{"id":"https://openalex.org/W4386661003","doi":"https://doi.org/10.1093/eurheartj/ehab724.2994","title":"Meta-analysis of clinical trials comparing triple versus dual antithrombotic therapy on risk reduction of stent thrombosis after percutaneous coronary intervention in atrial fibrillation patients","display_name":"Meta-analysis of clinical trials comparing triple versus dual antithrombotic therapy on risk reduction of stent thrombosis after percutaneous coronary intervention in atrial fibrillation patients","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W4386661003","doi":"https://doi.org/10.1093/eurheartj/ehab724.2994"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehab724.2994","doi":"https://doi.org/10.1093/eurheartj/ehab724.2994","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.2994","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.2994/41050942/ehab724.2994.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4386661003"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.2994/41050942/ehab724.2994.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082394801","display_name":"Sabeeh Shams","orcid":"https://orcid.org/0000-0001-7363-1493","observed_orcids":["https://orcid.org/0000-0001-7363-1493"]},"institutions":[{"id":"https://openalex.org/I4210127133","display_name":"Blackpool Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/03444yt49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210127133"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S S Shams","raw_affiliation_strings":["Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom","institution_ids":["https://openalex.org/I4210127133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058166930","display_name":"Omar Assaf","orcid":"https://orcid.org/0000-0003-3385-5059","observed_orcids":["https://orcid.org/0000-0003-3385-5059"]},"institutions":[{"id":"https://openalex.org/I4210127133","display_name":"Blackpool Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/03444yt49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210127133"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"O Assaf","raw_affiliation_strings":["Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom","institution_ids":["https://openalex.org/I4210127133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087638050","display_name":"Aysha Basir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127133","display_name":"Blackpool Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/03444yt49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210127133"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A B Basir","raw_affiliation_strings":["Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom","institution_ids":["https://openalex.org/I4210127133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108863149","display_name":"T C Choudhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127133","display_name":"Blackpool Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/03444yt49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210127133"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T C Choudhury","raw_affiliation_strings":["Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom","institution_ids":["https://openalex.org/I4210127133"]}]},{"author_position":"last","author":{"id":null,"display_name":"K W Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127133","display_name":"Blackpool Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/03444yt49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210127133"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K W Wong","raw_affiliation_strings":["Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blackpool Teaching Hospitals NHS Trust, Blackpool, United Kingdom","institution_ids":["https://openalex.org/I4210127133"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210127133"],"apc_list":{"value":3918,"currency":"EUR","value_usd":4592},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.8823000192642212,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.09889999777078629,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triple-antithrombotic-therapy","display_name":"triple antithrombotic therapy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dual-antiplatelet-therapy","display_name":"dual antiplatelet therapy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/stent-thrombosis","display_name":"stent thrombosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9129999876022339},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.9049999713897705},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oral-anticoagulants","display_name":"oral anticoagulants","score":0.7599999904632568},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.7229999899864197},{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.8240000009536743},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.8209999799728394},{"id":"https://openalex.org/keywords/p2y12-inhibitors","display_name":"P2Y12 inhibitors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.6510000228881836},{"id":"https://openalex.org/keywords/stroke-prevention","display_name":"stroke prevention","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9677679538726807},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.7644413113594055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7187016010284424},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.6982038617134094},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.6586752533912659},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6293351054191589},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.623981237411499},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.5852979421615601},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.5841113328933716},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.537325918674469},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5086368322372437},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4560241401195526},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.4323950409889221},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.4217790365219116},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4208829402923584},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehab724.2994","doi":"https://doi.org/10.1093/eurheartj/ehab724.2994","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.2994","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.2994/41050942/ehab724.2994.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/ehab724.2994","doi":"https://doi.org/10.1093/eurheartj/ehab724.2994","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.2994","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.2994/41050942/ehab724.2994.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386661003.pdf","grobid_xml":"https://content.openalex.org/works/W4386661003.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3170340202","https://openalex.org/W4388801704","https://openalex.org/W2998489500","https://openalex.org/W2809670257","https://openalex.org/W3096928241","https://openalex.org/W2776629303","https://openalex.org/W4205612623","https://openalex.org/W4390816285","https://openalex.org/W2979554814","https://openalex.org/W2982411438"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Coronary":[2],"artery":[3],"disease":[4],"(CAD)":[5],"is":[6,66,129,304],"a":[7],"leading":[8],"cause":[9],"of":[10,62,75,98,121,134,171,190,215,224,268,297,314,323,333,347,372],"mortality":[11],"worldwide.":[12],"Atrial":[13],"fibrillation":[14],"(AF)":[15],"and":[16,41,49,57,108,162,197,219,318,366],"CAD":[17,58,163],"frequently":[18],"coexist.":[19],"Patients":[20,54,82],"with":[21,33,55,68,84,105,143,160,195,307,354,360],"acute":[22],"coronary":[23,28],"syndrome":[24],"(ACS)":[25],"requiring":[26,164,358],"percutaneous":[27],"intervention":[29],"(PCI)":[30],"are":[31,59],"treated":[32,83,142],"dual":[34],"antiplatelet":[35,365],"therapy":[36,71,87,157,192,259],"(DAPT)":[37],"-":[38],"i.e.,":[39,89,238],"aspirin":[40],"P2Y12":[42,319],"inhibitor-":[43],"to":[44,112,205,263,340],"prevent":[45],"stent":[46,135,175,216],"thrombosis":[47,217],"(ST)":[48,218],"recurrent":[50,336],"myocardial":[51,172],"infarction":[52,173],"(MI).":[53],"AF":[56,161,196,361],"at":[60],"risk":[61,65,97,133,214,267,296,322,332,378],"stroke.":[63],"Stroke":[64],"reduced":[67,321],"oral":[69,78,92],"anticoagulant":[70,79,93,367],"(warfarin)":[72],"or":[73,100,174,199,280,300,316,325,335],"one":[74],"the":[76,122,132,154,169,188,207,213,230,292,295,331,345],"direct":[77],"agents":[80],"(DOACs).":[81],"triple":[85],"antithrombotic":[86,156,191],"(TAT)-":[88],"DAPT":[90],"plus":[91],"therapy-":[94],"suffer":[95],"higher":[96,139],"major":[99,298,324],"clinically":[101,301,326],"significant":[102,115,264,302,327],"bleeding":[103,299,303,328,377],"compared":[104,339],"DAT":[106,236,308,312,348],"(P2Y12":[107],"DOAC).":[109],"This":[110],"appeared":[111],"be":[113,138],"statistically":[114],"in":[116,140,193,229,266,352],"most":[117],"but":[118],"not":[119,261],"all":[120,185],"randomised":[123],"controlled":[124],"trials":[125],"(RCTs).":[126],"However,":[127],"it":[128],"unclear":[130],"whether":[131],"thrombosis/MI":[136],"might":[137],"patients":[141,159,194,226,353,357],"DAT.":[144],"Previous":[145],"meta-analyses":[146],"have":[147],"yielded":[148],"conflicting":[149],"conclusions.":[150],"Purpose":[151],"To":[152],"determine":[153],"optimum":[155],"for":[158],"PCI":[165,248,252,359],"and/or":[166,356],"ACS":[167,198,355],"regarding":[168],"incidence":[170],"thrombosis.":[176],"Methods":[177],"A":[178,201,222],"comprehensive":[179],"literature":[180],"search":[181],"was":[182,203],"done":[183],"identifying":[184],"RCTs":[186],"on":[187],"efficacy":[189],"PCI.":[200],"meta-analysis":[202],"performed":[204],"test":[206],"hypothesis":[208],"that":[209],"TAT":[210,234,351],"significantly":[211,305],"reduces":[212],"MI.":[220],"Results":[221],"total":[223],"11,542":[225],"were":[227],"included":[228],"5":[231],"RCTs,":[232],"comparing":[233],"vs":[235],"\u2013":[237],"WOEST":[239],"Trial":[240],"2013":[241],"[1],":[242],"PIONEER":[243],"AF-PCI":[244],"2016":[245],"[2],":[246],"RE-DUAL":[247],"2017":[249],"[3],":[250],"ENTRUST-AF":[251],"2019":[253,256],"[4],":[254],"AUGUSTUS":[255],"[5].":[257],"Triple":[258],"did":[260],"lead":[262],"reduction":[265],"Myocardial":[269],"Infarction":[270],"(MI)":[271],"[risk":[272],"ratio":[273],"(RR)":[274],"0.85,":[275],"95%":[276,285],"CI":[277,286],"0.69\u20131.04,":[278],"P=0.12],":[279],"Stent":[281],"Thrombosis":[282],"(RR":[283],"0.76,":[284],"0.51\u20131.12,":[287],"P=0.16).":[288],"[Figure":[289,309],"1]":[290],"On":[291],"other":[293],"hand,":[294],"lower":[306],"2].":[310],"Conclusion":[311],"comprising":[313],"warfarin":[315],"DOAC":[317],"inhibitor":[320],"without":[329],"increasing":[330],"ST":[334],"MI":[337],"as":[338],"TAT.":[341],"The":[342],"results":[343],"encourage":[344],"use":[346],"rather":[349],"than":[350],"who":[362],"require":[363],"combined":[364],"therapy.":[368],"Funding":[369],"Acknowledgement":[370],"Type":[371],"funding":[373],"sources:":[374],"None.":[375],"Major":[376]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2023-09-13T00:00:00"}