{"id":"https://openalex.org/W4386945541","doi":"https://doi.org/10.1007/s00109-023-02369-6","title":"The role of LOXL2 induced by glucose metabolism-activated NF-\u03baB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC","display_name":"The role of LOXL2 induced by glucose metabolism-activated NF-\u03baB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC","publication_year":2023,"publication_date":"2023-09-22","ids":{"openalex":"https://openalex.org/W4386945541","doi":"https://doi.org/10.1007/s00109-023-02369-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/37737908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10663195"},"language":"en","primary_location":{"id":"doi:10.1007/s00109-023-02369-6","doi":"https://doi.org/10.1007/s00109-023-02369-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00109-023-02369-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00109-023-02369-6.pdf","source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00109-023-02369-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030664225","display_name":"Yun Sun Lee","orcid":"https://orcid.org/0000-0002-1474-564X","observed_orcids":["https://orcid.org/0000-0002-1474-564X"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun Sun Lee","raw_affiliation_strings":["Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102007392","display_name":"Hyung Sun Kim","orcid":"https://orcid.org/0000-0002-9002-3569","observed_orcids":["https://orcid.org/0000-0002-9002-3569"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung Sun Kim","raw_affiliation_strings":["Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100647369","display_name":"Hyo Jung Kim","orcid":"https://orcid.org/0000-0002-3514-1247","observed_orcids":["https://orcid.org/0000-0002-3514-1247"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyo Jung Kim","raw_affiliation_strings":["Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-3514-1247","affiliations":[{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038314704","display_name":"Hyeon Woong Kang","orcid":"https://orcid.org/0000-0002-7633-2373","observed_orcids":["https://orcid.org/0000-0002-7633-2373"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeon Woong Kang","raw_affiliation_strings":["Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea","Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028092876","display_name":"Da Eun Lee","orcid":"https://orcid.org/0009-0003-3612-7062","observed_orcids":["https://orcid.org/0009-0003-3612-7062"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Da Eun Lee","raw_affiliation_strings":["Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036060341","display_name":"Myeong\u2010Jin Kim","orcid":"https://orcid.org/0000-0001-7949-5402","observed_orcids":["https://orcid.org/0000-0001-7949-5402"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myeong Jin Kim","raw_affiliation_strings":["Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea","Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033673139","display_name":"Woosol Chris Hong","orcid":"https://orcid.org/0009-0005-8139-4017","observed_orcids":["https://orcid.org/0009-0005-8139-4017"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woosol Chris Hong","raw_affiliation_strings":["Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017609912","display_name":"Ju Hyun Kim","orcid":"https://orcid.org/0000-0003-4587-7714","observed_orcids":["https://orcid.org/0000-0003-4587-7714","https://orcid.org/0000-0002-4303-4759"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju Hyun Kim","raw_affiliation_strings":["Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362655","display_name":"Min\u2010Soo Kim","orcid":"https://orcid.org/0000-0001-8760-4568","observed_orcids":["https://orcid.org/0000-0001-8760-4568","https://orcid.org/0000-0001-9854-2999"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minsoo Kim","raw_affiliation_strings":["Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea","Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000246711","display_name":"Jae\u2010Ho Cheong","orcid":"https://orcid.org/0000-0002-1703-1781","observed_orcids":["https://orcid.org/0000-0002-1703-1781"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Ho Cheong","raw_affiliation_strings":["Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea","Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Science, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100715667","display_name":"Joon Seong Park","orcid":"https://orcid.org/0000-0001-8048-9990","observed_orcids":["https://orcid.org/0000-0001-8048-9990"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210144108","display_name":"Gangnam Severance Hospital","ror":"https://ror.org/04ajwkn20","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Joon Seong Park","raw_affiliation_strings":["Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. jspark330@yuhs.ac","Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. jspark330@yuhs.ac","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]},{"raw_affiliation_string":"Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100715667"],"corresponding_institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210144108","https://openalex.org/I4210160791"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":1.7722,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.86666222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"11","first_page":"1449","last_page":"1464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.06530000269412994,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loxl2","display_name":"LOXL2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gemcitabine-resistance","display_name":"gemcitabine resistance","score":0.972000002861023},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.6840000152587891},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9639999866485596},{"id":"https://openalex.org/keywords/zeb1","display_name":"ZEB1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.950323224067688},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8371556997299194},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6338952779769897},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5070979595184326},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5040146708488464},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4884573519229889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38392820954322815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3611275553703308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3265165686607361},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32520532608032227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3211439251899719}],"mesh":[{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00109-023-02369-6","doi":"https://doi.org/10.1007/s00109-023-02369-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00109-023-02369-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00109-023-02369-6.pdf","source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2699030/v1","doi":"https://doi.org/10.21203/rs.3.rs-2699030/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2699030/v1","pdf_url":"https://www.researchsquare.com/article/rs-2699030/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-2261076/v1","doi":"https://doi.org/10.21203/rs.3.rs-2261076/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2261076/v1","pdf_url":"https://www.researchsquare.com/article/rs-2261076/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10663195","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10663195","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10663195/pdf/109_2023_Article_2369.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Mol Med (Berl)","raw_type":"Text"},{"id":"pmid:37737908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37737908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular medicine (Berlin, Germany)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00109-023-02369-6","doi":"https://doi.org/10.1007/s00109-023-02369-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00109-023-02369-6","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00109-023-02369-6.pdf","source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G108406549","display_name":null,"funder_award_id":"20009773","funder_id":"https://openalex.org/F4320321681","funder_display_name":"Ministry of Trade, Industry and Energy"},{"id":"https://openalex.org/G3529947803","display_name":null,"funder_award_id":"6-2015-0093","funder_id":"https://openalex.org/F4320335295","funder_display_name":"Yonsei University College of Medicine"},{"id":"https://openalex.org/G4202805893","display_name":null,"funder_award_id":"2022R1A2C1091712","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G5334033487","display_name":null,"funder_award_id":"2022R1A2C1004141","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5353518422","display_name":null,"funder_award_id":"2022R1A2C1004141","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G6636847381","display_name":null,"funder_award_id":"NRF 2022R1A2C1004141","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7614859097","display_name":null,"funder_award_id":"NRF 2022R1A2C1004141","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G8244242800","display_name":null,"funder_award_id":"20009773","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320335295","display_name":"Yonsei University College of Medicine","ror":"https://ror.org/01wjejq96"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386945541.pdf","grobid_xml":"https://content.openalex.org/works/W4386945541.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W810966027","https://openalex.org/W1527742565","https://openalex.org/W1875789692","https://openalex.org/W1963832813","https://openalex.org/W1968812902","https://openalex.org/W1987539891","https://openalex.org/W1998432624","https://openalex.org/W2023529679","https://openalex.org/W2023620203","https://openalex.org/W2029000257","https://openalex.org/W2034269086","https://openalex.org/W2037961348","https://openalex.org/W2055677253","https://openalex.org/W2059022111","https://openalex.org/W2061797905","https://openalex.org/W2095287544","https://openalex.org/W2100751052","https://openalex.org/W2102619694","https://openalex.org/W2102734246","https://openalex.org/W2110015442","https://openalex.org/W2111895881","https://openalex.org/W2116764617","https://openalex.org/W2117692326","https://openalex.org/W2119638459","https://openalex.org/W2131170195","https://openalex.org/W2131719921","https://openalex.org/W2142459000","https://openalex.org/W2154790710","https://openalex.org/W2157923000","https://openalex.org/W2160697532","https://openalex.org/W2165480504","https://openalex.org/W2170551349","https://openalex.org/W2321472906","https://openalex.org/W2593027881","https://openalex.org/W2603930437","https://openalex.org/W2742005115","https://openalex.org/W2746697572","https://openalex.org/W2750171873","https://openalex.org/W2768730083","https://openalex.org/W2912022088","https://openalex.org/W2972602909","https://openalex.org/W2982076056","https://openalex.org/W2986789573","https://openalex.org/W3025505765","https://openalex.org/W3036204386","https://openalex.org/W3047367048","https://openalex.org/W3129199640","https://openalex.org/W3137719687","https://openalex.org/W3161782839","https://openalex.org/W3169226148","https://openalex.org/W3175570129","https://openalex.org/W3216981455","https://openalex.org/W4200455887","https://openalex.org/W4210976084","https://openalex.org/W4220919673","https://openalex.org/W6631539384"],"related_works":["https://openalex.org/W4309066128","https://openalex.org/W2032755814","https://openalex.org/W2621988934","https://openalex.org/W4289131088","https://openalex.org/W2021251343","https://openalex.org/W2899513798","https://openalex.org/W2316941743","https://openalex.org/W2594036641","https://openalex.org/W2064830801","https://openalex.org/W4283794334"],"abstract_inverted_index":{"Abstract":[0],"Gemcitabine":[1],"is":[2,30,37],"considered":[3],"a":[4,159],"standard":[5],"treatment":[6],"for":[7,162],"pancreatic":[8,34,75,83,143,168,194],"cancer,":[9],"but":[10],"developing":[11],"drug":[12,52],"resistance":[13,53,184],"greatly":[14],"limits":[15],"the":[16,22,47,59,65,100,113,124,148],"effectiveness":[17],"of":[18,24,49,61,67,102,115,126,141],"chemotherapy":[19],"and":[20,36,41,64,71,86,104,117,130,146,185],"increases":[21,147],"rate":[23],"recurrence.":[25],"Lysyl":[26],"oxide-like":[27],"2":[28],"(LOXL2)":[29],"highly":[31],"expressed":[32],"in":[33,39,51,73,81,152,166,181],"cancer":[35,84,127,144],"involved":[38],"carcinogenesis":[40],"EMT":[42,70,107],"regulation.":[43],"However,":[44],"studies":[45],"on":[46,69],"role":[48,180],"LOXL2":[50,62,68,103,121,137,164,175],"are":[54],"limited.":[55],"Here,":[56],"we":[57],"investigated":[58],"mechanism":[60,161],"induction":[63],"effect":[66],"CSC":[72],"gemcitabine-resistant":[74,82,142,167],"cancer.":[76,169,195],"Glucose":[77],"metabolism":[78],"was":[79,89,109],"activated":[80],"cells,":[85],"NF-\u03baB":[87,93],"signaling":[88,135],"regulated":[90],"accordingly.":[91],"Activated":[92],"directly":[94],"induces":[95],"transcription":[96],"by":[97,112,132],"binding":[98],"to":[99,150,192],"promoters":[101],"ZEB1.":[105],"The":[106],"process":[108],"significantly":[110],"inhibited":[111],"coregulation":[114],"ZEB1":[116],"LOXL2.":[118],"In":[119],"addition,":[120],"inhibition":[122],"reduced":[123],"expression":[125],"stemness":[128,131],"markers":[129],"regulating":[133],"MAPK":[134],"activity.":[136],"inhibits":[138],"tumor":[139],"growth":[140],"cells":[145],"sensitivity":[149],"gemcitabine":[151,183],"mouse":[153],"models.":[154],"Key":[155],"messages":[156],"We":[157],"identified":[158],"specific":[160],"inducing":[163],"overexpression":[165],"Taken":[170],"together,":[171],"our":[172],"results":[173],"suggest":[174],"has":[176],"an":[177,188],"important":[178],"regulatory":[179],"maintaining":[182],"may":[186],"be":[187],"effective":[189],"therapeutic":[190],"target":[191],"treat":[193]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-09-23T00:00:00"}
