{"id":"https://openalex.org/W4386593253","doi":null,"title":"INSM1 promotes breast carcinogenesis by regulating C-MYC.","display_name":"INSM1 promotes breast carcinogenesis by regulating C-MYC.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4386593253","pmid":"https://pubmed.ncbi.nlm.nih.gov/37693125","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492136"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10492136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492136","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492136","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056771189","display_name":"Yinan Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinan Guan","raw_affiliation_strings":["Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002955613","display_name":"Yulu Sun","orcid":"https://orcid.org/0000-0002-9625-5782","observed_orcids":["https://orcid.org/0000-0002-9625-5782"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yulu Sun","raw_affiliation_strings":["Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001637333","display_name":"Zheying Liu","orcid":"https://orcid.org/0000-0002-7654-6873","observed_orcids":["https://orcid.org/0000-0002-7654-6873"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheying Liu","raw_affiliation_strings":["Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China","Department of Clinical Medicine, Southeast Univeristy School Nanjing 210008, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]},{"raw_affiliation_string":"Department of Clinical Medicine, Southeast Univeristy School Nanjing 210008, Jiangsu, China","institution_ids":["https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343721","display_name":"Yin Zhang","orcid":"https://orcid.org/0000-0002-5591-645X","observed_orcids":["https://orcid.org/0000-0002-5591-645X"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Zhang","raw_affiliation_strings":["Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101681948","display_name":"Meng Cao","orcid":"https://orcid.org/0000-0001-9166-2824","observed_orcids":["https://orcid.org/0000-0001-9166-2824"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Cao","raw_affiliation_strings":["Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100391941","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-3422-0402","observed_orcids":["https://orcid.org/0000-0002-3422-0402"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075539266","display_name":"Jinqiu Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinqiu Tao","raw_affiliation_strings":["Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018949000","display_name":"Yongzhong Yao","orcid":"https://orcid.org/0000-0001-7593-8878","observed_orcids":["https://orcid.org/0000-0001-7593-8878","https://orcid.org/0000-0002-6243-9559"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongzhong Yao","raw_affiliation_strings":["Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University Nanjing 210008, Jiangsu, China","institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6557,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61526784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"13","issue":"8","first_page":"3500","last_page":"3516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6563000082969666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6563000082969666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.09690000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insm1","display_name":"INSM1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8119999766349792},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9089999794960022},{"id":"https://openalex.org/keywords/skp2","display_name":"Skp2","score":0.996999979019165},{"id":"https://openalex.org/keywords/zinc-finger-transcription-factor","display_name":"zinc finger transcription factor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8190000057220459},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.800000011920929},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8013288974761963},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6766157150268555},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6614482998847961},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6325284242630005},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5002810955047607},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4927206337451935},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4877803921699524},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.45393335819244385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4233567714691162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4082634150981903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38817402720451355},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3607408404350281},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.11472147703170776},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0938442051410675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10492136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492136","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:37693125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37693125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10492136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492136","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1159008209","https://openalex.org/W1514595034","https://openalex.org/W1833597743","https://openalex.org/W1965213880","https://openalex.org/W1972780353","https://openalex.org/W1973081892","https://openalex.org/W1977077315","https://openalex.org/W1978727792","https://openalex.org/W1995947885","https://openalex.org/W2001122852","https://openalex.org/W2004490137","https://openalex.org/W2008757142","https://openalex.org/W2008937231","https://openalex.org/W2011924190","https://openalex.org/W2023028445","https://openalex.org/W2095594768","https://openalex.org/W2103974450","https://openalex.org/W2149158840","https://openalex.org/W2324947948","https://openalex.org/W2334173351","https://openalex.org/W2464803094","https://openalex.org/W2559538376","https://openalex.org/W2611165173","https://openalex.org/W2729251358","https://openalex.org/W2738006884","https://openalex.org/W2746755082","https://openalex.org/W2769764436","https://openalex.org/W2771004856","https://openalex.org/W2790401975","https://openalex.org/W2792378956","https://openalex.org/W2806421539","https://openalex.org/W2806999890","https://openalex.org/W2808674607","https://openalex.org/W2809591561","https://openalex.org/W2886400739","https://openalex.org/W2889309975","https://openalex.org/W2898130799","https://openalex.org/W2911439110","https://openalex.org/W2921457104","https://openalex.org/W2944025126","https://openalex.org/W2944505153","https://openalex.org/W2945098171","https://openalex.org/W2953616395","https://openalex.org/W2972580544","https://openalex.org/W2979291688","https://openalex.org/W3000681710","https://openalex.org/W3006138035","https://openalex.org/W3007097494","https://openalex.org/W3009187843","https://openalex.org/W3010944678","https://openalex.org/W3011099141","https://openalex.org/W3015634062","https://openalex.org/W3029505615","https://openalex.org/W3087263436","https://openalex.org/W3091852583","https://openalex.org/W3093872008","https://openalex.org/W3097723675","https://openalex.org/W3112501641","https://openalex.org/W3125923658","https://openalex.org/W3128646645","https://openalex.org/W3135146710","https://openalex.org/W3161654656","https://openalex.org/W3173153622","https://openalex.org/W3175832306","https://openalex.org/W3196329163","https://openalex.org/W3208215140","https://openalex.org/W3216886539","https://openalex.org/W4210907946","https://openalex.org/W4211031961","https://openalex.org/W4220952638"],"related_works":["https://openalex.org/W3116714567","https://openalex.org/W2945098171","https://openalex.org/W4414104071","https://openalex.org/W3087263436","https://openalex.org/W3197619527","https://openalex.org/W4390870741","https://openalex.org/W3037328337","https://openalex.org/W4413208202","https://openalex.org/W2052841818","https://openalex.org/W2078932680"],"abstract_inverted_index":{"Insulinoma-associated":[0],"protein-1":[1],"(INSM1),":[2],"which":[3,188],"is":[4],"highly":[5],"expressed":[6],"in":[7,31,47,63,95,142,170,189,214],"various":[8],"neuroendocrine":[9],"tumors,":[10],"functions":[11],"as":[12,242],"a":[13,130,243],"zinc":[14],"finger":[15],"transcription":[16],"factor":[17],"capable":[18],"of":[19,24,45,52,61,104,120,151,159,167,207],"regulating":[20],"the":[21,41,59,87,102,117,155,165,195,201,205,226],"biological":[22,157],"behavior":[23],"tumor":[25,126,210],"cells.":[26],"However,":[27],"its":[28],"specific":[29],"role":[30,42],"breast":[32,48,64,96,107,124,143,160,215,234,247],"cancer":[33,65,97,108,125,144,161,235,248],"remains":[34],"unclear.":[35],"This":[36],"study":[37,199],"aims":[38],"to":[39,57,85,209],"investigate":[40],"and":[43,67,80,92,112,146,163,182,212,225],"mechanism":[44],"INSM1":[46,62,90,105,121,138,152,181,208,221,241],"cancer.":[49,216],"A":[50],"total":[51],"158":[53],"cohorts":[54],"were":[55,83],"recruited":[56],"examine":[58],"expression":[60,91],"tissues":[66,72],"their":[68],"corresponding":[69],"adjacent":[70],"normal":[71],"using":[73],"immunohistochemistry.":[74],"Follow-up":[75],"data,":[76],"along":[77],"with":[78,148,231],"clinical":[79],"pathological":[81],"information,":[82],"collected":[84],"analyze":[86],"correlation":[88],"between":[89,180],"survival":[93],"outcomes":[94],"patients.":[98],"Additionally,":[99],"we":[100,128,218],"investigated":[101],"impact":[103],"on":[106,123],"cell":[109],"proliferation,":[110],"migration,":[111],"aggregation.":[113],"To":[114],"further":[115],"explore":[116],"regulatory":[118],"effect":[119],"knockdown":[122],"growth,":[127],"utilized":[129],"xenograft":[131,168],"mouse":[132],"model.":[133],"The":[134],"results":[135],"revealed":[136],"that":[137,220],"was":[139],"significantly":[140],"overexpressed":[141],"patients":[145],"correlated":[147],"prognosis.":[149],"Knockdown":[150],"notably":[153],"impaired":[154],"malignant":[156],"effects":[158],"cells":[162],"inhibited":[164],"growth":[166,213],"tumors":[169],"nude":[171],"mice.":[172],"Importantly,":[173],"our":[174],"data":[175],"also":[176],"suggests":[177],"an":[178],"interaction":[179],"S-phase":[183],"kinase-associated":[184],"protein":[185],"2":[186],"(SKP2),":[187],"turn":[190],"regulates":[191,223],"C-MYC,":[192],"thereby":[193],"affecting":[194],"p-ERK":[196,227],"pathway.":[197],"Our":[198],"provides":[200],"first":[202],"evidence":[203],"demonstrating":[204],"contribution":[206],"formation":[211],"Furthermore,":[217],"found":[219],"positively":[222],"C-MYC":[224],"pathway":[228],"by":[229],"interacting":[230],"SKP2":[232],"during":[233],"development.":[236],"Collectively,":[237],"these":[238],"findings":[239],"highlight":[240],"promising":[244],"target":[245],"for":[246],"treatment.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-09-12T00:00:00"}