{"id":"https://openalex.org/W4386629652","doi":"https://doi.org/10.1155/2023/4965223","title":"High-Fat Mouse Model to Explore the Relationship between Abnormal Lipid Metabolism and Enolase in Pancreatic Cancer","display_name":"High-Fat Mouse Model to Explore the Relationship between Abnormal Lipid Metabolism and Enolase in Pancreatic Cancer","publication_year":2023,"publication_date":"2023-09-12","ids":{"openalex":"https://openalex.org/W4386629652","doi":"https://doi.org/10.1155/2023/4965223","pmid":"https://pubmed.ncbi.nlm.nih.gov/37731842","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10509005"},"language":"en","primary_location":{"id":"doi:10.1155/2023/4965223","doi":"https://doi.org/10.1155/2023/4965223","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2023/4965223","pdf_url":"https://downloads.hindawi.com/journals/mi/2023/4965223.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/mi/2023/4965223.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000237887","display_name":"Lin Qin","orcid":"https://orcid.org/0000-0001-5114-5291","observed_orcids":["https://orcid.org/0000-0001-5114-5291"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]},{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Qin","raw_affiliation_strings":["Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China","School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China","School of Pharmaceutical Science, Kunming Medical University, Kunming, Yunnan 650500, China","Yunnan Clinical Medical Center for Endocrine and Metabolic Diseases, Kunming, Yunnan 650000, China","Yunnan Province Clinical Research Center for Metabolic diseases, Kunming, Yunnan 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China","institution_ids":["https://openalex.org/I4210120169"]},{"raw_affiliation_string":"School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"School of Pharmaceutical Science, Kunming Medical University, Kunming, Yunnan 650500, China","institution_ids":["https://openalex.org/I26080491"]},{"raw_affiliation_string":"Yunnan Clinical Medical Center for Endocrine and Metabolic Diseases, Kunming, Yunnan 650000, China","institution_ids":[]},{"raw_affiliation_string":"Yunnan Province Clinical Research Center for Metabolic diseases, Kunming, Yunnan 650000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Sun","raw_affiliation_strings":["Affiliated Hospital of Yunnan University, Qingnian Road, Kunming, Yunnan 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Yunnan University, Qingnian Road, Kunming, Yunnan 650000, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104189683","display_name":"Li Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Shi","raw_affiliation_strings":["Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China","Yunnan Clinical Medical Center for Endocrine and Metabolic Diseases, Kunming, Yunnan 650000, China","Yunnan Province Clinical Research Center for Metabolic diseases, Kunming, Yunnan 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China","institution_ids":["https://openalex.org/I4210120169"]},{"raw_affiliation_string":"Yunnan Clinical Medical Center for Endocrine and Metabolic Diseases, Kunming, Yunnan 650000, China","institution_ids":[]},{"raw_affiliation_string":"Yunnan Province Clinical Research Center for Metabolic diseases, Kunming, Yunnan 650000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046082048","display_name":"Yushan Xu","orcid":"https://orcid.org/0009-0006-8978-1684","observed_orcids":["https://orcid.org/0009-0006-8978-1684"]},"institutions":[{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yushan Xu","raw_affiliation_strings":["Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China","Yunnan Clinical Medical Center for Endocrine and Metabolic Diseases, Kunming, Yunnan 650000, China","Yunnan Province Clinical Research Center for Metabolic diseases, Kunming, Yunnan 650000, China"],"raw_orcid":"https://orcid.org/0009-0006-8978-1684","affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China","institution_ids":["https://openalex.org/I4210120169"]},{"raw_affiliation_string":"Yunnan Clinical Medical Center for Endocrine and Metabolic Diseases, Kunming, Yunnan 650000, China","institution_ids":[]},{"raw_affiliation_string":"Yunnan Province Clinical Research Center for Metabolic diseases, Kunming, Yunnan 650000, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055924995","display_name":"Rongping Zhang","orcid":"https://orcid.org/0000-0002-0349-2982","observed_orcids":["https://orcid.org/0000-0002-0349-2982"]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rongping Zhang","raw_affiliation_strings":["School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China"],"raw_orcid":"https://orcid.org/0000-0002-0349-2982","affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China","institution_ids":["https://openalex.org/I46975222"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5046082048","https://openalex.org/A5055924995"],"corresponding_institution_ids":["https://openalex.org/I4210120169","https://openalex.org/I46975222"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":1.0541,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75590073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7680000066757202},{"id":"https://openalex.org/keywords/enolase","display_name":"enolase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8769999742507935},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.875},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7009999752044678},{"id":"https://openalex.org/keywords/neuron-specific-enolase","display_name":"neuron-specific enolase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enolase-1","display_name":"alpha-enolase","score":0.7850000262260437},{"id":"https://openalex.org/keywords/eno3","display_name":"ENO3","score":1.0},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.6029999852180481},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C188618488","wikidata":"https://www.wikidata.org/wiki/Q24776639","display_name":"Enolase","level":3,"score":0.8543103933334351},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8109408020973206},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.556891918182373},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5484288334846497},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5350578427314758},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5289307236671448},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4899510443210602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4302107095718384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3920110762119293},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3863873779773712},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1744183897972107}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010751","descriptor_name":"Phosphopyruvate Hydratase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2023/4965223","doi":"https://doi.org/10.1155/2023/4965223","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2023/4965223","pdf_url":"https://downloads.hindawi.com/journals/mi/2023/4965223.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10509005","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10509005","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10509005/pdf/MI2023-4965223.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators Inflamm","raw_type":"Text"},{"id":"pmid:37731842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37731842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of inflammation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:857e20035482487ebf1131b5b353a261","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/857e20035482487ebf1131b5b353a261","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mediators of Inflammation, Vol 2023 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2023/4965223","doi":"https://doi.org/10.1155/2023/4965223","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2023/4965223","pdf_url":"https://downloads.hindawi.com/journals/mi/2023/4965223.pdf","source":{"id":"https://openalex.org/S107442880","display_name":"Mediators of Inflammation","issn_l":"0962-9351","issn":["0962-9351","1466-1861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediators of Inflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G107424295","display_name":null,"funder_award_id":"202201AY070001-066","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1312277610","display_name":null,"funder_award_id":"202201AY070001","funder_id":"https://openalex.org/F4320325440","funder_display_name":"Yunnan Provincial Science and Technology Department"},{"id":"https://openalex.org/G1671261364","display_name":null,"funder_award_id":"YNWR-YLXZ-2019-019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1843402506","display_name":null,"funder_award_id":"RLMY20220005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2007823169","display_name":null,"funder_award_id":"202005AE160004","funder_id":"https://openalex.org/F4320325440","funder_display_name":"Yunnan Provincial Science and Technology Department"},{"id":"https://openalex.org/G2669639741","display_name":null,"funder_award_id":"82160164","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3360939530","display_name":null,"funder_award_id":"202001AY070001-205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3954201383","display_name":null,"funder_award_id":"202101BA070001-110","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G39755813","display_name":null,"funder_award_id":"CXTD202106","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G4279135347","display_name":null,"funder_award_id":"202102AA100056","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G437578662","display_name":null,"funder_award_id":"202102AA100056","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4518818521","display_name":null,"funder_award_id":"RLMY20220005","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G5331184933","display_name":null,"funder_award_id":"81960109","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G5584970878","display_name":null,"funder_award_id":"202001AY070001-205","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G5686245998","display_name":null,"funder_award_id":"CXTD202209","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5940817435","display_name":null,"funder_award_id":"202005AE160004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6039301706","display_name":null,"funder_award_id":"82160164","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G6614823898","display_name":null,"funder_award_id":"CXTD202106","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6672762866","display_name":null,"funder_award_id":"CXTD202209","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G7358683507","display_name":"miR-150-5p\u5728\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u6fc0\u7d20\u62b5\u6297\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u7814\u7a76","funder_award_id":"81960109","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7364144606","display_name":null,"funder_award_id":"202101BA070001-110","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G7408373146","display_name":null,"funder_award_id":"202201AY070001-066","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G8183633562","display_name":null,"funder_award_id":"202005AE160004","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"},{"id":"https://openalex.org/G8318211723","display_name":null,"funder_award_id":"YNWR-YLXZ-2019-019","funder_id":"https://openalex.org/F4320322268","funder_display_name":"Kunming Medical University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322268","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259"},{"id":"https://openalex.org/F4320325440","display_name":"Yunnan Provincial Science and Technology Department","ror":"https://ror.org/03whqdf70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386629652.pdf","grobid_xml":"https://content.openalex.org/works/W4386629652.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1958915959","https://openalex.org/W1976284083","https://openalex.org/W1986003562","https://openalex.org/W1986206386","https://openalex.org/W1994630337","https://openalex.org/W1996510149","https://openalex.org/W2020536190","https://openalex.org/W2032392097","https://openalex.org/W2101375502","https://openalex.org/W2111159494","https://openalex.org/W2119845886","https://openalex.org/W2139645938","https://openalex.org/W2158819616","https://openalex.org/W2165577181","https://openalex.org/W2229582722","https://openalex.org/W2415557067","https://openalex.org/W2565332095","https://openalex.org/W2589088675","https://openalex.org/W2786036412","https://openalex.org/W2797616334","https://openalex.org/W2807564217","https://openalex.org/W2807730951","https://openalex.org/W2810965302","https://openalex.org/W2906327979","https://openalex.org/W2911569413","https://openalex.org/W2919413784","https://openalex.org/W2922490226","https://openalex.org/W2951730201","https://openalex.org/W2969031316","https://openalex.org/W2980701091","https://openalex.org/W2986173619","https://openalex.org/W2998743175","https://openalex.org/W3009418815","https://openalex.org/W3105103426","https://openalex.org/W3160510935","https://openalex.org/W3189876813","https://openalex.org/W3194627617","https://openalex.org/W4200326740","https://openalex.org/W4205614370"],"related_works":["https://openalex.org/W3150650239","https://openalex.org/W4393095960","https://openalex.org/W3142545369","https://openalex.org/W4399629266","https://openalex.org/W4416889642","https://openalex.org/W2315240600","https://openalex.org/W1982795450","https://openalex.org/W7037231079","https://openalex.org/W2081263253","https://openalex.org/W7154555324"],"abstract_inverted_index":{"Malignant":[0],"tumors":[1],"have":[2],"become":[3],"a":[4,19,46,75,86,118],"major":[5],"social":[6],"health":[7],"problem":[8],"that":[9,214,308],"seriously":[10],"threatens":[11],"human":[12],"health,":[13],"among":[14],"which":[15,306],"pancreatic":[16,61,83,92,112,122,132,154,178,197,220,239,264,286,293,327],"cancer":[17,62,113,179,183,221,229,287,328],"has":[18,38,260],"high":[20,32,139],"degree":[21],"of":[22,80,82,91,111,121,153,219,236,276,285,313,319],"malignancy,":[23],"difficult":[24],"diagnosis":[25,225],"and":[26,31,35,60,73,85,126,128,136,158,173,181,195,201,207,231,256,271,279,322],"treatment,":[27],"short":[28],"survival":[29],"time,":[30],"mortality.":[33],"More":[34],"more":[36],"attention":[37],"been":[39],"paid":[40],"to":[41,102,156],"abnormal":[42,56,105],"lipid":[43,57,106,140],"metabolism":[44,107],"as":[45],"momentous":[47],"carcinogenesis":[48],"mechanism.":[49],"Here,":[50],"we":[51],"explored":[52],"the":[53,97,109,151,202,215,232,273,297,303,311,317,326],"relationship":[54],"between":[55,192,204],"metabolism,":[58],"enolase,":[59],"by":[63,145,315],"clinical":[64],"data":[65],"analysis.":[66],"A":[67],"high-fat":[68],"mouse":[69,78,89],"model":[70,79,120],"was":[71,210],"constructed,":[72],"then,":[74],"subcutaneous":[76,282],"tumorigenesis":[77],"carcinoma":[81,93,123,133,155,198,240,245,294],"cells":[84,94,152],"metastatic":[87],"neoplasm":[88],"pattern":[90],"injected":[95,301],"through":[96,302],"tail":[98,304],"vein":[99],"were":[100,185,199],"constructed":[101,117],"explore":[103],"whether":[104,138],"affects":[108],"progression":[110],"in":[114,131,189,281,288,296,299],"mice.":[115,289],"We":[116,212],"high-lipid":[119],"cell":[124,134,329],"lines":[125,135],"knockdown":[127],"overexpressed":[129],"enolase":[130,147,175,209,234,254],"investigated":[137],"regulates":[141],"epithelial-mesenchymal":[142],"transition":[143],"(EMT)":[144],"upregulating":[146],"(ENO),":[148],"thereby":[149],"promoting":[150,325],"invade":[157],"migrate.":[159],"Triglycerides,":[160],"total":[161],"cholesterol,":[162],"free":[163],"cholesterin,":[164],"high-density":[165],"lipoprotein":[166,170],"cholesterol":[167,171],"(HDL-C),":[168],"low-density":[169],"(LDL-C),":[172],"neuron-specific":[174,208,233,253],"(NSE)":[176],"from":[177],"patients":[180,184,193,222,237],"nonpancreatic":[182,228,244],"tested.":[186],"The":[187],"differences":[188],"blood":[190,205],"lipids":[191,206],"with":[194,238,252],"without":[196],"compared,":[200],"correlation":[203],"analyzed.":[211],"confirmed":[213,307],"serum":[216,257],"triglyceride":[217,258],"level":[218,235,248,259],"at":[223],"initial":[224],"is":[226,241,249],"overtopping":[227],"patients,":[230],"better":[242],"than":[243],"sufferers.":[246],"Triglyceride":[247],"positively":[250],"correlated":[251],"level,":[255],"predictive":[261],"value":[262],"for":[263],"cancer.":[265],"Hyperlipidemia":[266],"can":[267],"promote":[268],"tumor":[269,283],"growth":[270],"increase":[272],"expression":[274,318],"levels":[275],"ENO1,":[277,320],"ENO2,":[278,321],"ENO3":[280],"formation":[284],"Additional":[290],"hyperlipidemia":[291,309],"promoted":[292],"metastasis":[295],"lung":[298],"mice":[300],"vein,":[305],"accelerated":[310],"process":[312],"EMT":[314],"increasing":[316],"ENO3,":[323],"therefore":[324],"metastasis.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-13T00:00:00"}