{"id":"https://openalex.org/W4386593227","doi":null,"title":"Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/\u03b2-catenin signaling pathway.","display_name":"Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/\u03b2-catenin signaling pathway.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4386593227","pmid":"https://pubmed.ncbi.nlm.nih.gov/37692966","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492086"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10492086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492086","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492086/pdf/ajtr0015-5047.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492086/pdf/ajtr0015-5047.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103231932","display_name":"Jianfei Shi","orcid":"https://orcid.org/0009-0002-2061-2584","observed_orcids":["https://orcid.org/0009-0002-2061-2584","https://orcid.org/0000-0002-4891-6689"]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfei Shi","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109702028","display_name":"Hua Zhang","orcid":"https://orcid.org/0009-0006-3833-3881","observed_orcids":["https://orcid.org/0009-0006-3833-3881"]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua Zhang","raw_affiliation_strings":["Department of Infectious Diseases, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Guangjie Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangjie Han","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344683","display_name":"Jinfeng Wang","orcid":"https://orcid.org/0000-0002-6687-9420","observed_orcids":["https://orcid.org/0000-0002-6687-9420","https://orcid.org/0000-0002-0572-0395"]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinfeng Wang","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103120239","display_name":"Xin Han","orcid":"https://orcid.org/0000-0002-9176-1141","observed_orcids":["https://orcid.org/0000-0002-9176-1141"]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Han","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023496790","display_name":"Man Zhao","orcid":"https://orcid.org/0000-0001-7368-1079","observed_orcids":["https://orcid.org/0000-0001-7368-1079"]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Man Zhao","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102935807","display_name":"Xiaoling Duan","orcid":"https://orcid.org/0000-0003-2219-3467","observed_orcids":["https://orcid.org/0000-0003-2219-3467"]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoling Duan","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112544363","display_name":"Lili Mi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Mi","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100369004","display_name":"Ning Li","orcid":"https://orcid.org/0000-0002-1626-5519","observed_orcids":["https://orcid.org/0000-0002-1626-5519"]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Li","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaolei Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolei Yin","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037343926","display_name":"Cuizhen Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuizhen Li","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101969160","display_name":"Fei Yin","orcid":"https://orcid.org/0009-0008-7647-9894","observed_orcids":["https://orcid.org/0009-0008-7647-9894","https://orcid.org/0000-0003-2430-9267"]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Yin","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University Shijiazhuang 050019, Hebei, P. R. China","institution_ids":["https://openalex.org/I4210106405"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210106405"],"apc_list":null,"apc_paid":null,"fwci":0.3022,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.4094722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"15","issue":"8","first_page":"5047","last_page":"5070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.8349999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.14390000700950623,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrine","display_name":"matrine","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7940000295639038},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.6890000104904175},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.7099999785423279},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8964453339576721},{"id":"https://openalex.org/C2776545273","wikidata":"https://www.wikidata.org/wiki/Q6787831","display_name":"Matrine","level":2,"score":0.8165169954299927},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7883641719818115},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7129567861557007},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7108065485954285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6096743941307068},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5407626032829285},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.45944368839263916},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.44983798265457153},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.44962698221206665},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4327276647090912},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31990373134613037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2942991256713867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21004146337509155},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.20403817296028137},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07794758677482605},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10492086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492086","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492086/pdf/ajtr0015-5047.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:37692966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37692966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10492086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492086","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492086/pdf/ajtr0015-5047.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322163","display_name":"Natural Science Foundation of Hebei Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334208","display_name":"Hebei Provincial Health and Family Planning Commission","ror":"https://ror.org/01pktrj81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386593227.pdf","grobid_xml":"https://content.openalex.org/works/W4386593227.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1498931318","https://openalex.org/W1820070451","https://openalex.org/W1984087164","https://openalex.org/W2050310941","https://openalex.org/W2088710771","https://openalex.org/W2158378236","https://openalex.org/W2464113591","https://openalex.org/W2507782850","https://openalex.org/W2561978423","https://openalex.org/W2569389775","https://openalex.org/W2607399422","https://openalex.org/W2736102792","https://openalex.org/W2770634512","https://openalex.org/W2772769372","https://openalex.org/W2792646273","https://openalex.org/W2889646458","https://openalex.org/W2894408476","https://openalex.org/W2909312563","https://openalex.org/W2932470287","https://openalex.org/W2952311394","https://openalex.org/W2995913683","https://openalex.org/W3007122106","https://openalex.org/W3019635545","https://openalex.org/W3034293218","https://openalex.org/W3038066351","https://openalex.org/W3048475086","https://openalex.org/W3086308345","https://openalex.org/W3103854553","https://openalex.org/W3136584587","https://openalex.org/W3158642709","https://openalex.org/W3169705253","https://openalex.org/W3173725877","https://openalex.org/W3194658429","https://openalex.org/W3204022284","https://openalex.org/W4205450289","https://openalex.org/W4213229018","https://openalex.org/W4229079206","https://openalex.org/W4232620598"],"related_works":["https://openalex.org/W2993189318","https://openalex.org/W2803297160","https://openalex.org/W4391151346","https://openalex.org/W2920458898","https://openalex.org/W4379376754","https://openalex.org/W3217289739","https://openalex.org/W2106016059","https://openalex.org/W2040592336","https://openalex.org/W2146122330","https://openalex.org/W7133549654"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Hepatocellular":[1],"carcinoma":[2,123],"(HCC)":[3],"is":[4,34],"a":[5,110],"malignant":[6],"tumor":[7],"with":[8,128,208],"high":[9],"morbidity":[10],"and":[11,19,53,69,105,126,147,166,169,196,219],"mortality.":[12],"Despite":[13],"rapid":[14],"progress":[15],"in":[16,46,83,109,124,150,206,229],"targeted":[17],"therapy":[18],"immunotherapy":[20],"for":[21],"HCC":[22,47,78,152,172],"over":[23],"the":[24,28,38,62,65,70,97,100,136,139,143,161,175,184,187,192,225],"past":[25],"10":[26],"years,":[27],"overall":[29],"efficacy":[30],"remains":[31],"unsatisfactory.":[32],"This":[33],"mainly":[35],"due":[36],"to":[37,50,120],"presence":[39],"of":[40,44,77,89,113,138,145,171,178,186,194],"an":[41],"intrahepatic":[42,217],"microenvironment":[43],"cirrhosis":[45],"patients,":[48],"leading":[49],"cancer":[51],"recurrence":[52],"drug":[54],"resistance.":[55],"METHODS:":[56],"In":[57,154,174],"this":[58],"study,":[59],"we":[60,81,95],"investigated":[61],"correlations":[63],"between":[64,99],"Wnt-1/\u03b2-catenin":[66,101,140,162,188,226],"signaling":[67,102,141,189,227],"pathway":[68,228],"prognosis":[71],"as":[72,74],"well":[73],"liver":[75,198],"function":[76],"patients.":[79],"Additionally,":[80],"conducted":[82],"vitro":[84],"experiments":[85],"using":[86],"different":[87],"concentrations":[88],"matrine":[90,117,158,181],"on":[91],"HuH-7":[92,155],"cells.":[93,173],"Furthermore,":[94],"verified":[96],"associations":[98],"pathway,":[103,142,163,190],"inflammation,":[104,218],"epithelial-mesenchymal":[106],"transition":[107],"(EMT)":[108],"rat":[111,176],"model":[112,177],"pre-hepatocellular":[114,122,179],"carcinoma.":[115,131],"Finally,":[116],"was":[118],"employed":[119],"treat":[121],"rats":[125],"patients":[127,207],"advanced":[129,209],"hepatocellular":[130],"RESULTS:":[132],"The":[133],"results":[134],"demonstrated":[135],"activation":[137,185],"occurrence":[144,193],"EMT,":[146,165,195,215],"exacerbated":[148],"inflammation":[149],"human":[151],"tissues.":[153],"cell":[156],"experiments,":[157],"effectively":[159],"downregulated":[160],"reversed":[164,191],"suppressed":[167],"migration":[168],"invasion":[170],"carcinoma,":[180],"dose-dependently":[182],"inhibited":[183],"alleviated":[197],"inflammation.":[199],"Matrine":[200,212],"analogues":[201],"exhibited":[202],"promising":[203],"hepatoprotective":[204],"effects":[205],"HCC.":[210,230],"CONCLUSIONS:":[211],"can":[213],"reverse":[214],"alleviate":[216],"counteract":[220],"immune":[221],"depletion":[222],"by":[223],"inhibiting":[224]},"counts_by_year":[{"year":2025,"cited_by_count":4}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-09-12T00:00:00"}