{"id":"https://openalex.org/W4386760002","doi":"https://doi.org/10.7759/cureus.45327","title":"Definitive Treatment of Brain Metastases From a Neuroendocrine Tumor With Peptide Receptor Radionuclide Therapy With 177Lutetium DOTATATE: A Case Report","display_name":"Definitive Treatment of Brain Metastases From a Neuroendocrine Tumor With Peptide Receptor Radionuclide Therapy With 177Lutetium DOTATATE: A Case Report","publication_year":2023,"publication_date":"2023-09-15","ids":{"openalex":"https://openalex.org/W4386760002","doi":"https://doi.org/10.7759/cureus.45327","pmid":"https://pubmed.ncbi.nlm.nih.gov/37849592","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10577096"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.45327","doi":"https://doi.org/10.7759/cureus.45327","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7759/cureus.45327","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/162726/20230916-28062-qevvip.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://assets.cureus.com/uploads/case_report/pdf/162726/20230916-28062-qevvip.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Vivian Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivian Zhang","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University, Stanford, USA",". Department of Medicine and Medical Oncology, Stanford University, Stanford, USA",". Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Medicine and Medical Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008027539","display_name":"Kekoa Taparra","orcid":"https://orcid.org/0000-0001-8493-3868","observed_orcids":["https://orcid.org/0000-0001-8493-3868"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kekoa Taparra","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University, Stanford, USA",". Department of Medicine and Medical Oncology, Stanford University, Stanford, USA",". Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Medicine and Medical Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036188351","display_name":"George Albert Fisher","orcid":"https://orcid.org/0000-0002-6828-3938","observed_orcids":["https://orcid.org/0000-0002-6828-3938"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Fisher","raw_affiliation_strings":["Department of Medicine and Medical Oncology, Stanford University, Stanford, USA",". Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA",". Department of Radiation Oncology, Stanford University, Stanford, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Medical Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Radiation Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016095722","display_name":"Carina Mar\u00ed Aparici","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carina Aparici","raw_affiliation_strings":["Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA",". Department of Medicine and Medical Oncology, Stanford University, Stanford, USA",". Department of Radiation Oncology, Stanford University, Stanford, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Medicine and Medical Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Radiation Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072792947","display_name":"Scott G. Soltys","orcid":"https://orcid.org/0000-0002-5360-7063","observed_orcids":["https://orcid.org/0000-0002-5360-7063"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott G Soltys","raw_affiliation_strings":["Department of Radiation Oncology, Stanford University, Stanford, USA",". Department of Medicine and Medical Oncology, Stanford University, Stanford, USA",". Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Medicine and Medical Oncology, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":". Department of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072792947"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":0.7943,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72179937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"15","issue":"9","first_page":"e45327","last_page":"e45327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.09669999778270721,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7179999947547913},{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.8180000185966492},{"id":"https://openalex.org/keywords/gastroenteropancreatic-neuroendocrine-tumors","display_name":"gastroenteropancreatic neuroendocrine tumors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/peptide-receptor-radionuclide-therapy","display_name":"peptide receptor radionuclide therapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/177lu-dotatate","display_name":"177Lu-DOTATATE","score":0.847000002861023},{"id":"https://openalex.org/keywords/small-intestinal-neuroendocrine-tumors","display_name":"small bowel neuroendocrine tumors","score":0.878000020980835},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9447656273841858},{"id":"https://openalex.org/C2993559085","wikidata":"https://www.wikidata.org/wiki/Q2126444","display_name":"Radionuclide therapy","level":2,"score":0.8162558078765869},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.7209962010383606},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.683428168296814},{"id":"https://openalex.org/C3017732841","wikidata":"https://www.wikidata.org/wiki/Q25098597","display_name":"Peptide receptor","level":3,"score":0.6830650568008423},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4834173917770386},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.461273193359375},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44621920585632324},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4155002236366272},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18745943903923035},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.08012831211090088}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.45327","doi":"https://doi.org/10.7759/cureus.45327","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7759/cureus.45327","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/162726/20230916-28062-qevvip.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10577096","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10577096","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10577096/pdf/cureus-0015-00000045327.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:37849592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37849592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.45327","doi":"https://doi.org/10.7759/cureus.45327","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7759/cureus.45327","pdf_url":"https://assets.cureus.com/uploads/case_report/pdf/162726/20230916-28062-qevvip.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386760002.pdf","grobid_xml":"https://content.openalex.org/works/W4386760002.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1596743017","https://openalex.org/W1990509102","https://openalex.org/W2060030424","https://openalex.org/W2068863981","https://openalex.org/W2091849681","https://openalex.org/W2108613323","https://openalex.org/W2112064092","https://openalex.org/W2254079930","https://openalex.org/W2573369749","https://openalex.org/W2608160487","https://openalex.org/W2946613157","https://openalex.org/W3040054525","https://openalex.org/W3213534889"],"related_works":["https://openalex.org/W4321598801","https://openalex.org/W4226357515","https://openalex.org/W4396972436","https://openalex.org/W4282833074","https://openalex.org/W4382599861","https://openalex.org/W2981499856","https://openalex.org/W2899492862","https://openalex.org/W4387159931","https://openalex.org/W4214922619","https://openalex.org/W3033013261"],"abstract_inverted_index":{"Gastroenteropancreatic":[0],"neuroendocrine":[1],"tumors":[2],"(GEP-NETs)":[3],"are":[4],"rare":[5],"malignancies":[6],"that":[7],"arise":[8],"from":[9,42,44,83],"secretory":[10],"endocrine":[11],"cells":[12],"of":[13,33,39,53,71,74,81],"the":[14,27,37,51],"gastroenteropancreatic":[15],"system.":[16],"Clinical":[17],"outcomes":[18],"have":[19,90],"improved":[20],"for":[21,99],"patients":[22],"with":[23,57,62,68,96],"GEP-NETs":[24,43],"due":[25],"to":[26],"development":[28],"and":[29,64],"recent":[30],"FDA":[31],"approval":[32],"177Lutetium":[34,45,75],"DOTATATE.":[35,76],"However,":[36],"response":[38],"brain":[40,65,88,100],"metastases":[41,66,89],"DOTATATE":[46],"is":[47],"unreported.":[48],"We":[49],"present":[50],"case":[52],"an":[54],"81-year-old":[55],"man":[56],"low-grade":[58],"small":[59],"bowel":[60],"GEP-NET":[61],"liver":[63],"treated":[67],"a":[69],"total":[70],"six":[72],"cycles":[73],"With":[77],"over":[78],"three":[79],"years":[80],"follow-up":[82],"his":[84,87],"initial":[85],"treatment,":[86],"had":[91],"complete":[92],"or":[93,102],"partial":[94],"responses,":[95],"no":[97],"need":[98],"radiotherapy":[101],"radiosurgery.":[103]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-09-16T00:00:00"}