{"id":"https://openalex.org/W4386859372","doi":"https://doi.org/10.1126/scisignal.adh4210","title":"The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells","display_name":"The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by PTBP1 to enable invadopodia formation in colorectal cancer cells","publication_year":2023,"publication_date":"2023-09-19","ids":{"openalex":"https://openalex.org/W4386859372","doi":"https://doi.org/10.1126/scisignal.adh4210","pmid":"https://pubmed.ncbi.nlm.nih.gov/37725664"},"language":"en","primary_location":{"id":"doi:10.1126/scisignal.adh4210","doi":"https://doi.org/10.1126/scisignal.adh4210","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.adh4210","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-1538014/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057840497","display_name":"Danxiu Li","orcid":"https://orcid.org/0000-0002-7359-4378","observed_orcids":["https://orcid.org/0000-0002-7359-4378"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Danxiu Li","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":"https://orcid.org/0000-0002-7359-4378","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121816497","display_name":"Xin Wang","orcid":"https://orcid.org/0009-0007-0821-8548","observed_orcids":["https://orcid.org/0009-0007-0821-8548"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":"https://orcid.org/0009-0007-0821-8548","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082030295","display_name":"Hui Miao","orcid":"https://orcid.org/0000-0001-7350-7820","observed_orcids":["https://orcid.org/0000-0001-7350-7820"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Miao","raw_affiliation_strings":["Center for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China"],"raw_orcid":"https://orcid.org/0000-0001-7350-7820","affiliations":[{"raw_affiliation_string":"Center for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458921","display_name":"Hao Liu","orcid":"https://orcid.org/0009-0006-6173-5598","observed_orcids":["https://orcid.org/0009-0006-6173-5598"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019942906","display_name":"Maogui Pang","orcid":"https://orcid.org/0000-0002-1192-2655","observed_orcids":["https://orcid.org/0000-0002-1192-2655"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maogui Pang","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":"https://orcid.org/0000-0002-1192-2655","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101556387","display_name":"Hao Guo","orcid":"https://orcid.org/0000-0002-9289-9775","observed_orcids":["https://orcid.org/0000-0002-9289-9775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Guo","raw_affiliation_strings":["State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co. Ltd., Nanjing, Jiangsu 210042, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co. Ltd., Nanjing, Jiangsu 210042, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114025670","display_name":"Minghui Ge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minghui Ge","raw_affiliation_strings":["State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co. Ltd., Nanjing, Jiangsu 210042, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co. Ltd., Nanjing, Jiangsu 210042, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084529927","display_name":"Sarah E. Glass","orcid":"https://orcid.org/0000-0002-0642-2656","observed_orcids":["https://orcid.org/0000-0002-0642-2656"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah E. Glass","raw_affiliation_strings":["Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":"https://orcid.org/0000-0002-0642-2656","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062616205","display_name":"Stephan Emmrich","orcid":"https://orcid.org/0000-0002-0537-4242","observed_orcids":["https://orcid.org/0000-0002-0537-4242"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan Emmrich","raw_affiliation_strings":["Department of Biology, University of Rochester, Rochester, NY 14627, USA"],"raw_orcid":"https://orcid.org/0000-0002-0537-4242","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Rochester, Rochester, NY 14627, USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Songtao Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songtao Ji","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087167187","display_name":"Yun Zhou","orcid":"https://orcid.org/0000-0001-7353-620X","observed_orcids":["https://orcid.org/0000-0001-7353-620X"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Zhou","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044695931","display_name":"Xiaoni Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoni Ye","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huajie Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huajie Mao","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378656","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0003-1580-1356","observed_orcids":["https://orcid.org/0000-0003-1580-1356","https://orcid.org/0009-0009-7012-5216","https://orcid.org/0000-0002-1980-539X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Biomedical Informatics and Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics and Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453211","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0002-5684-7396","observed_orcids":["https://orcid.org/0000-0002-5684-7396"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Liu","raw_affiliation_strings":["Department of Biomedical Informatics and Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics and Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329535","display_name":"Tae\u2010Wan Kim","orcid":"https://orcid.org/0000-0002-7202-009X","observed_orcids":["https://orcid.org/0000-0002-7202-009X"]},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Taewan Kim","raw_affiliation_strings":["Department of Anatomy, Histology & Developmental Biology, Base for International Science and Technology Cooperation, Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen University, Shenzhen, Guangdong 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology & Developmental Biology, Base for International Science and Technology Cooperation, Carson Cancer Stem Cell Vaccines R&D Center, International Cancer Center, Shenzhen University, Shenzhen, Guangdong 518055, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030406251","display_name":"Jan\u2010Henning Klusmann","orcid":"https://orcid.org/0000-0002-1070-0727","observed_orcids":["https://orcid.org/0000-0002-1070-0727"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan-Henning Klusmann","raw_affiliation_strings":["Pediatric Hematology and Oncology, Department of Pediatrics, Goethe University Frankfurt, Frankfurt (Main) 60590, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1070-0727","affiliations":[{"raw_affiliation_string":"Pediatric Hematology and Oncology, Department of Pediatrics, Goethe University Frankfurt, Frankfurt (Main) 60590, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055801372","display_name":"Cunxi Li","orcid":"https://orcid.org/0000-0003-1264-042X","observed_orcids":["https://orcid.org/0000-0003-1264-042X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cunxi Li","raw_affiliation_strings":["Jiaen Genetics Laboratory, Beijing Jiaen Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0003-1264-042X","affiliations":[{"raw_affiliation_string":"Jiaen Genetics Laboratory, Beijing Jiaen Hospital, Beijing 100191, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080821647","display_name":"Zhenxiong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenxiong Liu","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101563918","display_name":"Haifeng Jin","orcid":"https://orcid.org/0000-0001-8357-9377","observed_orcids":["https://orcid.org/0000-0001-8357-9377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haifeng Jin","raw_affiliation_strings":["Department of Gastroenterology, 980th Hospital of PLA Joint Logistics Support Force, Shijiazhuang, Hebei 050082, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, 980th Hospital of PLA Joint Logistics Support Force, Shijiazhuang, Hebei 050082, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762839","display_name":"Yongzhan Nie","orcid":"https://orcid.org/0000-0003-1124-4548","observed_orcids":["https://orcid.org/0000-0003-1124-4548"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongzhan Nie","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078303906","display_name":"Kaichun Wu","orcid":"https://orcid.org/0000-0002-0699-9666","observed_orcids":["https://orcid.org/0000-0002-0699-9666"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaichun Wu","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":"https://orcid.org/0000-0002-0699-9666","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100715251","display_name":"Daiming Fan","orcid":"https://orcid.org/0000-0002-2466-5002","observed_orcids":["https://orcid.org/0000-0002-2466-5002","https://orcid.org/0000-0003-0426-8971"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daiming Fan","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054624830","display_name":"Xu Song","orcid":"https://orcid.org/0000-0002-4852-3658","observed_orcids":["https://orcid.org/0000-0002-4852-3658"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Song","raw_affiliation_strings":["Center for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China"],"raw_orcid":"https://orcid.org/0000-0002-4852-3658","affiliations":[{"raw_affiliation_string":"Center for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121816497","display_name":"Xin Wang","orcid":"https://orcid.org/0009-0007-0821-8548","observed_orcids":["https://orcid.org/0009-0007-0821-8548"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103669293","display_name":"Ling Li","orcid":"https://orcid.org/0000-0002-2112-2627","observed_orcids":["https://orcid.org/0000-0002-2112-2627"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ling Li","raw_affiliation_strings":["Center for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China"],"raw_orcid":"https://orcid.org/0000-0002-2112-2627","affiliations":[{"raw_affiliation_string":"Center for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001475437","display_name":"Yuanyuan Lu","orcid":"https://orcid.org/0000-0003-0194-8074","observed_orcids":["https://orcid.org/0000-0003-0194-8074","https://orcid.org/0009-0005-2649-8913"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuanyuan Lu","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":"https://orcid.org/0000-0003-0194-8074","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046054581","display_name":"Xiaodi Zhao","orcid":"https://orcid.org/0000-0002-1817-803X","observed_orcids":["https://orcid.org/0000-0002-1817-803X"]},"institutions":[{"id":"https://openalex.org/I4210089514","display_name":"National Clinical Research Center for Digestive Diseases","ror":"https://ror.org/00a2x9d51","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089514"]},{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaodi Zhao","raw_affiliation_strings":["Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China"],"raw_orcid":"https://orcid.org/0000-0002-1817-803X","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Tangdu Hospital, Xijing Hospital of Digestive Diseases, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, China","institution_ids":["https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5001475437","https://openalex.org/A5046054581","https://openalex.org/A5057840497","https://openalex.org/A5082030295","https://openalex.org/A5100458921","https://openalex.org/A5103669293","https://openalex.org/A5121816497"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089514","https://openalex.org/I4210154136","https://openalex.org/I4210158926","https://openalex.org/I9916479"],"apc_list":null,"apc_paid":null,"fwci":2.5868,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.91865637,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"16","issue":"803","first_page":"eadh4210","last_page":"eadh4210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.08720000088214874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9890000224113464},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.8949999809265137},{"id":"https://openalex.org/keywords/smarca1","display_name":"SMARCA1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ptbp1","display_name":"PTBP1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/invadopodia","display_name":"invadopodia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.7879999876022339},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.828000009059906},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.628000020980835},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8429999947547913},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.875},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.7113736867904663},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7028900384902954},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6654167175292969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6647371649742126},{"id":"https://openalex.org/C2777793812","wikidata":"https://www.wikidata.org/wiki/Q7226903","display_name":"Polypyrimidine tract-binding protein","level":5,"score":0.5954415798187256},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5806811451911926},{"id":"https://openalex.org/C200786668","wikidata":"https://www.wikidata.org/wiki/Q3498029","display_name":"Invadopodia","level":4,"score":0.5420523285865784},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.5358337759971619},{"id":"https://openalex.org/C73758832","wikidata":"https://www.wikidata.org/wiki/Q7578564","display_name":"Splicing factor","level":5,"score":0.5126616358757019},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46567341685295105},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.4458841383457184},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.42742496728897095},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.41928961873054504},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3772975504398346},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3757478594779968},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3236265778541565},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30105912685394287},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19389218091964722}],"mesh":[{"descriptor_ui":"D000069261","descriptor_name":"Podosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034441","descriptor_name":"Heterogeneous-Nuclear Ribonucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038941","descriptor_name":"Polypyrimidine Tract-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1126/scisignal.adh4210","doi":"https://doi.org/10.1126/scisignal.adh4210","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.adh4210","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-1538014/v2","doi":"https://doi.org/10.21203/rs.3.rs-1538014/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1538014/v2","pdf_url":"https://www.researchsquare.com/article/rs-1538014/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:37725664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37725664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science signaling","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1538014/v2","doi":"https://doi.org/10.21203/rs.3.rs-1538014/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1538014/v2","pdf_url":"https://www.researchsquare.com/article/rs-1538014/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1329594798","display_name":null,"funder_award_id":"2017QNRC001]","funder_id":"https://openalex.org/F4320311778","funder_display_name":"China Association for Science and Technology"},{"id":"https://openalex.org/G14562893","display_name":null,"funder_award_id":"81822031","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2120767766","display_name":null,"funder_award_id":"31671347","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2623776173","display_name":null,"funder_award_id":"81871913","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G329449993","display_name":null,"funder_award_id":"20200812161921001","funder_id":"https://openalex.org/F4320326705","funder_display_name":"Science, Technology and Innovation Commission of Shenzhen Municipality"},{"id":"https://openalex.org/G3821265254","display_name":null,"funder_award_id":"82222058","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G494023775","display_name":null,"funder_award_id":"82073120","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6738043051","display_name":null,"funder_award_id":"2017QNRC001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6796456343","display_name":null,"funder_award_id":"81972224","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7406503040","display_name":null,"funder_award_id":"82073197","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7707877687","display_name":null,"funder_award_id":"82173256","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320311778","display_name":"China Association for Science and Technology","ror":"https://ror.org/035vmht26"},{"id":"https://openalex.org/F4320313998","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326705","display_name":"Science, Technology and Innovation Commission of Shenzhen Municipality","ror":null},{"id":"https://openalex.org/F4320327612","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386859372.pdf","grobid_xml":"https://content.openalex.org/works/W4386859372.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1533127962","https://openalex.org/W1865140308","https://openalex.org/W1963501822","https://openalex.org/W1967778417","https://openalex.org/W1969161156","https://openalex.org/W1974898488","https://openalex.org/W1985143502","https://openalex.org/W1988787904","https://openalex.org/W2018114690","https://openalex.org/W2027260842","https://openalex.org/W2028198233","https://openalex.org/W2042086006","https://openalex.org/W2045884961","https://openalex.org/W2053855164","https://openalex.org/W2058781335","https://openalex.org/W2066231767","https://openalex.org/W2097572021","https://openalex.org/W2107171098","https://openalex.org/W2116432038","https://openalex.org/W2117116688","https://openalex.org/W2117691023","https://openalex.org/W2122358139","https://openalex.org/W2122683221","https://openalex.org/W2130410032","https://openalex.org/W2136785472","https://openalex.org/W2153268494","https://openalex.org/W2154241726","https://openalex.org/W2165200432","https://openalex.org/W2166566864","https://openalex.org/W2167786463","https://openalex.org/W2260715119","https://openalex.org/W2395807466","https://openalex.org/W2505384565","https://openalex.org/W2555357497","https://openalex.org/W2560385907","https://openalex.org/W2586630468","https://openalex.org/W2594091455","https://openalex.org/W2597422592","https://openalex.org/W2605986786","https://openalex.org/W2614855056","https://openalex.org/W2766837662","https://openalex.org/W2769407685","https://openalex.org/W2794038133","https://openalex.org/W2883929619","https://openalex.org/W2889104271","https://openalex.org/W2906076922","https://openalex.org/W2914485122","https://openalex.org/W2934231425","https://openalex.org/W2944157576","https://openalex.org/W2945489918","https://openalex.org/W2970033143","https://openalex.org/W2970045605","https://openalex.org/W2980949872","https://openalex.org/W2996752412","https://openalex.org/W3006556144","https://openalex.org/W3011137119","https://openalex.org/W3011709397","https://openalex.org/W3080761215","https://openalex.org/W3109804732","https://openalex.org/W3115880421","https://openalex.org/W3125263525","https://openalex.org/W3139737861","https://openalex.org/W3159017136","https://openalex.org/W3159024074","https://openalex.org/W3163092889","https://openalex.org/W3209656321","https://openalex.org/W3212694683","https://openalex.org/W4249273120","https://openalex.org/W4295900651","https://openalex.org/W4312109262"],"related_works":["https://openalex.org/W4313432501","https://openalex.org/W4224042852","https://openalex.org/W4401346548","https://openalex.org/W4412151068","https://openalex.org/W3010700839","https://openalex.org/W2916591247","https://openalex.org/W4200116133","https://openalex.org/W2982118749","https://openalex.org/W3101516721","https://openalex.org/W4409402418"],"abstract_inverted_index":{"Abstract":[0],"Alternative":[1],"splicing":[2,98,135],"(AS)":[3],"of":[4,44,107,137,143,230],"pre-mRNAs":[5],"is":[6,63],"an":[7,118],"essential":[8],"process":[9,25],"that":[10,22,35,61,81,169,189,214],"regulates":[11],"gene":[12,111],"expression":[13],"and":[14,51,70,76,89,94,139,156,176,182,201,227],"functional":[15],"diversity,":[16],"yet":[17],"the":[18,96,108,133,141,190],"underlying":[19],"regulatory":[20],"mechanisms":[21],"control":[23],"this":[24],"during":[26],"cancer":[27,57],"metastasis":[28],"are":[29],"not":[30],"clear.":[31],"Here,":[32],"we":[33,187],"uncovered":[34],"a":[36,144,208,212,223],"long":[37,145],"non-coding":[38],"RNA":[39,97],"(lncRNA),":[40],"MIR99AHG,":[41],"mediates":[42],"regulation":[43],"AS":[45,220],"to":[46,93,123,152,218],"alter":[47],"chromatin":[48,109],"remodeler":[49],"function":[50],"promote":[52],"invadopodia":[53,160],"formation":[54],"in":[55,66,77,178,198],"colorectal":[56],"(CRC).":[58],"We":[59],"found":[60,151],"MIR99AHG":[62,82,91,115,170,203],"highly":[64],"expressed":[65],"metastatic":[67],"CRC":[68,85,180,199],"cells":[69,200],"patient":[71,184],"tissue":[72],"samples.":[73],"In":[74],"vitro":[75],"vivo":[78],"assays":[79],"showed":[80,188],"potently":[83],"drove":[84],"cell":[86,154],"motility,":[87],"invasion,":[88],"metastasis.":[90],"bound":[92],"stabilized":[95],"factor":[99],"PTBP1,":[100],"which":[101],"cooperatively":[102],"increased":[103],"cassette":[104],"exon":[105],"inclusion":[106],"remodeling":[110],"SMARCA1":[112,129,138,149],".":[113],"Mechanistically,":[114],"acted":[116],"as":[117],"address":[119],"label":[120],"for":[121,211],"PTBP1":[122,175,217],"fine-tune":[124],"its":[125],"binding":[126],"pattern":[127],"on":[128],"pre-mRNA,":[130],"thereby":[131],"controlling":[132],"skipping-to-inclusion":[134],"switch":[136],"favouring":[140],"production":[142],"isoform":[146],"(SMARCA1-L).":[147],"Canonical":[148],"was":[150,164,171],"suppress":[153],"migration":[155],"invasiveness":[157],"by":[158],"inhibiting":[159],"formation,":[161],"but":[162],"SMARCA1-L":[163,177],"functionally":[165],"inert.":[166],"Clinicaldata":[167],"revealed":[168],"positively":[172],"correlated":[173],"with":[174,192,216],"human":[179],"specimens":[181],"predicted":[183],"outcome.":[185],"Furthermore,":[186],"crosstalk":[191],"cancer-associated":[193],"fibroblasts":[194],"triggers":[195],"TGF-\u03b2/SAMD":[196],"signalling":[197],"activates":[202],"expression.":[204],"Our":[205],"findings":[206],"establish":[207],"novel":[209],"mechanism":[210],"lncRNA":[213],"interacts":[215],"regulate":[219],"process,":[221],"providing":[222],"potential":[224],"therapeutic":[225],"target":[226],"predictive":[228],"biomarker":[229],"CRC.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-09-20T00:00:00"}