{"id":"https://openalex.org/W4386600306","doi":"https://doi.org/10.1016/j.jve.2023.100348","title":"The central nervous system is a potential reservoir and possible origin of drug resistance in hepatitis B infection","display_name":"The central nervous system is a potential reservoir and possible origin of drug resistance in hepatitis B infection","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386600306","doi":"https://doi.org/10.1016/j.jve.2023.100348","pmid":"https://pubmed.ncbi.nlm.nih.gov/37771603","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10523273"},"language":"en","primary_location":{"id":"doi:10.1016/j.jve.2023.100348","doi":"https://doi.org/10.1016/j.jve.2023.100348","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jve.2023.100348","pdf_url":null,"source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jve.2023.100348","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084578229","display_name":"Lijun Xu","orcid":"https://orcid.org/0000-0001-7352-2086","observed_orcids":["https://orcid.org/0000-0001-7352-2086"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lijun Xu","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-7352-2086","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101149723","display_name":"Minghan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghan Zhou","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031115351","display_name":"Xiuming Peng","orcid":"https://orcid.org/0000-0001-7043-3862","observed_orcids":["https://orcid.org/0000-0001-7043-3862"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuming Peng","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","Department of Respiratory Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China","National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Respiratory Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003916505","display_name":"Yufan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufan Xu","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","Department of Pathology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Pathology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007101675","display_name":"Huang Fan","orcid":"https://orcid.org/0000-0002-7525-9290","observed_orcids":["https://orcid.org/0000-0002-7525-9290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fan Huang","raw_affiliation_strings":["Department of Infectious Disease, Jianxin Hospital of Fujian Province, Fuzhou, China","Department of Infectious Disease, Jianxin Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Jianxin Hospital of Fujian Province, Fuzhou, China","institution_ids":[]},{"raw_affiliation_string":"Department of Infectious Disease, Jianxin Hospital, Fuzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104111427","display_name":"Linyun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linyun Wang","raw_affiliation_strings":["College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057321483","display_name":"Xiaorong Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaorong Peng","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","Department of Respiratory Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China","National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Respiratory Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083958093","display_name":"Zongxing Yang","orcid":"https://orcid.org/0000-0002-4711-2910","observed_orcids":["https://orcid.org/0000-0002-4711-2910"]},"institutions":[{"id":"https://openalex.org/I4210140800","display_name":"Hangzhou Xixi hospital","ror":"https://ror.org/04zkkh342","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140800"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongxing Yang","raw_affiliation_strings":["Department II of Infectious Diseases, Xixi Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department II of Infectious Diseases, Xixi Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210140800","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ran Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Tao","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035848422","display_name":"Guanjing Lang","orcid":"https://orcid.org/0000-0003-0071-2924","observed_orcids":["https://orcid.org/0000-0003-0071-2924"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanjing Lang","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qing Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Cao","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029921391","display_name":"Minwei Li","orcid":"https://orcid.org/0000-0001-6296-2764","observed_orcids":["https://orcid.org/0000-0001-6296-2764"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minwei Li","raw_affiliation_strings":["National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101653743","display_name":"Ying Sophie Huang","orcid":"https://orcid.org/0000-0001-5466-5014","observed_orcids":["https://orcid.org/0000-0001-5466-5014","https://orcid.org/0000-0002-1100-4109"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Huang","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012174269","display_name":"Biao Zhu","orcid":"https://orcid.org/0000-0003-2980-4849","observed_orcids":["https://orcid.org/0000-0003-2980-4849","https://orcid.org/0009-0006-6089-9187"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I4391768041","display_name":"State Key Laboratory of Diagnosis and Treatment of Infectious Diseases","ror":"https://ror.org/00325dg83","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768041","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biao Zhu","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101616953","display_name":"Yan Hai Xu","orcid":"https://orcid.org/0000-0003-4718-1681","observed_orcids":["https://orcid.org/0000-0003-4718-1681"]},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Xu","raw_affiliation_strings":["Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","Department of Pathology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Pathology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084578229"],"corresponding_institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I4391768041","https://openalex.org/I76130692"],"apc_list":{"value":2260,"currency":"USD","value_usd":2260},"apc_paid":{"value":2260,"currency":"USD","value_usd":2260},"fwci":1.0809,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.73759233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"3","first_page":"100348","last_page":"100348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9739999771118164},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.890999972820282},{"id":"https://openalex.org/keywords/reverse-transcriptase-mutations","display_name":"reverse transcriptase mutations","score":0.8849999904632568},{"id":"https://openalex.org/keywords/rtl180m","display_name":"rtL180M","score":0.9620000123977661},{"id":"https://openalex.org/keywords/quasispecies","display_name":"quasispecies","score":0.8299999833106995},{"id":"https://openalex.org/keywords/viral-compartmentalization","display_name":"viral compartmentalization","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hiv-hbv-coinfection","display_name":"HIV/HBV coinfection","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lamivudine","display_name":"lamivudine","score":0.8029999732971191},{"id":"https://openalex.org/keywords/entecavir","display_name":"entecavir","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hbv-dna-detection","display_name":"HBV DNA detection","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.8334522843360901},{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.7886403799057007},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6240217089653015},{"id":"https://openalex.org/C2776175608","wikidata":"https://www.wikidata.org/wiki/Q418586","display_name":"Entecavir","level":5,"score":0.6014764904975891},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.4901729226112366},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.4615187346935272},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.4522155523300171},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.42088618874549866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3823409676551819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38021451234817505},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.17441865801811218},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14297276735305786},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1315675973892212},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.11306032538414001},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08751308917999268}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jve.2023.100348","doi":"https://doi.org/10.1016/j.jve.2023.100348","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jve.2023.100348","pdf_url":null,"source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},{"id":"doi:10.1101/2023.04.05.535804","doi":"https://doi.org/10.1101/2023.04.05.535804","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.04.05.535804","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/04/07/2023.04.05.535804.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10523273","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10523273","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10523273/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virus Erad","raw_type":"Text"},{"id":"pmid:37771603","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37771603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virus eradication","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9aeac24e13694697b77e6141af5ae8ea","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9aeac24e13694697b77e6141af5ae8ea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Virus Eradication, Vol 9, Iss 3, Pp 100348- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jve.2023.100348","doi":"https://doi.org/10.1016/j.jve.2023.100348","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jve.2023.100348","pdf_url":null,"source":{"id":"https://openalex.org/S2764990692","display_name":"Journal of Virus Eradication","issn_l":"2055-6640","issn":["2055-6640","2055-6659"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virus Eradication","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386600306.pdf","grobid_xml":"https://content.openalex.org/works/W4386600306.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W98600634","https://openalex.org/W1844576826","https://openalex.org/W1876100835","https://openalex.org/W1990607808","https://openalex.org/W1999090783","https://openalex.org/W2019192674","https://openalex.org/W2046630371","https://openalex.org/W2053214484","https://openalex.org/W2053417564","https://openalex.org/W2060900308","https://openalex.org/W2069869637","https://openalex.org/W2093880239","https://openalex.org/W2100256719","https://openalex.org/W2101049127","https://openalex.org/W2148535109","https://openalex.org/W2151197540","https://openalex.org/W2156552801","https://openalex.org/W2171820897","https://openalex.org/W2360307815","https://openalex.org/W2527732320","https://openalex.org/W2886926637","https://openalex.org/W2910419788","https://openalex.org/W2916754771","https://openalex.org/W2963554933","https://openalex.org/W2965105181","https://openalex.org/W2970147901","https://openalex.org/W3090243589","https://openalex.org/W3157342528"],"related_works":["https://openalex.org/W4362705954","https://openalex.org/W1999090783","https://openalex.org/W7214123038","https://openalex.org/W2024241031","https://openalex.org/W2139573306","https://openalex.org/W2013488617","https://openalex.org/W2101049127","https://openalex.org/W7095532351","https://openalex.org/W2215007428","https://openalex.org/W4413397575"],"abstract_inverted_index":{"Background:":[0],"The":[1,111],"significance":[2],"of":[3,35,57,77,113,189],"hepatitis":[4],"B":[5],"virus":[6],"(HBV)":[7],"in":[8,54,108,118,125,129,172,182,195],"cerebrospinal":[9],"fluid":[10],"(CSF)":[11],"is":[12,165],"unclear.":[13],"Methods:":[14],"Synchronous":[15],"serum":[16,84,120,197],"and":[17,33,46,61,99,102,115,121,170,177,192,198],"CSF":[18,56,76,122,164,173],"samples":[19],"were":[20,41,72,123],"collected":[21],"from":[22,74,180],"13":[23],"patients.":[24],"HBV":[25,50,70,85,168,171,190],"DNA,":[26],"full-length":[27,69],"genome,":[28],"quasispecies,":[29,92],"phylogenetic":[30,100],"tree,":[31],"compartmentalization":[32,98],"mutation":[34,178],"the":[36,55,75,109,130,187],"reverse":[37],"transcriptase":[38],"(RT)":[39],"region":[40],"performed":[42],"based":[43],"on":[44],"PCR":[45],"sequencing":[47],"methods.":[48],"Results:":[49],"DNA":[51],"was":[52],"detected":[53],"3":[58],"antiviral-na\u00efve":[59],"individuals":[60,88,127],"1":[62],"individual":[63],"after":[64],"successful":[65],"antiviral":[66],"therapy.":[67],"Complete":[68],"genomes":[71],"isolated":[73],"5":[78,103],"individuals,":[79],"including":[80],"2":[81],"with":[82],"undetectable":[83],"DNA.":[86],"Ten":[87],"exhibited":[89],"distinct":[90,175],"CSF-serum":[91,96],"8":[93],"harbored":[94],"independent":[95],"genetic":[97],"trees,":[101],"lamivudine/entecavir-associated":[104],"resistance":[105],"mutations":[106,117,194],"only":[107],"CSF.":[110,199],"frequencies":[112],"rtL180M":[114,191],"rtM204I/V":[116,156,193],"both":[119,196],"higher":[124],"HIV-HBV-coinfected":[126],"than":[128],"HBV-monoinfected":[131],"ones":[132],"(serum:":[133],"rtL180M:":[134,149],"3.9%":[135],"vs.":[136,143,151,158],"0,":[137,144,152],"P":[138,145,153,160],"=":[139,154,161],"0.004;":[140],"rtM204I/V:":[141],"21.3%":[142],"<":[146],"0.001;":[147],"CSF:":[148],"7.6%":[150,157],"0.026;":[155],"1.6%,":[159],"0.097).":[162],"Conclusion:":[163],"a":[166],"potential":[167],"reservoir,":[169],"harbors":[174],"evolution":[176],"characteristics":[179],"those":[181],"serum.":[183],"HIV":[184],"infection":[185],"increases":[186],"possibility":[188]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-09-12T00:00:00"}
