{"id":"https://openalex.org/W4386861495","doi":"https://doi.org/10.1002/eji.202350536","title":"Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression","display_name":"Glycolytic metabolite phosphoenolpyruvate protects host from viral infection through promoting AATK expression","publication_year":2023,"publication_date":"2023-09-19","ids":{"openalex":"https://openalex.org/W4386861495","doi":"https://doi.org/10.1002/eji.202350536","pmid":"https://pubmed.ncbi.nlm.nih.gov/37724936"},"language":"en","primary_location":{"id":"doi:10.1002/eji.202350536","doi":"https://doi.org/10.1002/eji.202350536","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.202350536","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.202350536","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.202350536","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089792039","display_name":"Lu Zhao","orcid":"https://orcid.org/0000-0003-2515-4439","observed_orcids":["https://orcid.org/0000-0003-2515-4439"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":null,"type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Zhao","raw_affiliation_strings":["Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China","Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-2515-4439","affiliations":[{"raw_affiliation_string":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]},{"raw_affiliation_string":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088722713","display_name":"Renjie Song","orcid":"https://orcid.org/0009-0003-4306-8478","observed_orcids":["https://orcid.org/0009-0003-4306-8478","https://orcid.org/0009-0000-8348-3711"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":null,"type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Renjie Song","raw_affiliation_strings":["Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China","Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]},{"raw_affiliation_string":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100693703","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0002-5636-030X","observed_orcids":["https://orcid.org/0000-0002-5636-030X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210122727","display_name":"Suzhou Institute of Systems Medicine","ror":"https://ror.org/02szepc22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210122727","https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":null,"type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China","Suzhou Institute of Systems Medicine Chinese Academy of Medical Sciences  Suzhou China","Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China","Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-5636-030X","affiliations":[{"raw_affiliation_string":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]},{"raw_affiliation_string":"Suzhou Institute of Systems Medicine Chinese Academy of Medical Sciences  Suzhou China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210122727"]},{"raw_affiliation_string":"Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]},{"raw_affiliation_string":"Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210122727"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100693703"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210122727","https://openalex.org/I4391767653"],"apc_list":{"value":4120,"currency":"USD","value_usd":4120},"apc_paid":{"value":4120,"currency":"USD","value_usd":4120},"fwci":0.2627,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.46915741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"53","issue":"12","first_page":"e2350536","last_page":"e2350536"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphoenolpyruvate","display_name":"phosphoenolpyruvate","score":1.0},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.7639999985694885},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6890000104904175},{"id":"https://openalex.org/keywords/host-metabolism","display_name":"host metabolism","score":0.5989999771118164},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.6690000295639038},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.47200000286102295},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.856248140335083},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.786979079246521},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7458556294441223},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6315876245498657},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5599570274353027},{"id":"https://openalex.org/C143937172","wikidata":"https://www.wikidata.org/wiki/Q303568","display_name":"Phosphoenolpyruvate carboxykinase","level":3,"score":0.4977467358112335},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4654944837093353},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.4542241394519806},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4130435585975647},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.4117642045021057},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3737090826034546},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3710019886493683},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.30640605092048645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3034154772758484},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29142653942108154},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.18175512552261353},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11565631628036499},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07332104444503784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010728","descriptor_name":"Phosphoenolpyruvate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.202350536","doi":"https://doi.org/10.1002/eji.202350536","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.202350536","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.202350536","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:37724936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37724936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/eji.202350536","doi":"https://doi.org/10.1002/eji.202350536","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.202350536","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.202350536","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1672157580","display_name":null,"funder_award_id":"2019-2021QNRC001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2377164642","display_name":null,"funder_award_id":"82071793","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2893822505","display_name":null,"funder_award_id":"20220484065","funder_id":"https://openalex.org/F4320334978","funder_display_name":"Beijing Nova Program"},{"id":"https://openalex.org/G4530760485","display_name":null,"funder_award_id":"2021-I2M-1","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G5408292840","display_name":null,"funder_award_id":"82322028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5645044787","display_name":null,"funder_award_id":"2021-I2M-1-017","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G6280678692","display_name":null,"funder_award_id":"7212069","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"},{"id":"https://openalex.org/G6665774762","display_name":null,"funder_award_id":"2021QNRC001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8823111422","display_name":null,"funder_award_id":"82388201","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320334978","display_name":"Beijing Nova Program","ror":"https://ror.org/034k14f91"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386861495.pdf","grobid_xml":"https://content.openalex.org/works/W4386861495.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1596236557","https://openalex.org/W1966545599","https://openalex.org/W1971725639","https://openalex.org/W1974066433","https://openalex.org/W1980142948","https://openalex.org/W1980175190","https://openalex.org/W2010052045","https://openalex.org/W2039910403","https://openalex.org/W2053209083","https://openalex.org/W2072517432","https://openalex.org/W2087867900","https://openalex.org/W2115617484","https://openalex.org/W2119203909","https://openalex.org/W2133402546","https://openalex.org/W2160551785","https://openalex.org/W2176430082","https://openalex.org/W2289080497","https://openalex.org/W2322711197","https://openalex.org/W2517728041","https://openalex.org/W2603622367","https://openalex.org/W2652888557","https://openalex.org/W2728269885","https://openalex.org/W2766398869","https://openalex.org/W2770136793","https://openalex.org/W2792106006","https://openalex.org/W2905020668","https://openalex.org/W2910202957","https://openalex.org/W2925098066","https://openalex.org/W2947020562","https://openalex.org/W2963402728","https://openalex.org/W2969864448","https://openalex.org/W2995832176","https://openalex.org/W2997389909","https://openalex.org/W3036215764","https://openalex.org/W3092056473","https://openalex.org/W3102694569","https://openalex.org/W3120010238","https://openalex.org/W3136749291","https://openalex.org/W3139503800","https://openalex.org/W3149583946","https://openalex.org/W3152249737","https://openalex.org/W3176910263","https://openalex.org/W4210744364","https://openalex.org/W4214916863","https://openalex.org/W4225384899","https://openalex.org/W4225725937","https://openalex.org/W4282843783","https://openalex.org/W4283691064","https://openalex.org/W4288080510","https://openalex.org/W4297244184"],"related_works":["https://openalex.org/W3138254422","https://openalex.org/W2102326449","https://openalex.org/W2032099305","https://openalex.org/W2738322136","https://openalex.org/W2343381749","https://openalex.org/W1996999543","https://openalex.org/W2059794436","https://openalex.org/W2518258943","https://openalex.org/W2520044352","https://openalex.org/W1545989146"],"abstract_inverted_index":{"Viral":[0],"infections":[1],"can":[2],"result":[3],"in":[4,11,22,29,43,96,99,163,184],"metabolism":[5],"rewiring":[6],"of":[7,61,76,109,117,128,131,142,151,161,176,180],"host":[8],"cells,":[9],"which":[10],"turn":[12],"affects":[13],"the":[14,23,73,107,115,126,148,173,181],"viral":[15,45,57,81,87,110,120,136,166,186],"lifecycle.":[16],"Phosphoenolpyruvate":[17],"(PEP),":[18],"a":[19,157],"metabolic":[20],"intermediate":[21],"glycolytic":[24],"pathway,":[25],"plays":[26],"important":[27],"roles":[28],"several":[30],"biological":[31],"processes":[32],"including":[33],"anti-tumor":[34],"T":[35],"cell":[36],"immunity.":[37],"However,":[38],"whether":[39],"PEP":[40,54,77,83,102,123,162],"might":[41],"participate":[42],"modulating":[44],"infection":[46,88],"remains":[47],"largely":[48],"unknown.":[49],"Here,":[50],"we":[51],"demonstrate":[52],"that":[53,72],"generally":[55],"inhibits":[56],"replication":[58,111,137,167],"via":[59],"upregulation":[60,179],"apoptosis-associated":[62],"tyrosine":[63],"kinase":[64],"(AATK)":[65],"expression.":[66],"Targeted":[67],"metabolomic":[68],"analyses":[69],"have":[70],"shown":[71],"intracellular":[74],"level":[75],"was":[78],"increased":[79,140],"upon":[80],"infection.":[82,121],"treatment":[84],"significantly":[85,124],"restricted":[86],"and":[89,98,112,138],"hence":[90],"declined":[91],"subsequent":[92],"inflammatory":[93],"response":[94],"both":[95],"vitro":[97],"vivo.":[100],"Besides,":[101],"took":[103],"inhibitory":[104],"effect":[105,150],"on":[106],"stage":[108],"also":[113],"decreased":[114],"mortality":[116],"mice":[118],"with":[119],"Mechanistically,":[122],"promoted":[125],"expression":[127],"AATK.":[129],"Knockdown":[130],"AATK":[132,145,170],"led":[133],"to":[134],"enhanced":[135],"consequent":[139],"levels":[141],"cytokines.":[143],"Moreover,":[144],"deficiency":[146],"disabled":[147],"antiviral":[149],"PEP.":[152],"Together,":[153],"our":[154],"study":[155],"reveals":[156],"previously":[158],"unknown":[159],"role":[160],"broadly":[164],"inhibiting":[165],"by":[168],"promoting":[169],"expression,":[171],"highlighting":[172],"potential":[174],"application":[175],"activation":[177],"or":[178],"PEP-AATK":[182],"axis":[183],"controlling":[185],"infections.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}