{"id":"https://openalex.org/W4386595615","doi":"https://doi.org/10.1208/s12248-023-00852-z","title":"Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic Therapeutics","display_name":"Immunoinformatic Risk Assessment of Host Cell Proteins During Process Development for Biologic Therapeutics","publication_year":2023,"publication_date":"2023-09-11","ids":{"openalex":"https://openalex.org/W4386595615","doi":"https://doi.org/10.1208/s12248-023-00852-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/37697150"},"language":"en","primary_location":{"id":"doi:10.1208/s12248-023-00852-z","doi":"https://doi.org/10.1208/s12248-023-00852-z","is_oa":true,"landing_page_url":"https://doi.org/10.1208/s12248-023-00852-z","pdf_url":"https://link.springer.com/content/pdf/10.1208/s12248-023-00852-z.pdf","source":{"id":"https://openalex.org/S74983066","display_name":"The AAPS Journal","issn_l":"1550-7416","issn":["1550-7416"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The AAPS Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1208/s12248-023-00852-z.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083405419","display_name":"Kirk D. Haltaufderhyde","orcid":"https://orcid.org/0009-0009-8584-1725","observed_orcids":["https://orcid.org/0009-0009-8584-1725"]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirk Haltaufderhyde","raw_affiliation_strings":["EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA"],"raw_orcid":"https://orcid.org/0009-0009-8584-1725","affiliations":[{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109886715","display_name":"Brian Roberts","orcid":"https://orcid.org/0000-0002-6366-3165","observed_orcids":["https://orcid.org/0000-0002-6366-3165"]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Roberts","raw_affiliation_strings":["EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025115282","display_name":"Sundos Khan","orcid":"https://orcid.org/0000-0001-9426-715X","observed_orcids":["https://orcid.org/0000-0001-9426-715X"]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sundos Khan","raw_affiliation_strings":["EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102849637","display_name":"Frances E. Terry","orcid":"https://orcid.org/0000-0002-8670-4310","observed_orcids":["https://orcid.org/0000-0002-8670-4310"]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances Terry","raw_affiliation_strings":["EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051172421","display_name":"Christine Boyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine M. Boyle","raw_affiliation_strings":["EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111095785","display_name":"Mitchell McAllister","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell McAllister","raw_affiliation_strings":["EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053675979","display_name":"William D Martin","orcid":"https://orcid.org/0000-0001-8694-494X","observed_orcids":["https://orcid.org/0000-0001-8694-494X"]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Martin","raw_affiliation_strings":["EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103383132","display_name":"Amy S. Rosenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Rosenberg","raw_affiliation_strings":["EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I4210147457"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089204881","display_name":"Anne Searls De Groot","orcid":"https://orcid.org/0000-0001-5911-1459","observed_orcids":["https://orcid.org/0000-0001-5911-1459"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I4210147457","display_name":"EpiVax (United States)","ror":"https://ror.org/055qxpb63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210147457"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anne S. De Groot","raw_affiliation_strings":["Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, USA. AnnieD@EpiVax.com","EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA. AnnieD@EpiVax.com","EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, USA. AnnieD@EpiVax.com","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA. AnnieD@EpiVax.com","institution_ids":["https://openalex.org/I4210147457"]},{"raw_affiliation_string":"EpiVax, Inc, 188 Valley St #424, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I4210147457"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089204881"],"corresponding_institution_ids":["https://openalex.org/I165733156","https://openalex.org/I4210147457"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.456,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.4230038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"25","issue":"5","first_page":"87","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/host-cell-proteins","display_name":"host cell proteins","score":0.984000027179718},{"id":"https://openalex.org/keywords/immunogenicity-risk-assessment","display_name":"immunogenicity risk assessment","score":0.8130000233650208},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.7570000290870667},{"id":"https://openalex.org/keywords/epitope-conservation","display_name":"epitope conservation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/therapeutic-biologics","display_name":"biologic therapeutics","score":0.7850000262260437},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8930000066757202},{"id":"https://openalex.org/keywords/process-development","display_name":"process development","score":0.6029999852180481},{"id":"https://openalex.org/keywords/impurity-classification","display_name":"impurity classification","score":0.4729999899864197},{"id":"https://openalex.org/keywords/immunoinformatics","display_name":"immunoinformatics","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.8484269976615906},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8132695555686951},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6995651721954346},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6726561784744263},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6066238284111023},{"id":"https://openalex.org/C94795543","wikidata":"https://www.wikidata.org/wiki/Q3813754","display_name":"Human proteome project","level":4,"score":0.5627045631408691},{"id":"https://openalex.org/C2988729646","wikidata":"https://www.wikidata.org/wiki/Q838129","display_name":"Process development","level":2,"score":0.5413846969604492},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.5048268437385559},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.48481956124305725},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.47727006673812866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43398380279541016},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43145060539245605},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3681645393371582},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3535831868648529},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.313865065574646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2555943727493286},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.25435304641723633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20083624124526978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17432650923728943},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1539493203163147},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C195094911","wikidata":"https://www.wikidata.org/wiki/Q14167904","display_name":"Process management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1208/s12248-023-00852-z","doi":"https://doi.org/10.1208/s12248-023-00852-z","is_oa":true,"landing_page_url":"https://doi.org/10.1208/s12248-023-00852-z","pdf_url":"https://link.springer.com/content/pdf/10.1208/s12248-023-00852-z.pdf","source":{"id":"https://openalex.org/S74983066","display_name":"The AAPS Journal","issn_l":"1550-7416","issn":["1550-7416"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The AAPS Journal","raw_type":"journal-article"},{"id":"pmid:37697150","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37697150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The AAPS journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1208/s12248-023-00852-z","doi":"https://doi.org/10.1208/s12248-023-00852-z","is_oa":true,"landing_page_url":"https://doi.org/10.1208/s12248-023-00852-z","pdf_url":"https://link.springer.com/content/pdf/10.1208/s12248-023-00852-z.pdf","source":{"id":"https://openalex.org/S74983066","display_name":"The AAPS Journal","issn_l":"1550-7416","issn":["1550-7416"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The AAPS Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6417148885","display_name":null,"funder_award_id":"U01 FD007760","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"}],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386595615.pdf","grobid_xml":"https://content.openalex.org/works/W4386595615.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1867707303","https://openalex.org/W1944657476","https://openalex.org/W1950627877","https://openalex.org/W1964339501","https://openalex.org/W1970089737","https://openalex.org/W1992802035","https://openalex.org/W1992816819","https://openalex.org/W1993182604","https://openalex.org/W2000373820","https://openalex.org/W2015997589","https://openalex.org/W2018922312","https://openalex.org/W2023805450","https://openalex.org/W2024748688","https://openalex.org/W2036241558","https://openalex.org/W2053893045","https://openalex.org/W2058499405","https://openalex.org/W2072880634","https://openalex.org/W2086437884","https://openalex.org/W2090941195","https://openalex.org/W2093343938","https://openalex.org/W2098019483","https://openalex.org/W2099600971","https://openalex.org/W2099665987","https://openalex.org/W2108393524","https://openalex.org/W2114191814","https://openalex.org/W2116299223","https://openalex.org/W2121690674","https://openalex.org/W2134153749","https://openalex.org/W2134342374","https://openalex.org/W2139257335","https://openalex.org/W2148612170","https://openalex.org/W2149426025","https://openalex.org/W2160705247","https://openalex.org/W2161846584","https://openalex.org/W2164309192","https://openalex.org/W2164621639","https://openalex.org/W2166304356","https://openalex.org/W2166808662","https://openalex.org/W2321732269","https://openalex.org/W2485045083","https://openalex.org/W2531029516","https://openalex.org/W2568634256","https://openalex.org/W2591993483","https://openalex.org/W2593211227","https://openalex.org/W2608948397","https://openalex.org/W2791947331","https://openalex.org/W2801235050","https://openalex.org/W2909600249","https://openalex.org/W2914365593","https://openalex.org/W2929385899","https://openalex.org/W2963248601","https://openalex.org/W2999919945","https://openalex.org/W3011425027","https://openalex.org/W3016073437","https://openalex.org/W3039467801","https://openalex.org/W3118414301","https://openalex.org/W3135716007","https://openalex.org/W3140226555","https://openalex.org/W3152794373","https://openalex.org/W3153417802","https://openalex.org/W3157559964","https://openalex.org/W3164344715","https://openalex.org/W3164675080","https://openalex.org/W3168140637","https://openalex.org/W3171080219","https://openalex.org/W3187379044","https://openalex.org/W3203248391","https://openalex.org/W3203253787","https://openalex.org/W4220802570","https://openalex.org/W4283796775","https://openalex.org/W4303981572","https://openalex.org/W4313893167","https://openalex.org/W4321436885","https://openalex.org/W4377564687","https://openalex.org/W4384502106","https://openalex.org/W7074192807"],"related_works":["https://openalex.org/W4412892472","https://openalex.org/W4393219634","https://openalex.org/W4414121574","https://openalex.org/W2098019483","https://openalex.org/W1991980434","https://openalex.org/W2121690674","https://openalex.org/W3026932109","https://openalex.org/W7223291425","https://openalex.org/W4409106030","https://openalex.org/W7168259776"],"abstract_inverted_index":{"The":[0],"identification":[1],"and":[2,33,44,60,108,114],"removal":[3],"of":[4,41,103,136],"host":[5],"cell":[6,42,111,120],"proteins":[7],"(HCPs)":[8],"from":[9],"biologic":[10],"products":[11],"is":[12],"a":[13,39,94],"critical":[14],"step":[15],"in":[16,38,122],"drug":[17,68],"development.":[18],"Despite":[19],"recent":[20],"improvements":[21],"to":[22,58,145],"purification":[23],"processes,":[24],"biologics":[25],"such":[26],"as":[27],"monoclonal":[28],"antibodies,":[29],"enzyme":[30],"replacement":[31],"therapies,":[32],"vaccines":[34],"that":[35,71,74,87,98,132],"are":[36,75,88],"manufactured":[37],"range":[40],"lines":[43],"purified":[45],"using":[46],"diverse":[47],"processes":[48],"may":[49,81],"contain":[50,72],"HCP":[51,104,142],"impurities,":[52],"making":[53],"it":[54],"necessary":[55],"for":[56,66,139],"developers":[57],"identify":[59],"quantify":[61],"impurities":[62,143],"during":[63],"process":[64],"development":[65],"each":[67],"product.":[69],"HCPs":[70],"sequences":[73,105],"less":[76],"conserved":[77],"with":[78,117],"human":[79,124],"homologs":[80],"be":[82],"more":[83,89],"immunogenic":[84,101],"than":[85],"those":[86],"conserved.":[90],"We":[91],"have":[92],"developed":[93],"computational":[95],"tool,":[96],"ISPRI-HCP,":[97],"estimates":[99],"the":[100,123,134],"potential":[102],"by":[106],"evaluating":[107],"quantifying":[109],"T":[110,119],"epitope":[112],"density":[113],"relative":[115],"conservation":[116],"similar":[118],"epitopes":[121],"proteome.":[125],"Here":[126],"we":[127],"describe":[128],"several":[129],"case":[130],"studies":[131],"support":[133],"use":[135],"this":[137],"method":[138],"classifying":[140],"candidate":[141],"according":[144],"their":[146],"immunogenicity":[147],"risk.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-09-12T00:00:00"}
