{"id":"https://openalex.org/W4386657076","doi":"https://doi.org/10.17077/etd.005918","title":"A risky journey for Break-Induced Replication","display_name":"A risky journey for Break-Induced Replication","publication_year":2021,"publication_date":"2021-08-01","ids":{"openalex":"https://openalex.org/W4386657076","doi":"https://doi.org/10.17077/etd.005918"},"language":"en","primary_location":{"id":"doi:10.17077/etd.005918","doi":"https://doi.org/10.17077/etd.005918","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.005918","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12813432220002771/13837804580002771","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100352447","display_name":"Liping Liu","orcid":"https://orcid.org/0000-0002-8467-5210","observed_orcids":["https://orcid.org/0000-0002-8467-5210","https://orcid.org/0009-0000-8868-5902"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liping Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070502223","display_name":"Anna Malkova","orcid":"https://orcid.org/0000-0002-3880-1781","observed_orcids":["https://orcid.org/0000-0002-3880-1781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Malkova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071778345","display_name":"Sarit Smolikove","orcid":"https://orcid.org/0000-0003-0062-3606","observed_orcids":["https://orcid.org/0000-0003-0062-3606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarit Smolikove","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107498994","display_name":"Marc S. Wold","orcid":"https://orcid.org/0000-0002-4580-1624","observed_orcids":["https://orcid.org/0000-0002-4580-1624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Wold","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4580-1624","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084572289","display_name":"Josep M. Comeron","orcid":"https://orcid.org/0000-0002-1256-6437","observed_orcids":["https://orcid.org/0000-0002-1256-6437"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josep Comeron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067010771","display_name":"Christopher S. Stipp","orcid":"https://orcid.org/0000-0002-0828-3207","observed_orcids":["https://orcid.org/0000-0002-0828-3207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Stipp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100352447"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/break-induced-replication","display_name":"break-induced replication","score":0.7829999923706055},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8960000276565552},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.8930000066757202},{"id":"https://openalex.org/keywords/pif1-helicase","display_name":"Pif1 helicase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pol32","display_name":"Pol32","score":0.9229999780654907},{"id":"https://openalex.org/keywords/alternative-lengthening-of-telomeres","display_name":"alternative lengthening of telomeres","score":0.6700000166893005},{"id":"https://openalex.org/keywords/chromothripsis","display_name":"chromothripsis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/complex-chromosomal-rearrangements","display_name":"complex chromosomal rearrangements","score":0.8299999833106995},{"id":"https://openalex.org/keywords/frameshift-mutation","display_name":"frameshift mutation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.5820000171661377},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.367000013589859},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.7523974180221558},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43646135926246643},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3601173758506775},{"id":"https://openalex.org/C108827166","wikidata":"https://www.wikidata.org/wiki/Q175975","display_name":"Internet privacy","level":1,"score":0.32866787910461426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.253047913312912},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.08921274542808533}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17077/etd.005918","doi":"https://doi.org/10.17077/etd.005918","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.005918","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},{"id":"pmh:oai:alma.01IOWA_INST:11813432230002771","doi":null,"is_oa":true,"landing_page_url":"https://iro.uiowa.edu/esploro/outputs/doctoral/A-risky-journey-for-Break-Induced-Replication/9984124470702771","pdf_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12813432220002771/13837804580002771","source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"}],"best_oa_location":{"id":"pmh:oai:alma.01IOWA_INST:11813432230002771","doi":null,"is_oa":true,"landing_page_url":"https://iro.uiowa.edu/esploro/outputs/doctoral/A-risky-journey-for-Break-Induced-Replication/9984124470702771","pdf_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12813432220002771/13837804580002771","source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386657076.pdf","grobid_xml":"https://content.openalex.org/works/W4386657076.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082619072","https://openalex.org/W2077570881","https://openalex.org/W2607210226","https://openalex.org/W2144839130","https://openalex.org/W2468183311","https://openalex.org/W4402072671","https://openalex.org/W2052202220","https://openalex.org/W2002791847","https://openalex.org/W4413410162","https://openalex.org/W4252273540"],"abstract_inverted_index":{"Break":[0],"Induced":[1],"Replication":[2],"(BIR)":[3],"is":[4,74,81,97,124,128,148,206,260,389,434,558,628,635,677,697,711,724,757,832,870,922,978,1012,1081,1088],"one":[5],"of":[6,50,66,91,115,134,229,244,258,284,322,334,350,360,378,384,397,400,470,512,549,563,575,600,617,625,642,652,704,715,735,746,755,763,788,797,828,845,855,942,945,966,1003,1030,1042,1073,1077,1086,1103,1137,1158],"the":[7,34,38,239,327,348,357,376,382,395,402,417,492,509,513,538,561,598,623,640,650,665,702,744,753,761,792,807,826,843,887,967,1001,1075,1084,1133,1138,1156,1159],"homologous":[8],"recombination":[9],"pathways":[10],"to":[11,32,36,44,57,156,170,180,185,196,217,227,242,262,320,325,338,363,374,415,419,426,436,460,465,486,504,529,560,607,610,663,679,728,873,885,913,981,1019,1036,1111],"repair":[12,564,864,886,1115,1140,1160],"DNA":[13,158,481,565,601,670],"double":[14,1097],"strand":[15],"breaks.":[16],"BIR":[17,54,73,96,123,153,166,177,192,205,213,220,259,285,302,340,379,406,411,433,454,462,471,474,489,506,550,576,589,604,618,626,653,657,676,687,705,719,756,777,800,819,863,884,900,917,946,958,973,993,1005,1045,1057,1079,1092,1107],"plays":[18],"important":[19,261,268,468,532,1021,1148],"roles":[20,359],"in":[21,76,173,189,209,346,355,366,381,394,537,586,720,760,767,825,842,1023,1132,1154],"main-":[22],"taining":[23],"genomic":[24,182,274,874,1025,1144],"integrity.":[25],"For":[26,139,368],"example,":[27,140,369],"it":[28,69,370,429,696,893,921],"has":[29,193,200,342,412,1016,1046],"been":[30,194,201,413,1017,1049],"proposed":[31,195,414,662],"be":[33,364,416,608],"pathway":[35,418,661],"recover":[37,420,664],"collapsed":[39,421,666],"replication":[40,94,422,667,878,1032],"fork":[41,668,879,1033],"at":[42,144,424,520,669,699,737,780,889,948],"hard":[43,425,1035],"replicate":[45,427,1037],"regions,":[46,428],"and":[47,110,127,136,276,296,308,464,491,496,581,584,717,741,881,907,926,932,1083,1126],"approximately":[48],"15%":[49],"cancer":[51,248,293],"cells":[52,272,1071],"use":[53],"(ALT":[55],"pathway)":[56],"maintain":[58,273],"their":[59,587],"telomeres.":[60],"Previous":[61],"studies":[62],"determined":[63,546,572],"many":[64,174,344],"characteristics":[65],"BIR.":[67,121,367,729,971,1008,1068],"Specifically,":[68,544,1009],"was":[70,371,527,605,859,894,911],"shown":[71],"that":[72,147,204,243,388,484,534,547,573,585,611,622,649,686,752,772,813,835,915,1062,1117],"conducted":[75],"a":[77,93,100,112,131,145,215,445,479,541,660,690,712,786,803,833,837,851,952,1013,1031,1040,1055,1100],"conservative":[78],"way":[79],"which":[80,237,457,557,634,831,876,1011,1109],"different":[82,234],"from":[83,233,701,929],"semi-conservative":[84],"replica-":[85],"tion":[86],"during":[87,152,165,567,603,612,656,1007,1044,1067],"S-phase.":[88],"Furthermore,":[89,595],"instead":[90],"using":[92,905,1054],"fork,":[95],"driven":[98],"by":[99,516,619,924,934,976,1027,1142,1151],"migrating":[101],"D-loop.":[102],"In":[103,440,748,840,902,1051,1069],"addition,":[104,749,841],"several":[105,253,531],"proteins,":[106],"including":[107,473,673],"Pif1":[108,385],"helicases":[109],"Pol32,":[111],"non-essential":[113],"subunit":[114],"Pol":[116],"are":[117,1118],"specifically":[118],"required":[119],"for":[120,292,391,452,540,779,821,1120],"Moreover,":[122],"highly":[125,764],"error-prone,":[126],"associated":[129,246],"with":[130,247,252,806,1090],"high":[132,849],"level":[133,745,1076],"mutations":[135,142],"chromosome":[137,224,230,515,931,1065],"rearrangements.":[138],"frameshift":[141],"occur":[143],"rate":[146,599,624,641,651],"1000":[149],"folds":[150],"higher":[151,853],"as":[154,249,251,352,354,449],"compared":[155],"S-phase":[157,613,643],"replication,":[159,614],"while":[160],"base":[161],"substitutions":[162],"often":[163,178],"form":[164],"mutation":[167],"clusters":[168],"similar":[169,184,241,559,609],"those":[171,186],"observed":[172,860],"cancers.":[175],"Also,":[176,408,570],"leads":[179,1110],"complex":[181,223],"rearrangements":[183,225,1066,1131],"taking":[187],"place":[188,703],"cancer.":[190],"Thus,":[191],"underlie":[197],"carcinogenesis.":[198],"It":[199],"also":[202,277,288,742,811,817,999],"demonstrated":[203,621,1061,1146],"indeed":[207],"activated":[208],"precancerous":[210],"cells.":[211,1135],"Interrupted":[212],"provokes":[214],"switch":[216],"micro-homology":[218],"mediated":[219],"(MMBIR)":[221],"promoting":[222,1028],"leading":[226],"joining":[228],"segments":[231],"originating":[232],"chromosomal":[235],"positions,":[236],"makes":[238],"outcome":[240],"chromothripsis":[245],"well":[250,353],"other":[254],"genetic":[255,1104],"diseases.The":[256],"mechanism":[257,286],"understand":[263],"because":[264,986],"its":[265,306,310,316],"knowledge":[266],"brings":[267],"insight":[269],"into":[270,278],"how":[271,279,897],"integrity,":[275],"genomes":[280],"get":[281],"destabilized.":[282],"Knowledge":[283],"can":[287,688],"provide":[289],"potential":[290],"targets":[291],"prevention,":[294],"intervention,":[295],"treatment.":[297],"Previously,":[298],"researchers":[299],"who":[300],"studied":[301],"focused":[303],"only":[304,694],"on":[305,309,629,727,791,799],"initiation":[307,548,754,778,801,820],"completion":[311],"but":[312,693],"could":[313],"not":[314,372,895,1047],"study":[315],"intermediate":[317,332],"steps":[318],"due":[319,980],"lack":[321],"proper":[323],"methods":[324],"follow":[326,339,461,505],"D-loop":[328],"extension":[329],"step":[330,333],"(the":[331],"BIR).":[335],"This":[336,476,939],"inability":[337],"progression":[341,463],"caused":[343,975],"problems":[345],"determining":[347,356],"kinetics":[349,472],"BIR,":[351],"exact":[358],"proteins":[361],"known":[362],"involved":[365],"possible":[373],"determine":[375,466],"length":[377,511],"synthesis":[380,507,551,566,577,602,627,654],"absence":[383,396,588,827],"(DNA":[386],"helicase":[387],"essential":[390],"BIR)":[392],"or":[393],"various":[398,467,521],"subunits":[399],"Pol,":[401],"main":[403],"polymerase":[404],"driving":[405],"progression.":[407,658,901],"even":[409,596,960],"though":[410,597],"forks":[423],"remained":[430,535],"unknown":[431],"whether":[432],"capable":[435],"traverse":[437,689,1029],"such":[438,682,708],"regions.":[439],"this":[441,524,903,1052],"research,":[442,904,997,1053],"I":[443,526,545,571,647,684,750,770,810,910,998,1059],"developed":[444],"novel":[446],"assay,":[447],"termed":[448],"AMBER":[450,620,906],"(Assay":[451],"Monitoring":[453],"Elongation":[455],"Rate),":[456],"allowed":[458],"me":[459],"parameters":[469],"rate.":[475],"assay":[477],"combines":[478],"new":[480],"preparation":[482],"protocol":[483],"allows":[485],"preserve":[487],"unfinished":[488],"products":[490,1080],"most":[493],"precise":[494],"detection":[495],"quantification":[497],"technique":[498],"called":[499],"digital":[500],"droplet":[501],"PCR":[502],"(ddPCR)":[503],"along":[508],"entire":[510],"template":[514,793,930],"copy":[517],"number":[518],"increases":[519,655],"loci.":[522],"Using":[523],"method,":[525],"able":[528,912],"answer":[530],"questions":[533],"open":[536],"field":[539],"long":[542,856],"time.":[543],"starts":[552],"2.5":[553],"hours":[554,824],"after":[555,970],"DSB,":[556],"start":[562],"gene":[568,834],"conversion.":[569],"elongation":[574],"requires":[578],"Pif1,":[579],"Pol32":[580],"primase":[582],"activities,":[583],"cannot":[590],"extend":[591],"more":[592,1121],"than":[593,639,1122],"5-20kb.":[594],"believed":[606],"my":[615,995],"analysis":[616],"average":[630],"0.5kb":[631],"per":[632],"minute,":[633],"about":[636,822],"6-fold":[637],"lower":[638],"replication.":[644],"Of":[645],"note,":[646],"found":[648,685,812],"As":[659],"fragile":[671],"sites":[672,740],"transcription":[674,691,716,723,738,775,789,798,808,816],"unit,":[675,692],"supposed":[678],"go":[680],"through":[681,785,1034],"places.":[683],"when":[695,722,916],"located":[698],"distance":[700],"initiation.":[706],"During":[707],"traverse,":[709],"there":[710],"transient":[713,731],"stalling":[714,732,974],"possibly":[718],"cases":[721],"oriented":[725],"head-":[726],"Such":[730],"causes":[733,877,964],"accumulation":[734],"rPolII":[736],"termination":[739,944],"increase":[743],"mutagenesis.":[747],"discovered":[751,771],"strongly":[758],"inhibited":[759],"vicinity":[762],"transcribed":[765],"units":[766],"either":[768],"orientation.":[769],"head-on":[773,847],"orientated":[774,815,848],"blocks":[776,818],"least":[781],"10":[782,823],"hours,":[783],"likely":[784],"stabilization":[787],"machinery":[790],"DNA.":[794],"The":[795,972],"effect":[796],"showed":[802,1099],"direct":[804],"correlation":[805],"level.":[809],"co-directionally":[814],"SIN3":[829],"gene,":[830],"encodes":[836],"histone":[838],"deacetylase.":[839],"presence":[844],"proximal":[846],"transcription,":[850],"significantly":[852],"fraction":[854],"resection":[857],"events":[858,947],"among":[861],"successful":[862],"events.":[865],"Interstitial":[866],"telomere":[867,937],"sequence":[868],"(ITS)":[869],"another":[871],"threat":[872],"instability,":[875],"collapse":[880],"may":[882],"involve":[883],"DSB":[888,1114],"ITS":[890,898,919,925,949,968],"site,":[891],"however,":[892,1039],"clear":[896],"affects":[899],"deep":[908],"sequencing,":[909],"show":[914],"traverses":[918],"((TTAGGG)~40),":[920],"blocked":[923],"then":[927],"dissociates":[928],"terminated":[933],"de":[935],"novo":[936],"addition.":[938],"process":[940],"results":[941],"premature":[943],"region.":[950],"Interestingly,":[951,1094],"shorter":[953],"ITS,":[954],"(TTAGGG)28":[955,962],"doesn\u2019t":[956,990],"cause":[957,991,1128],"pre-maturation,":[959],"though,":[961],"still":[963],"changes":[965],"sequences":[969,988],"ITS~40":[977],"unlikely":[979],"forming":[982],"G4":[983,987],"secondary":[984],"structure,":[985],"itself":[989],"notable":[992],"stalling.During":[994],"Ph.D.":[996],"investigated":[1000],"function":[1002],"some":[1004],"players":[1006],"Rrm3,":[1010,1074],"Pif1-like":[1014],"helicase,":[1015],"reported":[1018],"play":[1020],"role":[1022,1041,1149],"maintaining":[1024],"stability":[1026],"regions;":[1038],"Rrm3":[1043,1063],"yet":[1048],"reported.":[1050],"disomic":[1056],"system,":[1058],"have":[1060],"inhibits":[1064],"yeast":[1070],"deficient":[1072],"abnormal":[1078],"increased,":[1082],"defect":[1085],"rrm3":[1087,1095],"synergistic":[1089],"pif1-m2":[1091,1096],"defect.":[1093],"mutant":[1098],"unique":[1101],"pattern":[1102],"instability":[1105],"following":[1106],"initiation,":[1108],"persistent":[1112],"un-stabilized":[1113],"intermediates":[1116],"maintained":[1119],"20":[1123],"cell":[1124],"cycles":[1125],"eventually":[1127],"heterogeneous":[1129],"genome":[1130],"progeny":[1134],"Analysis":[1136],"rearranged":[1139],"outcomes":[1141],"whole":[1143],"sequencing":[1145],"an":[1147],"played":[1150],"Ty":[1152],"elements":[1153],"mediating":[1155],"formation":[1157],"intermediates.":[1161]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-09-13T00:00:00"}