{"id":"https://openalex.org/W4386726229","doi":"https://doi.org/10.1371/journal.pdig.0000334","title":"A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach","display_name":"A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach","publication_year":2023,"publication_date":"2023-09-13","ids":{"openalex":"https://openalex.org/W4386726229","doi":"https://doi.org/10.1371/journal.pdig.0000334","pmid":"https://pubmed.ncbi.nlm.nih.gov/37703231","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10499205"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pdig.0000334","doi":"https://doi.org/10.1371/journal.pdig.0000334","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pdig.0000334","pdf_url":"https://journals.plos.org/digitalhealth/article/file?id=10.1371/journal.pdig.0000334&type=printable","source":{"id":"https://openalex.org/S4210221150","display_name":"PLOS Digital Health","issn_l":"2767-3170","issn":["2767-3170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Digital Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/digitalhealth/article/file?id=10.1371/journal.pdig.0000334&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004239077","display_name":"Ralph Kwame Akyea","orcid":"https://orcid.org/0000-0003-4529-8237","observed_orcids":["https://orcid.org/0000-0003-4529-8237"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ralph K. Akyea","raw_affiliation_strings":["PRISM Research Group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4529-8237","affiliations":[{"raw_affiliation_string":"PRISM Research Group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076026606","display_name":"George Ntaios","orcid":"https://orcid.org/0000-0002-0629-9248","observed_orcids":["https://orcid.org/0000-0002-0629-9248"]},"institutions":[{"id":"https://openalex.org/I145722265","display_name":"University of Thessaly","ror":"https://ror.org/04v4g9h31","country_code":"GR","type":"education","lineage":["https://openalex.org/I145722265"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"George Ntaios","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece","institution_ids":["https://openalex.org/I145722265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057258772","display_name":"Evangelos Kontopantelis","orcid":"https://orcid.org/0000-0001-6450-5815","observed_orcids":["https://orcid.org/0000-0001-6450-5815"]},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Evangelos Kontopantelis","raw_affiliation_strings":["Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), The University of Manchester, Manchester, United Kingdom","Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]},{"raw_affiliation_string":"Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre (MAHSC), The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034130684","display_name":"Georgios A. Georgiopoulos","orcid":"https://orcid.org/0000-0001-7661-5253","observed_orcids":["https://orcid.org/0000-0001-7661-5253"]},"institutions":[{"id":"https://openalex.org/I1324925910","display_name":"St Thomas' Hospital","ror":"https://ror.org/054gk2851","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324925910","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Georgios Georgiopoulos","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, St Thomas Hospital, King's College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, St Thomas Hospital, King's College London, London, United Kingdom","institution_ids":["https://openalex.org/I1324925910","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006072420","display_name":"Daniele Soria","orcid":"https://orcid.org/0000-0002-0164-8218","observed_orcids":["https://orcid.org/0000-0002-0164-8218"]},"institutions":[{"id":"https://openalex.org/I20581793","display_name":"University of Kent","ror":"https://ror.org/00xkeyj56","country_code":"GB","type":"education","lineage":["https://openalex.org/I20581793"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniele Soria","raw_affiliation_strings":["School of Computing, University of Kent, Canterbury, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computing, University of Kent, Canterbury, United Kingdom","institution_ids":["https://openalex.org/I20581793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039782389","display_name":"Folkert Wouter Asselbergs","orcid":"https://orcid.org/0000-0002-1692-8669","observed_orcids":["https://orcid.org/0000-0002-1692-8669"]},"institutions":[{"id":"https://openalex.org/I4210142469","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210142469"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Folkert W. Asselbergs","raw_affiliation_strings":["Amsterdam University Medical Centers, Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands","Health Data Research UK and Institute of Health Informatics, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amsterdam University Medical Centers, Department of Cardiology, University of Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Health Data Research UK and Institute of Health Informatics, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210142469","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041602186","display_name":"Joe Kai","orcid":"https://orcid.org/0000-0001-9040-9384","observed_orcids":["https://orcid.org/0000-0001-9040-9384"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joe Kai","raw_affiliation_strings":["PRISM Research Group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PRISM Research Group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016161989","display_name":"Stephen Franklin Weng","orcid":"https://orcid.org/0000-0002-5281-9590","observed_orcids":["https://orcid.org/0000-0002-5281-9590"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen F. Weng","raw_affiliation_strings":["PRISM Research Group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PRISM Research Group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091023678","display_name":"Nadeem Qureshi","orcid":"https://orcid.org/0000-0003-4909-0644","observed_orcids":["https://orcid.org/0000-0003-4909-0644"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nadeem Qureshi","raw_affiliation_strings":["PRISM Research Group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PRISM Research Group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5004239077"],"corresponding_institution_ids":["https://openalex.org/I142263535"],"apc_list":{"value":2575,"currency":"USD","value_usd":2575},"apc_paid":{"value":2575,"currency":"USD","value_usd":2575},"fwci":2.8097,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.91578503,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2","issue":"9","first_page":"e0000334","last_page":"e0000334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.7820000052452087},{"id":"https://openalex.org/keywords/phenotypic-clusters","display_name":"phenotypic clusters","score":0.8500000238418579},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cardiovascular-outcomes","display_name":"cardiovascular outcomes","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.6539999842643738},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8830000162124634},{"id":"https://openalex.org/keywords/peripheral-vascular-disease","display_name":"peripheral vascular disease","score":0.9739999771118164},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9990000128746033},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.7350000143051147},{"id":"https://openalex.org/keywords/unsupervised-clustering","display_name":"unsupervised clustering","score":0.7590000033378601},{"id":"https://openalex.org/keywords/incident-stroke","display_name":"incident stroke","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.8094960451126099},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7865698337554932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7785686254501343},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6619446277618408},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5835158228874207},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48219218850135803},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46048980951309204},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.4515300989151001},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.35381537675857544},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pdig.0000334","doi":"https://doi.org/10.1371/journal.pdig.0000334","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pdig.0000334","pdf_url":"https://journals.plos.org/digitalhealth/article/file?id=10.1371/journal.pdig.0000334&type=printable","source":{"id":"https://openalex.org/S4210221150","display_name":"PLOS Digital Health","issn_l":"2767-3170","issn":["2767-3170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Digital Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10499205","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10499205","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10499205/pdf/pdig.0000334.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Digit Health","raw_type":"Text"},{"id":"pmid:37703231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37703231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS digital health","raw_type":"Journal Article"},{"id":"pmh:oai:kar.kent.ac.uk:102765","doi":null,"is_oa":true,"landing_page_url":"https://kar.kent.ac.uk/102765/7/Stroke%20phenotypic%20clusters%20-%20Manuscript%20-%20Accepted%20version%20by%20journal%20-%20Aug2023%20%281%29.docx","pdf_url":"https://kar.kent.ac.uk/102765/1/Soria_A_population.pdf","source":{"id":"https://openalex.org/S4377196264","display_name":"Kent Academic Repository (University of Kent)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20581793","host_organization_name":"University of Kent","host_organization_lineage":["https://openalex.org/I20581793"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:nottingham-repository.worktribe.com:25060559","doi":null,"is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/25060559/1/Stroke%20Phenotypic%20Clusters","pdf_url":"https://nottingham-repository.worktribe.com/file/25060559/1/Stroke%20Phenotypic%20Clusters","source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/79157d2c-521b-42f9-9c08-bfb1f5e4e32b","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/79157d2c-521b-42f9-9c08-bfb1f5e4e32b","pdf_url":"https://pure.amsterdamumc.nl/files/142741719/A-population-based-study-exploring-phenotypic-clusters-and-clinical-outcomes-in-stroke-using-unsupervised-machine-learni.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Akyea, R K, Ntaios, G, Kontopantelis, E, Georgiopoulos, G, Soria, D, Asselbergs, F W, Kai, J, Weng, S F & Qureshi, N 2023, 'A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach', PLOS digital health, vol. 2, no. 9 September, e0000334, pp. e0000334. https://doi.org/10.1371/journal.pdig.0000334","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai::25060559","doi":null,"is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/25060559","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pdig00:0000334","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/digitalhealth/article?id=10.1371/journal.pdig.0000334","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8fb7ba230ba34d808d0648bf0c68d18b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8fb7ba230ba34d808d0648bf0c68d18b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Digital Health, Vol 2, Iss 9, p e0000334 (2023)","raw_type":"article"},{"id":"pmh:oai:https://nottingham-repository.worktribe.com/:25060559","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1371/journal.pdig.0000334","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/be86ac0d-00f0-4c4d-9afe-5c403a500ca9","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/be86ac0d-00f0-4c4d-9afe-5c403a500ca9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Akyea, R K, Ntaios, G, Kontopantelis, E, Georgiopoulos, G, Soria, D, Asselbergs, F W, Kai, J, Weng, S F & Qureshi, N 2023, 'A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach', PL o S Digital Health, vol. 2, no. 9, pp. e0000334. https://doi.org/10.1371/journal.pdig.0000334","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pdig.0000334","doi":"https://doi.org/10.1371/journal.pdig.0000334","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pdig.0000334","pdf_url":"https://journals.plos.org/digitalhealth/article/file?id=10.1371/journal.pdig.0000334&type=printable","source":{"id":"https://openalex.org/S4210221150","display_name":"PLOS Digital Health","issn_l":"2767-3170","issn":["2767-3170"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Digital Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3237226643","display_name":null,"funder_award_id":"SPCR-150","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320336046","display_name":"NIHR School for Primary Care Research","ror":"https://ror.org/03wz10q85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386726229.pdf","grobid_xml":"https://content.openalex.org/works/W4386726229.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W311320695","https://openalex.org/W1480729244","https://openalex.org/W1678889691","https://openalex.org/W1852065298","https://openalex.org/W1869983108","https://openalex.org/W1937033430","https://openalex.org/W1999945328","https://openalex.org/W2026660718","https://openalex.org/W2034024435","https://openalex.org/W2041031177","https://openalex.org/W2076670312","https://openalex.org/W2106715003","https://openalex.org/W2109003100","https://openalex.org/W2118502261","https://openalex.org/W2119852447","https://openalex.org/W2124247204","https://openalex.org/W2132279603","https://openalex.org/W2135046866","https://openalex.org/W2143885411","https://openalex.org/W2149686080","https://openalex.org/W2153832807","https://openalex.org/W2156665896","https://openalex.org/W2170075065","https://openalex.org/W2200285648","https://openalex.org/W2473875350","https://openalex.org/W2544063755","https://openalex.org/W2569711455","https://openalex.org/W2790501791","https://openalex.org/W2805627121","https://openalex.org/W2808133395","https://openalex.org/W2944890781","https://openalex.org/W2944988359","https://openalex.org/W2969436956","https://openalex.org/W2999615587","https://openalex.org/W3096750261","https://openalex.org/W3121528591","https://openalex.org/W3129803974","https://openalex.org/W3164908038"],"related_works":["https://openalex.org/W4294967895","https://openalex.org/W7211970814","https://openalex.org/W7160426452","https://openalex.org/W2995094083","https://openalex.org/W3084896783","https://openalex.org/W4413993451","https://openalex.org/W4409344833","https://openalex.org/W4310052211","https://openalex.org/W4409225974","https://openalex.org/W4391386481"],"abstract_inverted_index":{"Individuals":[0],"developing":[1],"stroke":[2,38,49,167,223,231,267,299],"have":[3],"varying":[4,143],"clinical":[5,57,145],"characteristics,":[6],"demographic,":[7],"and":[8,23,42,50,63,91,136,168,202,224,228,248,281],"biochemical":[9],"profiles.":[10],"This":[11,26,285],"heterogeneity":[12],"in":[13,66,77,149,173,216,241],"phenotypic":[14,40],"characteristics":[15,146],"can":[16,268],"impact":[17],"on":[18],"cardiovascular":[19,52,283],"disease":[20,125,131],"(CVD)":[21],"morbidity":[22],"mortality":[24,170,226],"outcomes.":[25,53,284,303],"study":[27],"uses":[28],"a":[29,260],"novel":[30],"clustering":[31,71],"approach":[32],"to":[33,89,105,289,300],"stratify":[34],"individuals":[35],"with":[36,84,142,151,155,265,276,297],"incident":[37,85,152,266,298],"into":[39,271],"clusters":[41,177],"evaluates":[43],"the":[44,67,117,162,174,291],"differential":[45,277],"burden":[46],"of":[47,95,116,164,254,263,279,293],"recurrent":[48,127,166,222,230,280],"other":[51,175],"We":[54],"used":[55,76,104],"linked":[56],"data":[58],"from":[59,87],"primary":[60],"care,":[61],"hospitalisations,":[62],"death":[64],"records":[65],"UK.":[68],"A":[69],"data-driven":[70],"analysis":[72],"(kamila":[73],"algorithm)":[74],"was":[75,103,171],"48,114":[78],"patients":[79,150,264,296],"aged":[80],"\u2265":[81],"18":[82],"years":[83],"stroke,":[86,128],"1-Jan-1998":[88],"31-Dec-2017":[90],"no":[92],"prior":[93],"history":[94],"serious":[96],"vascular":[97,130],"events.":[98],"Cox":[99],"proportional":[100],"hazards":[101],"regression":[102],"estimate":[106],"hazard":[107,184],"ratios":[108],"(HRs)":[109],"for":[110,114,220,238,295],"subsequent":[111,229,239],"adverse":[112],"outcomes,":[113],"each":[115],"generated":[118],"clusters.":[119],"Adverse":[120],"outcomes":[121],"included":[122],"coronary":[123],"heart":[124,133,244],"(CHD),":[126],"peripheral":[129],"(PVD),":[132],"failure,":[134,245],"CVD-related":[135,169,246],"all-cause":[137,225,249],"mortality.":[138,250],"Four":[139],"distinct":[140],"phenotypes":[141,275],"underlying":[144],"were":[147,218,235],"identified":[148],"stroke.":[153],"Compared":[154],"cluster":[156,191,203],"1":[157],"(n":[158],"=":[159,181,194,206],"5,201,":[160],"10.8%),":[161],"risk":[163,217,240,278],"composite":[165,221],"higher":[172],"3":[176,192],"(cluster":[178],"2":[179],"[n":[180,193,205],"18,655,":[182],"38.8%]:":[183],"ratio":[185],"[HR],":[186],"1.07;":[187],"95%":[188,199,211],"CI,":[189,200],"1.02-1.12;":[190],"10,244,":[195],"21.3%]:":[196],"HR,":[197,209],"1.20;":[198],"1.14-1.26;":[201],"4":[204],"14,014,":[207],"29.1%]:":[208],"1.44;":[210],"CI:":[212],"1.37-1.50).":[213],"Similar":[214],"trends":[215],"observed":[219],"outcome,":[227],"outcome.":[232],"However,":[233],"results":[234],"not":[236],"consistent":[237],"CHD,":[242],"PVD,":[243],"mortality,":[247],"In":[251],"this":[252],"proof":[253],"principle":[255],"study,":[256],"we":[257],"demonstrated":[258],"how":[259],"heterogenous":[261],"population":[262],"be":[269],"stratified":[270],"four":[272],"relatively":[273],"homogenous":[274],"major":[282],"offers":[286],"an":[287],"opportunity":[288],"revisit":[290],"stratification":[292],"care":[294],"improve":[301],"patient":[302]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-15T00:00:00"}