{"id":"https://openalex.org/W4386933952","doi":"https://doi.org/10.3390/jcdd10090406","title":"The Role of Advanced Glycation End-Product Levels Measured by Skin Autofluorescence in the Development of Mitral Annular Calcification","display_name":"The Role of Advanced Glycation End-Product Levels Measured by Skin Autofluorescence in the Development of Mitral Annular Calcification","publication_year":2023,"publication_date":"2023-09-20","ids":{"openalex":"https://openalex.org/W4386933952","doi":"https://doi.org/10.3390/jcdd10090406","pmid":"https://pubmed.ncbi.nlm.nih.gov/37754835","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10531500"},"language":"en","primary_location":{"id":"doi:10.3390/jcdd10090406","doi":"https://doi.org/10.3390/jcdd10090406","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcdd10090406","pdf_url":"https://www.mdpi.com/2308-3425/10/9/406/pdf?version=1695280684","source":{"id":"https://openalex.org/S2738607712","display_name":"Journal of Cardiovascular Development and Disease","issn_l":"2308-3425","issn":["2308-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Development and Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2308-3425/10/9/406/pdf?version=1695280684","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027224551","display_name":"Bedrettin Boyraz","orcid":"https://orcid.org/0000-0003-1831-182X","observed_orcids":["https://orcid.org/0000-0003-1831-182X"]},"institutions":[{"id":"https://openalex.org/I4387154996","display_name":"Mudanya \u00dcniversitesi","ror":"https://ror.org/05khk0h97","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387154996"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Bedrettin Boyraz","raw_affiliation_strings":["Cardiology Department, Medicalpark Hospital, Health Science Faculty, Mudanya University, Bursa 16950, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-1831-182X","affiliations":[{"raw_affiliation_string":"Cardiology Department, Medicalpark Hospital, Health Science Faculty, Mudanya University, Bursa 16950, Turkey","institution_ids":["https://openalex.org/I4387154996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039138333","display_name":"Tezcan Peker","orcid":"https://orcid.org/0000-0002-2489-5430","observed_orcids":["https://orcid.org/0000-0002-2489-5430"]},"institutions":[{"id":"https://openalex.org/I4387154996","display_name":"Mudanya \u00dcniversitesi","ror":"https://ror.org/05khk0h97","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387154996"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tezcan Peker","raw_affiliation_strings":["Cardiology Department, Medicalpark Hospital, Health Science Faculty, Mudanya University, Bursa 16950, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Medicalpark Hospital, Health Science Faculty, Mudanya University, Bursa 16950, Turkey","institution_ids":["https://openalex.org/I4387154996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027224551"],"corresponding_institution_ids":["https://openalex.org/I4387154996"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2224},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2224},"fwci":0.2001,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37168142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"9","first_page":"406","last_page":"406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.8672000169754028,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.8672000169754028,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.1251000016927719,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitral-annular-calcification","display_name":"mitral annular calcification","score":0.925000011920929},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9639999866485596},{"id":"https://openalex.org/keywords/skin-autofluorescence","display_name":"skin autofluorescence","score":0.9990000128746033},{"id":"https://openalex.org/keywords/age-receptor","display_name":"AGE receptor","score":0.6990000009536743},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9259999990463257},{"id":"https://openalex.org/keywords/degenerative-aortic-valve-disease","display_name":"degenerative aortic valve disease","score":0.7070000171661377},{"id":"https://openalex.org/keywords/risk-prediction","display_name":"risk prediction","score":0.6029999852180481},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.7799999713897705},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C2776997535","wikidata":"https://www.wikidata.org/wiki/Q2556837","display_name":"Advanced glycation end-product","level":4,"score":0.8155626654624939},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.7803270816802979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7166986465454102},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6613146066665649},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6171690821647644},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.5981205701828003},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5357799530029297},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.498706579208374},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.46628403663635254},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.44247251749038696},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4388885498046875},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4102003574371338},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35724467039108276},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3357480764389038},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2990546226501465}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jcdd10090406","doi":"https://doi.org/10.3390/jcdd10090406","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcdd10090406","pdf_url":"https://www.mdpi.com/2308-3425/10/9/406/pdf?version=1695280684","source":{"id":"https://openalex.org/S2738607712","display_name":"Journal of Cardiovascular Development and Disease","issn_l":"2308-3425","issn":["2308-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Development and Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10531500","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10531500","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10531500/pdf/jcdd-10-00406.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cardiovasc Dev Dis","raw_type":"Text"},{"id":"pmid:37754835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37754835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular development and disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d9664da162a64f668358bb06c7185b51","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d9664da162a64f668358bb06c7185b51","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cardiovascular Development and Disease, Vol 10, Iss 9, p 406 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/jcdd10090406","doi":"https://doi.org/10.3390/jcdd10090406","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcdd10090406","pdf_url":"https://www.mdpi.com/2308-3425/10/9/406/pdf?version=1695280684","source":{"id":"https://openalex.org/S2738607712","display_name":"Journal of Cardiovascular Development and Disease","issn_l":"2308-3425","issn":["2308-3425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Development and Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386933952.pdf","grobid_xml":"https://content.openalex.org/works/W4386933952.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1973039380","https://openalex.org/W1982711845","https://openalex.org/W2008586394","https://openalex.org/W2013231030","https://openalex.org/W2017666880","https://openalex.org/W2017992093","https://openalex.org/W2041678308","https://openalex.org/W2058016077","https://openalex.org/W2070168725","https://openalex.org/W2070558810","https://openalex.org/W2098933502","https://openalex.org/W2102106421","https://openalex.org/W2107243407","https://openalex.org/W2108858561","https://openalex.org/W2112124628","https://openalex.org/W2125187806","https://openalex.org/W2157177024","https://openalex.org/W2159602704","https://openalex.org/W2172703205","https://openalex.org/W2559774877","https://openalex.org/W2808573490","https://openalex.org/W2911597488","https://openalex.org/W2912503275","https://openalex.org/W2953613525","https://openalex.org/W2966307444","https://openalex.org/W3004876838","https://openalex.org/W3009862485","https://openalex.org/W3011349816","https://openalex.org/W3028169423","https://openalex.org/W3034860513","https://openalex.org/W3083828841","https://openalex.org/W3178270230","https://openalex.org/W3206509633","https://openalex.org/W3210413281","https://openalex.org/W4205656213","https://openalex.org/W4210581071","https://openalex.org/W4288081280","https://openalex.org/W4293149759","https://openalex.org/W4296241715"],"related_works":["https://openalex.org/W2296037171","https://openalex.org/W2006724072","https://openalex.org/W4210603686","https://openalex.org/W4379791608","https://openalex.org/W4389944977","https://openalex.org/W2267757028","https://openalex.org/W2141553045","https://openalex.org/W4410330739","https://openalex.org/W2726290504","https://openalex.org/W7207642259"],"abstract_inverted_index":{"As":[0],"a":[1,85,144,156,167],"person":[2],"ages,":[3],"mitral":[4,10],"annular":[5],"calcification":[6],"develops":[7],"in":[8,42,70,120,143],"the":[9,46,53,63,104,111,121,159],"annulus":[11],"with":[12],"increasing":[13,52],"frequency.":[14],"Lipid":[15],"deposition,":[16],"inflammation,":[17],"and":[18,50,74,92,100,108,174,187],"aging-related":[19],"degeneration":[20],"have":[21],"been":[22],"cited":[23],"as":[24,84,136],"potential":[25],"causes":[26],"of":[27,48,55,103,140,170,193],"this":[28],"pathophysiology,":[29],"though":[30],"there":[31],"is":[32],"currently":[33],"no":[34],"conclusive":[35],"evidence":[36],"to":[37,45,59,184],"support":[38],"this.":[39],"AGEs":[40],"accumulate":[41],"tissues":[43],"due":[44],"glycation":[47],"proteins":[49],"lipids,":[51],"release":[54],"proinflammatory":[56],"cytokines":[57],"secondary":[58],"oxidative":[60],"stress":[61],"through":[62],"AGE":[64,67,101,115,132,179],"receptor.":[65],"The":[66,96,131],"levels":[68,102,116,133,180],"increase":[69],"diabetic":[71],"microvascular":[72],"complications":[73],"degenerative":[75],"aortic":[76],"valve":[77],"disease.":[78],"Our":[79],"study":[80,87],"was":[81,161],"planned":[82],"prospectively":[83],"case\u2013control":[86],"involving":[88],"94":[89,93],"MAC-positive":[90,122],"patients":[91,105,190],"MAC-negative":[94],"patients.":[95],"demographics,":[97],"echocardiographic":[98],"data":[99],"were":[106,117,134,177],"measured":[107],"recorded":[109],"using":[110],"skin":[112],"autofluorescence":[113],"method.":[114],"significantly":[118],"higher":[119],"patient":[123],"group":[124],"(3.2":[125],"vs.":[126],"2.7;":[127],"p":[128,152],"<":[129,153],"0.001).":[130,154],"observed":[135],"an":[137],"independent":[138],"predictor":[139],"MAC":[141],"development":[142],"regression":[145],"analysis":[146],"(OR:":[147],"8.05,":[148],"95%":[149],"CI:":[150,164],"3.74\u201317.33,":[151],"In":[155],"ROC-curve":[157],"analysis,":[158],"AUC":[160],"0.79":[162],"(95%":[163],"0.72\u20130.85).":[165],"At":[166],"cut-off":[168],"value":[169],"2.7,":[171],"79.7%":[172],"sensitivity":[173],"69.1%":[175],"specificity":[176],"observed.":[178],"can":[181],"be":[182],"used":[183],"cheaply,":[185],"easily":[186],"non-invasively":[188],"identify":[189],"at":[191],"risk":[192],"developing":[194],"MAC.":[195]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-09-22T00:00:00"}
