{"id":"https://openalex.org/W4386726366","doi":"https://doi.org/10.4049/immunohorizons.2300050","title":"Acute Respiratory Illness Is Associated with Memory T Cell Differentiation and Other Immune Cell Changes in an Age-Associated Manner","display_name":"Acute Respiratory Illness Is Associated with Memory T Cell Differentiation and Other Immune Cell Changes in an Age-Associated Manner","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386726366","doi":"https://doi.org/10.4049/immunohorizons.2300050","pmid":"https://pubmed.ncbi.nlm.nih.gov/37707792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10590771"},"language":"en","primary_location":{"id":"doi:10.4049/immunohorizons.2300050","doi":"https://doi.org/10.4049/immunohorizons.2300050","is_oa":true,"landing_page_url":"https://doi.org/10.4049/immunohorizons.2300050","pdf_url":"https://journals.aai.org/immunohorizons/article-pdf/7/9/611/1639859/ih2300050.pdf","source":{"id":"https://openalex.org/S4210228433","display_name":"ImmunoHorizons","issn_l":"2573-7732","issn":["2573-7732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ImmunoHorizons","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.aai.org/immunohorizons/article-pdf/7/9/611/1639859/ih2300050.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092866720","display_name":"Shreya S. Ugale","orcid":"https://orcid.org/0000-0002-2859-2437","observed_orcids":["https://orcid.org/0000-0002-2859-2437"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shreya S Ugale","raw_affiliation_strings":["*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA"],"raw_orcid":"https://orcid.org/0000-0002-2859-2437","affiliations":[{"raw_affiliation_string":"*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007825628","display_name":"Tyson H. Holmes","orcid":"https://orcid.org/0000-0002-5512-4583","observed_orcids":["https://orcid.org/0000-0002-5512-4583"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyson H Holmes","raw_affiliation_strings":["*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109246188","display_name":"Sofia Maysel-Auslender","orcid":"https://orcid.org/0009-0001-8573-3726","observed_orcids":["https://orcid.org/0009-0001-8573-3726"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sofia Maysel-Auslender","raw_affiliation_strings":["*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064302758","display_name":"Scott Dexter Boyd","orcid":"https://orcid.org/0000-0003-0963-044X","observed_orcids":["https://orcid.org/0000-0003-0963-044X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott D Boyd","raw_affiliation_strings":["\u2020Department of Pathology, Stanford University School of Medicine, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Pathology, Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013153304","display_name":"Cornelia L. Dekker","orcid":"https://orcid.org/0000-0002-3871-918X","observed_orcids":["https://orcid.org/0000-0002-3871-918X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cornelia L Dekker","raw_affiliation_strings":["\u2021Department of Pediatrics, Stanford University School of Medicine, Stanford, CA"],"raw_orcid":"https://orcid.org/0000-0002-3871-918X","affiliations":[{"raw_affiliation_string":"\u2021Department of Pediatrics, Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025539602","display_name":"Mark M. Davis","orcid":"https://orcid.org/0000-0001-6868-657X","observed_orcids":["https://orcid.org/0000-0001-6868-657X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark M Davis","raw_affiliation_strings":["*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA"],"raw_orcid":"https://orcid.org/0000-0001-6868-657X","affiliations":[{"raw_affiliation_string":"*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068399737","display_name":"Holden Terry Maecker","orcid":"https://orcid.org/0000-0003-0795-9946","observed_orcids":["https://orcid.org/0000-0003-0795-9946","https://orcid.org/0000-0001-5389-0906"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Holden T Maecker","raw_affiliation_strings":["*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA"],"raw_orcid":"https://orcid.org/0000-0003-0795-9946","affiliations":[{"raw_affiliation_string":"*Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068399737"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":1700,"currency":"USD","value_usd":1700},"apc_paid":{"value":1700,"currency":"USD","value_usd":1700},"fwci":0.3272,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.50156325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"7","issue":"9","first_page":"611","last_page":"618"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-illness","display_name":"acute respiratory illness","score":0.9729999899864197},{"id":"https://openalex.org/keywords/influenza","display_name":"influenza","score":0.5360000133514404},{"id":"https://openalex.org/keywords/memory-t-cell-differentiation","display_name":"memory T cell differentiation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/age-related-immune-changes","display_name":"age-related immune changes","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/effector-memory-t-cells","display_name":"effector memory T cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.8389999866485596},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.6779999732971191},{"id":"https://openalex.org/keywords/t-cell-phenotype","display_name":"T cell phenotype","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.70702064037323},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6960388422012329},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6953786611557007},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5790250301361084},{"id":"https://openalex.org/C2777367678","wikidata":"https://www.wikidata.org/wiki/Q2304808","display_name":"Memory T cell","level":4,"score":0.5146099328994751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5085052251815796},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4930872619152069},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46288415789604187},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.45770689845085144},{"id":"https://openalex.org/C2775982045","wikidata":"https://www.wikidata.org/wiki/Q6959842","display_name":"Naive T cell","level":5,"score":0.4363020956516266},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.13329976797103882},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09142729640007019},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06721529364585876},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4049/immunohorizons.2300050","doi":"https://doi.org/10.4049/immunohorizons.2300050","is_oa":true,"landing_page_url":"https://doi.org/10.4049/immunohorizons.2300050","pdf_url":"https://journals.aai.org/immunohorizons/article-pdf/7/9/611/1639859/ih2300050.pdf","source":{"id":"https://openalex.org/S4210228433","display_name":"ImmunoHorizons","issn_l":"2573-7732","issn":["2573-7732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ImmunoHorizons","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10590771","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10590771","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10590771/pdf/ih2300050.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunohorizons","raw_type":"Text"},{"id":"pmid:37707792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37707792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ImmunoHorizons","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4049/immunohorizons.2300050","doi":"https://doi.org/10.4049/immunohorizons.2300050","is_oa":true,"landing_page_url":"https://doi.org/10.4049/immunohorizons.2300050","pdf_url":"https://journals.aai.org/immunohorizons/article-pdf/7/9/611/1639859/ih2300050.pdf","source":{"id":"https://openalex.org/S4210228433","display_name":"ImmunoHorizons","issn_l":"2573-7732","issn":["2573-7732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ImmunoHorizons","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1047591048","display_name":"Mechanisms and Duration of Immunity to SARS-CoV-2","funder_award_id":"U54CA260517","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6685717490","display_name":"Vaccination and infection: indicators of immunological health and responsiveness","funder_award_id":"U19AI090019","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8204573347","display_name":"Effects of aging on primary and secondary vaccine responses in a 15-year longitudinal cohort","funder_award_id":"R01AI130398","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000891052","display_name":"Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro","funder_award_id":"U19AI057229","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000899458","display_name":"High resolution longitudinal immune monitoring for elucidating immune aging dynamics","funder_award_id":"P01AI153559","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386726366.pdf","grobid_xml":"https://content.openalex.org/works/W4386726366.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W36066722","https://openalex.org/W1960623812","https://openalex.org/W2017219476","https://openalex.org/W2050146790","https://openalex.org/W2051974385","https://openalex.org/W2054393027","https://openalex.org/W2054733960","https://openalex.org/W2063695575","https://openalex.org/W2075632360","https://openalex.org/W2076983697","https://openalex.org/W2081068112","https://openalex.org/W2116319049","https://openalex.org/W2137378887","https://openalex.org/W2153039996","https://openalex.org/W2170904230","https://openalex.org/W2176524527","https://openalex.org/W2428114060","https://openalex.org/W2902652978","https://openalex.org/W2919822707","https://openalex.org/W2952958102","https://openalex.org/W3027752479","https://openalex.org/W4206729087","https://openalex.org/W4319461391","https://openalex.org/W6717579330"],"related_works":["https://openalex.org/W2052444641","https://openalex.org/W1593811388","https://openalex.org/W3164211277","https://openalex.org/W2412807878","https://openalex.org/W2051628322","https://openalex.org/W110247572","https://openalex.org/W2283200493","https://openalex.org/W3180619345","https://openalex.org/W3124834542","https://openalex.org/W2046586993"],"abstract_inverted_index":{"Respiratory":[0],"viruses":[1],"such":[2],"as":[3,34,138,140],"influenza":[4],"are":[5],"encountered":[6],"multiple":[7,178],"times":[8],"through":[9],"infection":[10],"and/or":[11],"vaccination":[12],"and":[13,37,71,88,92,99,113,134,149,185,190,204],"thus":[14],"have":[15],"the":[16,61],"potential":[17],"to":[18,44],"shape":[19],"immune":[20,52],"cell":[21,29,40,90,102,158,179,202,208],"phenotypes":[22,53],"over":[23],"time.":[24],"In":[25,47,76],"particular,":[26],"memory":[27,145],"T":[28,39,101,132,136,147,192,201],"compartments":[30],"may":[31],"be":[32],"affected,":[33],"both":[35],"CD4+":[36,98,131,189],"CD8+":[38,100,146,191],"responses":[41],"likely":[42],"contribute":[43],"viral":[45],"control.":[46],"this":[48],"study,":[49],"we":[50,84],"assessed":[51],"using":[54],"cytometry":[55],"by":[56],"time":[57],"of":[58,64,82,119,188],"flight":[59],"in":[60,129,143,152,171,211],"peripheral":[62],"blood":[63],"22":[65,72],"humans":[66],"with":[67,105,155,173,214],"acute":[68,197],"respiratory":[69,198],"illness":[70,199],"age-matched":[73],"noninfected":[74,112,153,167],"controls.":[75,108],"younger":[77],"infected":[78,114,165],"individuals":[79,116,154],"(1-19":[80],"y":[81,118],"age),":[83],"found":[85],"decreased":[86],"B":[87,183,207],"NK":[89],"frequencies":[91,159,209],"a":[93,127],"shift":[94],"toward":[95],"more":[96],"effector-like":[97],"phenotypes,":[103],"compared":[104,213],"young":[106,212],"healthy":[107],"Significant":[109],"differences":[110,170],"between":[111],"older":[115,215],"(30-74":[117],"age)":[120],"were":[121,160,175],"not":[122],"seen.":[123],"We":[124,194],"also":[125],"observed":[126,176],"decrease":[128],"naive":[130],"cells":[133,137,148,151,184],"CD27+CD8+":[135],"well":[139],"an":[141],"increase":[142],"effector":[144],"NKT":[150],"age.":[156],"When":[157],"regressed":[161],"against":[162],"age":[163,174],"for":[164,177],"versus":[166],"subjects,":[168],"significant":[169],"trends":[172],"types.":[180],"These":[181],"included":[182],"various":[186],"subsets":[187],"cells.":[193],"conclude":[195],"that":[196],"drives":[200],"differentiation":[203],"decreases":[205],"circulating":[206],"preferentially":[210],"individuals.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-15T00:00:00"}