{"id":"https://openalex.org/W4386593530","doi":null,"title":"Low RPMB indicates better disease-free survival of adjuvant radiotherapy after radical surgery in thymoma.","display_name":"Low RPMB indicates better disease-free survival of adjuvant radiotherapy after radical surgery in thymoma.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4386593530","pmid":"https://pubmed.ncbi.nlm.nih.gov/37692947","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492043"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10492043","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492043","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492043/pdf/ajtr0015-5457.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492043/pdf/ajtr0015-5457.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101695847","display_name":"Ning An","orcid":"https://orcid.org/0000-0002-8018-4238","observed_orcids":["https://orcid.org/0000-0002-8018-4238"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning An","raw_affiliation_strings":["Department of Radiation Oncology, The Affiliated Hospital of Qingdao University Qingdao 266003, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Affiliated Hospital of Qingdao University Qingdao 266003, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360610","display_name":"Cui Li","orcid":"https://orcid.org/0000-0001-9777-9628","observed_orcids":["https://orcid.org/0000-0001-9777-9628"]},"institutions":[{"id":"https://openalex.org/I4210097945","display_name":"Linyi People's Hospital","ror":"https://ror.org/011r8ce56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097945"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Cui","raw_affiliation_strings":["Department of Oncology, The People's Hospital of Pingyi County Linyi 273399, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The People's Hospital of Pingyi County Linyi 273399, Shandong, China","institution_ids":["https://openalex.org/I4210097945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101430500","display_name":"Xue Cheng Yang","orcid":"https://orcid.org/0000-0002-1659-7791","observed_orcids":["https://orcid.org/0000-0002-1659-7791","https://orcid.org/0000-0002-3540-2910"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Yang","raw_affiliation_strings":["Department of Medical Oncology, The Affiliated Hospital of Qingdao University Qingdao 266003, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Affiliated Hospital of Qingdao University Qingdao 266003, Shandong, China","institution_ids":["https://openalex.org/I4210116869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1616,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.40053741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"8","first_page":"5457","last_page":"5468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymoma","display_name":"thymoma","score":1.0},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radical-surgery","display_name":"radical surgery","score":0.7390000224113464},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8259999752044678},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7289999723434448},{"id":"https://openalex.org/keywords/treatment-selection","display_name":"treatment selection","score":0.5479999780654907},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7398281097412109},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.7348825931549072},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.686275839805603},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.566489577293396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5216070413589478},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5036172270774841},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.48026275634765625},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4518350064754486},{"id":"https://openalex.org/C3018454096","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant radiotherapy","level":3,"score":0.4511626362800598},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4501403272151947},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4286537766456604},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41540664434432983},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3694012761116028},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.330860435962677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13582023978233337},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10398262739181519},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.059011489152908325},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10492043","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492043","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492043/pdf/ajtr0015-5457.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:37692947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37692947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10492043","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492043","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492043/pdf/ajtr0015-5457.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2139235618","display_name":null,"funder_award_id":"81802271","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7155098242","display_name":null,"funder_award_id":"81801734","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7933522964","display_name":null,"funder_award_id":"ZR2019QH003","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386593530.pdf","grobid_xml":"https://content.openalex.org/works/W4386593530.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W852888104","https://openalex.org/W1528035347","https://openalex.org/W1533555842","https://openalex.org/W1755052449","https://openalex.org/W1967304777","https://openalex.org/W1977023571","https://openalex.org/W1979686917","https://openalex.org/W1983886870","https://openalex.org/W1984737590","https://openalex.org/W2021691838","https://openalex.org/W2026343134","https://openalex.org/W2034339271","https://openalex.org/W2042464369","https://openalex.org/W2042913529","https://openalex.org/W2049659575","https://openalex.org/W2052378950","https://openalex.org/W2065087624","https://openalex.org/W2065810879","https://openalex.org/W2067780695","https://openalex.org/W2070747210","https://openalex.org/W2072497490","https://openalex.org/W2073405926","https://openalex.org/W2074549036","https://openalex.org/W2078708232","https://openalex.org/W2082477824","https://openalex.org/W2091342567","https://openalex.org/W2091841264","https://openalex.org/W2092124969","https://openalex.org/W2093172432","https://openalex.org/W2095012429","https://openalex.org/W2104048219","https://openalex.org/W2104738859","https://openalex.org/W2105736926","https://openalex.org/W2133536006","https://openalex.org/W2139863684","https://openalex.org/W2153183895","https://openalex.org/W2167445450","https://openalex.org/W2170996980","https://openalex.org/W2171828042","https://openalex.org/W2173456459","https://openalex.org/W2203201709","https://openalex.org/W2228223040","https://openalex.org/W2423314399","https://openalex.org/W3034264030","https://openalex.org/W3121507906","https://openalex.org/W3150184237","https://openalex.org/W4206662285","https://openalex.org/W4233749076","https://openalex.org/W4300658822","https://openalex.org/W4302818917"],"related_works":["https://openalex.org/W4309569628","https://openalex.org/W7124267334","https://openalex.org/W7124266478","https://openalex.org/W7124322745","https://openalex.org/W3141518831","https://openalex.org/W2147558605","https://openalex.org/W1997076019","https://openalex.org/W2106585743","https://openalex.org/W7124454069","https://openalex.org/W7124313383"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"current":[2],"use":[3],"of":[4,23,35,62],"adjuvant":[5,48,87],"radiotherapy":[6,49,88],"in":[7,53,89],"thymoma":[8],"(THYM)":[9],"following":[10],"radical":[11],"surgery":[12],"is":[13,20],"primarily":[14],"based":[15],"on":[16],"clinical":[17],"factors":[18],"and":[19],"a":[21,29,76],"subject":[22],"ongoing":[24],"debate.":[25],"METHODS:":[26],"We":[27],"developed":[28],"new":[30],"biomarker,":[31],"promotor":[32],"methylation":[33,60],"burden":[34],"Deoxyribonucleic":[36,63],"acid":[37,64],"repair":[38,66],"genes":[39],"(RPMB),":[40],"to":[41,79],"identify":[42,80],"patients":[43,82],"who":[44,83],"may":[45,74],"benefit":[46,85],"from":[47,86,93],"after":[50],"complete":[51],"resection":[52],"THYM.":[54],"RPMB":[55,73],"quantitatively":[56],"measures":[57],"the":[58],"promoter":[59],"level":[61],"(DNA)":[65],"genes.":[67],"RESULTS:":[68],"=":[69],"0.028).":[70],"CONCLUSIONS:":[71],"Low":[72],"be":[75],"potential":[77],"indicator":[78],"suitable":[81],"can":[84],"THYM,":[90],"sparing":[91],"others":[92],"treatment":[94],"toxicity.":[95]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-12T00:00:00"}