{"id":"https://openalex.org/W4386924185","doi":"https://doi.org/10.1186/s12951-023-02098-5","title":"Hypoxic mesenchymal stem cell-derived exosomes promote the survival of skin flaps after ischaemia\u2013reperfusion injury via mTOR/ULK1/FUNDC1 pathways","display_name":"Hypoxic mesenchymal stem cell-derived exosomes promote the survival of skin flaps after ischaemia\u2013reperfusion injury via mTOR/ULK1/FUNDC1 pathways","publication_year":2023,"publication_date":"2023-09-21","ids":{"openalex":"https://openalex.org/W4386924185","doi":"https://doi.org/10.1186/s12951-023-02098-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/37735391","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10514998"},"language":"en","primary_location":{"id":"doi:10.1186/s12951-023-02098-5","doi":"https://doi.org/10.1186/s12951-023-02098-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-023-02098-5","pdf_url":"https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-023-02098-5","source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-023-02098-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100686896","display_name":"Chao Deng","orcid":"https://orcid.org/0009-0006-0435-3980","observed_orcids":["https://orcid.org/0009-0006-0435-3980"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Deng","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kangkang Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kangkang Dong","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100712534","display_name":"Yong-Jun Liu","orcid":"https://orcid.org/0000-0002-6709-5951","observed_orcids":["https://orcid.org/0000-0002-6709-5951"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongjun Liu","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420347","display_name":"Ken Chen","orcid":"https://orcid.org/0000-0003-4013-5279","observed_orcids":["https://orcid.org/0000-0003-4013-5279"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ken Chen","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113005535","display_name":"Chuwei Min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuwei Min","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086159090","display_name":"Zheming Cao","orcid":"https://orcid.org/0000-0002-9610-305X","observed_orcids":["https://orcid.org/0000-0002-9610-305X"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheming Cao","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006157945","display_name":"Panfeng Wu","orcid":"https://orcid.org/0000-0003-1106-4045","observed_orcids":["https://orcid.org/0000-0003-1106-4045"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panfeng Wu","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039143977","display_name":"Gaojie Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaojie Luo","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051028973","display_name":"Gechang Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gechang Cheng","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026473596","display_name":"Liming Qing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liming Qing","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China. qingliming0338@163.com","Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China. qingliming0338@163.com","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110988426","display_name":"Juyu Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juyu Tang","raw_affiliation_strings":["Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China. tangjuyu@csu.edu.cn","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, China. tangjuyu@csu.edu.cn","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China. tangjuyu@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, China. tangjuyu@csu.edu.cn","institution_ids":["https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026473596","https://openalex.org/A5110988426"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":3.7234,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.95610545,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"340","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10599","display_name":"Reconstructive Surgery and Microvascular Techniques","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cell-derived-exosomes","display_name":"mesenchymal stem cell-derived exosomes","score":0.902999997138977},{"id":"https://openalex.org/keywords/hypoxic-preconditioning","display_name":"hypoxic preconditioning","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8579999804496765},{"id":"https://openalex.org/keywords/skin-flap-necrosis","display_name":"skin flap necrosis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/flap-survival","display_name":"flap survival","score":0.925000011920929},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8479999899864197},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7860000133514404},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.5580000281333923},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.7929580211639404},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.67885422706604},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5952391624450684},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.47404003143310547},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4326780438423157},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42173531651496887},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3694666028022766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3488598167896271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23974719643592834},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20741376280784607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1214110255241394},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.09828346967697144},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071189","descriptor_name":"Autophagy-Related Protein-1 Homolog","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12951-023-02098-5","doi":"https://doi.org/10.1186/s12951-023-02098-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-023-02098-5","pdf_url":"https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-023-02098-5","source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10514998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10514998","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10514998/pdf/12951_2023_Article_2098.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nanobiotechnology","raw_type":"Text"},{"id":"pmid:37735391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37735391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nanobiotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c9f4a923a52d4313a4e1a8357780a758","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c9f4a923a52d4313a4e1a8357780a758","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-23 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12951-023-02098-5","doi":"https://doi.org/10.1186/s12951-023-02098-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-023-02098-5","pdf_url":"https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-023-02098-5","source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1339161852","display_name":null,"funder_award_id":"81901978","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3460544264","display_name":null,"funder_award_id":"81871577","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4094640588","display_name":null,"funder_award_id":"82272508","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8919876645","display_name":null,"funder_award_id":"82072194","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386924185.pdf","grobid_xml":"https://content.openalex.org/works/W4386924185.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1499298071","https://openalex.org/W1523693806","https://openalex.org/W1553793487","https://openalex.org/W1584433563","https://openalex.org/W1952596824","https://openalex.org/W1966804724","https://openalex.org/W1976512976","https://openalex.org/W1990728465","https://openalex.org/W1994823455","https://openalex.org/W2024234833","https://openalex.org/W2038976751","https://openalex.org/W2052853635","https://openalex.org/W2056504998","https://openalex.org/W2070536046","https://openalex.org/W2073654090","https://openalex.org/W2076252412","https://openalex.org/W2079355772","https://openalex.org/W2082796078","https://openalex.org/W2112795897","https://openalex.org/W2144059623","https://openalex.org/W2149447394","https://openalex.org/W2160666689","https://openalex.org/W2164945122","https://openalex.org/W2345721849","https://openalex.org/W2371948111","https://openalex.org/W2558389982","https://openalex.org/W2581455542","https://openalex.org/W2603979534","https://openalex.org/W2608333216","https://openalex.org/W2786184869","https://openalex.org/W2802344499","https://openalex.org/W2808911710","https://openalex.org/W2900756811","https://openalex.org/W2903201035","https://openalex.org/W2906694638","https://openalex.org/W2912418307","https://openalex.org/W2935822819","https://openalex.org/W2944806358","https://openalex.org/W2946181872","https://openalex.org/W2970264099","https://openalex.org/W2990308001","https://openalex.org/W2996134710","https://openalex.org/W3013608179","https://openalex.org/W3027716168","https://openalex.org/W3042195964","https://openalex.org/W3048927596","https://openalex.org/W3092969909","https://openalex.org/W3095604405","https://openalex.org/W3102011730","https://openalex.org/W3108936441","https://openalex.org/W3119766279","https://openalex.org/W3135459743","https://openalex.org/W3149067652","https://openalex.org/W3162279108","https://openalex.org/W3170875479","https://openalex.org/W3209175961","https://openalex.org/W3215977515","https://openalex.org/W4200135443","https://openalex.org/W4214924704","https://openalex.org/W4220938112","https://openalex.org/W4249579699","https://openalex.org/W4281395816","https://openalex.org/W4283368520","https://openalex.org/W4283828180","https://openalex.org/W4288884742","https://openalex.org/W4303945917"],"related_works":["https://openalex.org/W2797694909","https://openalex.org/W4303945917","https://openalex.org/W4390349692","https://openalex.org/W4296551008","https://openalex.org/W4403815957","https://openalex.org/W2184551308","https://openalex.org/W7117451550","https://openalex.org/W2022988379","https://openalex.org/W2996134710","https://openalex.org/W7162239052"],"abstract_inverted_index":{"Abstract":[0],"Flap":[1],"necrosis,":[2],"the":[3,61,69,72,164,176,194,215,239,246],"most":[4],"prevalent":[5],"postoperative":[6],"complication":[7],"of":[8,64,75,178,196,206,217,242,248],"reconstructive":[9],"surgery,":[10],"is":[11],"significantly":[12,114],"associated":[13],"with":[14],"ischaemia\u2013reperfusion":[15,79,125,147,197,250],"injury.":[16,251],"Recent":[17],"research":[18],"indicates":[19],"that":[20,46,109,138],"exosomes":[21,77,110,244],"derived":[22],"from":[23,48,111,146],"bone":[24],"marrow":[25],"mesenchymal":[26],"stem":[27],"cells":[28,145],"(BMSCs)":[29],"hold":[30],"potential":[31],"therapeutic":[32,240],"applications":[33],"in":[34,53,78,124,150,153,245],"several":[35,179],"diseases.":[36],"Traditionally,":[37],"BMSCs":[38,113],"are":[39],"cultured":[40],"under":[41],"normoxic":[42,172],"conditions,":[43],"a":[44,58,85,189],"setting":[45],"diverges":[47],"their":[49,76],"physiological":[50],"hypoxic":[51,62,229],"environment":[52],"vivo.":[54],"Consequently,":[55],"we":[56,161],"propose":[57],"method":[59,236],"involving":[60],"preconditioning":[63,230],"BMSCs,":[65],"aimed":[66],"at":[67],"exploring":[68],"function":[70],"and":[71,97,121,128,133,152,158,171,183,210,220,222,234],"specific":[73],"mechanisms":[74],"skin":[80,94],"flaps.":[81,199],"This":[82,200],"study":[83],"constructed":[84],"3":[86],"\u00d7":[87],"6":[88,104],"cm":[89],"2":[90],"caudal":[91],"superficial":[92],"epigastric":[93],"flap":[95,116,249],"model":[96],"subjected":[98],"it":[99],"to":[100,142],"ischaemic":[101],"conditions":[102],"for":[103,237],"h.":[105],"Our":[106],"findings":[107],"reveal":[108],"hypoxia-pretreated":[112],"promoted":[115],"survival,":[117],"decrease":[118],"MCP-1,":[119],"IL-1\u03b2,":[120],"IL-6":[122],"levels":[123],"injured":[126,198],"flap,":[127],"reduce":[129],"oxidative":[130],"stress":[131],"injury":[132,148],"apoptosis.":[134],"Moreover,":[135],"results":[136],"indicated":[137],"Hypo-Exo":[139,170,192],"provides":[140],"protection":[141],"vascular":[143],"endothelial":[144],"both":[149],"vivo":[151],"vitro.":[154],"Through":[155],"high-throughput":[156],"sequencing":[157],"bioinformatics":[159],"analysis,":[160],"further":[162,224],"compared":[163],"differential":[165],"miRNA":[166],"expression":[167,216],"profiles":[168],"between":[169],"exosomes.":[173],"Results":[174],"display":[175],"enrichment":[177],"pathways,":[180],"including":[181],"autophagy":[182],"mTOR.":[184],"We":[185],"have":[186],"also":[187],"elucidated":[188],"mechanism":[190,201],"wherein":[191],"promotes":[193],"survival":[195],"involves":[202],"carrying":[203],"large":[204],"amounts":[205],"miR-421-3p,":[207],"which":[208],"target":[209],"regulate":[211],"mTOR,":[212],"thereby":[213],"upregulating":[214],"phosphorylated":[218],"ULK1":[219],"FUNDC1,":[221],"subsequently":[223],"activating":[225],"autophagy.":[226],"In":[227],"summary,":[228],"constitutes":[231],"an":[232],"effective":[233],"promising":[235],"optimizing":[238],"effects":[241],"BMSC-derived":[243],"treatment":[247]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-09-22T00:00:00"}