{"id":"https://openalex.org/W4386877832","doi":"https://doi.org/10.1107/s2053230x23008002","title":"Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1","display_name":"Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1","publication_year":2023,"publication_date":"2023-09-18","ids":{"openalex":"https://openalex.org/W4386877832","doi":"https://doi.org/10.1107/s2053230x23008002","pmid":"https://pubmed.ncbi.nlm.nih.gov/37728609","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10565794"},"language":"en","primary_location":{"id":"doi:10.1107/s2053230x23008002","doi":"https://doi.org/10.1107/s2053230x23008002","is_oa":false,"landing_page_url":"https://doi.org/10.1107/s2053230x23008002","pdf_url":null,"source":{"id":"https://openalex.org/S4210171526","display_name":"Acta Crystallographica Section F Structural Biology Communications","issn_l":"2053-230X","issn":["2053-230X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section F Structural Biology Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10565794/pdf/f-79-00257.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092906296","display_name":"Julia Moorefield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126820664","display_name":"Vassar College","ror":"https://ror.org/022x6qg61","country_code":"US","type":"education","lineage":["https://openalex.org/I126820664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Moorefield","raw_affiliation_strings":["Department of Chemistry, Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA","institution_ids":["https://openalex.org/I126820664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038432270","display_name":"Yagmur Konuk","orcid":"https://orcid.org/0000-0003-1971-6706","observed_orcids":["https://orcid.org/0000-0003-1971-6706"]},"institutions":[{"id":"https://openalex.org/I126820664","display_name":"Vassar College","ror":"https://ror.org/022x6qg61","country_code":"US","type":"education","lineage":["https://openalex.org/I126820664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yagmur Konuk","raw_affiliation_strings":["Department of Chemistry, Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA"],"raw_orcid":"https://orcid.org/0000-0003-1971-6706","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA","institution_ids":["https://openalex.org/I126820664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104264522","display_name":"Jordan O. Norman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126820664","display_name":"Vassar College","ror":"https://ror.org/022x6qg61","country_code":"US","type":"education","lineage":["https://openalex.org/I126820664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan O. Norman","raw_affiliation_strings":["Department of Chemistry, Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA","institution_ids":["https://openalex.org/I126820664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040420507","display_name":"Jan A. Abendroth","orcid":"https://orcid.org/0000-0002-8229-3243","observed_orcids":["https://orcid.org/0000-0002-8229-3243"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Abendroth","raw_affiliation_strings":["Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","UCB Biosciences, 7869 Day Road West, Bainbridge Island, WA 98110, USA"],"raw_orcid":"https://orcid.org/0000-0002-8229-3243","affiliations":[{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"UCB Biosciences, 7869 Day Road West, Bainbridge Island, WA 98110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006004732","display_name":"Thomas E. Edwards","orcid":"https://orcid.org/0000-0002-0474-8003","observed_orcids":["https://orcid.org/0000-0002-0474-8003"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Edwards","raw_affiliation_strings":["Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","UCB Biosciences, 7869 Day Road West, Bainbridge Island, WA 98110, USA"],"raw_orcid":"https://orcid.org/0000-0002-0474-8003","affiliations":[{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"UCB Biosciences, 7869 Day Road West, Bainbridge Island, WA 98110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058862337","display_name":"Donald D. Lorimer","orcid":"https://orcid.org/0000-0002-9638-8083","observed_orcids":["https://orcid.org/0000-0002-9638-8083"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald D. Lorimer","raw_affiliation_strings":["Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","UCB Biosciences, 7869 Day Road West, Bainbridge Island, WA 98110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"UCB Biosciences, 7869 Day Road West, Bainbridge Island, WA 98110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081252601","display_name":"Stephen J. Mayclin","orcid":"https://orcid.org/0000-0002-1600-4554","observed_orcids":["https://orcid.org/0000-0002-1600-4554"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Mayclin","raw_affiliation_strings":["Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","UCB Biosciences, 7869 Day Road West, Bainbridge Island, WA 98110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"UCB Biosciences, 7869 Day Road West, Bainbridge Island, WA 98110, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051588174","display_name":"Bart L. Staker","orcid":"https://orcid.org/0000-0001-9570-5086","observed_orcids":["https://orcid.org/0000-0001-9570-5086"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bart L. Staker","raw_affiliation_strings":["Seattle Children's Research Institute, University of Washington, Seattle, Washington, USA","Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Research Institute, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4405262941"]},{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102936260","display_name":"Justin K. Craig","orcid":"https://orcid.org/0000-0001-5275-438X","observed_orcids":["https://orcid.org/0000-0001-5275-438X"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin K. Craig","raw_affiliation_strings":["Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077030950","display_name":"Kayleigh F. Barrett","orcid":"https://orcid.org/0000-0003-0327-1693","observed_orcids":["https://orcid.org/0000-0003-0327-1693"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayleigh F. Barett","raw_affiliation_strings":["Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054621827","display_name":"Lynn K. Barrett","orcid":"https://orcid.org/0009-0005-6815-7594","observed_orcids":["https://orcid.org/0009-0005-6815-7594"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn K. Barrett","raw_affiliation_strings":["Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005944101","display_name":"Wesley C. Van Voorhis","orcid":"https://orcid.org/0000-0001-6141-2015","observed_orcids":["https://orcid.org/0000-0001-6141-2015"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley C. Van Voorhis","raw_affiliation_strings":["Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043469393","display_name":"Peter John Myler","orcid":"https://orcid.org/0000-0002-0056-0513","observed_orcids":["https://orcid.org/0000-0002-0056-0513"]},"institutions":[{"id":"https://openalex.org/I1294824412","display_name":"Center for Infectious Disease Research","ror":"https://ror.org/04jkbnw46","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1294824412"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Myler","raw_affiliation_strings":["Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","Seattle Children's Research Institute, University of Washington, Seattle, Washington, USA"],"raw_orcid":"https://orcid.org/0000-0002-0056-0513","affiliations":[{"raw_affiliation_string":"Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA","institution_ids":["https://openalex.org/I1294824412"]},{"raw_affiliation_string":"Seattle Children's Research Institute, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4405262941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013118750","display_name":"Krystle J. McLaughlin","orcid":"https://orcid.org/0000-0003-4105-1042","observed_orcids":["https://orcid.org/0000-0003-4105-1042"]},"institutions":[{"id":"https://openalex.org/I126820664","display_name":"Vassar College","ror":"https://ror.org/022x6qg61","country_code":"US","type":"education","lineage":["https://openalex.org/I126820664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krystle J. McLaughlin","raw_affiliation_strings":["Department of Chemistry, Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA","institution_ids":["https://openalex.org/I126820664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3100,"currency":"USD","value_usd":3100},"apc_paid":null,"fwci":0.6043,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67462687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"79","issue":"10","first_page":"257","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11916","display_name":"Legionella and Acanthamoeba research","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inorganic-pyrophosphatase","display_name":"inorganic pyrophosphatase","score":0.984000027179718},{"id":"https://openalex.org/keywords/legionella-pneumophila","display_name":"Legionella pneumophila","score":0.9850000143051147},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ob-fold","display_name":"OB-fold","score":0.460999995470047},{"id":"https://openalex.org/keywords/magnesium-cofactor","display_name":"magnesium cofactor","score":0.6959999799728394},{"id":"https://openalex.org/keywords/pyrophosphate-hydrolysis","display_name":"pyrophosphate hydrolysis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/orthophosphate","display_name":"orthophosphate","score":0.6859999895095825},{"id":"https://openalex.org/keywords/legionnaires-disease","display_name":"Legionnaires' disease","score":0.875},{"id":"https://openalex.org/keywords/bacterial-enzymes","display_name":"bacterial enzymes","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2776118409","wikidata":"https://www.wikidata.org/wiki/Q147885","display_name":"Legionella pneumophila","level":3,"score":0.9454830884933472},{"id":"https://openalex.org/C2908737895","wikidata":"https://www.wikidata.org/wiki/Q67198600","display_name":"Pyrophosphatases","level":3,"score":0.8799525499343872},{"id":"https://openalex.org/C2780091537","wikidata":"https://www.wikidata.org/wiki/Q67198600","display_name":"Pyrophosphatase","level":3,"score":0.6301162838935852},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.5399944186210632},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5027039051055908},{"id":"https://openalex.org/C2777008805","wikidata":"https://www.wikidata.org/wiki/Q2063923","display_name":"Inorganic pyrophosphatase","level":4,"score":0.5006577968597412},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47349104285240173},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4635806083679199},{"id":"https://openalex.org/C2779164008","wikidata":"https://www.wikidata.org/wiki/Q158013","display_name":"Legionella","level":3,"score":0.43357226252555847},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.393082857131958},{"id":"https://openalex.org/C2776043855","wikidata":"https://www.wikidata.org/wiki/Q55506489","display_name":"Pyrophosphate","level":3,"score":0.3899162709712982},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3798646628856659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37760186195373535},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007877","descriptor_name":"Legionnaires' Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007877","descriptor_name":"Legionnaires' Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016952","descriptor_name":"Legionella pneumophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043564","descriptor_name":"Inorganic Pyrophosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1107/s2053230x23008002","doi":"https://doi.org/10.1107/s2053230x23008002","is_oa":false,"landing_page_url":"https://doi.org/10.1107/s2053230x23008002","pdf_url":null,"source":{"id":"https://openalex.org/S4210171526","display_name":"Acta Crystallographica Section F Structural Biology Communications","issn_l":"2053-230X","issn":["2053-230X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section F Structural Biology Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10565794","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10565794","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10565794/pdf/f-79-00257.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallogr F Struct Biol Commun","raw_type":"Text"},{"id":"pmid:37728609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37728609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta crystallographica. Section F, Structural biology communications","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10565794","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10565794","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10565794/pdf/f-79-00257.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallogr F Struct Biol Commun","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1580077915","display_name":null,"funder_award_id":"HHSN272201700059C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2844423583","display_name":null,"funder_award_id":"28277","funder_id":"https://openalex.org/F4320306487","funder_display_name":"Research Corporation for Science Advancement"},{"id":"https://openalex.org/G7351986862","display_name":null,"funder_award_id":"75N93022C00036","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000909391","display_name":"ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling","funder_award_id":"R01GM129325","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306487","display_name":"Research Corporation for Science Advancement","ror":"https://ror.org/00jp8d455"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386877832.pdf","grobid_xml":"https://content.openalex.org/works/W4386877832.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W640874369","https://openalex.org/W1617738283","https://openalex.org/W1888049263","https://openalex.org/W1969672293","https://openalex.org/W1971661467","https://openalex.org/W1973521366","https://openalex.org/W1985549638","https://openalex.org/W2006424854","https://openalex.org/W2008758289","https://openalex.org/W2011697274","https://openalex.org/W2016787579","https://openalex.org/W2021664722","https://openalex.org/W2024818482","https://openalex.org/W2035249050","https://openalex.org/W2036289278","https://openalex.org/W2048363281","https://openalex.org/W2054194043","https://openalex.org/W2060260319","https://openalex.org/W2061444720","https://openalex.org/W2062769121","https://openalex.org/W2082819416","https://openalex.org/W2094994732","https://openalex.org/W2105086858","https://openalex.org/W2106108423","https://openalex.org/W2112688493","https://openalex.org/W2120125327","https://openalex.org/W2124026197","https://openalex.org/W2130479394","https://openalex.org/W2136246773","https://openalex.org/W2143815085","https://openalex.org/W2144081223","https://openalex.org/W2144998676","https://openalex.org/W2147874841","https://openalex.org/W2150195443","https://openalex.org/W2150419549","https://openalex.org/W2150511318","https://openalex.org/W2155188941","https://openalex.org/W2159211495","https://openalex.org/W2160725228","https://openalex.org/W2302473606","https://openalex.org/W2520563183","https://openalex.org/W2558795906","https://openalex.org/W2786774014","https://openalex.org/W2800951911","https://openalex.org/W2971789490","https://openalex.org/W2979284552","https://openalex.org/W3083406432","https://openalex.org/W3187633040","https://openalex.org/W4223552703","https://openalex.org/W4309858927","https://openalex.org/W4378952892"],"related_works":["https://openalex.org/W2087770859","https://openalex.org/W2068871471","https://openalex.org/W2085615552","https://openalex.org/W1822256774","https://openalex.org/W1936705259","https://openalex.org/W2763743102","https://openalex.org/W2064823286","https://openalex.org/W2921374256","https://openalex.org/W1831229176","https://openalex.org/W2074629060"],"abstract_inverted_index":{"Inorganic":[0,37],"pyrophosphate":[1],"(PP":[2],"i":[3,25,42,47,56,63],")":[4],"is":[5,83,133,153],"generated":[6],"as":[7,29],"an":[8],"intermediate":[9],"or":[10],"byproduct":[11,57],"of":[12,23,53,74,148,154],"many":[13,33,107],"fundamental":[14],"metabolic":[15],"pathways,":[16],"including":[17],"DNA/RNA":[18],"synthesis.":[19],"The":[20],"intracellular":[21],"concentration":[22],"PP":[24,41,55],"must":[26],"be":[27],"regulated":[28],"buildup":[30],"can":[31],"inhibit":[32],"critical":[34],"cellular":[35],"processes.":[36],"pyrophosphatases":[38],"(PPases)":[39],"hydrolyze":[40],"into":[43],"two":[44],"orthophosphates":[45],"(P":[46],"),":[48],"preventing":[49],"the":[50,54,71,99,125,149],"toxic":[51],"accumulation":[52],"in":[58,67],"cells":[59],"and":[60,97,144],"making":[61],"P":[62],"available":[64],"for":[65,129],"use":[66],"biosynthetic":[68],"pathways.":[69],"Here,":[70],"crystal":[72],"structure":[73],"a":[75,94,118,134],"family":[76,110],"I":[77,111],"inorganic":[78],"pyrophosphatase":[79],"from":[80],"Legionella":[81],"pneumophila":[82,90,142,151],"reported":[84],"at":[85],"2.0":[86],"\u00c5":[87],"resolution.":[88],"L.":[89,141,150],"PPase":[91],"(LpPPase)":[92],"adopts":[93],"homohexameric":[95],"assembly":[96],"shares":[98],"oligonucleotide/oligosaccharide-binding":[100],"(OB)":[101],"\u03b2-barrel":[102],"core":[103],"fold":[104],"common":[105],"to":[106],"other":[108],"bacterial":[109],"PPases.":[112],"LpPPase":[113],"demonstrated":[114],"hydrolytic":[115],"activity":[116],"against":[117],"general":[119],"substrate,":[120],"with":[121],"Mg":[122],"2+":[123],"being":[124],"preferred":[126],"metal":[127],"cofactor":[128],"catalysis.":[130],"Legionnaires'":[131],"disease":[132],"severe":[135],"respiratory":[136],"infection":[137],"caused":[138],"primarily":[139],"by":[140],",":[143],"thus":[145],"increased":[146],"characterization":[147],"proteome":[152],"interest.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-09-21T00:00:00"}