["Osmania Medical College, Hyderabad, Telangana, India"],"raw_orcid":"https://orcid.org/0009-0007-9645-8516","affiliations":[{"raw_affiliation_string":"Osmania Medical College, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I99557698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092902015","display_name":"Navya Pillikunte Doddareddy","orcid":"https://orcid.org/0009-0003-3207-4995","observed_orcids":["https://orcid.org/0009-0003-3207-4995","https://orcid.org/0009-0000-7934-7178"]},"institutions":[{"id":"https://openalex.org/I876098953","display_name":"Bangalore Medical College and Research Institute","ror":"https://ror.org/05qmk4a18","country_code":"IN","type":"education","lineage":["https://openalex.org/I286135121","https://openalex.org/I876098953"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Navya Pillikunte Doddareddy","raw_affiliation_strings":["Bangalore medical college and research Institute, Bangalore, India"],"raw_orcid":"https://orcid.org/0009-0003-3207-4995","affiliations":[{"raw_affiliation_string":"Bangalore medical college and research Institute, Bangalore, India","institution_ids":["https://openalex.org/I876098953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092797055","display_name":"Mudit Moondra","orcid":"https://orcid.org/0009-0001-0060-1098","observed_orcids":["https://orcid.org/0009-0001-0060-1098"]},"institutions":[{"id":"https://openalex.org/I2803033815","display_name":"Rabindranath Tagore Medical College","ror":"https://ror.org/007r42p71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2803033815"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mudit Moondra","raw_affiliation_strings":["RNT medical College, Rajasthan, Udaipur, India"],"raw_orcid":"https://orcid.org/0009-0001-0060-1098","affiliations":[{"raw_affiliation_string":"RNT medical College, Rajasthan, Udaipur, India","institution_ids":["https://openalex.org/I2803033815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030947325","display_name":"Mihirkumar P Parmar","orcid":"https://orcid.org/0000-0002-5110-1544","observed_orcids":["https://orcid.org/0000-0002-5110-1544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mihirkumar P. Parmar","raw_affiliation_strings":["Gujarat Medical Education and Research Society, Vadnagar, India"],"raw_orcid":"https://orcid.org/0000-0002-5110-1544","affiliations":[{"raw_affiliation_string":"Gujarat Medical Education and Research Society, Vadnagar, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014820675","display_name":"Vishal Venugopal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vishal Venugopal","raw_affiliation_strings":["Bhaarath Medical College and Hospital, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bhaarath Medical College and Hospital, Chennai, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-low-back-pain","display_name":"chronic low back pain","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tanezumab","display_name":"tanezumab","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cox-2-inhibitors","display_name":"COX-2 inhibitors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":0.9710000157356262},{"id":"https://openalex.org/keywords/etoricoxib","display_name":"etoricoxib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/valdecoxib","display_name":"valdecoxib","score":0.9909999966621399},{"id":"https://openalex.org/keywords/aceclofenac","display_name":"aceclofenac","score":0.9639999866485596},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":1.0},{"id":"https://openalex.org/keywords/naproxen","display_name":"naproxen","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.7680000066757202},{"id":"https://openalex.org/keywords/osteoarthritis-risk","display_name":"osteoarthritis risk","score":0.8220000267028809},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.5948624610900879},{"id":"https://openalex.org/C2776501849","wikidata":"https://www.wikidata.org/wiki/Q5781808","display_name":"Back pain","level":3,"score":0.47623851895332336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4398556649684906},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.31487786769866943},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.30550646781921387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05142778158187866}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-3359390/v1","doi":"https://doi.org/10.21203/rs.3.rs-3359390/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3359390/v1","pdf_url":"https://www.researchsquare.com/article/rs-3359390/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3359390/v1","doi":"https://doi.org/10.21203/rs.3.rs-3359390/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-3359390/v1","pdf_url":"https://www.researchsquare.com/article/rs-3359390/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386950344.pdf","grobid_xml":"https://content.openalex.org/works/W4386950344.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2011186711","https://openalex.org/W2011536372","https://openalex.org/W2013218243","https://openalex.org/W2022654991","https://openalex.org/W2032692165","https://openalex.org/W2049593278","https://openalex.org/W2085726649","https://openalex.org/W2091349116","https://openalex.org/W2106755981","https://openalex.org/W2118847068","https://openalex.org/W2138854915","https://openalex.org/W2157229623","https://openalex.org/W2414370374","https://openalex.org/W2599109470","https://openalex.org/W2970684805","https://openalex.org/W3152547100","https://openalex.org/W4318831610"],"related_works":["https://openalex.org/W4413892729","https://openalex.org/W2271873799","https://openalex.org/W2160242243","https://openalex.org/W4246373534","https://openalex.org/W2049593278","https://openalex.org/W4312094113","https://openalex.org/W2625971035","https://openalex.org/W2807606603","https://openalex.org/W7215252289","https://openalex.org/W2091349116"],"abstract_inverted_index":{"Abstract":[0],"Chronic":[1],"back":[2,31,111,154,185,227],"pain":[3,112],"is":[4],"an":[5,119],"ailment":[6],"that":[7,98,137],"impacts":[8],"people":[9],"of":[10,20,55,68,82,88,103,124,151,208],"all":[11,21],"ages":[12],"and":[13,50,64,91,122,166,197,211,221],"lasts":[14],"longer":[15],"than":[16],"12":[17],"weeks.":[18],"7.41%":[19],"Years":[22],"Lost":[23],"to":[24,71,158,170,183,219],"Disability":[25],"(YLD)":[26],"are":[27],"associated":[28,176,200],"with":[29,109,177,189,201],"low":[30,153,226],"pain,":[32,186],"which":[33],"makes":[34],"it":[35],"the":[36,40,53,66,79,83,101,131,143,149,206],"pathology":[37],"responsible":[38],"for":[39,115,148,192],"most":[41,144],"YLD,":[42],"surpassing":[43],"other":[44],"chronic":[45,110,152,225],"conditions":[46],"such":[47,57,163,194],"as":[48,58,164,195],"Diabetes":[49],"Depression.":[51],"Despite":[52,205],"prevalence":[54],"drugs":[56,61,69],"nonsteroidal":[59],"anti-inflammatory":[60],"(NSAIDs),":[62],"painkillers,":[63],"biologics,":[65],"types":[67],"administered":[70],"individuals":[72],"differ":[73],"greatly.":[74],"We":[75],"collected":[76],"data":[77],"from":[78],"PubMed":[80,84],"database":[81],"database,":[85],"National":[86],"Library":[87],"Medicine":[89],"(NIH),":[90],"Google":[92],"Scholar.":[93],"Randomized":[94],"controlled":[95],"trials":[96],"(RCTs)":[97],"explicitly":[99],"evaluate":[100],"effectiveness":[102],"various":[104],"NSAIDs":[105],"in":[106,223],"adult":[107],"patients":[108],"were":[113,141,168,199],"selected":[114],"this":[116],"study.":[117],"After":[118],"exhaustive":[120],"search":[121],"examination":[123],"numerous":[125],"publications,":[126],"only":[127],"8":[128],"articles":[129],"met":[130],"inclusion":[132],"criteria.":[133],"In":[134,156,181],"recent":[135],"studies":[136],"included":[138],"NSAIDs,":[139],"they":[140],"among":[142],"frequently":[145],"prescribed":[146],"medications":[147],"treatment":[150],"pain.":[155,228],"comparison":[157],"placebo,":[159],"selective":[160],"COX-II":[161,187],"inhibitors":[162,188],"celecoxib":[165],"etoricoxib":[167],"found":[169],"be":[171,217],"efficacious,":[172],"while":[173],"valdecoxib":[174],"was":[175],"serious":[178],"side":[179,203],"effects.":[180,204],"addition":[182],"reducing":[184],"a":[190],"preference":[191],"COX-II,":[193],"aceclofenac":[196],"diclofenac,":[198],"gastrointestinal":[202],"risk":[207],"joint":[209],"degeneration":[210],"accelerated":[212],"osteoarthritis,":[213],"intravenous":[214],"tanezumab":[215],"may":[216],"superior":[218],"naproxen":[220],"placebo":[222],"treating":[224]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-23T00:00:00"}
