{"id":"https://openalex.org/W4386879352","doi":"https://doi.org/10.3724/abbs.2023239","title":"Down-regulation of miR-486-5p expression inhibits the proliferation and invasion of human extravillous trophoblasts, and decreased peripheral plasma miR-486-5p level is associated with human early pregnancy loss","display_name":"Down-regulation of miR-486-5p expression inhibits the proliferation and invasion of human extravillous trophoblasts, and decreased peripheral plasma miR-486-5p level is associated with human early pregnancy loss","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386879352","doi":"https://doi.org/10.3724/abbs.2023239","pmid":"https://pubmed.ncbi.nlm.nih.gov/37803916","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10679875"},"language":"en","primary_location":{"id":"doi:10.3724/abbs.2023239","doi":"https://doi.org/10.3724/abbs.2023239","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3724/abbs.2023239","pdf_url":"https://www.sciengine.com/doi/pdf/5F3AD2B7F7F5478C951C4614C156A8B1","source":{"id":"https://openalex.org/S145090216","display_name":"Acta Biochimica et Biophysica Sinica","issn_l":"1672-9145","issn":["1672-9145","1745-7270"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochimica et Biophysica Sinica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciengine.com/doi/pdf/5F3AD2B7F7F5478C951C4614C156A8B1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yan Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Gu","raw_affiliation_strings":["The Second Hospital of Tianjin Medical University, Tianjin 300221, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Tianjin Medical University, Tianjin 300221, China","institution_ids":["https://openalex.org/I4210133270"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ning Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Song","raw_affiliation_strings":["Diagens Co. Ltd, Hangzhou 311121, China","Shanghai Key Laboratory of Reproductive Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diagens Co. Ltd, Hangzhou 311121, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Key Laboratory of Reproductive Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101941649","display_name":"Wenwen Gu","orcid":"https://orcid.org/0000-0003-4430-6223","observed_orcids":["https://orcid.org/0000-0003-4430-6223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-Wen Gu","raw_affiliation_strings":["NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Shanghai 200032, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104171355","display_name":"Linghan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092071","display_name":"Hangzhou Center for Disease Control and Prevention","ror":"https://ror.org/00dr1cn74","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210092071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linghan Chen","raw_affiliation_strings":["Hangzhou Yuhang Center for Disease Control and Prevention, Hangzhou 311113, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou Yuhang Center for Disease Control and Prevention, Hangzhou 311113, China","institution_ids":["https://openalex.org/I4210092071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342939","display_name":"Xuan Zhang","orcid":"https://orcid.org/0000-0003-0544-4519","observed_orcids":["https://orcid.org/0000-0003-0544-4519"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xuan Zhang","raw_affiliation_strings":["NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Shanghai 200032, China","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Jian Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":["NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Shanghai 200032, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100342939"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2181,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.45162196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"55","issue":"11","first_page":"1847","last_page":"1850"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.18629999458789825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-486-5p","display_name":"miR-486-5p","score":1.0},{"id":"https://openalex.org/keywords/microrna-downregulation","display_name":"microRNA downregulation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/extravillous-trophoblast","display_name":"extravillous trophoblast","score":0.9900000095367432},{"id":"https://openalex.org/keywords/trophoblast-proliferation","display_name":"trophoblast proliferation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/trophoblast-invasion","display_name":"trophoblast invasion","score":0.9539999961853027},{"id":"https://openalex.org/keywords/early-pregnancy-loss","display_name":"early pregnancy loss","score":0.921999990940094},{"id":"https://openalex.org/keywords/placental-development","display_name":"placental development","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5432636737823486},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.49669796228408813},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.48667842149734497},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4753910303115845},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.42753326892852783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4273967146873474},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4183278977870941},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3793215751647949},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34349697828292847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32963383197784424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30673348903656006},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17292428016662598},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16880127787590027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12115955352783203},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000022","descriptor_name":"Abortion, Spontaneous","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011225","descriptor_name":"Pre-Eclampsia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3724/abbs.2023239","doi":"https://doi.org/10.3724/abbs.2023239","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3724/abbs.2023239","pdf_url":"https://www.sciengine.com/doi/pdf/5F3AD2B7F7F5478C951C4614C156A8B1","source":{"id":"https://openalex.org/S145090216","display_name":"Acta Biochimica et Biophysica Sinica","issn_l":"1672-9145","issn":["1672-9145","1745-7270"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochimica et Biophysica Sinica","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10679875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10679875","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10679875/pdf/1672-9145-2023-55-11-1847.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochim Biophys Sin (Shanghai)","raw_type":"Text"},{"id":"pmid:37803916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37803916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta biochimica et biophysica Sinica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:51624f842ef84aa1b552eb060495f4a5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/51624f842ef84aa1b552eb060495f4a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Biochimica et Biophysica Sinica, Vol 55, Pp 1847-1850 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3724/abbs.2023239","doi":"https://doi.org/10.3724/abbs.2023239","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3724/abbs.2023239","pdf_url":"https://www.sciengine.com/doi/pdf/5F3AD2B7F7F5478C951C4614C156A8B1","source":{"id":"https://openalex.org/S145090216","display_name":"Acta Biochimica et Biophysica Sinica","issn_l":"1672-9145","issn":["1672-9145","1745-7270"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biochimica et Biophysica Sinica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1664181951","display_name":"MiR-486-5p\u5bf9\u7ed2\u6bdb\u5916\u6ecb\u517b\u5c42\u7ec6\u80de\u4e2dTNF\u03b1\u8868\u8fbe\u7684\u8c03\u63a7\u4f5c\u7528 \u53ca\u5176\u4e0e\u65e9\u671f\u81ea\u7136\u6d41\u4ea7\u7684\u5173\u8054","funder_award_id":"23ZR1457000","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386879352.pdf","grobid_xml":"https://content.openalex.org/works/W4386879352.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W73010688","https://openalex.org/W2022018332","https://openalex.org/W2092305002","https://openalex.org/W2112493515","https://openalex.org/W2265133056","https://openalex.org/W2275623647","https://openalex.org/W2796224907","https://openalex.org/W2811224267","https://openalex.org/W2928301382","https://openalex.org/W2982402236"],"related_works":["https://openalex.org/W4403917088","https://openalex.org/W3163700253","https://openalex.org/W4224243943","https://openalex.org/W3117984174","https://openalex.org/W3018997080","https://openalex.org/W7144297922","https://openalex.org/W2560965179","https://openalex.org/W4386501526","https://openalex.org/W4206728349","https://openalex.org/W3086153355"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-21T00:00:00"}