{"id":"https://openalex.org/W4386554388","doi":"https://doi.org/10.1155/2023/3324247","title":"Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo","display_name":"Papaverine Enhances the Oncolytic Effects of Newcastle Disease Virus on Breast Cancer In Vitro and In Vivo","publication_year":2023,"publication_date":"2023-09-08","ids":{"openalex":"https://openalex.org/W4386554388","doi":"https://doi.org/10.1155/2023/3324247","pmid":"https://pubmed.ncbi.nlm.nih.gov/37720338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10504052"},"language":"en","primary_location":{"id":"doi:10.1155/2023/3324247","doi":"https://doi.org/10.1155/2023/3324247","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2023/3324247","pdf_url":"https://downloads.hindawi.com/journals/ijmicro/2023/3324247.pdf","source":{"id":"https://openalex.org/S26007923","display_name":"International Journal of Microbiology","issn_l":"1687-918X","issn":["1687-918X","1687-9198"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/ijmicro/2023/3324247.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102878355","display_name":"Sura Akram Mohammed","orcid":"https://orcid.org/0000-0003-4997-1919","observed_orcids":["https://orcid.org/0000-0003-4997-1919"]},"institutions":[{"id":"https://openalex.org/I56409017","display_name":"Nahrain University","ror":"https://ror.org/05v2p9075","country_code":"IQ","type":"education","lineage":["https://openalex.org/I56409017"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Sura Akram","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, Al-Nahrain University, Baghdad, Iraq"],"raw_orcid":"https://orcid.org/0000-0003-4997-1919","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, Al-Nahrain University, Baghdad, Iraq","institution_ids":["https://openalex.org/I56409017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064015495","display_name":"Ahmed Majeed Al-Shammari","orcid":"https://orcid.org/0000-0002-2699-1514","observed_orcids":["https://orcid.org/0000-0002-2699-1514"]},"institutions":[{"id":"https://openalex.org/I15873915","display_name":"Mustansiriyah University","ror":"https://ror.org/05s04wy35","country_code":"IQ","type":"education","lineage":["https://openalex.org/I15873915"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Ahmed Majeed Al-Shammari","raw_affiliation_strings":["Experimental Therapy, Iraqi Center for Cancer and Medical Genetics Research, Mustansiriyah University, Baghdad, Iraq"],"raw_orcid":"https://orcid.org/0000-0002-2699-1514","affiliations":[{"raw_affiliation_string":"Experimental Therapy, Iraqi Center for Cancer and Medical Genetics Research, Mustansiriyah University, Baghdad, Iraq","institution_ids":["https://openalex.org/I15873915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062496879","display_name":"Hayder B. Sahib","orcid":"https://orcid.org/0000-0002-0939-5622","observed_orcids":["https://orcid.org/0000-0002-0939-5622"]},"institutions":[{"id":"https://openalex.org/I56409017","display_name":"Nahrain University","ror":"https://ror.org/05v2p9075","country_code":"IQ","type":"education","lineage":["https://openalex.org/I56409017"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Hayder B. Sahib","raw_affiliation_strings":["Department of Pharmacology, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq"],"raw_orcid":"https://orcid.org/0000-0002-0939-5622","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq","institution_ids":["https://openalex.org/I56409017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083227201","display_name":"Majid Sakhi Jabir","orcid":"https://orcid.org/0000-0003-0759-8298","observed_orcids":["https://orcid.org/0000-0003-0759-8298"]},"institutions":[{"id":"https://openalex.org/I171256487","display_name":"University of Technology - Iraq","ror":"https://ror.org/01w1ehb86","country_code":"IQ","type":"education","lineage":["https://openalex.org/I171256487"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Majid Sakhi Jabir","raw_affiliation_strings":["Department of Applied Science, University of Technology, Baghdad, Iraq"],"raw_orcid":"https://orcid.org/0000-0003-0759-8298","affiliations":[{"raw_affiliation_string":"Department of Applied Science, University of Technology, Baghdad, Iraq","institution_ids":["https://openalex.org/I171256487"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064015495"],"corresponding_institution_ids":["https://openalex.org/I15873915"],"apc_list":{"value":925,"currency":"USD","value_usd":925},"apc_paid":{"value":925,"currency":"USD","value_usd":925},"fwci":1.4574,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.80731382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papaverine","display_name":"papaverine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/newcastle-disease-virus","display_name":"Newcastle disease virus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7089999914169312},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.41499999165534973},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.6927052736282349},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6481519341468811},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5913024544715881},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5607044100761414},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5437991619110107},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5250898599624634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49762800335884094},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.472523033618927},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.45384377241134644},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.45186761021614075},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4181979298591614},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3985723853111267},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3749080300331116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2744603753089905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15652409195899963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06474566459655762},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2023/3324247","doi":"https://doi.org/10.1155/2023/3324247","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2023/3324247","pdf_url":"https://downloads.hindawi.com/journals/ijmicro/2023/3324247.pdf","source":{"id":"https://openalex.org/S26007923","display_name":"International Journal of Microbiology","issn_l":"1687-918X","issn":["1687-918X","1687-9198"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10504052","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10504052","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10504052/pdf/IJMICRO2023-3324247.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Microbiol","raw_type":"Text"},{"id":"pmid:37720338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37720338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:31bc936d9bef4b95a1e2319007363d01","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/31bc936d9bef4b95a1e2319007363d01","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Microbiology, Vol 2023 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2023/3324247","doi":"https://doi.org/10.1155/2023/3324247","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2023/3324247","pdf_url":"https://downloads.hindawi.com/journals/ijmicro/2023/3324247.pdf","source":{"id":"https://openalex.org/S26007923","display_name":"International Journal of Microbiology","issn_l":"1687-918X","issn":["1687-918X","1687-9198"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328902","display_name":"Mustansiriyah University","ror":"https://ror.org/05s04wy35"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386554388.pdf","grobid_xml":"https://content.openalex.org/works/W4386554388.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W166460480","https://openalex.org/W582946338","https://openalex.org/W1558969188","https://openalex.org/W1579973977","https://openalex.org/W1628808994","https://openalex.org/W1792521448","https://openalex.org/W1808107661","https://openalex.org/W1823151161","https://openalex.org/W1966174118","https://openalex.org/W1973207336","https://openalex.org/W1976549979","https://openalex.org/W1979918802","https://openalex.org/W1986947537","https://openalex.org/W2047071002","https://openalex.org/W2049929561","https://openalex.org/W2058706754","https://openalex.org/W2059843892","https://openalex.org/W2082041718","https://openalex.org/W2085635201","https://openalex.org/W2096439168","https://openalex.org/W2099295163","https://openalex.org/W2102650486","https://openalex.org/W2121623797","https://openalex.org/W2133190342","https://openalex.org/W2142676319","https://openalex.org/W2163041215","https://openalex.org/W2167279371","https://openalex.org/W2178437759","https://openalex.org/W2194429659","https://openalex.org/W2289993078","https://openalex.org/W2323343322","https://openalex.org/W2338261620","https://openalex.org/W2417715407","https://openalex.org/W2566859523","https://openalex.org/W2703722910","https://openalex.org/W2742930384","https://openalex.org/W2780349622","https://openalex.org/W2788640168","https://openalex.org/W2794021342","https://openalex.org/W2809644760","https://openalex.org/W2901651637","https://openalex.org/W2911937431","https://openalex.org/W2934289782","https://openalex.org/W2938054231","https://openalex.org/W2945723598","https://openalex.org/W2973892995","https://openalex.org/W2993839840","https://openalex.org/W3003781822","https://openalex.org/W3029344710","https://openalex.org/W3037471957","https://openalex.org/W3049143200","https://openalex.org/W3093283294","https://openalex.org/W3107389755","https://openalex.org/W3107778090","https://openalex.org/W3113357834","https://openalex.org/W4205954081","https://openalex.org/W4225615959","https://openalex.org/W4295273010","https://openalex.org/W4297492277"],"related_works":["https://openalex.org/W4407111854","https://openalex.org/W4408570400","https://openalex.org/W4403883436","https://openalex.org/W4324303508","https://openalex.org/W4321612479","https://openalex.org/W1977598547","https://openalex.org/W4387402189","https://openalex.org/W4403233672","https://openalex.org/W2415645228","https://openalex.org/W22501404"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,14,74,84,98,127,142,225,299],"is":[2,79],"a":[3,38,70,157,162,199,228,240,252,294],"lethal":[4],"disease":[5,61,117],"in":[6,129,132,208,248,272,286],"females":[7],"worldwide":[8],"and":[9,18,42,67,89,120,131,145,150,156,169,222,251,254,260],"needs":[10],"effective":[11],"treatment.":[12],"Targeting":[13],"cells":[15,85,226],"with":[16,37,86,153,227,244],"selective":[17,68],"safe":[19,66],"treatment":[20,238],"seems":[21],"like":[22],"the":[23,49,59,94,108,112,175,184,191,216,273,282,288],"best":[24],"choice,":[25],"as":[26,81],"most":[27],"chemotherapeutic":[28],"drugs":[29],"act":[30],"unselectively.":[31],"Papaverine":[32],"showed":[33,214],"promising":[34,295],"antitumor":[35,185,242,289],"activity":[36,186,290],"high":[39],"safety":[40],"profile":[41],"increased":[43],"blood":[44],"flow":[45],"through":[46,301],"vasodilation.":[47],"At":[48],"same":[50],"time,":[51],"it":[52,82],"was":[53,203],"widely":[54],"noticed":[55],"that":[56,215],"virotherapy":[57],"using":[58],"Newcastle":[60,116],"virus":[62,91,118],"proved":[63],"to":[64,101,205,263],"be":[65],"against":[69,125,224],"broad":[71],"range":[72],"of":[73,111,115,183,257,284,291],"cells.":[75,234],"Furthermore,":[76],"combination":[77,110,217,237,274],"therapy":[78,218,275,300],"favorable,":[80],"attacks":[83],"multiple":[87],"mechanisms":[88],"enhances":[90],"entrance":[92],"into":[93],"tumor":[95,180,249],"mass,":[96],"overcoming":[97],"cells\u2019":[99],"resistance":[100],"therapy.":[102],"Therefore,":[103],"we":[104],"aimed":[105],"at":[106],"assessing":[107],"novel":[109],"AMHA1":[113],"strain":[114],"(NDV)":[119],"nonnarcotic":[121],"opium":[122],"alkaloid":[123],"(papaverine)":[124],"breast":[126,141,298],"models":[128],"vitro":[130,136],"vivo.":[133],"Methods.":[134],"In":[135,211,235,277],"experiments":[137,173],"used":[138,174,204],"two":[139],"human":[140],"cell":[143,148,163],"lines":[144],"one":[146],"normal":[147,233],"line":[149],"were":[151],"treated":[152],"NDV,":[154,292],"papaverine,":[155],"combination.":[158],"The":[159],"study":[160,280],"included":[161,187],"viability":[164],"MTT":[165],"assay,":[166],"morphological":[167],"analysis,":[168],"apoptosis":[170,223,269],"detection.":[171],"Animal":[172],"AN3":[176],"mouse":[177],"mammary":[178],"adenocarcinoma":[179],"model.":[181],"Evaluation":[182],"growth":[188],"inhibition":[189],"measurement;":[190],"immunohistochemistry":[192],"assay":[193,202],"measured":[194],"caspase":[195],"protein":[196,270],"expression.":[197],"Finally,":[198],"semiquantitative":[200],"microarray":[201],"screen":[206],"changes":[207],"apoptotic":[209],"proteins.":[210],"vitro,":[212],"results":[213],"induces":[219],"synergistic":[220],"cytotoxicity":[221],"negligible":[229],"cytotoxic":[230],"effect":[231,243],"on":[232],"vivo,":[236],"induced":[239],"significant":[241,255],"an":[245],"obvious":[246],"regression":[247],"size":[250],"remarkable":[253],"expression":[256],"caspase-3,":[258],"caspase-8,":[259],"caspase-9":[261],"compared":[262],"monotherapies.":[264],"Microarray":[265],"analysis":[266],"shows":[267],"higher":[268],"levels":[271],"group.":[276],"conclusion,":[278],"this":[279],"demonstrated":[281],"role":[283],"papaverine":[285],"enhancing":[287],"suggesting":[293],"strategy":[296],"for":[297],"nonchemotherapeutic":[302],"drugs.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-09-09T00:00:00"}