{"id":"https://openalex.org/W4386886541","doi":"https://doi.org/10.1016/j.neurobiolaging.2023.09.005","title":"9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer\u2019s disease neuropathology and neuroinflammation in Alzheimer\u2019s disease-like mouse models","display_name":"9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer\u2019s disease neuropathology and neuroinflammation in Alzheimer\u2019s disease-like mouse models","publication_year":2023,"publication_date":"2023-09-20","ids":{"openalex":"https://openalex.org/W4386886541","doi":"https://doi.org/10.1016/j.neurobiolaging.2023.09.005","pmid":"https://pubmed.ncbi.nlm.nih.gov/38381472"},"language":"en","primary_location":{"id":"doi:10.1016/j.neurobiolaging.2023.09.005","doi":"https://doi.org/10.1016/j.neurobiolaging.2023.09.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2023.09.005","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079851366","display_name":"Rachel Twitto\u2010Greenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rachel Twitto-Greenberg","raw_affiliation_strings":["The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel; The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel","The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel","The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel","The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel; The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799810450"]},{"raw_affiliation_string":"The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085512958","display_name":"Sigal Liraz Zaltsman","orcid":"https://orcid.org/0000-0001-9519-2989","observed_orcids":["https://orcid.org/0000-0001-9519-2989"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I207073550","display_name":"Ono Academic College","ror":"https://ror.org/02td5wn81","country_code":"IL","type":"education","lineage":["https://openalex.org/I207073550"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sigal Liraz-Zaltsman","raw_affiliation_strings":["The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel; Department of Pharmacology, Institute for Drug Research, Hebrew University, Jerusalem, Israel; Institutes for Health and Medical Professions, Department of Sports Therapy, Ono Academic College, Kyrat-Ono, Israel","Department of Pharmacology, Institute for Drug Research, Hebrew University, Jerusalem, Israel","Institutes for Health and Medical Professions, Department of Sports Therapy, Ono Academic College, Kyrat-Ono, Israel","The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel; Department of Pharmacology, Institute for Drug Research, Hebrew University, Jerusalem, Israel; Institutes for Health and Medical Professions, Department of Sports Therapy, Ono Academic College, Kyrat-Ono, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I207073550","https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Department of Pharmacology, Institute for Drug Research, Hebrew University, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Institutes for Health and Medical Professions, Department of Sports Therapy, Ono Academic College, Kyrat-Ono, Israel","institution_ids":["https://openalex.org/I207073550"]},{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041008015","display_name":"Daniel M. Michaelson","orcid":"https://orcid.org/0000-0001-5431-6244","observed_orcids":["https://orcid.org/0000-0001-5431-6244"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniel M. Michaelson","raw_affiliation_strings":["The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019579904","display_name":"Ori Liraz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ori Liraz","raw_affiliation_strings":["The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001934539","display_name":"Irit Lubitz","orcid":"https://orcid.org/0000-0003-4099-5156","observed_orcids":["https://orcid.org/0000-0003-4099-5156"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Irit Lubitz","raw_affiliation_strings":["The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022334517","display_name":"Dana Atrakchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dana Atrakchi-Baranes","raw_affiliation_strings":["The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026848738","display_name":"Chen Shemesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Chen Shemesh","raw_affiliation_strings":["The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006940992","display_name":"Uri Ashery","orcid":"https://orcid.org/0000-0001-6338-7888","observed_orcids":["https://orcid.org/0000-0001-6338-7888"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Uri Ashery","raw_affiliation_strings":["The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067817849","display_name":"Itzik Cooper","orcid":"https://orcid.org/0000-0003-0723-5542","observed_orcids":["https://orcid.org/0000-0003-0723-5542"]},"institutions":[{"id":"https://openalex.org/I207073550","display_name":"Ono Academic College","ror":"https://ror.org/02td5wn81","country_code":"IL","type":"education","lineage":["https://openalex.org/I207073550"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Itzik Cooper","raw_affiliation_strings":["The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel; Institutes for Health and Medical Professions, Department of Sports Therapy, Ono Academic College, Kyrat-Ono, Israel","Institutes for Health and Medical Professions, Department of Sports Therapy, Ono Academic College, Kyrat-Ono, Israel","The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel; Institutes for Health and Medical Professions, Department of Sports Therapy, Ono Academic College, Kyrat-Ono, Israel","institution_ids":["https://openalex.org/I207073550","https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Institutes for Health and Medical Professions, Department of Sports Therapy, Ono Academic College, Kyrat-Ono, Israel","institution_ids":["https://openalex.org/I207073550"]},{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113211353","display_name":"Ayelet Harari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ayelet Harari","raw_affiliation_strings":["The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075176331","display_name":"Dror Harats","orcid":"https://orcid.org/0009-0009-6456-6752","observed_orcids":["https://orcid.org/0009-0009-6456-6752"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dror Harats","raw_affiliation_strings":["The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel; The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel","The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel","The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel; The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2799810450"]},{"raw_affiliation_string":"The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012569127","display_name":"Michal Schnaider Beeri","orcid":"https://orcid.org/0000-0002-4254-9742","observed_orcids":["https://orcid.org/0000-0002-4254-9742"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michal Schnaider-Beeri","raw_affiliation_strings":["The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070045481","display_name":"Aviv Shaish","orcid":"https://orcid.org/0000-0003-0203-9569","observed_orcids":["https://orcid.org/0000-0003-0203-9569"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]},{"id":"https://openalex.org/I72373871","display_name":"Achva Academic College","ror":"https://ror.org/024hcay96","country_code":"IL","type":"education","lineage":["https://openalex.org/I72373871"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Aviv Shaish","raw_affiliation_strings":["The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel; Department of Life Sciences, Achva Academic College, Be'er-Tuvia Regional Council, Israel. Electronic address: aviv.shaish@sheba.health.gov.il","Department of Life Sciences, Achva Academic College, Be'er-Tuvia Regional Council, Israel","The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel; Department of Life Sciences, Achva Academic College, Be'er-Tuvia Regional Council, Israel. Electronic address: aviv.shaish@sheba.health.gov.il","institution_ids":["https://openalex.org/I2799810450","https://openalex.org/I72373871"]},{"raw_affiliation_string":"Department of Life Sciences, Achva Academic College, Be'er-Tuvia Regional Council, Israel","institution_ids":["https://openalex.org/I72373871"]},{"raw_affiliation_string":"The Bert W. Strassburger Metabolic Center, Sheba Medical Center, Ramat-Gan, Israel","institution_ids":["https://openalex.org/I2799810450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070045481"],"corresponding_institution_ids":["https://openalex.org/I2799810450","https://openalex.org/I72373871"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":1.2343,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.78016184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"133","issue":null,"first_page":"16","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/9-cis-beta-carotene","display_name":"9-cis beta-carotene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dunaliella-bardawil","display_name":"Dunaliella bardawil","score":0.9210000038146973},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/tg2576-mice","display_name":"Tg2576 mice","score":0.9020000100135803},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.984000027179718},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.6480000019073486},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.9586830139160156},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9143213033676147},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6161656379699707},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.5876085162162781},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.533245325088501},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5173822641372681},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5109092593193054},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.48049962520599365},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.47083520889282227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44360771775245667},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44028240442276},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.43385380506515503},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37551969289779663},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3683469295501709},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.340778648853302},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24597030878067017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19979515671730042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.054253458976745605},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000090862","descriptor_name":"Neuroinflammatory Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019207","descriptor_name":"beta Carotene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019207","descriptor_name":"beta Carotene","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neurobiolaging.2023.09.005","doi":"https://doi.org/10.1016/j.neurobiolaging.2023.09.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2023.09.005","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},{"id":"pmid:38381472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38381472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of aging","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W1187966713","https://openalex.org/W1784761870","https://openalex.org/W1968014528","https://openalex.org/W1970175895","https://openalex.org/W1972805775","https://openalex.org/W1975798253","https://openalex.org/W1976792807","https://openalex.org/W1979614498","https://openalex.org/W1981691199","https://openalex.org/W1983478022","https://openalex.org/W1984139645","https://openalex.org/W1984391631","https://openalex.org/W1984541066","https://openalex.org/W1987562492","https://openalex.org/W1994554610","https://openalex.org/W1995830102","https://openalex.org/W1997550127","https://openalex.org/W2002060477","https://openalex.org/W2003966687","https://openalex.org/W2004225262","https://openalex.org/W2008527141","https://openalex.org/W2010847250","https://openalex.org/W2011066781","https://openalex.org/W2011885704","https://openalex.org/W2011982570","https://openalex.org/W2017972820","https://openalex.org/W2022886877","https://openalex.org/W2023357335","https://openalex.org/W2038111587","https://openalex.org/W2039272108","https://openalex.org/W2041238959","https://openalex.org/W2047950591","https://openalex.org/W2055883416","https://openalex.org/W2060220993","https://openalex.org/W2070030133","https://openalex.org/W2077966741","https://openalex.org/W2079733100","https://openalex.org/W2081388499","https://openalex.org/W2082251914","https://openalex.org/W2089196961","https://openalex.org/W2089938835","https://openalex.org/W2090857330","https://openalex.org/W2094298920","https://openalex.org/W2098977708","https://openalex.org/W2099370040","https://openalex.org/W2109727228","https://openalex.org/W2124267367","https://openalex.org/W2125577585","https://openalex.org/W2130471591","https://openalex.org/W2132043124","https://openalex.org/W2132223509","https://openalex.org/W2133197725","https://openalex.org/W2141325921","https://openalex.org/W2142437226","https://openalex.org/W2144761196","https://openalex.org/W2151561616","https://openalex.org/W2154243350","https://openalex.org/W2164008528","https://openalex.org/W2167372953","https://openalex.org/W2168130410","https://openalex.org/W2169152986","https://openalex.org/W2194857322","https://openalex.org/W2255878573","https://openalex.org/W2327051377","https://openalex.org/W2426168356","https://openalex.org/W2488887877","https://openalex.org/W2494451530","https://openalex.org/W2556752226","https://openalex.org/W2587821175","https://openalex.org/W2745586739","https://openalex.org/W2752591735","https://openalex.org/W2794459022","https://openalex.org/W2884329601","https://openalex.org/W2887837239","https://openalex.org/W2911636401","https://openalex.org/W2944016326","https://openalex.org/W2945882966","https://openalex.org/W2961689264","https://openalex.org/W2972738335","https://openalex.org/W2980761221","https://openalex.org/W3011484646","https://openalex.org/W3013937331","https://openalex.org/W3021410383","https://openalex.org/W3098520781","https://openalex.org/W3150015993","https://openalex.org/W4200096802","https://openalex.org/W4200273430","https://openalex.org/W4247532959","https://openalex.org/W4283719203","https://openalex.org/W6655136675","https://openalex.org/W6662219571","https://openalex.org/W6679470402","https://openalex.org/W6769709633"],"related_works":["https://openalex.org/W2935950194","https://openalex.org/W2970939855","https://openalex.org/W4415268108","https://openalex.org/W4401701668","https://openalex.org/W4223612729","https://openalex.org/W2178528599","https://openalex.org/W2804284220","https://openalex.org/W4416898742","https://openalex.org/W4310948923","https://openalex.org/W2084131436"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-21T00:00:00"}