{"id":"https://openalex.org/W4386561633","doi":"https://doi.org/10.1158/2767-9764.24107116.v1","title":"FIGURE 2 from Nanoparticle Delivery of Immunostimulatory Alu RNA for Cancer Immunotherapy","display_name":"FIGURE 2 from Nanoparticle Delivery of Immunostimulatory Alu RNA for Cancer Immunotherapy","publication_year":2023,"publication_date":"2023-09-08","ids":{"openalex":"https://openalex.org/W4386561633","doi":"https://doi.org/10.1158/2767-9764.24107116.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.24107116.v1","doi":"https://doi.org/10.1158/2767-9764.24107116.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2767-9764.24107116.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/2767-9764.24107116.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006798929","display_name":"Kyle M. Garland","orcid":"https://orcid.org/0000-0003-0722-4245","observed_orcids":["https://orcid.org/0000-0003-0722-4245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyle M. Garland","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0722-4245","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032619799","display_name":"Alexander J. Kwiatkowski","orcid":"https://orcid.org/0000-0001-5435-3555","observed_orcids":["https://orcid.org/0000-0001-5435-3555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander J. Kwiatkowski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5435-3555","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007263617","display_name":"John T. Tossberg","orcid":"https://orcid.org/0009-0005-2241-6730","observed_orcids":["https://orcid.org/0009-0005-2241-6730"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John T. Tossberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-2241-6730","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056838759","display_name":"Philip S. Crooke","orcid":"https://orcid.org/0000-0003-3872-3290","observed_orcids":["https://orcid.org/0000-0003-3872-3290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip S. Crooke","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3872-3290","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026728364","display_name":"Thomas M. Aune","orcid":"https://orcid.org/0000-0002-4968-4306","observed_orcids":["https://orcid.org/0000-0002-4968-4306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas M. Aune","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4968-4306","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037982412","display_name":"John T. Wilson","orcid":"https://orcid.org/0000-0002-9144-2634","observed_orcids":["https://orcid.org/0000-0002-9144-2634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John T. Wilson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9144-2634","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.09080000221729279,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/a-to-i-rna-editing","display_name":"A-to-I RNA editing","score":0.9779999852180481},{"id":"https://openalex.org/keywords/alu-rna","display_name":"Alu RNA","score":0.6880000233650208},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.800000011920929},{"id":"https://openalex.org/keywords/nanoparticle-delivery","display_name":"nanoparticle delivery","score":0.8230000138282776},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.6439999938011169},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/immunostimulatory-rna","display_name":"immunostimulatory RNA","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4212823212146759}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.24107116.v1","doi":"https://doi.org/10.1158/2767-9764.24107116.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2767-9764.24107116.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.24107116.v1","doi":"https://doi.org/10.1158/2767-9764.24107116.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2767-9764.24107116.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386558728","https://openalex.org/W4385954546","https://openalex.org/W3119533710","https://openalex.org/W4386559416","https://openalex.org/W3048730600","https://openalex.org/W4386541145","https://openalex.org/W4292560468","https://openalex.org/W3189208200","https://openalex.org/W7160520121","https://openalex.org/W3185619754"],"abstract_inverted_index":{"Bioinformatic":[0],"analysis":[1],"of":[2,35,84,98,155,179],"A-to-I":[3],"RNA":[4],"editing":[5],"in":[6,51,68,117,128,136,212],"human":[7],"melanoma.":[8],"A":[9],"and":[10,16,46,57,112,138,152,162,201],"B,":[11,66],"Negative":[12],"correlation":[13],"between":[14],"AEI":[15,21,42,71,141,161,165],"time":[17,50,94,116,133],"to":[18,33,159,177],"death.":[19],"A,":[20,69],"was":[22,55,61,72,134,166,199,205],"determined":[23,62,73,167,189,206],"from":[24,30,74,80,168,174,190],"RNA-seq":[25,75,169,191],"data":[26,76,170,192],"using":[27,77,171,193],"melanoma":[28,78,172,186],"samples":[29,79,173,187],"patients":[31,81,175],"prior":[32,176],"onset":[34,83,178],"therapy":[36,85],"(N":[37,86],"=":[38,87,120,144],"23).":[39,88],"Y-axis":[40,108],"is":[41,48,109,114],"for":[43,184],"each":[44],"sample,":[45],"X-axis":[47,113],"survival":[49,93,115,132,221],"weeks.":[52],"Spearman":[53,197],"r":[54,198],"calculated,":[56,200],"the":[58,194,202],"P":[59,119,143,148,203],"value":[60,204],"by":[63,207],"Gaussian":[64,208],"approximation.":[65,209],"As":[67,127,211],"except":[70,130,214],"after":[82],"C,":[89,129],"Kaplan\u2013Meier":[90],"curve":[91],"comparing":[92],"as":[95],"a":[96],"function":[97],"high":[99,137],"(i.e.,":[100,104],">50)":[101],"or":[102],"low":[103,139],"<50)":[105],"pre-therapy":[106,140,160],"AEI.":[107],"percent":[110],"survival,":[111],"weeks,":[118],"0.02,":[121],"log":[122],"rank":[123],"(Mantel\u2013Cox":[124],"test).":[125],"D,":[126],"median":[131],"compared":[135,219],"groups,":[142],"0.04;":[145],"*":[146],"represents":[147],"<":[149],"0.05.":[150],"E":[151],"F,":[153,210],"Correlation":[154],"ADAR":[156,181,215],"mRNA":[157,182,216],"levels":[158,183,217],"survival.":[163],"E,":[164,213],"therapy.":[180],"individual":[185],"were":[188],"DeSeq":[195],"package.":[196],"are":[218],"with":[220],"times.":[222]},"counts_by_year":[],"updated_date":"2026-09-05T08:02:43.246662","created_date":"2023-09-09T00:00:00"}