{"id":"https://openalex.org/W4386624255","doi":"https://doi.org/10.1093/cercor/bhad329","title":"Mendelian randomization analysis implicates bidirectional associations between brain imaging-derived phenotypes and ischemic stroke","display_name":"Mendelian randomization analysis implicates bidirectional associations between brain imaging-derived phenotypes and ischemic stroke","publication_year":2023,"publication_date":"2023-09-11","ids":{"openalex":"https://openalex.org/W4386624255","doi":"https://doi.org/10.1093/cercor/bhad329","pmid":"https://pubmed.ncbi.nlm.nih.gov/37697910"},"language":"en","primary_location":{"id":"doi:10.1093/cercor/bhad329","doi":"https://doi.org/10.1093/cercor/bhad329","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cercor/bhad329","pdf_url":"https://academic.oup.com/cercor/article-pdf/33/21/10848/52131805/bhad329.pdf","source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cercor/article-pdf/33/21/10848/52131805/bhad329.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035532030","display_name":"Yiming Jia","orcid":"https://orcid.org/0000-0002-3624-7879","observed_orcids":["https://orcid.org/0000-0002-3624-7879"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Jia","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":"https://orcid.org/0000-0002-3624-7879","affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101289458","display_name":"Hongyan Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Sun","raw_affiliation_strings":["Department of Medical Imaging, The Affiliated Guangji Hospital of Soochow University , Suzhou 215137 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, The Affiliated Guangji Hospital of Soochow University , Suzhou 215137 , China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085253928","display_name":"Lulu Sun","orcid":"https://orcid.org/0000-0002-9927-0654","observed_orcids":["https://orcid.org/0000-0002-9927-0654"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lulu Sun","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100429073","display_name":"Yinan Wang","orcid":"https://orcid.org/0000-0003-2967-6058","observed_orcids":["https://orcid.org/0000-0003-2967-6058"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinan Wang","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698352","display_name":"Qingyun Xu","orcid":"https://orcid.org/0000-0001-7733-3813","observed_orcids":["https://orcid.org/0000-0001-7733-3813"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyun Xu","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330506","display_name":"Yi Liu","orcid":"https://orcid.org/0000-0002-2051-440X","observed_orcids":["https://orcid.org/0000-0002-2051-440X"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Liu","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060067563","display_name":"Xinyue Chang","orcid":"https://orcid.org/0000-0001-7027-3889","observed_orcids":["https://orcid.org/0000-0001-7027-3889","https://orcid.org/0009-0006-7927-5761"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Chang","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104217050","display_name":"Yu He","orcid":"https://orcid.org/0009-0005-9604-2145","observed_orcids":["https://orcid.org/0009-0005-9604-2145","https://orcid.org/0000-0002-9319-737X","https://orcid.org/0000-0003-0523-6082"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu He","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024181264","display_name":"Daoxia Guo","orcid":"https://orcid.org/0000-0002-4537-0705","observed_orcids":["https://orcid.org/0000-0002-4537-0705"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daoxia Guo","raw_affiliation_strings":["School of Nursing, Suzhou Medical College of Soochow University , Suzhou 215123 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Suzhou Medical College of Soochow University , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067704857","display_name":"Mengyao Shi","orcid":"https://orcid.org/0000-0002-5883-0416","observed_orcids":["https://orcid.org/0000-0002-5883-0416"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Shi","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102806685","display_name":"Guo\u2010Chong Chen","orcid":"https://orcid.org/0000-0002-6815-5653","observed_orcids":["https://orcid.org/0000-0002-6815-5653"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo-Chong Chen","raw_affiliation_strings":["Department of Nutrition and Food Hygiene , School of Public Health, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, , Suzhou 215123 , China","Department of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Hygiene , School of Public Health, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113418765","display_name":"Jin Zheng","orcid":"https://orcid.org/0000-0002-0309-8678","observed_orcids":["https://orcid.org/0000-0002-0309-8678"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zheng","raw_affiliation_strings":["Department of Neurology , Minhang Hospital, , Shanghai 200433 , China","Fudan University , Minhang Hospital, , Shanghai 200433 , China","Department of Neurology, Minhang Hospital, Fudan University, Shanghai 200433, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology , Minhang Hospital, , Shanghai 200433 , China","institution_ids":[]},{"raw_affiliation_string":"Fudan University , Minhang Hospital, , Shanghai 200433 , China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Department of Neurology, Minhang Hospital, Fudan University, Shanghai 200433, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100429040","display_name":"Yonghong Zhang","orcid":"https://orcid.org/0000-0001-6188-3490","observed_orcids":["https://orcid.org/0000-0001-6188-3490"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonghong Zhang","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044500204","display_name":"Zhengbao Zhu","orcid":"https://orcid.org/0000-0001-5500-0014","observed_orcids":["https://orcid.org/0000-0001-5500-0014","https://orcid.org/0000-0002-4363-7357"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhengbao Zhu","raw_affiliation_strings":["Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":[]},{"raw_affiliation_string":"Suzhou Medical College of Soochow University , School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, , Suzhou 215123 , China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Ministry of Education (MOE) Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044500204"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":{"value":4798,"currency":"USD","value_usd":4798},"apc_paid":null,"fwci":0.6741,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60170198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"33","issue":"21","first_page":"10848","last_page":"10857"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.37959998846054077,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.07119999825954437,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9890000224113464},{"id":"https://openalex.org/keywords/imaging-derived-phenotypes","display_name":"imaging-derived phenotypes","score":0.968999981880188},{"id":"https://openalex.org/keywords/bidirectional-causality","display_name":"bidirectional causality","score":0.6899999976158142},{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/white-matter-microstructure","display_name":"white matter microstructure","score":0.8360000252723694},{"id":"https://openalex.org/keywords/superior-fronto-occipital-fasciculus","display_name":"superior fronto-occipital fasciculus","score":0.9480000138282776},{"id":"https://openalex.org/keywords/internal-capsule","display_name":"internal capsule","score":0.6610000133514404},{"id":"https://openalex.org/keywords/thalamic-radiation","display_name":"thalamic radiation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.9259999990463257},{"id":"https://openalex.org/keywords/third-ventricle","display_name":"third ventricle","score":0.7609999775886536},{"id":"https://openalex.org/keywords/stroke-risk-factors","display_name":"stroke risk factors","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9257016777992249},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7211711406707764},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5848772525787354},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5465058088302612},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.5141692161560059},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.45504868030548096},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.4471997618675232},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.439762145280838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36768215894699097},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36058908700942993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33350831270217896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.324634850025177},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.28943800926208496},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.20621463656425476},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.20183563232421875},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.1657528579235077},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.1555943489074707},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11098131537437439},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000083242","descriptor_name":"Ischemic Stroke","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/cercor/bhad329","doi":"https://doi.org/10.1093/cercor/bhad329","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cercor/bhad329","pdf_url":"https://academic.oup.com/cercor/article-pdf/33/21/10848/52131805/bhad329.pdf","source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},{"id":"pmid:37697910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37697910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral cortex (New York, N.Y. : 1991)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/cercor/bhad329","doi":"https://doi.org/10.1093/cercor/bhad329","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cercor/bhad329","pdf_url":"https://academic.oup.com/cercor/article-pdf/33/21/10848/52131805/bhad329.pdf","source":{"id":"https://openalex.org/S117898428","display_name":"Cerebral Cortex","issn_l":"1047-3211","issn":["1047-3211","1460-2199"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cerebral Cortex","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1758595148","display_name":null,"funder_award_id":"82103917","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386624255.pdf","grobid_xml":"https://content.openalex.org/works/W4386624255.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1972696558","https://openalex.org/W2007704605","https://openalex.org/W2008483626","https://openalex.org/W2023999015","https://openalex.org/W2033793704","https://openalex.org/W2073140640","https://openalex.org/W2088182380","https://openalex.org/W2094276045","https://openalex.org/W2105897659","https://openalex.org/W2113870612","https://openalex.org/W2118008714","https://openalex.org/W2118822739","https://openalex.org/W2272741817","https://openalex.org/W2324862792","https://openalex.org/W2520048741","https://openalex.org/W2522532977","https://openalex.org/W2550933031","https://openalex.org/W2618381302","https://openalex.org/W2725404076","https://openalex.org/W2762490747","https://openalex.org/W2784368959","https://openalex.org/W2784825428","https://openalex.org/W2789774760","https://openalex.org/W2791863121","https://openalex.org/W2805983714","https://openalex.org/W2809955381","https://openalex.org/W2883978164","https://openalex.org/W2909598358","https://openalex.org/W2912181988","https://openalex.org/W2943085208","https://openalex.org/W2950591584","https://openalex.org/W2950625872","https://openalex.org/W2955177623","https://openalex.org/W2967393462","https://openalex.org/W2997775611","https://openalex.org/W3035311636","https://openalex.org/W3042936392","https://openalex.org/W3110145409","https://openalex.org/W3156441252","https://openalex.org/W3160314569","https://openalex.org/W3179090394","https://openalex.org/W3188068149","https://openalex.org/W3189424812","https://openalex.org/W3197233575","https://openalex.org/W3198867996","https://openalex.org/W4200157084","https://openalex.org/W4211191711","https://openalex.org/W4225827153","https://openalex.org/W4236833867","https://openalex.org/W4304084123"],"related_works":["https://openalex.org/W4385235567","https://openalex.org/W4413905668","https://openalex.org/W4408767103","https://openalex.org/W6976998033","https://openalex.org/W4408254638","https://openalex.org/W4390667230","https://openalex.org/W4410313734","https://openalex.org/W4304084123","https://openalex.org/W4414538107","https://openalex.org/W4413427957"],"abstract_inverted_index":{"Brian":[0],"imaging-derived":[1,36],"phenotypes":[2,37],"(IDPs)":[3],"have":[4],"been":[5],"suggested":[6,179],"to":[7,130,197],"be":[8,131],"associated":[9,63,132],"with":[10,64,133],"ischemic":[11,44,65,126,187],"stroke,":[12,66],"but":[13],"the":[14,30,72,83,92,96,104,114,122,145,160,169,190],"causality":[15],"between":[16,34],"them":[17],"remains":[18],"unclear.":[19],"In":[20,121],"this":[21],"bidirectional":[22,175],"two-sample":[23,176],"Mendelian":[24],"randomization":[25],"(MR)":[26],"study,":[27],"we":[28],"explored":[29],"potential":[31],"causal":[32],"relationship":[33],"461":[35],"(n":[38,46],"=":[39,47],"33,224,":[40],"UK":[41],"Biobank)":[42],"and":[43,111,166,182,201],"stroke":[45,127,188],"34,217":[48],"cases/406,111":[49],"controls,":[50],"Multiancestry":[51],"Genome-Wide":[52],"Association":[53],"Study":[54],"of":[55,95,147,168],"Stroke).":[56],"Forward":[57],"MR":[58,124,177],"analyses":[59],"identified":[60,129],"five":[61,180],"IDPs":[62],"including":[67,136],"mean":[68],"diffusivity":[69],"(MD)":[70],"in":[71,82,91,103,113,144,159],"right":[73,97,105,115],"superior":[74,85,116],"fronto-occipital":[75,86],"fasciculus":[76,87],"(1.22":[77],"[95%":[78,152],"CI,":[79],"1.11-1.34]),":[80],"MD":[81,90,102,112],"left":[84],"(1.30":[88],"[1.17-1.44]),":[89],"anterior":[93,106],"limb":[94],"internal":[98],"capsule":[99],"(1.36":[100],"[1.22-1.51]),":[101],"thalamic":[107,117],"radiation":[108,118],"(1.17":[109],"[1.09-1.26]),":[110],"(1.23":[119],"[1.11-1.35]).":[120],"reverse":[123],"analyses,":[125],"was":[128],"three":[134,183],"IDPs,":[135],"high":[137],"isotropic":[138],"or":[139],"free":[140],"water":[141],"volume":[142,167],"fraction":[143],"body":[146],"corpus":[148],"callosum":[149],"(beta,":[150],"0.189":[151],"confidence":[153],"interval,":[154],"0.107-0.271]),":[155],"orientation":[156],"dispersion":[157],"index":[158],"pontine":[161],"crossing":[162],"tract":[163],"(0.175":[164],"[0.093-0.257]),":[165],"third":[170],"ventricle":[171],"(0.219":[172],"[0.138-0.301]).":[173],"This":[174],"study":[178],"predictors":[181],"diagnostic":[184],"markers":[185],"for":[186],"at":[189],"brain-imaging":[191],"level.":[192],"Further":[193],"studies":[194],"are":[195],"warranted":[196],"replicate":[198],"our":[199],"findings":[200],"clarify":[202],"underlying":[203],"mechanisms.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-13T00:00:00"}