{"id":"https://openalex.org/W4386660581","doi":"https://doi.org/10.1093/eurheartj/ehab724.1279","title":"Implications of left ventricular function on short-term outcomes in COVID-19 patients with myocardial injury","display_name":"Implications of left ventricular function on short-term outcomes in COVID-19 patients with myocardial injury","publication_year":2021,"publication_date":"2021-10-01","ids":{"openalex":"https://openalex.org/W4386660581","doi":"https://doi.org/10.1093/eurheartj/ehab724.1279"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehab724.1279","doi":"https://doi.org/10.1093/eurheartj/ehab724.1279","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.1279","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.1279/41055143/ehab724.1279.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.1279/41055143/ehab724.1279.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026517781","display_name":"Giorgio A. Medranda","orcid":"https://orcid.org/0000-0001-9804-3786","observed_orcids":["https://orcid.org/0000-0001-9804-3786"]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Medranda","raw_affiliation_strings":["MedStar Heart and Vascular Institute, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Heart and Vascular Institute, Washington, DC, United States of America","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B C Case","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B C Case","raw_affiliation_strings":["MedStar Heart and Vascular Institute, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Heart and Vascular Institute, Washington, DC, United States of America","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077347512","display_name":"Hank Rappaport","orcid":"https://orcid.org/0000-0002-1496-8966","observed_orcids":["https://orcid.org/0000-0002-1496-8966"]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Rappaport","raw_affiliation_strings":["MedStar Heart and Vascular Institute, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Heart and Vascular Institute, Washington, DC, United States of America","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014005338","display_name":"C Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Zhang","raw_affiliation_strings":["MedStar Heart and Vascular Institute, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Heart and Vascular Institute, Washington, DC, United States of America","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040440529","display_name":"Charan Yerasi","orcid":"https://orcid.org/0000-0002-3916-3216","observed_orcids":["https://orcid.org/0000-0002-3916-3216"]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Yerasi","raw_affiliation_strings":["MedStar Heart and Vascular Institute, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Heart and Vascular Institute, Washington, DC, United States of America","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077189358","display_name":"Brian J. Forrestal","orcid":"https://orcid.org/0000-0001-6385-9136","observed_orcids":["https://orcid.org/0000-0001-6385-9136"]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B J Forrestal","raw_affiliation_strings":["MedStar Heart and Vascular Institute, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Heart and Vascular Institute, Washington, DC, United States of America","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026126106","display_name":"Chava Chezar-Azzerad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Chezar-Azzerad","raw_affiliation_strings":["MedStar Heart and Vascular Institute, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Heart and Vascular Institute, Washington, DC, United States of America","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052993534","display_name":"William S. Weintraub","orcid":"https://orcid.org/0000-0002-5384-5571","observed_orcids":["https://orcid.org/0000-0002-5384-5571"]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W S Weintraub","raw_affiliation_strings":["MedStar Heart and Vascular Institute, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Heart and Vascular Institute, Washington, DC, United States of America","institution_ids":["https://openalex.org/I4210154815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002279235","display_name":"Ron Waksman","orcid":"https://orcid.org/0000-0002-4063-9226","observed_orcids":["https://orcid.org/0000-0002-4063-9226","https://orcid.org/0000-0002-9514-3367"]},"institutions":[{"id":"https://openalex.org/I4210154815","display_name":"MedStar Heart & Vascular Institute","ror":"https://ror.org/0405m4551","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210154815","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Waksman","raw_affiliation_strings":["MedStar Heart and Vascular Institute, Washington, DC, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Heart and Vascular Institute, Washington, DC, United States of America","institution_ids":["https://openalex.org/I4210154815"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210154815"],"apc_list":{"value":3918,"currency":"EUR","value_usd":4592},"apc_paid":null,"fwci":0.0792,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4956655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"42","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9990000128746033},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.9929999709129333},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"ejection fraction","score":0.9419999718666077},{"id":"https://openalex.org/keywords/takotsubo-cardiomyopathy","display_name":"takotsubo cardiomyopathy","score":0.7910000085830688},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hospital-readmission","display_name":"hospital readmission","score":0.875},{"id":"https://openalex.org/keywords/short-term-outcomes","display_name":"short-term outcomes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8180000185966492},{"id":"https://openalex.org/keywords/troponin","display_name":"troponin","score":0.6819999814033508},{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.967262864112854},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7376534342765808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6600354313850403},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.650475263595581},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.5834766626358032},{"id":"https://openalex.org/C144469398","wikidata":"https://www.wikidata.org/wiki/Q24785650","display_name":"Troponin T","level":3,"score":0.5132663249969482},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.4726532995700836},{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.47087275981903076},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.4634283781051636},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.3672337532043457},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.3306022584438324},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18281400203704834},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehab724.1279","doi":"https://doi.org/10.1093/eurheartj/ehab724.1279","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.1279","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.1279/41055143/ehab724.1279.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/ehab724.1279","doi":"https://doi.org/10.1093/eurheartj/ehab724.1279","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehab724.1279","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/42/Supplement_1/ehab724.1279/41055143/ehab724.1279.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386660581.pdf","grobid_xml":"https://content.openalex.org/works/W4386660581.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3195782846","https://openalex.org/W4200529621","https://openalex.org/W3121223705","https://openalex.org/W3085008547","https://openalex.org/W3080166208","https://openalex.org/W4388942636","https://openalex.org/W4283259290","https://openalex.org/W4414516871","https://openalex.org/W3093590865","https://openalex.org/W4380795557"],"abstract_inverted_index":{"Abstract":[0],"Background/Introduction":[1],"Myocardial":[2],"injury":[3,53,101,200,250],"is":[4],"a":[5,17,57],"complication":[6],"of":[7,21,51,99,112,128,139,198,229,243,248,258],"coronavirus":[8],"disease":[9],"2019":[10],"(COVID-19).":[11],"Purpose":[12],"We":[13,39],"sought":[14],"to":[15,45,238],"describe":[16],"large":[18],"multi-centre":[19],"experience":[20],"COVID-19":[22,42,90,193,244],"patients":[23,43,86,108,130,194,221,245],"with":[24,49,69,89,135,151,196,222,246],"myocardial":[25,52,100,199,249],"injury,":[26],"examining":[27],"the":[28,241],"prognostic":[29],"role":[30],"left":[31,252],"ventricular":[32,253],"function":[33],"plays":[34],"on":[35],"short-term":[36,209],"outcomes.":[37],"Methods":[38],"included":[40],"adult":[41,85],"admitted":[44,88,195],"our":[46,81],"health":[47],"system":[48],"evidence":[50,98,138,197,228,247],"and":[54,75,119,142,154,232,251],"who":[55,109,207,214],"underwent":[56,110],"transthoracic":[58],"echocardiogram":[59],"(TTE)":[60],"during":[61],"index":[62],"admission.":[63],"Patients":[64,213],"were":[65,87,106,172],"dichotomized":[66],"into":[67],"those":[68,150,206],"reduced":[70,117,133,152,224],"ejection":[71],"fraction":[72],"(EF;":[73],"<50%)":[74],"preserved":[76,122,155],"EF":[77,118,123,153,156],"(>50%).":[78],"Results":[79],"Across":[80],"11-hospital":[82],"system,":[83],"5032":[84],"from":[91],"March-September":[92],"2020.":[93],"Of":[94],"these,":[95],"235":[96],"had":[97,116,131,217,227],"(troponin":[102],">1":[103],"ng/mL).":[104],"Included":[105],"134":[107],"TTE,":[111],"whom":[113],"43.3%":[114],"(n=58)":[115],"56.7%":[120],"(n=76)":[121],"(Figure":[124,189],"1).":[125],"A":[126],"subset":[127],"6":[129,162,183],"newly":[132,223],"EF,":[134,225],"5":[136],"demonstrating":[137],"stress":[140,230],"cardiomyopathy":[141,231],"subsequently":[143],"dying.":[144],"Overall,":[145],"mortality":[146,210],"was":[147,211],"high":[148],"in":[149,174],"(in-hospital:":[157],"34.5%":[158],"vs.":[159,165,180,186],"28.9%;":[160],"p=0.494;":[161],"months:":[163,184],"63.6%":[164],"50.0%;":[166],"p=0.167;":[167],"Kaplan-Meier":[168],"estimates:":[169],"p=0.2886).":[170],"Readmissions":[171],"frequent":[173,218],"both":[175],"groups":[176],"(30":[177],"days:":[178],"22.2%":[179],"26.0%;":[181],"p=0.162;":[182],"52.0%":[185],"54.5%;":[187],"p=0.839)":[188],"2).":[190],"Conclusions":[191],"Many":[192],"did":[201],"not":[202],"undergo":[203],"TTE.":[204],"For":[205],"did,":[208],"high.":[212],"survived":[215],"hospitalisation":[216],"readmissions.":[219],"In":[220],"most":[226],"expired.":[233],"Larger":[234],"studies":[235],"are":[236],"needed":[237],"fully":[239],"evaluate":[240],"prognosis":[242],"dysfunction.":[254],"Funding":[255],"Acknowledgement":[256],"Type":[257],"funding":[259],"sources:":[260],"None.":[261],"Figure":[262],"1Figure":[263],"2":[264]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2023-09-13T00:00:00"}