{"id":"https://openalex.org/W4386689918","doi":"https://doi.org/10.1186/s13578-023-01115-2","title":"A novel 3D bilayer hydrogel tri-culture system for studying functional motor units","display_name":"A novel 3D bilayer hydrogel tri-culture system for studying functional motor units","publication_year":2023,"publication_date":"2023-09-12","ids":{"openalex":"https://openalex.org/W4386689918","doi":"https://doi.org/10.1186/s13578-023-01115-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/37700376","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10496371"},"language":"en","primary_location":{"id":"doi:10.1186/s13578-023-01115-2","doi":"https://doi.org/10.1186/s13578-023-01115-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-023-01115-2","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-023-01115-2","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-023-01115-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008095508","display_name":"Yu\u2010Lung Lin","orcid":"https://orcid.org/0000-0001-5437-9958","observed_orcids":["https://orcid.org/0000-0001-5437-9958"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Yu-Lung Lin","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA","International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan","The Ph.D. Program for Translational Medicine, College of Medical Sciences and Technology, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"The Ph.D. Program for Translational Medicine, College of Medical Sciences and Technology, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059370818","display_name":"Jennifer Nhieu","orcid":"https://orcid.org/0000-0002-2448-6127","observed_orcids":["https://orcid.org/0000-0002-2448-6127"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Nhieu","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003716022","display_name":"Thomas A. Lerdall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Lerdall","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046318545","display_name":"Liming Chang Milbauer","orcid":"https://orcid.org/0000-0002-9286-699X","observed_orcids":["https://orcid.org/0000-0002-9286-699X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liming Milbauer","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003526409","display_name":"Chin-Wen Wei","orcid":"https://orcid.org/0000-0002-6795-2757","observed_orcids":["https://orcid.org/0000-0002-6795-2757"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chin-Wen Wei","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118899029","display_name":"Dong Jun Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Jun Lee","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071900791","display_name":"Sang-Hyun Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sang-Hyun Oh","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038294089","display_name":"Stanley A. Thayer","orcid":"https://orcid.org/0000-0002-0856-6522","observed_orcids":["https://orcid.org/0000-0002-0856-6522"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley Thayer","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034365665","display_name":"Li\u2010Na Wei","orcid":"https://orcid.org/0000-0002-6376-8506","observed_orcids":["https://orcid.org/0000-0002-6376-8506"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li-Na Wei","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. weixx009@umn.edu","Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-6376-8506","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. weixx009@umn.edu","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034365665"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.2662,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.44066809,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"13","issue":"1","first_page":"168","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.334199994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.334199994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.20409999787807465,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.12489999830722809,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motor-units","display_name":"motor units","score":0.9089999794960022},{"id":"https://openalex.org/keywords/alpha-motor-neurons","display_name":"alpha motoneurons","score":0.8190000057220459},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bilayer-hydrogel","display_name":"bilayer hydrogel","score":0.9430000185966492},{"id":"https://openalex.org/keywords/neuromuscular-disorders","display_name":"neuromuscular disorders","score":0.7570000290870667},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.8849999904632568},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.6909999847412109},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.5879999995231628},{"id":"https://openalex.org/keywords/in-vitro-model","display_name":"in vitro model","score":0.47600001096725464},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.6804055571556091},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.630454957485199},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5812627077102661},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.5440101623535156},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4487883746623993},{"id":"https://openalex.org/C2781425072","wikidata":"https://www.wikidata.org/wiki/Q1889028","display_name":"Motor unit","level":2,"score":0.44600266218185425},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4430452287197113},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44261157512664795},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4356982409954071},{"id":"https://openalex.org/C2775912687","wikidata":"https://www.wikidata.org/wiki/Q2422765","display_name":"Motor nerve","level":2,"score":0.414753258228302},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3841598629951477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3614250421524048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3509093225002289},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14204594492912292},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.12601682543754578},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10852935910224915}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13578-023-01115-2","doi":"https://doi.org/10.1186/s13578-023-01115-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-023-01115-2","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-023-01115-2","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10496371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10496371","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10496371/pdf/13578_2023_Article_1115.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biosci","raw_type":"Text"},{"id":"pmid:37700376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37700376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & bioscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1304f456ea644715b5d166b7407a722e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1304f456ea644715b5d166b7407a722e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell & Bioscience, Vol 13, Iss 1, Pp 1-14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13578-023-01115-2","doi":"https://doi.org/10.1186/s13578-023-01115-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-023-01115-2","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-023-01115-2","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1122316658","display_name":"Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathways","funder_award_id":"R01DK060521","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1801249269","display_name":null,"funder_award_id":"2025124","funder_id":"https://openalex.org/F4320337392","funder_display_name":"Division of Electrical, Communications and Cyber Systems"},{"id":"https://openalex.org/G310967942","display_name":null,"funder_award_id":"ECCS- 2025124","funder_id":"https://openalex.org/F4320337392","funder_display_name":"Division of Electrical, Communications and Cyber Systems"},{"id":"https://openalex.org/G8695498661","display_name":"Non-canonical signaling of retinoic acid by Cellular Retinoic Acid Binding Protein 1","funder_award_id":"F31DK123999","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G878574498","display_name":"NNCI: Midwest Nano Infrastructure Corridor (MINIC)","funder_award_id":"2025124","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000868342","display_name":"TR2 nuclear receptor in vitamin A signaling","funder_award_id":"R01NS132277","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320313320","display_name":"Minnesota Environment and Natural Resources Trust Fund","ror":null},{"id":"https://openalex.org/F4320314252","display_name":"Legislative-Citizen Commission on Minnesota Resources","ror":"https://ror.org/0036jb858"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337392","display_name":"Division of Electrical, Communications and Cyber Systems","ror":"https://ror.org/01krpsy48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386689918.pdf","grobid_xml":"https://content.openalex.org/works/W4386689918.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2010869886","https://openalex.org/W2015034722","https://openalex.org/W2075697181","https://openalex.org/W2115456845","https://openalex.org/W2152235865","https://openalex.org/W2254047323","https://openalex.org/W2470932240","https://openalex.org/W2522536498","https://openalex.org/W2616508231","https://openalex.org/W2719903628","https://openalex.org/W2752650605","https://openalex.org/W2803819386","https://openalex.org/W2945467118","https://openalex.org/W2948819273","https://openalex.org/W3000070822","https://openalex.org/W3000741476","https://openalex.org/W3080621658","https://openalex.org/W3101808636","https://openalex.org/W3152163450","https://openalex.org/W3174514934","https://openalex.org/W3210907785","https://openalex.org/W3213599326","https://openalex.org/W4205791787","https://openalex.org/W4206486443","https://openalex.org/W4214685853","https://openalex.org/W4288458075","https://openalex.org/W4297478874","https://openalex.org/W4301585073"],"related_works":["https://openalex.org/W6921100097","https://openalex.org/W2799698729","https://openalex.org/W2493265938","https://openalex.org/W3092072927","https://openalex.org/W2945467118","https://openalex.org/W7160629118","https://openalex.org/W3098527940","https://openalex.org/W2738327644","https://openalex.org/W203073418","https://openalex.org/W7140170905"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"A":[2,91],"motor":[3,12],"unit":[4],"(MU)":[5],"is":[6,23],"formed":[7],"by":[8],"a":[9,75,101,112,116,122,164,228],"single":[10],"alpha":[11],"neuron":[13],"(MN)":[14],"and":[15,65,105,195,205,221,224,232,238,259],"the":[16,32,52,69,96,132,141,157,242],"muscle":[17],"fibers":[18],"it":[19],"innervates.":[20],"The":[21,39,136,147,170],"MU":[22,33,168,175,180,209],"essential":[24],"for":[25,144,167,230,266],"all":[26],"voluntary":[27],"movements.":[28],"Functional":[29],"deficits":[30],"in":[31,35,48,55,89,197,207,219],"result":[34],"neuromuscular":[36,189],"disorders":[37],"(NMDs).":[38],"pathological":[40,216],"mechanisms":[41],"underlying":[42],"most":[43],"NMDs":[44,220],"remain":[45],"poorly":[46],"understood,":[47],"part":[49],"due":[50],"to":[51,110,130,214],"lack":[53],"of":[54,68,100,244,255,262],"vitro":[56,208],"models":[57],"that":[58],"can":[59,87,225],"comprehensively":[60],"recapitulate":[61],"multistage":[62],"intercellular":[63],"interactions":[64],"physiological":[66,231],"function":[67],"MU.":[70],"Results":[71],"We":[72,120],"have":[73],"designed":[74,109],"novel":[76],"three-dimensional":[77],"(3D)":[78],"bilayer":[79,117,133,247],"hydrogel":[80,118,124,134,138,248],"tri-culture":[81,114],"system":[82,250],"where":[83],"architecturally":[84],"organized":[85,179,204],"MUs":[86],"form":[88,131],"vitro.":[90],"sequential":[92],"co-culture":[93,249],"procedure":[94],"using":[95],"three":[97],"cell":[98,107,264],"types":[99,265],"MU,":[102],"MN,":[103],"myoblast,":[104],"Schwann":[106,152],"was":[108],"construct":[111],"co-differentiating":[113],"on":[115,187],"matrix.":[119],"utilized":[121],"\u00b5-molded":[123,137],"with":[125,150],"an":[126,178,212],"additional":[127],"Matrigel":[128,148],"layer":[129,139],"device.":[135],"provides":[140,163,211],"topological":[142],"cues":[143],"myoblast":[145],"differentiation.":[146],"layer,":[149],"embedded":[151],"cells,":[153],"not":[154],"only":[155],"separates":[156],"MNs":[158],"from":[159],"myoblasts":[160],"but":[161],"also":[162],"proper":[165],"micro-environment":[166],"development.":[169],"completed":[171],"model":[172,210],"shows":[173],"key":[174],"features":[176],"including":[177],"structure,":[181],"myelinated":[182],"nerves,":[183],"aligned":[184],"myotubes":[185],"innervated":[186],"clustered":[188],"junctions":[190],"(NMJs),":[191],"MN-driven":[192],"myotube":[193],"contractions,":[194],"increases":[196],"cytosolic":[198],"Ca2+":[199],"upon":[200],"stimulation.":[201],"Conclusions":[202],"This":[203],"functional":[206],"opportunity":[213],"study":[215],"events":[217],"involved":[218],"peripheral":[222],"neuropathies,":[223],"serve":[226],"as":[227,236],"platform":[229],"pharmacological":[233],"studies":[234],"such":[235],"modeling":[237],"drug":[239],"screening.":[240],"Technically,":[241],"rational":[243],"this":[245],"3D":[246],"exploits":[251],"multiple":[252],"distinct":[253],"properties":[254],"hydrogels,":[256],"facilitating":[257],"effective":[258],"efficient":[260],"co-culturing":[261],"diverse":[263],"tissue":[267],"engineering.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-09-13T00:00:00"}