{"id":"https://openalex.org/W4386948049","doi":"https://doi.org/10.1016/j.ygyno.2023.06.190","title":"Trial in progress: A phase two trial of nirogacestat, a gamma-secretase inhibitor, in patients with recurrent ovarian granulosa cell tumors (NCT05348356) (1284)","display_name":"Trial in progress: A phase two trial of nirogacestat, a gamma-secretase inhibitor, in patients with recurrent ovarian granulosa cell tumors (NCT05348356) (1284)","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386948049","doi":"https://doi.org/10.1016/j.ygyno.2023.06.190"},"language":"en","primary_location":{"id":"doi:10.1016/j.ygyno.2023.06.190","doi":"https://doi.org/10.1016/j.ygyno.2023.06.190","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ygyno.2023.06.190","pdf_url":"http://www.gynecologiconcology-online.net/article/S0090825823009903/pdf","source":{"id":"https://openalex.org/S2574783","display_name":"Gynecologic Oncology","issn_l":"0090-8258","issn":["0090-8258","1095-6859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.gynecologiconcology-online.net/article/S0090825823009903/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076246054","display_name":"Panagiotis A. Konstantinopoulos","orcid":"https://orcid.org/0000-0002-1032-1479","observed_orcids":["https://orcid.org/0000-0002-1032-1479"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Panagiotis Konstantinopoulos","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, MA, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jocelyn Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272447","display_name":"SpringWorks Therapeutics (United States)","ror":"https://ror.org/0466xvm69","country_code":"US","type":"company","lineage":["https://openalex.org/I4405272447"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jocelyn Lewis","raw_affiliation_strings":["SpringWorks Therapeutics, Inc., Stamford, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SpringWorks Therapeutics, Inc., Stamford, CT, United States","institution_ids":["https://openalex.org/I4405272447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103495870","display_name":"Todd Shearer","orcid":"https://orcid.org/0009-0009-6106-2778","observed_orcids":["https://orcid.org/0009-0009-6106-2778"]},"institutions":[{"id":"https://openalex.org/I4405272447","display_name":"SpringWorks Therapeutics (United States)","ror":"https://ror.org/0466xvm69","country_code":"US","type":"company","lineage":["https://openalex.org/I4405272447"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Shearer","raw_affiliation_strings":["SpringWorks Therapeutics, Inc., Stamford, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SpringWorks Therapeutics, Inc., Stamford, CT, United States","institution_ids":["https://openalex.org/I4405272447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071162954","display_name":"Heather S. Kaiser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272447","display_name":"SpringWorks Therapeutics (United States)","ror":"https://ror.org/0466xvm69","country_code":"US","type":"company","lineage":["https://openalex.org/I4405272447"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Kaiser","raw_affiliation_strings":["SpringWorks Therapeutics, Inc., Stamford, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SpringWorks Therapeutics, Inc., Stamford, CT, United States","institution_ids":["https://openalex.org/I4405272447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033267651","display_name":"Caroline J. Breitbach","orcid":"https://orcid.org/0000-0002-5731-1163","observed_orcids":["https://orcid.org/0000-0002-5731-1163"]},"institutions":[{"id":"https://openalex.org/I4405272447","display_name":"SpringWorks Therapeutics (United States)","ror":"https://ror.org/0466xvm69","country_code":"US","type":"company","lineage":["https://openalex.org/I4405272447"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Breitbach","raw_affiliation_strings":["SpringWorks Therapeutics, Inc., Stamford, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SpringWorks Therapeutics, Inc., Stamford, CT, United States","institution_ids":["https://openalex.org/I4405272447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112509456","display_name":"Shinta Cheng","orcid":"https://orcid.org/0009-0005-4924-6567","observed_orcids":["https://orcid.org/0009-0005-4924-6567"]},"institutions":[{"id":"https://openalex.org/I4405272447","display_name":"SpringWorks Therapeutics (United States)","ror":"https://ror.org/0466xvm69","country_code":"US","type":"company","lineage":["https://openalex.org/I4405272447"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shinta Cheng","raw_affiliation_strings":["SpringWorks Therapeutics, Inc., Stamford, CT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SpringWorks Therapeutics, Inc., Stamford, CT, United States","institution_ids":["https://openalex.org/I4405272447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.7187,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.71413017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"176","issue":null,"first_page":"S177","last_page":"S178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-granulosa-cell-tumor","display_name":"ovarian granulosa cell tumor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/nirogacestat","display_name":"nirogacestat","score":0.9459999799728394},{"id":"https://openalex.org/keywords/gamma-secretase-inhibitors","display_name":"gamma-secretase inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/recurrent-ovarian-cancer","display_name":"recurrent ovarian cancer","score":0.7590000033378601},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/foxl2-mutation","display_name":"FOXL2 mutation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.675000011920929},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8230000138282776},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.7540000081062317},{"id":"https://openalex.org/keywords/sex-cord-stromal-tumors","display_name":"sex cord-stromal tumors","score":0.7649999856948853},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.5580000281333923},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8743242621421814},{"id":"https://openalex.org/C2778171954","wikidata":"https://www.wikidata.org/wiki/Q15328541","display_name":"Gamma secretase","level":2,"score":0.6525111198425293},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5163275599479675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44821399450302124},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.44215071201324463},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4108359217643738},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40768295526504517},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.34103190898895264},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08975118398666382},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.062376320362091064}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ygyno.2023.06.190","doi":"https://doi.org/10.1016/j.ygyno.2023.06.190","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ygyno.2023.06.190","pdf_url":"http://www.gynecologiconcology-online.net/article/S0090825823009903/pdf","source":{"id":"https://openalex.org/S2574783","display_name":"Gynecologic Oncology","issn_l":"0090-8258","issn":["0090-8258","1095-6859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ygyno.2023.06.190","doi":"https://doi.org/10.1016/j.ygyno.2023.06.190","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ygyno.2023.06.190","pdf_url":"http://www.gynecologiconcology-online.net/article/S0090825823009903/pdf","source":{"id":"https://openalex.org/S2574783","display_name":"Gynecologic Oncology","issn_l":"0090-8258","issn":["0090-8258","1095-6859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386948049.pdf","grobid_xml":"https://content.openalex.org/works/W4386948049.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7119925087","https://openalex.org/W4392369960","https://openalex.org/W2106883887","https://openalex.org/W2050677695","https://openalex.org/W2010521246","https://openalex.org/W2598181800","https://openalex.org/W2327605656","https://openalex.org/W4234390761","https://openalex.org/W1985034607","https://openalex.org/W2020718538"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-09-23T00:00:00"}
