{"id":"https://openalex.org/W4386603136","doi":"https://doi.org/10.3389/fendo.2023.1234237","title":"Bone safety of dual-release hydrocortisone in patients with autoimmune primary adrenal insufficiency","display_name":"Bone safety of dual-release hydrocortisone in patients with autoimmune primary adrenal insufficiency","publication_year":2023,"publication_date":"2023-09-11","ids":{"openalex":"https://openalex.org/W4386603136","doi":"https://doi.org/10.3389/fendo.2023.1234237","pmid":"https://pubmed.ncbi.nlm.nih.gov/37766685","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10519793"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2023.1234237","doi":"https://doi.org/10.3389/fendo.2023.1234237","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1234237","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1234237/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1234237/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072698787","display_name":"Fabio Bioletto","orcid":"https://orcid.org/0000-0001-7550-7023","observed_orcids":["https://orcid.org/0000-0001-7550-7023"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Bioletto","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002406819","display_name":"Marco Barale","orcid":"https://orcid.org/0000-0003-3441-2014","observed_orcids":["https://orcid.org/0000-0003-3441-2014"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Barale","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004767668","display_name":"Mirko Parasiliti\u2010Caprino","orcid":"https://orcid.org/0000-0002-6930-7073","observed_orcids":["https://orcid.org/0000-0002-6930-7073"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mirko Parasiliti-Caprino","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087048780","display_name":"Jacopo Giannelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jacopo Giannelli","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037112637","display_name":"Lorenzo Campioni","orcid":"https://orcid.org/0009-0001-7328-2892","observed_orcids":["https://orcid.org/0009-0001-7328-2892"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Campioni","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018102029","display_name":"Vincenzo Cappiello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Cappiello","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055709094","display_name":"Maria Chiara Di Carlo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Chiara Di Carlo","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007907892","display_name":"Ezio Ghigo","orcid":"https://orcid.org/0000-0002-2809-8105","observed_orcids":["https://orcid.org/0000-0002-2809-8105"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ezio Ghigo","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118774586","display_name":"Procopio Massimo","orcid":"https://orcid.org/0009-0000-0751-3798","observed_orcids":["https://orcid.org/0009-0000-0751-3798"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Procopio","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009173044","display_name":"Roberta Giordano","orcid":"https://orcid.org/0000-0001-8713-3532","observed_orcids":["https://orcid.org/0000-0001-8713-3532"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Roberta Giordano","raw_affiliation_strings":["Department of Clinical and Biological Sciences, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Biological Sciences, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009173044"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.2354,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.80079914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":null,"first_page":"1234237","last_page":"1234237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.09650000184774399,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-replacement-therapy","display_name":"glucocorticoid replacement therapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8360000252723694},{"id":"https://openalex.org/keywords/trabecular-bone-score","display_name":"trabecular bone score","score":0.9800000190734863},{"id":"https://openalex.org/keywords/vertebral-fractures","display_name":"vertebral fractures","score":0.8410000205039978},{"id":"https://openalex.org/keywords/fracture-risk","display_name":"fracture risk","score":0.949999988079071},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.9700000286102295},{"id":"https://openalex.org/keywords/glucocorticoid-induced-osteoporosis","display_name":"glucocorticoid-induced osteoporosis","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2778129406","wikidata":"https://www.wikidata.org/wiki/Q2507454","display_name":"Adrenal insufficiency","level":2,"score":0.8250462412834167},{"id":"https://openalex.org/C2911038130","wikidata":"https://www.wikidata.org/wiki/Q8282","display_name":"Primary Adrenal Insufficiency","level":3,"score":0.765120804309845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6531409621238708},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.5814010500907898},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4041443169116974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38272911310195923}],"mesh":[{"descriptor_ui":"D000224","descriptor_name":"Addison Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3389/fendo.2023.1234237","doi":"https://doi.org/10.3389/fendo.2023.1234237","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1234237","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1234237/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10519793","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10519793","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10519793/pdf/fendo-14-1234237.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmid:37766685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37766685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:620af21ccbb449a7a96eeb28fb17e1f7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/620af21ccbb449a7a96eeb28fb17e1f7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 14 (2023)","raw_type":"article"},{"id":"pmh:oai:iris.unito.it:2318/1940630","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2318/1940630","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2023.1234237","doi":"https://doi.org/10.3389/fendo.2023.1234237","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2023.1234237","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2023.1234237/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324041","display_name":"Universit\u00e0 degli Studi di Torino","ror":"https://ror.org/048tbm396"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386603136.pdf","grobid_xml":"https://content.openalex.org/works/W4386603136.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1191353728","https://openalex.org/W1548081233","https://openalex.org/W1972567404","https://openalex.org/W1983391342","https://openalex.org/W1986533422","https://openalex.org/W1993345945","https://openalex.org/W2006989668","https://openalex.org/W2021280621","https://openalex.org/W2059894643","https://openalex.org/W2068308990","https://openalex.org/W2072014838","https://openalex.org/W2090899240","https://openalex.org/W2108430953","https://openalex.org/W2109123900","https://openalex.org/W2120077291","https://openalex.org/W2124011858","https://openalex.org/W2126029954","https://openalex.org/W2132382547","https://openalex.org/W2137769079","https://openalex.org/W2141231045","https://openalex.org/W2154889019","https://openalex.org/W2156536474","https://openalex.org/W2163631026","https://openalex.org/W2169198657","https://openalex.org/W2169302270","https://openalex.org/W2171133944","https://openalex.org/W2313153847","https://openalex.org/W2404404185","https://openalex.org/W2563919593","https://openalex.org/W2622070501","https://openalex.org/W2743794575","https://openalex.org/W2783478910","https://openalex.org/W2793613692","https://openalex.org/W2801554786","https://openalex.org/W2808631980","https://openalex.org/W2883346410","https://openalex.org/W2980917643","https://openalex.org/W2981625496","https://openalex.org/W2999688780","https://openalex.org/W3015204213","https://openalex.org/W3037974438","https://openalex.org/W3046755228","https://openalex.org/W3122447372","https://openalex.org/W3152822525","https://openalex.org/W3164566314","https://openalex.org/W3210373320","https://openalex.org/W3216859588","https://openalex.org/W4211192934","https://openalex.org/W4289521846","https://openalex.org/W4308121354","https://openalex.org/W4309558037"],"related_works":["https://openalex.org/W4389448725","https://openalex.org/W4289521846","https://openalex.org/W4391750125","https://openalex.org/W2255823515","https://openalex.org/W2167483966","https://openalex.org/W2597155438","https://openalex.org/W4285097846","https://openalex.org/W2325561954","https://openalex.org/W3152822525","https://openalex.org/W2400498051"],"abstract_inverted_index":{"Background":[0],"Conventional":[1],"glucocorticoids":[2],"(C-GC)":[3],"replacement":[4],"regimens":[5,246],"have":[6],"a":[7,35,107,145,161,184,234],"detrimental":[8,200],"effect":[9,201],"on":[10,40,52,207],"skeletal":[11],"health":[12],"in":[13,225,237],"patients":[14,59,226],"with":[15,60,67,72,96,104,183,218,227],"adrenal":[16],"insufficiency":[17],"(AI),":[18],"ultimately":[19],"leading":[20],"to":[21,76,98,195,205,223,232],"an":[22],"increased":[23],"fracture":[24,181,208,248],"risk.":[25,209,249],"The":[26],"novel":[27],"dual-release":[28],"hydrocortisone":[29],"(DR-HC)":[30],"formulations":[31],"are":[32,55],"characterized":[33,143],"by":[34,144,160],"more":[36],"favourable":[37],"safety":[38],"profile":[39],"various":[41],"clinical":[42],"endpoints.":[43],"Data":[44],"comparing":[45],"the":[46,81,90,177,198,238,241],"impact":[47],"of":[48,165,180,186,202,240],"C-GC":[49,68,105,224],"and":[50,69,126,159,247],"DR-HC":[51,215],"bone,":[53],"however,":[54],"scarce.":[56],"Methods":[57],"Twenty-seven":[58],"autoimmune":[61],"primary":[62],"AI":[63],"(PAI;":[64],"13":[65],"treated":[66,71,103],"14":[70],"DR-HC)":[73],"were":[74,94,142],"evaluated":[75],"compare":[77],"bone-related":[78,220],"parameters":[79],"between":[80,89,243],"two":[82,91],"treatment":[83,245],"groups.":[84],"Results":[85],"No":[86],"significant":[87],"differences":[88],"treatments":[92],"groups":[93],"observed":[95,199],"respect":[97],"bone":[99,109,148],"turnover":[100],"markers.":[101],"Patients":[102],"showed":[106],"lower":[108,146],"mineral":[110],"density":[111],"(BMD)":[112],"at":[113,127,189],"lumbar":[114],"spine":[115],"(LS;":[116],"0.791":[117],"\u00b1":[118,122,132,136,152,156],"0.195":[119],"vs.":[120,134,154,171],"0.942":[121],"0.124":[123],"g/cm2,":[124,138],"p=0.025)":[125],"femoral":[128],"neck":[129],"(FN;":[130],"0.633":[131],"0.114":[133],"0.716":[135],"0.088":[137],"p=0.045).":[139],"Moreover,":[140,229],"they":[141],"trabecular":[147],"score":[149],"(TBS;":[150],"1.236":[151],"0.035":[153],"1.383":[155],"0.030,":[157],"p=0.004)":[158],"higher":[162],"mean":[163],"number":[164],"vertebral":[166],"fractures":[167],"per":[168],"patient":[169],"(0.75":[170],"0":[172],"fractures,":[173],"p=0.002).":[174],"TBS":[175,230],"was":[176,193],"best":[178],"predictor":[179],"risk,":[182],"pseudo-R2":[185],"0.593;":[187],"moreover,":[188],"mediation":[190,239],"analysis,":[191],"it":[192],"able":[194],"fully":[196],"explain":[197],"C-GC,":[203],"compared":[204,222],"DR-HC,":[206],"Conclusions":[210],"These":[211],"results":[212],"suggest":[213],"that":[214],"is":[216],"associated":[217],"less":[219],"complications":[221],"PAI.":[228],"seems":[231],"play":[233],"pivotal":[235],"role":[236],"relationship":[242],"glucocorticoid":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-12T00:00:00"}
