{"id":"https://openalex.org/W4386563960","doi":"https://doi.org/10.1007/s00432-023-05354-1","title":"Ang-2 is a potential molecular marker for lymphatic metastasis and better response to bevacizumab therapy in ovarian cancer","display_name":"Ang-2 is a potential molecular marker for lymphatic metastasis and better response to bevacizumab therapy in ovarian cancer","publication_year":2023,"publication_date":"2023-09-08","ids":{"openalex":"https://openalex.org/W4386563960","doi":"https://doi.org/10.1007/s00432-023-05354-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/37684509","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10620258"},"language":"en","primary_location":{"id":"doi:10.1007/s00432-023-05354-1","doi":"https://doi.org/10.1007/s00432-023-05354-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00432-023-05354-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00432-023-05354-1.pdf","source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00432-023-05354-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034657258","display_name":"Annabelle Volk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Annabelle Volk","raw_affiliation_strings":["Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. an.volk@uke.de","Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. an.volk@uke.de","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082090217","display_name":"Karen Legler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karen Legler","raw_affiliation_strings":["Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053577375","display_name":"Fabienne Hamester","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabienne Hamester","raw_affiliation_strings":["Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089567856","display_name":"Sascha Kuerti","orcid":"https://orcid.org/0000-0003-0829-6072","observed_orcids":["https://orcid.org/0000-0003-0829-6072"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sascha Kuerti","raw_affiliation_strings":["Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010094706","display_name":"Kathrin Eylmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Eylmann","raw_affiliation_strings":["Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069445149","display_name":"Maila Ro\u00dfberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maila Rossberg","raw_affiliation_strings":["Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071055386","display_name":"Barbara Schmalfeldt","orcid":"https://orcid.org/0000-0001-8142-2915","observed_orcids":["https://orcid.org/0000-0001-8142-2915"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Barbara Schmalfeldt","raw_affiliation_strings":["Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015835780","display_name":"Leticia Oliveira\u2010Ferrer","orcid":"https://orcid.org/0000-0002-9075-0280","observed_orcids":["https://orcid.org/0000-0002-9075-0280"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leticia Oliveira-Ferrer","raw_affiliation_strings":["Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034657258"],"corresponding_institution_ids":["https://openalex.org/I4210108711"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.0127,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.76472235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"149","issue":"17","first_page":"15957","last_page":"15967"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/intraperitoneal-dissemination","display_name":"intraperitoneal dissemination","score":0.8259999752044678},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/molecular-biomarkers","display_name":"molecular biomarkers","score":0.6399999856948853},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.7668144702911377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7525460720062256},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7460652589797974},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6332660913467407},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5957481861114502},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5806446671485901},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5612415671348572},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.5072593092918396},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.49209755659103394},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4661867022514343},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34365636110305786},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3217775225639343},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2368558645248413}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00432-023-05354-1","doi":"https://doi.org/10.1007/s00432-023-05354-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00432-023-05354-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00432-023-05354-1.pdf","source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10620258","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10620258","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10620258/pdf/432_2023_Article_5354.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer Res Clin Oncol","raw_type":"Text"},{"id":"pmid:37684509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37684509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cancer research and clinical oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s00432-023-05354-1","doi":"https://doi.org/10.1007/s00432-023-05354-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00432-023-05354-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00432-023-05354-1.pdf","source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335947","display_name":"Universit\u00e4tsklinikum Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386563960.pdf","grobid_xml":"https://content.openalex.org/works/W4386563960.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1571910417","https://openalex.org/W1966932597","https://openalex.org/W1968014316","https://openalex.org/W1970875645","https://openalex.org/W1985008806","https://openalex.org/W1988851886","https://openalex.org/W2028284049","https://openalex.org/W2036447543","https://openalex.org/W2088356680","https://openalex.org/W2099028752","https://openalex.org/W2102195694","https://openalex.org/W2106010518","https://openalex.org/W2135947389","https://openalex.org/W2165143139","https://openalex.org/W2166432374","https://openalex.org/W2237151091","https://openalex.org/W2615726315","https://openalex.org/W2755839425","https://openalex.org/W2915403143","https://openalex.org/W2943864790","https://openalex.org/W2944933026","https://openalex.org/W2990030343","https://openalex.org/W2992107509","https://openalex.org/W2999082340","https://openalex.org/W3023274953","https://openalex.org/W3025217711","https://openalex.org/W3099043519","https://openalex.org/W4211185980","https://openalex.org/W4239207515","https://openalex.org/W4281630588","https://openalex.org/W4292528108"],"related_works":["https://openalex.org/W2125853921","https://openalex.org/W2033954320","https://openalex.org/W1968014316","https://openalex.org/W2376149174","https://openalex.org/W2043064695","https://openalex.org/W2399195235","https://openalex.org/W2362792212","https://openalex.org/W4312630333","https://openalex.org/W3206189723","https://openalex.org/W4416625581"],"abstract_inverted_index":{"PURPOSE:":[0],"In":[1,83,166],"ovarian":[2,80,96],"cancer,":[3],"there":[4],"are":[5,44],"two":[6],"main":[7],"routes":[8],"of":[9,29,69,79,95,129],"metastasis,":[10],"namely":[11],"intraperitoneal":[12,161],"and":[13,58,77,87,107,136,217],"retroperitoneal.":[14],"Their":[15],"biologic":[16],"background":[17],"is":[18,49,59,147],"poorly":[19],"understood.":[20],"Identifying":[21],"molecular":[22,73,205],"markers":[23,36],"involved":[24,54],"might":[25,221],"enable":[26],"the":[27,67],"development":[28],"tailored":[30],"therapy":[31,193],"regimens.":[32],"Moreover,":[33],"no":[34],"reliable":[35],"for":[37,207,218],"response":[38],"to":[39,158,179,212,214],"anti-angiogenic":[40],"treatment":[41,78],"with":[42,61,152,169,181,186,194,209],"bevacizumab":[43,224],"yet":[45],"established.":[46],"Angiopoietin-2":[47],"(Ang-2)":[48],"an":[50],"angiogenic":[51],"growth":[52,163],"factor,":[53],"in":[55,75,92,115,120,150,198],"lymphatic":[56],"activation":[57],"associated":[60],"tumor":[62,93,131,162],"progression.":[63],"Here,":[64],"we":[65],"assessed":[66],"potential":[68],"Ang-2":[70,90,113,145,171,183,188,200],"as":[71,203],"a":[72,204],"marker":[74,206],"metastasis":[76],"cancer.":[81],"METHODS:":[82],"our":[84],"study,":[85],"quantitative":[86],"qualitative":[88],"protein":[89],"expression":[91,146,172,189],"tissue":[94],"cancer":[97],"patients":[98,168,180,208,219],"was":[99],"analyzed":[100],"by":[101],"Western":[102],"blot":[103],"(n":[104,109,124],"=":[105,110,125],"138)":[106],"immunohistochemistry":[108],"58).":[111],"Further,":[112],"levels":[114,128],"blood":[116],"samples":[117],"were":[118,134,139],"quantified":[119],"enzyme-linked":[121],"immunosorbent":[122],"assay":[123],"38).":[126],"Expression":[127],"different":[130],"spread":[132,213],"patterns":[133],"evaluated,":[135],"survival":[137,177],"analyses":[138],"made.":[140],"RESULTS:":[141],"We":[142],"observed":[143],"that":[144],"significantly":[148,174,191],"higher":[149],"tumors":[151,210],"retroperitoneal":[153],"dissemination":[154],"(pT1a-pT3b,":[155],"pN1)":[156],"compared":[157,178],"those":[159],"showing":[160],"(pT3c,":[164],"pN0).":[165],"addition,":[167],"high":[170,187],"have":[173],"longer":[175],"overall":[176],"low":[182],"expression.":[184],"Patients":[185],"benefit":[190,222],"from":[192,223],"bevacizumab.":[195],"CONCLUSION:":[196],"All":[197],"all,":[199],"may":[201],"serve":[202],"prone":[211],"lymph":[215],"nodes":[216],"who":[220],"therapy.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-10T00:00:00"}
