{"id":"https://openalex.org/W4386854881","doi":"https://doi.org/10.1149/ma2023-0191143mtgabs","title":"Carbon Nanotube Optical Reporters for Cancer Drug Discovery","display_name":"Carbon Nanotube Optical Reporters for Cancer Drug Discovery","publication_year":2023,"publication_date":"2023-08-28","ids":{"openalex":"https://openalex.org/W4386854881","doi":"https://doi.org/10.1149/ma2023-0191143mtgabs"},"language":"en","primary_location":{"id":"doi:10.1149/ma2023-0191143mtgabs","doi":"https://doi.org/10.1149/ma2023-0191143mtgabs","is_oa":false,"landing_page_url":"https://doi.org/10.1149/ma2023-0191143mtgabs","pdf_url":null,"source":{"id":"https://openalex.org/S4210168594","display_name":"ECS Meeting Abstracts","issn_l":"1091-8213","issn":["1091-8213","2151-2035","2151-2043","2152-8365"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311669","host_organization_name":"Institute of Physics","host_organization_lineage":["https://openalex.org/P4310311669"],"host_organization_lineage_names":["Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ECS Meeting Abstracts","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037355958","display_name":"Daniel A. Heller","orcid":"https://orcid.org/0000-0002-6866-0000","observed_orcids":["https://orcid.org/0000-0002-6866-0000"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Heller","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-6866-0000","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055441545","display_name":"Stephen B. Ruiz","orcid":"https://orcid.org/0000-0002-1634-9798","observed_orcids":["https://orcid.org/0000-0002-1634-9798"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Ruiz","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center","Weill Cornell Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075165285","display_name":"Prakrit Vaibhav Jena","orcid":"https://orcid.org/0000-0001-5493-3058","observed_orcids":["https://orcid.org/0000-0001-5493-3058"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prakrit Jena","raw_affiliation_strings":["Lime Therapeutics","Memorial Sloan Kettering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lime Therapeutics","institution_ids":[]},{"raw_affiliation_string":"Memorial Sloan Kettering","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017097164","display_name":"Christopher Peter Horoszko","orcid":"https://orcid.org/0000-0003-2344-4707","observed_orcids":["https://orcid.org/0000-0003-2344-4707"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Horoszko","raw_affiliation_strings":["Memorial Sloan Kettering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089413115","display_name":"Daniel E. Tylawsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E Tylawsky","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center","Weill Cornell Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Weill Cornell Medicine","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068929256","display_name":"Declan Gwynne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Declan Gwynne","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"MA2023-01","issue":"9","first_page":"1143","last_page":"1143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.4399000108242035,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.4399000108242035,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.7749999761581421},{"id":"https://openalex.org/keywords/lysosomal-lipid-accumulation","display_name":"lysosomal lipid accumulation","score":0.968999981880188},{"id":"https://openalex.org/keywords/phospholipase-inhibition","display_name":"phospholipase inhibition","score":0.8029999732971191},{"id":"https://openalex.org/keywords/redox-stress","display_name":"redox stress","score":0.777999997138977},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.7519999742507935},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6608058214187622},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6388823986053467},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5373228192329407},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4861862063407898},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4752364158630371},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.45752179622650146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43447256088256836},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43038323521614075},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3717438280582428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.248970627784729},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14030897617340088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08761152625083923},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1149/ma2023-0191143mtgabs","doi":"https://doi.org/10.1149/ma2023-0191143mtgabs","is_oa":false,"landing_page_url":"https://doi.org/10.1149/ma2023-0191143mtgabs","pdf_url":null,"source":{"id":"https://openalex.org/S4210168594","display_name":"ECS Meeting Abstracts","issn_l":"1091-8213","issn":["1091-8213","2151-2035","2151-2043","2152-8365"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311669","host_organization_name":"Institute of Physics","host_organization_lineage":["https://openalex.org/P4310311669"],"host_organization_lineage_names":["Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ECS Meeting Abstracts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405591155","https://openalex.org/W2952318715","https://openalex.org/W4247206815","https://openalex.org/W2803461613","https://openalex.org/W2342653932","https://openalex.org/W7037139131","https://openalex.org/W4386867044","https://openalex.org/W2343662915","https://openalex.org/W4386854964","https://openalex.org/W2252735612"],"abstract_inverted_index":{"The":[0],"identification":[1],"of":[2,17,66,78,81,88,135,147],"therapeutic":[3],"vulnerabilities":[4],"in":[5,43,90,104,115,120],"cancers":[6],"has":[7,24],"been":[8],"substantially":[9],"aided":[10],"by":[11],"tools":[12],"that":[13,40,51,75,96,125,130],"advance":[14],"the":[15,44,71,76,86,91,145],"monitoring":[16],"cellular":[18],"processes":[19],"and":[20,60,108,119,141],"analytes.":[21],"Our":[22,122],"laboratory":[23],"developed":[25],"optical":[26],"sensors":[27],"using":[28,70],"carbon":[29,127],"nanotubes":[30],"to":[31],"detect":[32],"intracellular":[33,136],"analytes,":[34],"including":[35],"a":[36,64,101,126,132],"reporter":[37,129],"for":[38,144],"lipids":[39,89],"specifically":[41],"accumulate":[42],"lysosome.":[45],"Using":[46],"this":[47],"reporter,":[48,73],"we":[49],"found":[50,95],"certain":[52,97],"cancer":[53,116],"cell":[54,113,117],"lines":[55,118],"exhibit":[56],"lysosomal":[57],"lipid":[58,72],"dysfunction":[59],"accumulation.":[61],"We":[62],"screened":[63],"library":[65],"lipid-modulating":[67],"experimental":[68],"therapeutics":[69],"finding":[74],"inhibition":[77],"some":[79],"classes":[80],"phospholipase":[82,98],"enzymes":[83,99],"can":[84,111,138],"abrogate":[85],"accumulation":[87],"lysosomes.":[92],"Follow-up":[93],"studies":[94],"have":[100],"protective":[102],"role":[103],"regulating":[105],"redox":[106],"stress,":[107],"if":[109],"inhibited":[110],"induce":[112],"death":[114],"vivo.":[121],"work":[123],"demonstrated":[124],"nanotube":[128],"provides":[131],"new":[133],"type":[134],"measurement":[137],"enable":[139],"target":[140],"discovery":[142],"efforts":[143],"treatment":[146],"cancer.":[148]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-09-20T00:00:00"}
