{"id":"https://openalex.org/W4386901936","doi":"https://doi.org/10.4103/ijciis.ijciis_14_23","title":"What is the right gentamicin dose for multiple trauma patients? A Monte Carlo simulation exploration study","display_name":"What is the right gentamicin dose for multiple trauma patients? A Monte Carlo simulation exploration study","publication_year":2023,"publication_date":"2023-07-01","ids":{"openalex":"https://openalex.org/W4386901936","doi":"https://doi.org/10.4103/ijciis.ijciis_14_23","pmid":"https://pubmed.ncbi.nlm.nih.gov/38023581","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10664035"},"language":"en","primary_location":{"id":"doi:10.4103/ijciis.ijciis_14_23","doi":"https://doi.org/10.4103/ijciis.ijciis_14_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijciis.ijciis_14_23","pdf_url":null,"source":{"id":"https://openalex.org/S2764375788","display_name":"International Journal of Critical Illness and Injury Science","issn_l":"2229-5151","issn":["2229-5151","2231-5004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Critical Illness and Injury Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4103/ijciis.ijciis_14_23","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112864208","display_name":"Mohammad Yaseen Abbasi","orcid":"https://orcid.org/0000-0002-2083-8084","observed_orcids":["https://orcid.org/0000-0002-2083-8084"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Mohammad Yaseen Abbasi","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince Songkla University, Hat Yai, Songkhla, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince Songkla University, Hat Yai, Songkhla, Thailand","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060198581","display_name":"Kamonthip Wiwattanawongsa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kamonthip Wiwattanawongsa","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince Songkla University, Hat Yai, Songkhla, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince Songkla University, Hat Yai, Songkhla, Thailand","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013396055","display_name":"Weerachai Chaijamorn","orcid":"https://orcid.org/0000-0003-3781-5062","observed_orcids":["https://orcid.org/0000-0003-3781-5062"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Weerachai Chaijamorn","raw_affiliation_strings":["Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathum Wan, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathum Wan, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014178126","display_name":"Taniya Charoensareerat","orcid":"https://orcid.org/0000-0002-1100-2162","observed_orcids":["https://orcid.org/0000-0002-1100-2162"]},"institutions":[{"id":"https://openalex.org/I114432228","display_name":"Siam University","ror":"https://ror.org/04j3saz95","country_code":"TH","type":"education","lineage":["https://openalex.org/I114432228"]},{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Taniya Charoensareerat","raw_affiliation_strings":["Faculty of Pharmacy, Siam University, Bangwa, Pasicharoen, Bangkok, Thailand","Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince Songkla University, Hat Yai, Songkhla, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Siam University, Bangwa, Pasicharoen, Bangkok, Thailand","institution_ids":["https://openalex.org/I114432228"]},{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince Songkla University, Hat Yai, Songkhla, Thailand","institution_ids":["https://openalex.org/I131868736"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057341590","display_name":"Thitima Doungngern","orcid":"https://orcid.org/0000-0002-4281-6476","observed_orcids":["https://orcid.org/0000-0002-4281-6476"]},"institutions":[{"id":"https://openalex.org/I131868736","display_name":"Prince of Songkla University","ror":"https://ror.org/0575ycz84","country_code":"TH","type":"education","lineage":["https://openalex.org/I131868736"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Thitima Doungngern","raw_affiliation_strings":["Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince Songkla University, Hat Yai, Songkhla, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince Songkla University, Hat Yai, Songkhla, Thailand","institution_ids":["https://openalex.org/I131868736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057341590"],"corresponding_institution_ids":["https://openalex.org/I131868736"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15028787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"3","first_page":"118","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11080","display_name":"Surgical site infection prevention","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dose-optimization","display_name":"dose optimization","score":0.7279999852180481},{"id":"https://openalex.org/keywords/polytrauma","display_name":"polytrauma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/infection-control","display_name":"infection control","score":0.5720000267028809},{"id":"https://openalex.org/keywords/gram-negative-infections","display_name":"gram-negative bacterial infection","score":0.7990000247955322},{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-targets","display_name":"pharmacokinetic/pharmacodynamic targets","score":0.7979999780654907},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.718999981880188},{"id":"https://openalex.org/keywords/trauma-patients","display_name":"trauma patients","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.9365931749343872},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.886612594127655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8660427927970886},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6471057534217834},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.6439933776855469},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6003478765487671},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.5828224420547485},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4575783610343933},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4159674346446991},{"id":"https://openalex.org/C192670549","wikidata":"https://www.wikidata.org/wiki/Q5361061","display_name":"Elimination rate constant","level":4,"score":0.41231730580329895},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4103242754936218},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33780616521835327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2761930525302887},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2377053201198578},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.07637766003608704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0681162178516388},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.05289599299430847}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4103/ijciis.ijciis_14_23","doi":"https://doi.org/10.4103/ijciis.ijciis_14_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijciis.ijciis_14_23","pdf_url":null,"source":{"id":"https://openalex.org/S2764375788","display_name":"International Journal of Critical Illness and Injury Science","issn_l":"2229-5151","issn":["2229-5151","2231-5004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Critical Illness and Injury Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10664035","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10664035","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Crit Illn Inj Sci","raw_type":"Text"},{"id":"pmid:38023581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38023581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of critical illness and injury science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4103/ijciis.ijciis_14_23","doi":"https://doi.org/10.4103/ijciis.ijciis_14_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijciis.ijciis_14_23","pdf_url":null,"source":{"id":"https://openalex.org/S2764375788","display_name":"International Journal of Critical Illness and Injury Science","issn_l":"2229-5151","issn":["2229-5151","2231-5004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Critical Illness and Injury Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1632966311","https://openalex.org/W1760819893","https://openalex.org/W1983789514","https://openalex.org/W1984838924","https://openalex.org/W1988855414","https://openalex.org/W2004026051","https://openalex.org/W2005795932","https://openalex.org/W2033315842","https://openalex.org/W2048706332","https://openalex.org/W2097945561","https://openalex.org/W2115565824","https://openalex.org/W2144999694","https://openalex.org/W2153615679","https://openalex.org/W2158889234","https://openalex.org/W2179850291","https://openalex.org/W2263006604","https://openalex.org/W2323846580","https://openalex.org/W2325940634","https://openalex.org/W2337641841","https://openalex.org/W2397330844","https://openalex.org/W2550868400","https://openalex.org/W2620127262","https://openalex.org/W2754662782","https://openalex.org/W2885745171","https://openalex.org/W2900159876","https://openalex.org/W3022327571","https://openalex.org/W3092783549","https://openalex.org/W4243622919","https://openalex.org/W4249712200","https://openalex.org/W4283592562"],"related_works":["https://openalex.org/W4383216099","https://openalex.org/W2804378440","https://openalex.org/W3025152220","https://openalex.org/W4229022670","https://openalex.org/W4367060740","https://openalex.org/W4206422333","https://openalex.org/W2415101280","https://openalex.org/W2785973099","https://openalex.org/W2070046316","https://openalex.org/W2536618917"],"abstract_inverted_index":{"Background:":[0],"The":[1,13,58,65,108,119,140,182],"appropriate":[2],"dose":[3,20,121,143,158],"of":[4,21,27,42,103,110,122,135,159,184,193,204],"gentamicin":[5,22,43,123,142,160,191,202],"is":[6],"important":[7],"to":[8,16,23,50,73,95,144,162,209,231],"prevent":[9,145,210],"and":[10,33,132],"treat":[11],"infections.":[12,225],"study":[14],"aimed":[15],"determine":[17],"the":[18,25,69,74,84,91,101,113,127,133,148,168,176],"optimal":[19,120,141],"achieve":[24],"probability":[26,183],"pharmacokinetic/pharmacodynamic":[28],"(PK)":[29],"targets":[30],"for":[31,56,83,100,170,196,223],"efficacy":[32,128],"safety":[34],"in":[35,44,212],"multiple":[36,45,215],"trauma":[37,46],"patients.":[38],"Methods:":[39],"PK":[40,54],"parameters":[41],"patients":[47,213],"were":[48],"gathered":[49],"develop":[51],"a":[52],"one-compartment":[53],"model":[55],"prediction.":[57],"Monte":[59],"Carlo":[60],"simulation":[61],"method":[62],"was":[63,81,99,112,124,130,137,150,153,179,186],"performed.":[64],"24-h":[66],"area":[67],"under":[68],"concentration":[70,77,94,116],"time":[71],"curve":[72],"minimum":[75,114],"inhibitory":[76],"ratio":[78,97],"(AUC24h/MIC)":[79],"\u226550":[80],"defined":[82],"infection":[85,106,146,174],"prevention":[86],"target.":[87,107],"AUC24h/MIC":[88],"\u2265110":[89],"or":[90],"maximum":[92],"serum":[93,115],"MIC":[96,149,178],"\u22658-10":[98],"treatment":[102],"serious":[104,172,224],"Gram-negative":[105,173],"risk":[109,134],"nephrotoxicity":[111,136,185],"\u22652":[117],"mg/L.":[118,181],"determined":[125],"when":[126,147,175],"target":[129,169],">90%":[131],"lowest.":[138],"Results:":[139],"<1":[151],"mg/L":[152],"6-7":[154,205],"mg/kg/day.":[155],"A":[156],"higher":[157],"up":[161],"10":[163],"mg/kg/day":[164,195],"could":[165,219],"not":[166,220],"reach":[167],"treating":[171],"expected":[177],"\u22651":[180],"minimal":[187],"at":[188],"0.2-4%":[189],"with":[190,214],"doses":[192,203],"5-10":[194],"3":[197],"days.":[198],"Conclusions:":[199],"Once":[200],"daily":[201],"mg/kg":[206],"are":[207,229],"recommended":[208,222],"infections":[211],"trauma.":[216],"Gentamicin":[217],"monotherapy":[218],"be":[221],"Further":[226],"clinical":[227],"studies":[228],"required":[230],"confirm":[232],"our":[233],"results.":[234]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-21T00:00:00"}