{"id":"https://openalex.org/W4386583752","doi":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27","title":"Search for Novel Antagonist/S of HIF-1\u03b1 from Selected Synthetic Analgesics/ Bioactive Flavonoids: An In-Silico Approach","display_name":"Search for Novel Antagonist/S of HIF-1\u03b1 from Selected Synthetic Analgesics/ Bioactive Flavonoids: An In-Silico Approach","publication_year":2023,"publication_date":"2023-09-10","ids":{"openalex":"https://openalex.org/W4386583752","doi":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27"},"language":"en","primary_location":{"id":"doi:10.22376/ijlpr.2023.13.6.p12-p27","doi":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27","is_oa":true,"landing_page_url":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27","pdf_url":null,"source":{"id":"https://openalex.org/S4210204561","display_name":"International Journal of Life Science and Pharma Research","issn_l":"2250-0480","issn":["2250-0480"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Life Science and Pharma Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101562541","display_name":"Moumita Saha","orcid":"https://orcid.org/0000-0002-4473-3092","observed_orcids":["https://orcid.org/0000-0002-4473-3092"]},"institutions":[{"id":"https://openalex.org/I1288043984","display_name":"Techno India University","ror":"https://ror.org/00v1y6t69","country_code":"IN","type":"education","lineage":["https://openalex.org/I1288043984"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Moumita Saha","raw_affiliation_strings":["Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India","institution_ids":["https://openalex.org/I1288043984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rumana Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288043984","display_name":"Techno India University","ror":"https://ror.org/00v1y6t69","country_code":"IN","type":"education","lineage":["https://openalex.org/I1288043984"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rumana Rahman","raw_affiliation_strings":["Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India","institution_ids":["https://openalex.org/I1288043984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anisha Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288043984","display_name":"Techno India University","ror":"https://ror.org/00v1y6t69","country_code":"IN","type":"education","lineage":["https://openalex.org/I1288043984"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anisha Mukherjee","raw_affiliation_strings":["Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India","institution_ids":["https://openalex.org/I1288043984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042514079","display_name":"Chandreyi Ghosh","orcid":"https://orcid.org/0000-0002-3675-6868","observed_orcids":["https://orcid.org/0000-0002-3675-6868"]},"institutions":[{"id":"https://openalex.org/I1288043984","display_name":"Techno India University","ror":"https://ror.org/00v1y6t69","country_code":"IN","type":"education","lineage":["https://openalex.org/I1288043984"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandreyi Ghosh","raw_affiliation_strings":["Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India","institution_ids":["https://openalex.org/I1288043984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024375401","display_name":"Sirshendu Chatterjee","orcid":"https://orcid.org/0000-0001-6281-4286","observed_orcids":["https://orcid.org/0000-0001-6281-4286"]},"institutions":[{"id":"https://openalex.org/I1288043984","display_name":"Techno India University","ror":"https://ror.org/00v1y6t69","country_code":"IN","type":"education","lineage":["https://openalex.org/I1288043984"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sirshendu Chatterjee","raw_affiliation_strings":["Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Techno India University, West Bengal, EM-4, Salt Lake, Sector- V, Kolkata- 700091, West Bengal, India","institution_ids":["https://openalex.org/I1288043984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1288043984"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11361542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1","display_name":"HIF-1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/letrozole","display_name":"letrozole","score":0.8640000224113464},{"id":"https://openalex.org/keywords/naringenin","display_name":"naringenin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":1.0},{"id":"https://openalex.org/keywords/phenacetin","display_name":"phenacetin","score":0.9079999923706055},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8880000114440918},{"id":"https://openalex.org/keywords/synthetic-analgesics","display_name":"synthetic analgesics","score":0.9190000295639038},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7770000100135803},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7559999823570251},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5614789724349976},{"id":"https://openalex.org/C2776848411","wikidata":"https://www.wikidata.org/wiki/Q418374","display_name":"Naringenin","level":4,"score":0.5338135361671448},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5282574892044067},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.4987773895263672},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43094468116760254},{"id":"https://openalex.org/C2776601336","wikidata":"https://www.wikidata.org/wiki/Q1107734","display_name":"Diosgenin","level":2,"score":0.41268664598464966},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.39635130763053894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21234238147735596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19933080673217773},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22376/ijlpr.2023.13.6.p12-p27","doi":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27","is_oa":true,"landing_page_url":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27","pdf_url":null,"source":{"id":"https://openalex.org/S4210204561","display_name":"International Journal of Life Science and Pharma Research","issn_l":"2250-0480","issn":["2250-0480"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Life Science and Pharma Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22376/ijlpr.2023.13.6.p12-p27","doi":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27","is_oa":true,"landing_page_url":"https://doi.org/10.22376/ijlpr.2023.13.6.p12-p27","pdf_url":null,"source":{"id":"https://openalex.org/S4210204561","display_name":"International Journal of Life Science and Pharma Research","issn_l":"2250-0480","issn":["2250-0480"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Life Science and Pharma Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7220493644","https://openalex.org/W4400764716","https://openalex.org/W4413342809","https://openalex.org/W4415429025","https://openalex.org/W4409811774","https://openalex.org/W4224041013","https://openalex.org/W2060372016","https://openalex.org/W2893118438","https://openalex.org/W4283769499","https://openalex.org/W2024032081"],"abstract_inverted_index":{"Computer":[0],"aided":[1],"drug":[2,7,47,54],"designing":[3],"as":[4,6],"well":[5],"repurposing":[8],"implies":[9],"the":[10,19,33,36,63,68,83,94,98,110,118,138,142,174,181,189,206],"usage":[11],"of":[12,18,21,35,85,93,97,120,132],"molecular":[13,25],"modelling":[14],"techniques":[15],"like":[16],"analysis":[17,112],"structures":[20],"receptor":[22],"and":[23,28,113,125,164],"ligand,":[24],"docking,":[26],"pharmacokinetics":[27],"toxicity":[29],"prediction,":[30],"to":[31,43,50,116,137,199],"explain":[32],"bioactivity":[34],"synthetic":[37],"molecules":[38],"or":[39,49],"plant":[40],"secondary":[41],"metabolites":[42],"design":[44],"more":[45],"efficient":[46],"candidates":[48],"repurpose":[51],"an":[52],"old":[53],"in":[55,74],"new":[56],"diseases.":[57],"Numerous":[58],"studies":[59],"have":[60],"demonstrated":[61],"that":[62,171],"low":[64],"oxygen":[65],"environment":[66],"inside":[67],"cell":[69],"is":[70],"a":[71,196],"key":[72],"factor":[73,89],"developing":[75],"breast":[76,86,133,201],"cancer":[77,122,134,202],"metastasis.":[78,135],"To":[79],"gain":[80],"insight":[81],"into":[82],"spread":[84],"cancer,":[87],"hypoxia-inducible":[88],"1":[90],"(HIF-1),":[91],"one":[92],"master":[95],"regulators":[96],"hypoxic":[99],"response,":[100],"has":[101,173,180],"been":[102],"intensively":[103],"explored.":[104],"Our":[105],"current":[106],"research":[107],"focuses":[108],"on":[109,129],"insilico":[111],"comparative":[114],"study":[115,169],"evaluate":[117],"effects":[119],"different":[121],"drugs,":[123],"analgesics,":[124],"plant-derived":[126],"flavonoid":[127],"compounds":[128],"HIF-1\u03b1":[130,186],"regulation":[131],"According":[136],"study,":[139],"Quercetin":[140,172,193],"shows":[141],"maximum":[143],"binding":[144,176,183],"affinity,":[145],"i.e.,":[146],"-8.2":[147],"kcal/":[148],"mol.":[149],"followed":[150],"by":[151,204],"Letrozole":[152],"(-7.3":[153],"kcal/mol.),":[154],"Naringenin":[155],"(-7.11":[156],"kcal/mol),":[157,160,163],"Tamoxifen":[158],"(-7.07":[159],"Phenacetin":[161],"(-6.16":[162],"Aspirin":[165,179],"(-5.7":[166],"kcal/mol).":[167],"The":[168],"highlighted":[170],"strongest":[175],"affinity":[177,184],"whereas":[178],"least":[182,190],"with":[185],"protein.":[187],"Hence":[188],"toxic":[191],"compound":[192],"can":[194],"be":[195],"good":[197],"candidate":[198],"control":[200],"metastasis":[203],"modulating":[205],"HIF-1":[207],"pathway.":[208]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-09-11T00:00:00"}