{"id":"https://openalex.org/W4386818227","doi":"https://doi.org/10.1113/jp284412","title":"The mega\u2010evolution of life with its three memory systems depends on sender\u2013receiver communication and problem\u2010solving. A narrative review","display_name":"The mega\u2010evolution of life with its three memory systems depends on sender\u2013receiver communication and problem\u2010solving. A narrative review","publication_year":2023,"publication_date":"2023-09-18","ids":{"openalex":"https://openalex.org/W4386818227","doi":"https://doi.org/10.1113/jp284412","pmid":"https://pubmed.ncbi.nlm.nih.gov/37721172"},"language":"en","primary_location":{"id":"doi:10.1113/jp284412","doi":"https://doi.org/10.1113/jp284412","is_oa":true,"landing_page_url":"https://doi.org/10.1113/jp284412","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP284412","source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP284412","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065071678","display_name":"Arnold DE LOOF","orcid":"https://orcid.org/0000-0002-8788-5301","observed_orcids":["https://orcid.org/0000-0002-8788-5301"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Arnold De Loof","raw_affiliation_strings":["Department of Biology of the KU Leuven, Functional Genomics and Proteomics Group, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology of the KU Leuven, Functional Genomics and Proteomics Group, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065071678"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":4940,"currency":"USD","value_usd":4940},"apc_paid":{"value":4940,"currency":"USD","value_usd":4940},"fwci":1.2034,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.75657895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"602","issue":"11","first_page":"2417","last_page":"2431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sender-receiver-communication","display_name":"sender-receiver communication","score":0.8299999833106995},{"id":"https://openalex.org/keywords/information-transfer","display_name":"information transmission","score":0.5920000076293945},{"id":"https://openalex.org/keywords/genetic-memory","display_name":"ancestral memory","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cognitive-memory","display_name":"cognitive memory","score":0.9539999961853027},{"id":"https://openalex.org/keywords/problem-solving","display_name":"problem solving","score":0.6570000052452087},{"id":"https://openalex.org/keywords/adaptation","display_name":"adaptation","score":0.5669999718666077},{"id":"https://openalex.org/keywords/concept-of-life","display_name":"concept of life","score":0.7310000061988831},{"id":"https://openalex.org/keywords/evolution-of-life","display_name":"evolution of life","score":0.46700000762939453},{"id":"https://openalex.org/keywords/vital-force","display_name":"vital force","score":0.4440000057220459},{"id":"https://openalex.org/keywords/henri-bergson","display_name":"Henri Bergson","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C101097943","wikidata":"https://www.wikidata.org/wiki/Q5176983","display_name":"Counterintuitive","level":2,"score":0.6767442226409912},{"id":"https://openalex.org/C198104137","wikidata":"https://www.wikidata.org/wiki/Q974688","display_name":"Communication source","level":2,"score":0.6157686114311218},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.466228723526001},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4635668694972992},{"id":"https://openalex.org/C199033989","wikidata":"https://www.wikidata.org/wiki/Q1318295","display_name":"Narrative","level":2,"score":0.4529536962509155},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.41992831230163574},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.419717401266098},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34769630432128906},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.33967724442481995},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.2765010595321655},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.2553606927394867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23358049988746643},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.2180217206478119},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19966650009155273},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.198088139295578},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003142","descriptor_name":"Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011340","descriptor_name":"Problem Solving","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1113/jp284412","doi":"https://doi.org/10.1113/jp284412","is_oa":true,"landing_page_url":"https://doi.org/10.1113/jp284412","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP284412","source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:37721172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37721172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/742909","doi":null,"is_oa":false,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/742909","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal Of Physiology-London, vol. 602 (11), (2417-2431)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1113/jp284412","doi":"https://doi.org/10.1113/jp284412","is_oa":true,"landing_page_url":"https://doi.org/10.1113/jp284412","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP284412","source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386818227.pdf","grobid_xml":"https://content.openalex.org/works/W4386818227.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W49347","https://openalex.org/W42779428","https://openalex.org/W186926089","https://openalex.org/W229723928","https://openalex.org/W605068603","https://openalex.org/W1547976002","https://openalex.org/W1556913189","https://openalex.org/W1571255846","https://openalex.org/W1593684180","https://openalex.org/W1978094575","https://openalex.org/W1991285543","https://openalex.org/W1992860213","https://openalex.org/W2004477593","https://openalex.org/W2039900497","https://openalex.org/W2042659427","https://openalex.org/W2043957490","https://openalex.org/W2054321086","https://openalex.org/W2055214702","https://openalex.org/W2093919744","https://openalex.org/W2106537583","https://openalex.org/W2126466006","https://openalex.org/W2149044504","https://openalex.org/W2152209670","https://openalex.org/W2162016759","https://openalex.org/W2196000340","https://openalex.org/W2235229113","https://openalex.org/W2278447904","https://openalex.org/W2325392585","https://openalex.org/W2410837675","https://openalex.org/W2410992401","https://openalex.org/W2464234541","https://openalex.org/W2475481088","https://openalex.org/W2525632238","https://openalex.org/W2595113947","https://openalex.org/W2739467950","https://openalex.org/W2749196733","https://openalex.org/W2787755244","https://openalex.org/W2807216026","https://openalex.org/W2907982520","https://openalex.org/W2922045584","https://openalex.org/W2992629375","https://openalex.org/W3011488657","https://openalex.org/W3025910065","https://openalex.org/W3041516289","https://openalex.org/W3092585719","https://openalex.org/W4230499274","https://openalex.org/W4252181808","https://openalex.org/W4285728514","https://openalex.org/W4286794567","https://openalex.org/W4299444877","https://openalex.org/W4300925890","https://openalex.org/W4308188862","https://openalex.org/W4309360323","https://openalex.org/W4375858910","https://openalex.org/W4377094550","https://openalex.org/W4380077748","https://openalex.org/W4385458330","https://openalex.org/W4386315668","https://openalex.org/W6632275150","https://openalex.org/W6840123602","https://openalex.org/W7028213685"],"related_works":["https://openalex.org/W4308188862","https://openalex.org/W2595113947","https://openalex.org/W2235229113","https://openalex.org/W2522853465","https://openalex.org/W2525632238","https://openalex.org/W2811201442","https://openalex.org/W2066898940","https://openalex.org/W4388119636","https://openalex.org/W6941161056","https://openalex.org/W4388939782"],"abstract_inverted_index":{"It":[0],"should":[1],"be":[2,33,214],"the":[3,13,21,66,109,118,120,134,225,244],"ultimate":[4],"goal":[5],"of":[6,9,15,70,73,76,83,94,112,137,142,188,203,228],"any":[7,81,201],"theory":[8],"evolution":[10,116,231],"to":[11,19,38,90,106,129,133,185,199,213],"delineate":[12],"contours":[14],"an":[16,53,169],"integrative":[17],"system":[18,172],"answer":[20,43],"question:":[22],"How":[23],"does":[24],"life":[25,222],"(in":[26,251],"all":[27,71,86,210],"its":[28,229],"complexity)":[29],"evolve":[30],"(which":[31],"can":[32,182],"called":[34],"mega-evolution)?":[35],"But":[36],"how":[37],"plausibly":[39],"define":[40],"'life'?":[41],"My":[42],"(1994-2023)":[44],"is:":[45],"'life'":[46],"sounds":[47],"like":[48],"a":[49,58,140,158,164,175,206],"noun,":[50],"but":[51,162,235,257],"denotes":[52,62],"activity,":[54],"and":[55,115,168,193,237,248],"thus":[56,174],"is":[57,103,205,224,243],"verb.":[59],"Life":[60],"(L)":[61],"nothing":[63],"else":[64],"than":[65,117],"total":[67],"sum":[68],"(\u2211)":[69],"acts":[72],"communication":[74,130,204],"(transfer":[75],"information)":[77],"(C)":[78],"executed":[79],"by":[80],"type":[82],"senders-receivers":[84],"at":[85,91],"their":[87],"levels":[88],"(up":[89],"least":[92],"15)":[93],"compartmental":[95],"organization:":[96],"L":[97],"=":[98],"\u2211C.":[99],"The":[100,146],"'communicating":[101],"compartment'":[102],"better":[104],"suited":[105],"serve":[107],"as":[108,126,132,150],"universal":[110],"unit":[111],"structure,":[113],"function":[114],"cell,":[119],"smallest":[121],"such":[122],"unit.":[123],"By":[124],"paying":[125],"much":[127],"importance":[128,198],"activity":[131],"Central":[135],"Dogma":[136],"molecular":[138],"biology,":[139],"wealth":[141],"new":[143],"insights":[144],"unfold.":[145],"major":[147],"ones":[148],"are":[149],"follows.":[151],"(1)":[152],"Living":[153],"compartments":[154,181],"have":[155,183],"not":[156,259],"only":[157],"genetic":[159,190],"memory":[160,171,177],"(DNA),":[161],"also":[163],"still":[165],"enigmatic":[166],"cognitive":[167],"electrical":[170],"(and":[173],"triple":[176],"system).":[178],"(2)":[179],"Complex":[180],"up":[184],"three":[186],"types":[187],"progeny:":[189],"descendants/children,":[191],"pupils/learners":[192],"electricians.":[194],"(3)":[195],"Of":[196],"particular":[197],"adaptation,":[200],"act":[202,208],"problem-solving":[207,218],"because":[209],"messages":[211],"need":[212],"decoded.":[215],"Hence":[216],"through":[217],"that":[219],"precedes":[220],"selection,":[221],"itself":[223],"driving":[226],"force":[227],"own":[230],"(a":[232],"very":[233],"clever":[234],"counterintuitive":[236],"unexpected":[238],"logical":[239],"deduction).":[240],"Perhaps,":[241],"this":[242],"'vital":[245],"force'":[246],"philosopher":[247],"Nobel":[249],"laureate":[250],"1927)":[252],"Henri":[253],"Bergson":[254],"searched":[255],"for":[256],"did":[258],"find.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-19T00:00:00"}