{"id":"https://openalex.org/W4386880969","doi":"https://doi.org/10.1097/yic.0000000000000487","title":"A comparative study of the efficacy of venlafaxine and naltrexone for relapse prevention in patients with opioid use disorder attributed to tramadol","display_name":"A comparative study of the efficacy of venlafaxine and naltrexone for relapse prevention in patients with opioid use disorder attributed to tramadol","publication_year":2023,"publication_date":"2023-09-20","ids":{"openalex":"https://openalex.org/W4386880969","doi":"https://doi.org/10.1097/yic.0000000000000487","pmid":"https://pubmed.ncbi.nlm.nih.gov/37729663"},"language":"en","primary_location":{"id":"doi:10.1097/yic.0000000000000487","doi":"https://doi.org/10.1097/yic.0000000000000487","is_oa":false,"landing_page_url":"https://doi.org/10.1097/yic.0000000000000487","pdf_url":null,"source":{"id":"https://openalex.org/S149156103","display_name":"International Clinical Psychopharmacology","issn_l":"0268-1315","issn":["0268-1315","1473-5857"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Clinical Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078399189","display_name":"Medhat Mohamed Bassiony","orcid":"https://orcid.org/0000-0001-9754-1847","observed_orcids":["https://orcid.org/0000-0001-9754-1847"]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Medhat M. Bassiony","raw_affiliation_strings":["Psychiatry Department, Faculty of Medicine, Zagazig University, Egypt","to Prof. Medhat Bassiony, Psychiatry Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt, Tel: +20 1126362677"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry Department, Faculty of Medicine, Zagazig University, Egypt","institution_ids":["https://openalex.org/I192398990"]},{"raw_affiliation_string":"to Prof. Medhat Bassiony, Psychiatry Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt, Tel: +20 1126362677","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028643157","display_name":"Nelly Rafat Abdel-Fattah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nelly R. Abdelfattah","raw_affiliation_strings":["Psychiatry Department, Faculty of Medicine, Zagazig University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry Department, Faculty of Medicine, Zagazig University, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108745662","display_name":"Amany Elshabrawy Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amany Elshabrawy","raw_affiliation_strings":["Psychiatry Department, Faculty of Medicine, Zagazig University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry Department, Faculty of Medicine, Zagazig University, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092906879","display_name":"Mary M. Adly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mary M. Adly","raw_affiliation_strings":["Psychiatry Department, Faculty of Medicine, Zagazig University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry Department, Faculty of Medicine, Zagazig University, Egypt","institution_ids":["https://openalex.org/I192398990"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078399189"],"corresponding_institution_ids":["https://openalex.org/I192398990"],"apc_list":null,"apc_paid":null,"fwci":0.8984,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73146057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"39","issue":"6","first_page":"341","last_page":"349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venlafaxine","display_name":"venlafaxine","score":0.8899999856948853},{"id":"https://openalex.org/keywords/naltrexone","display_name":"naltrexone","score":1.0},{"id":"https://openalex.org/keywords/tramadol-abuse","display_name":"tramadol abuse","score":0.9190000295639038},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.9940000176429749},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treatment-retention","display_name":"treatment retention","score":0.824999988079071},{"id":"https://openalex.org/keywords/opioid-antagonists","display_name":"opioid antagonists","score":0.48500001430511475},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.7580000162124634},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/addiction-treatment","display_name":"addiction treatment","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2777972943","wikidata":"https://www.wikidata.org/wiki/Q409587","display_name":"Naltrexone","level":4,"score":0.9583858251571655},{"id":"https://openalex.org/C2776466888","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine","level":4,"score":0.8947659730911255},{"id":"https://openalex.org/C2779777798","wikidata":"https://www.wikidata.org/wiki/Q407592","display_name":"Tramadol","level":3,"score":0.7481282949447632},{"id":"https://openalex.org/C2909532165","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine Hydrochloride","level":5,"score":0.6516194343566895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5414555072784424},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.49088507890701294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4827084541320801},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4753957688808441},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.47338858246803284},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4149141311645508},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3348085880279541},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.179691880941391},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.12932872772216797},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069470","descriptor_name":"Venlafaxine Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009271","descriptor_name":"Naltrexone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014147","descriptor_name":"Tramadol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/yic.0000000000000487","doi":"https://doi.org/10.1097/yic.0000000000000487","is_oa":false,"landing_page_url":"https://doi.org/10.1097/yic.0000000000000487","pdf_url":null,"source":{"id":"https://openalex.org/S149156103","display_name":"International Clinical Psychopharmacology","issn_l":"0268-1315","issn":["0268-1315","1473-5857"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Clinical Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:37729663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37729663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International clinical psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1559003248","https://openalex.org/W1970290447","https://openalex.org/W1972248539","https://openalex.org/W1979459872","https://openalex.org/W1981826840","https://openalex.org/W1983177549","https://openalex.org/W1991569159","https://openalex.org/W1996386893","https://openalex.org/W2014856588","https://openalex.org/W2018914766","https://openalex.org/W2022312732","https://openalex.org/W2023754866","https://openalex.org/W2026754599","https://openalex.org/W2027892376","https://openalex.org/W2058372784","https://openalex.org/W2066247102","https://openalex.org/W2067495470","https://openalex.org/W2074723518","https://openalex.org/W2076293542","https://openalex.org/W2082825002","https://openalex.org/W2086524334","https://openalex.org/W2093105837","https://openalex.org/W2106952430","https://openalex.org/W2110693827","https://openalex.org/W2118844917","https://openalex.org/W2123282949","https://openalex.org/W2126095527","https://openalex.org/W2129541019","https://openalex.org/W2140341041","https://openalex.org/W2145849285","https://openalex.org/W2149717129","https://openalex.org/W2149999684","https://openalex.org/W2160070901","https://openalex.org/W2222639829","https://openalex.org/W2418637474","https://openalex.org/W2427244209","https://openalex.org/W2480433457","https://openalex.org/W2559268826","https://openalex.org/W2606894497","https://openalex.org/W2654743586","https://openalex.org/W2729232923","https://openalex.org/W2782016491","https://openalex.org/W2789747820","https://openalex.org/W2790291866","https://openalex.org/W2791607419","https://openalex.org/W2792664586","https://openalex.org/W2895580410","https://openalex.org/W2916346632","https://openalex.org/W2921840616","https://openalex.org/W2958946344","https://openalex.org/W2978386152","https://openalex.org/W2980474540","https://openalex.org/W2991272684","https://openalex.org/W3081210529","https://openalex.org/W3152852530","https://openalex.org/W4232837283","https://openalex.org/W4244778838","https://openalex.org/W6814951500"],"related_works":["https://openalex.org/W3168308117","https://openalex.org/W2121179976","https://openalex.org/W4253918629","https://openalex.org/W6992978004","https://openalex.org/W4400587289","https://openalex.org/W2048931878","https://openalex.org/W6912509499","https://openalex.org/W2464809120","https://openalex.org/W2590954942","https://openalex.org/W1995344725"],"abstract_inverted_index":{"Tramadol":[0],"and":[1,28,96,110,135],"venlafaxine":[2,27,80,111,123],"share":[3],"similar":[4],"pharmacological":[5],"characteristics":[6],"that":[7],"may":[8],"allow":[9],"for":[10,14,48,81,92],"overlapping":[11],"therapeutic":[12],"indications":[13],"them.":[15],"The":[16,66,100],"objective":[17],"of":[18,26,33,74,79,102],"this":[19],"study":[20],"was":[21,105,138,155,186],"to":[22,70,157],"compare":[23],"the":[24,31,54,58,108,122,132,136],"efficacy":[25],"naltrexone":[29,75,109,133,176,190],"in":[30,121,126,131,163,177,180,191],"treatment":[32,127,164,192],"tramadol":[34,43,183],"abuse.":[35,184],"This":[36],"comparative":[37],"trial":[38],"included":[39],"95":[40],"patients":[41,67,104,181],"with":[42,161,182],"abuse":[44],"who":[45],"were":[46,68,86],"detoxified":[47],"2":[49],"weeks.":[50,83],"Twenty-eight":[51],"participants":[52,60,85,120,130],"underwent":[53],"maintenance":[55],"phase,":[56],"while":[57],"remaining":[59],"(n":[61],"=":[62,117,150,169],"67)":[63],"dropped":[64],"out.":[65],"randomized":[69],"use":[71,95],"50":[72],"mg/day":[73,78],"or":[76],"225":[77],"8":[82],"All":[84],"interviewed":[87],"using":[88],"SCID-I":[89],"(DSM-IV-TR)":[90],"criteria":[91],"diagnosing":[93],"substance":[94],"other":[97],"psychiatric":[98,153],"disorders.":[99],"proportion":[101],"relapsed":[103],"comparable":[106],"between":[107],"groups":[112],"(29.4%":[113],"vs.":[114,144,166],"30.4%,":[115],"P":[116,149,168],"0.9).":[118],"However,":[119],"group":[124],"stayed":[125],"longer":[128],"than":[129,189],"group,":[134],"difference":[137],"significant":[139],"(22.9":[140],"\u00b1":[141,146],"7.89":[142],"days":[143],"16.9":[145],"3.4":[147],"days,":[148],"0.01).":[151],"Only":[152],"comorbidity":[154],"found":[156],"be":[158],"significantly":[159],"associated":[160],"retention":[162],"(80%":[165],"22%,":[167],"0.005).":[170],"Venlafaxine":[171,185],"is":[172],"as":[173,175],"effective":[174,188],"preventing":[178],"relapse":[179],"more":[187],"retention.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-21T00:00:00"}