{"id":"https://openalex.org/W4386831544","doi":"https://doi.org/10.26434/chemrxiv-2023-2lwx8","title":"Mechanistic rationale for ketene formation during vaping","display_name":"Mechanistic rationale for ketene formation during vaping","publication_year":2023,"publication_date":"2023-09-18","ids":{"openalex":"https://openalex.org/W4386831544","doi":"https://doi.org/10.26434/chemrxiv-2023-2lwx8"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv-2023-2lwx8","doi":"https://doi.org/10.26434/chemrxiv-2023-2lwx8","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2023-2lwx8","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/6504a686b338ec988a8983d5/original/mechanistic-rationale-for-ketene-formation-during-vaping.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/6504a686b338ec988a8983d5/original/mechanistic-rationale-for-ketene-formation-during-vaping.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071370218","display_name":"Kaelas R. Munger","orcid":"https://orcid.org/0000-0002-4360-9954","observed_orcids":["https://orcid.org/0000-0002-4360-9954"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaelas Munger","raw_affiliation_strings":["Portland State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland State University","institution_ids":["https://openalex.org/I126345244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092895340","display_name":"Killian M. Anreise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Killian Anreise","raw_affiliation_strings":["Portland State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland State University","institution_ids":["https://openalex.org/I126345244"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Jensen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Jensen","raw_affiliation_strings":["Florascience, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florascience, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088358643","display_name":"David H. Peyton","orcid":"https://orcid.org/0000-0001-5828-055X","observed_orcids":["https://orcid.org/0000-0001-5828-055X"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Peyton","raw_affiliation_strings":["Portland State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portland State University","institution_ids":["https://openalex.org/I126345244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054319532","display_name":"Robert M. Strongin","orcid":"https://orcid.org/0000-0003-3777-8492","observed_orcids":["https://orcid.org/0000-0003-3777-8492"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Strongin","raw_affiliation_strings":["Portland State University"],"raw_orcid":"https://orcid.org/0000-0003-3777-8492","affiliations":[{"raw_affiliation_string":"Portland State University","institution_ids":["https://openalex.org/I126345244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13253","display_name":"Chemical Reactions and Mechanisms","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketenes","display_name":"ketenes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/e-cigarette-use","display_name":"vaping","score":0.8339999914169312},{"id":"https://openalex.org/keywords/e-cigarette-aerosol","display_name":"e-cigarette aerosol","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pyrolysis","display_name":"pyrolysis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/ethyl-acetate","display_name":"ethyl acetate","score":0.7419999837875366},{"id":"https://openalex.org/keywords/flavorants","display_name":"flavorants","score":0.9169999957084656},{"id":"https://openalex.org/keywords/phenyl-acetate","display_name":"phenyl acetate","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2778874822","wikidata":"https://www.wikidata.org/wiki/Q368158","display_name":"Ketene","level":2,"score":0.9978769421577454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6106550693511963},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.27702927589416504}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv-2023-2lwx8","doi":"https://doi.org/10.26434/chemrxiv-2023-2lwx8","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2023-2lwx8","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/6504a686b338ec988a8983d5/original/mechanistic-rationale-for-ketene-formation-during-vaping.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv-2023-2lwx8","doi":"https://doi.org/10.26434/chemrxiv-2023-2lwx8","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2023-2lwx8","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/6504a686b338ec988a8983d5/original/mechanistic-rationale-for-ketene-formation-during-vaping.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7028119136","display_name":"Toxicant Production and Mitigation in the Electronic-Cigarette Reaction Vessel","funder_award_id":"R01ES025257","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320309493","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386831544.pdf","grobid_xml":"https://content.openalex.org/works/W4386831544.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4239656832"],"related_works":["https://openalex.org/W4399583635","https://openalex.org/W4401108853","https://openalex.org/W4414600688","https://openalex.org/W3010753680","https://openalex.org/W4284958744","https://openalex.org/W3083206194","https://openalex.org/W4220998674","https://openalex.org/W2736814143","https://openalex.org/W7061302175","https://openalex.org/W4389485304"],"abstract_inverted_index":{"Ketene":[0],"is":[1,42,50,89,114,144],"one":[2],"of":[3,39,55,77,99],"the":[4,53,75,94,105],"most":[5],"toxic":[6],"vaping":[7,29,113],"emissions":[8],"identified":[9],"to":[10,20,35,92,117],"date.":[11],"However,":[12],"its":[13],"high":[14],"reactivity":[15],"renders":[16],"it":[17],"relatively":[18,95],"challenging":[19],"identify.":[21],"In":[22],"addition,":[23],"theoretical":[24,66],"studies":[25],"show":[26],"that":[27,109,126],"realistic":[28],"temperature":[30,97],"settings":[31],"are":[32,70],"too":[33],"low":[34,96],"produce":[36],"ketene.":[37,103],"Each":[38],"these":[40],"issues":[41],"addressed":[43],"herein.":[44],"First,":[45],"an":[46],"isotopically-labeled":[47],"acetate":[48,122],"precursor":[49],"used":[51],"for":[52,74],"identification":[54],"ketene":[56,110,127],"with":[57],"enhanced":[58],"rigor":[59],"in":[60],"vaped":[61],"aerosols.":[62],"Second,":[63],"discrepancies":[64],"between":[65],"and":[67,83],"experimental":[68],"findings":[69],"explained":[71],"by":[72],"accounting":[73],"effects":[76],"aerobic":[78],"(experimental)":[79],"versus":[80],"anaerobic":[81],"(simulated":[82],"theoretical)":[84],"pyrolysis":[85],"conditions.":[86],"This":[87,124],"finding":[88],"also":[90],"relevant":[91],"explaining":[93],"production":[98],"aerosol":[100],"toxicants":[101],"beyond":[102],"Moreover,":[104],"study":[106],"herein":[107],"shows":[108],"formation":[111],"during":[112,129],"not":[115],"limited":[116],"molecules":[118],"possessing":[119],"a":[120],"phenyl":[121],"substructure.":[123],"means":[125],"emission":[128],"vaping,":[130],"including":[131],"from":[132],"popular":[133],"flavorants":[134],"such":[135],"as":[136],"ethyl":[137],"acetate,":[138],"may":[139],"be":[140],"more":[141],"prevalent":[142],"than":[143],"currently":[145],"known.":[146]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-19T00:00:00"}