{"id":"https://openalex.org/W4386838445","doi":"https://doi.org/10.3390/nu15184011","title":"Elevated Erythritol: A Marker of Metabolic Dysregulation or Contributor to the Pathogenesis of Cardiometabolic Disease?","display_name":"Elevated Erythritol: A Marker of Metabolic Dysregulation or Contributor to the Pathogenesis of Cardiometabolic Disease?","publication_year":2023,"publication_date":"2023-09-16","ids":{"openalex":"https://openalex.org/W4386838445","doi":"https://doi.org/10.3390/nu15184011","pmid":"https://pubmed.ncbi.nlm.nih.gov/37764794","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10534702"},"language":"en","primary_location":{"id":"doi:10.3390/nu15184011","doi":"https://doi.org/10.3390/nu15184011","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu15184011","pdf_url":"https://www.mdpi.com/2072-6643/15/18/4011/pdf?version=1695014051","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/15/18/4011/pdf?version=1695014051","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009066882","display_name":"Tagreed A. Mazi","orcid":"https://orcid.org/0000-0002-1250-7234","observed_orcids":["https://orcid.org/0000-0002-1250-7234"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Tagreed A. Mazi","raw_affiliation_strings":["Department of Community Health Sciences-Clinical Nutrition, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Health Sciences-Clinical Nutrition, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056635157","display_name":"Kimber L. Stanhope","orcid":"https://orcid.org/0000-0002-2474-0914","observed_orcids":["https://orcid.org/0000-0002-2474-0914"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimber L. Stanhope","raw_affiliation_strings":["Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"],"raw_orcid":"https://orcid.org/0000-0002-2474-0914","affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009066882"],"corresponding_institution_ids":["https://openalex.org/I28022161"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.4399,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.38497874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"15","issue":"18","first_page":"4011","last_page":"4011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.22349999845027924,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythritol","display_name":"erythritol","score":1.0},{"id":"https://openalex.org/keywords/artificial-sweeteners","display_name":"artificial sweeteners","score":0.9399999976158142},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiometabolic-disease","display_name":"cardiometabolic disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.8539999723434448},{"id":"https://openalex.org/keywords/inborn-errors-of-metabolism","display_name":"inborn errors of metabolism","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2779626320","wikidata":"https://www.wikidata.org/wiki/Q421873","display_name":"Erythritol","level":2,"score":0.8942761421203613},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4710302948951721},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4698587656021118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4634063243865967},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.42487964034080505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.356339693069458},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3547403812408447},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33821481466293335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24072161316871643},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21612685918807983}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004896","descriptor_name":"Erythritol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010427","descriptor_name":"Pentose Phosphate Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/nu15184011","doi":"https://doi.org/10.3390/nu15184011","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu15184011","pdf_url":"https://www.mdpi.com/2072-6643/15/18/4011/pdf?version=1695014051","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10534702","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10534702","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10534702/pdf/nutrients-15-04011.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:37764794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37764794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.3390/nu15184011","doi":"https://doi.org/10.3390/nu15184011","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu15184011","pdf_url":"https://www.mdpi.com/2072-6643/15/18/4011/pdf?version=1695014051","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8866179833","display_name":"The effects of orange juice compared with sugar-sweetened beverage on risk factors and metabolic processes associated with the development of cardiovascular disease and type 2 diabetes","funder_award_id":"R01HL137716","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386838445.pdf","grobid_xml":"https://content.openalex.org/works/W4386838445.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1139124521","https://openalex.org/W1965029829","https://openalex.org/W1966222851","https://openalex.org/W1970946326","https://openalex.org/W1978211809","https://openalex.org/W1981334457","https://openalex.org/W1990490020","https://openalex.org/W1992742196","https://openalex.org/W2005882745","https://openalex.org/W2014217101","https://openalex.org/W2025613526","https://openalex.org/W2049666134","https://openalex.org/W2059248909","https://openalex.org/W2063466129","https://openalex.org/W2066067079","https://openalex.org/W2081490567","https://openalex.org/W2101240048","https://openalex.org/W2105216337","https://openalex.org/W2107333985","https://openalex.org/W2145068672","https://openalex.org/W2147663252","https://openalex.org/W2166381842","https://openalex.org/W2166761576","https://openalex.org/W2193179560","https://openalex.org/W2272486855","https://openalex.org/W2345119282","https://openalex.org/W2411337970","https://openalex.org/W2423847698","https://openalex.org/W2512481071","https://openalex.org/W2612498214","https://openalex.org/W2775218904","https://openalex.org/W2782097726","https://openalex.org/W2790748698","https://openalex.org/W2800008076","https://openalex.org/W2909080532","https://openalex.org/W2948432991","https://openalex.org/W2949616160","https://openalex.org/W2973043833","https://openalex.org/W3011639338","https://openalex.org/W3035544948","https://openalex.org/W3044158131","https://openalex.org/W3128193856","https://openalex.org/W3138309407","https://openalex.org/W3164487250","https://openalex.org/W3165804888","https://openalex.org/W3195448326","https://openalex.org/W3197265543","https://openalex.org/W4200352756","https://openalex.org/W4210453249","https://openalex.org/W4292451922","https://openalex.org/W4293773229","https://openalex.org/W4303184331","https://openalex.org/W4313472599","https://openalex.org/W4316465962","https://openalex.org/W4321326915","https://openalex.org/W4321748416","https://openalex.org/W4322492205","https://openalex.org/W4362638558","https://openalex.org/W4378380044","https://openalex.org/W6645343452","https://openalex.org/W6665043236"],"related_works":["https://openalex.org/W4322492205","https://openalex.org/W7106668918","https://openalex.org/W4380988726","https://openalex.org/W7168236789","https://openalex.org/W4401429230","https://openalex.org/W4402253441","https://openalex.org/W4404531822","https://openalex.org/W7214785262","https://openalex.org/W3168844103","https://openalex.org/W4378085695"],"abstract_inverted_index":{"Erythritol":[0,152],"is":[1,21],"a":[2,79,156],"non-nutritive":[3],"sugar":[4],"replacement":[5],"that":[6,17,37,55,66,92,220],"can":[7],"be":[8,69,154,181,218],"endogenously":[9],"produced":[10],"by":[11,166],"humans.":[12],"Witkowski":[13,176],"et":[14,177],"al.":[15,178],"reported":[16,93],"elevated":[18,100],"circulating":[19],"erythritol":[20,38,56,86,101,128,149,191,204,222],"associated":[22],"with":[23,50,88,98],"adverse":[24],"cardiovascular":[25],"events":[26],"in":[27,32,47,121,134,160],"three":[28],"independent":[29],"cohorts,":[30],"demonstrated":[31],"vitro":[33],"and":[34,42,75,137,172,205,227],"ex":[35],"vivo":[36],"promotes":[39,223],"platelet":[40,113,135,224],"activation,":[41,225],"showed":[43],"faster":[44],"clotting":[45],"time":[46],"mice":[48],"injected":[49],"erythritol.":[51],"It":[52],"was":[53],"concluded":[54,219],"fosters":[57],"enhanced":[58],"thrombosis.":[59],"This":[60],"narrative":[61],"review":[62],"presents":[63],"additional":[64],"evidence":[65],"needs":[67],"to":[68,85,104,180,198],"considered":[70],"when":[71],"evaluating":[72],"these":[73,212],"data":[74,141,210],"conclusions.":[76],"We":[77],"conducted":[78],"search":[80],"of":[81,107,127,145,148,158,175,190],"all":[82],"studies":[83,120],"related":[84],"exposure":[87],"focus":[89],"on":[90,142,193],"those":[91],"vascular":[94],"health":[95],"outcomes.":[96],"Patients":[97],"chronically":[99],"levels":[102,126],"due":[103],"inborn":[105],"errors":[106],"metabolism":[108],"do":[109,129],"not":[110,130],"exhibit":[111],"higher":[112],"activation":[114,136],"or":[115],"thrombosis":[116,138],"risk.":[117,207,229],"Most":[118],"long-term":[119,188],"which":[122],"animals":[123],"consumed":[124],"high":[125],"support":[131],"its":[132],"role":[133],"formation.":[139],"Clinical":[140,184],"the":[143,161,173,187,200],"effects":[144,189],"chronic":[146],"intake":[147],"are":[150,196,214],"limited.":[151],"may":[153],"merely":[155],"marker":[157],"dysregulation":[159],"Pentose":[162],"Phosphate":[163],"Pathway":[164],"caused":[165],"impaired":[167],"glycemia.":[168],"However,":[169],"this":[170],"suggestion":[171],"findings":[174],"need":[179],"further":[182],"examined.":[183],"trials":[185,213],"examining":[186],"consumption":[192],"cardiometabolic":[194,206,228],"outcomes":[195],"required":[197],"test":[199],"causality":[201],"between":[202],"dietary":[203,221],"Until":[208],"supportive":[209],"from":[211],"available,":[215],"it":[216],"cannot":[217],"thrombosis,":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-19T00:00:00"}