{"id":"https://openalex.org/W4386891196","doi":"https://doi.org/10.1038/s41422-023-00877-1","title":"Learning human liver biology in humanized mice","display_name":"Learning human liver biology in humanized mice","publication_year":2023,"publication_date":"2023-09-20","ids":{"openalex":"https://openalex.org/W4386891196","doi":"https://doi.org/10.1038/s41422-023-00877-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/37730939","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10770126"},"language":"en","primary_location":{"id":"doi:10.1038/s41422-023-00877-1","doi":"https://doi.org/10.1038/s41422-023-00877-1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41422-023-00877-1","pdf_url":"https://www.nature.com/articles/s41422-023-00877-1.pdf","source":{"id":"https://openalex.org/S128296271","display_name":"Cell Research","issn_l":"1001-0602","issn":["1001-0602","1748-7838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/s41422-023-00877-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024763403","display_name":"Brandon M. Lehrich","orcid":"https://orcid.org/0000-0003-1003-5605","observed_orcids":["https://orcid.org/0000-0003-1003-5605"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon M. Lehrich","raw_affiliation_strings":["Division of Experimental Pathology, Department of Pathology and Pittsburgh Liver Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Pathology, Department of Pathology and Pittsburgh Liver Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045031054","display_name":"Satdarshan P. Monga","orcid":"https://orcid.org/0000-0002-8437-3378","observed_orcids":["https://orcid.org/0000-0002-8437-3378"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Satdarshan P. Monga","raw_affiliation_strings":["Division of Experimental Pathology, Department of Pathology and Pittsburgh Liver Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu","Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu"],"raw_orcid":"https://orcid.org/0000-0002-8437-3378","affiliations":[{"raw_affiliation_string":"Division of Experimental Pathology, Department of Pathology and Pittsburgh Liver Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045031054"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.1243,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.38827216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"34","issue":"1","first_page":"9","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.02539999969303608,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.8650000095367432},{"id":"https://openalex.org/keywords/human-hepatocytes","display_name":"human hepatocytes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hepatocyte-metabolism","display_name":"hepatocyte metabolism","score":0.7360000014305115},{"id":"https://openalex.org/keywords/wnt2","display_name":"Wnt2","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sinusoidal-endothelial-cells","display_name":"sinusoidal endothelial cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/liver-microenvironment","display_name":"liver microenvironment","score":0.8320000171661377},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.6903053522109985},{"id":"https://openalex.org/C2776418720","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Human liver","level":3,"score":0.5644858479499817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45381420850753784},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4415455460548401},{"id":"https://openalex.org/C84084929","wikidata":"https://www.wikidata.org/wiki/Q339557","display_name":"Human biology","level":2,"score":0.4235241711139679},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.2218778133392334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12810230255126953},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.07603123784065247},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001695","descriptor_name":"Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41422-023-00877-1","doi":"https://doi.org/10.1038/s41422-023-00877-1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41422-023-00877-1","pdf_url":"https://www.nature.com/articles/s41422-023-00877-1.pdf","source":{"id":"https://openalex.org/S128296271","display_name":"Cell Research","issn_l":"1001-0602","issn":["1001-0602","1748-7838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10770126","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10770126","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10770126/pdf/41422_2023_Article_877.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Res","raw_type":"Text"},{"id":"pmid:37730939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37730939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41422-023-00877-1","doi":"https://doi.org/10.1038/s41422-023-00877-1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1038/s41422-023-00877-1","pdf_url":"https://www.nature.com/articles/s41422-023-00877-1.pdf","source":{"id":"https://openalex.org/S128296271","display_name":"Cell Research","issn_l":"1001-0602","issn":["1001-0602","1748-7838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1819063596","display_name":null,"funder_award_id":"F30CA284540","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8023790824","display_name":null,"funder_award_id":"R01DK62277","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8374299162","display_name":"Cellular Approaches to Tissue Engineering and Regeneration","funder_award_id":"T32EB001026","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000893816","display_name":"Investigating Immunosuppression in Beta-catenin-mutated Hepatocellular Carcinoma for Improved Precision Medicine Therapeutics","funder_award_id":"F30CA284540","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000914368","display_name":"Role of Wnt-Beta-catenin in liver development and metabolic zonation","funder_award_id":"R01DK062277","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386891196.pdf","grobid_xml":"https://content.openalex.org/works/W4386891196.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1976490723","https://openalex.org/W1987856679","https://openalex.org/W2069092694","https://openalex.org/W2084359831","https://openalex.org/W2767823610","https://openalex.org/W3134531270","https://openalex.org/W4304014516","https://openalex.org/W4361000000","https://openalex.org/W4385697737"],"related_works":["https://openalex.org/W4385697737","https://openalex.org/W4387106229","https://openalex.org/W2079907321","https://openalex.org/W2466854487","https://openalex.org/W2523091552","https://openalex.org/W2059347990","https://openalex.org/W4245505383","https://openalex.org/W1506171699","https://openalex.org/W4249764481","https://openalex.org/W2071124560"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-21T00:00:00"}