{"id":"https://openalex.org/W4386540463","doi":"https://doi.org/10.1186/s12885-023-11323-1","title":"Association between IL-10 gene polymorphisms (\u2212 1082 A/G, -819 T/C, -592 A/C) and hepatocellular carcinoma: a meta-analysis and trial sequential analysis","display_name":"Association between IL-10 gene polymorphisms (\u2212 1082 A/G, -819 T/C, -592 A/C) and hepatocellular carcinoma: a meta-analysis and trial sequential analysis","publication_year":2023,"publication_date":"2023-09-08","ids":{"openalex":"https://openalex.org/W4386540463","doi":"https://doi.org/10.1186/s12885-023-11323-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/37684564","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492326"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-023-11323-1","doi":"https://doi.org/10.1186/s12885-023-11323-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-023-11323-1","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-11323-1","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-11323-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112996814","display_name":"Teresa Tan Yen Mei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]},{"id":"https://openalex.org/I62370553","display_name":"IMU University","ror":"https://ror.org/04d4wjw61","country_code":"MY","type":"education","lineage":["https://openalex.org/I62370553"]}],"countries":["AU","MY"],"is_corresponding":false,"raw_author_name":"Teresa Tan Yen Mei","raw_affiliation_strings":["School of Medicine, International Medical University, Kuala Lumpur, Malaysia","School of Medicine, University of Adelaide, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, International Medical University, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I62370553"]},{"raw_affiliation_string":"School of Medicine, University of Adelaide, Adelaide, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046937085","display_name":"Htar Htar Aung","orcid":"https://orcid.org/0000-0003-4789-258X","observed_orcids":["https://orcid.org/0000-0003-4789-258X"]},"institutions":[{"id":"https://openalex.org/I62370553","display_name":"IMU University","ror":"https://ror.org/04d4wjw61","country_code":"MY","type":"education","lineage":["https://openalex.org/I62370553"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Htar Htar Aung","raw_affiliation_strings":["School of Medicine, International Medical University, Kuala Lumpur, Malaysia. htarswe65@gmail.com","School of Medicine, International Medical University, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, International Medical University, Kuala Lumpur, Malaysia. htarswe65@gmail.com","institution_ids":["https://openalex.org/I62370553"]},{"raw_affiliation_string":"School of Medicine, International Medical University, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I62370553"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wong Siew Tung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62370553","display_name":"IMU University","ror":"https://ror.org/04d4wjw61","country_code":"MY","type":"education","lineage":["https://openalex.org/I62370553"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Wong Siew Tung","raw_affiliation_strings":["School of Medicine, International Medical University, Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, International Medical University, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I62370553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013945584","display_name":"Cho Min Naing","orcid":"https://orcid.org/0000-0003-3425-7149","observed_orcids":["https://orcid.org/0000-0003-3425-7149"]},"institutions":[{"id":"https://openalex.org/I86467917","display_name":"James Cook University","ror":"https://ror.org/04gsp2c11","country_code":"AU","type":"education","lineage":["https://openalex.org/I86467917"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Cho Naing","raw_affiliation_strings":["Faculty of Tropical Health and Medicine, James Cook University, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Tropical Health and Medicine, James Cook University, Queensland, Australia","institution_ids":["https://openalex.org/I86467917"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046937085"],"corresponding_institution_ids":["https://openalex.org/I62370553"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.2321,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.20818015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"23","issue":"1","first_page":"842","last_page":"842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7031000256538391,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7031000256538391,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.17020000517368317,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10-gene-polymorphism","display_name":"IL-10 gene polymorphism","score":0.906000018119812},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.4410000145435333},{"id":"https://openalex.org/keywords/non-asian-populations","display_name":"non-Asian populations","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.4690000116825104},{"id":"https://openalex.org/keywords/trial-sequential-analysis","display_name":"trial sequential analysis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/required-information-size","display_name":"required information size","score":0.796999990940094},{"id":"https://openalex.org/keywords/recessive-model","display_name":"recessive model","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8226157426834106},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7128642797470093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6979284882545471},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.6472231149673462},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6394273638725281},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5134678483009338},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.41309237480163574}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12885-023-11323-1","doi":"https://doi.org/10.1186/s12885-023-11323-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-023-11323-1","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-11323-1","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10492326","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492326","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492326/pdf/12885_2023_Article_11323.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:37684564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37684564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Meta-Analysis"},{"id":"pmh:oai:researchonline.jcu.edu.au:80510","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.jcu.edu.au/80510/1/80510.pdf","pdf_url":"https://researchonline.jcu.edu.au/80510/1/80510.pdf","source":{"id":"https://openalex.org/S4377196350","display_name":"ResearchOnline - JCU (James Cook University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86467917","host_organization_name":"James Cook University","host_organization_lineage":["https://openalex.org/I86467917"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:0467efcc8df5454bb776067d2b036cdb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0467efcc8df5454bb776067d2b036cdb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 23, Iss 1, Pp 1-13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-023-11323-1","doi":"https://doi.org/10.1186/s12885-023-11323-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-023-11323-1","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-11323-1","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320325726","display_name":"International Medical University","ror":"https://ror.org/04d4wjw61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386540463.pdf","grobid_xml":"https://content.openalex.org/works/W4386540463.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W83654235","https://openalex.org/W929766628","https://openalex.org/W1878597039","https://openalex.org/W1976280893","https://openalex.org/W1993147606","https://openalex.org/W1996743123","https://openalex.org/W1999753630","https://openalex.org/W2000307707","https://openalex.org/W2000343974","https://openalex.org/W2006619058","https://openalex.org/W2017749666","https://openalex.org/W2025727499","https://openalex.org/W2046062863","https://openalex.org/W2048673010","https://openalex.org/W2050590372","https://openalex.org/W2055469806","https://openalex.org/W2056647439","https://openalex.org/W2078201270","https://openalex.org/W2088934402","https://openalex.org/W2102945991","https://openalex.org/W2103637700","https://openalex.org/W2116475791","https://openalex.org/W2123720885","https://openalex.org/W2126928020","https://openalex.org/W2128204670","https://openalex.org/W2135230337","https://openalex.org/W2140481064","https://openalex.org/W2140897859","https://openalex.org/W2142917088","https://openalex.org/W2157823046","https://openalex.org/W2161074777","https://openalex.org/W2164855536","https://openalex.org/W2165578318","https://openalex.org/W2171814532","https://openalex.org/W2186263798","https://openalex.org/W2254605550","https://openalex.org/W2287268909","https://openalex.org/W2315641321","https://openalex.org/W2337231636","https://openalex.org/W2411616513","https://openalex.org/W2501001740","https://openalex.org/W2529646902","https://openalex.org/W2581834274","https://openalex.org/W2593363470","https://openalex.org/W2763700772","https://openalex.org/W2792729876","https://openalex.org/W2893835498","https://openalex.org/W2970088184","https://openalex.org/W3011816813","https://openalex.org/W3017097169","https://openalex.org/W3021764608","https://openalex.org/W3033316557","https://openalex.org/W3081739378","https://openalex.org/W3128646645","https://openalex.org/W3211488171","https://openalex.org/W4231070070","https://openalex.org/W4251343507"],"related_works":["https://openalex.org/W2078201270","https://openalex.org/W6977450521","https://openalex.org/W6939783537","https://openalex.org/W6977452581","https://openalex.org/W6958610632","https://openalex.org/W6958340805","https://openalex.org/W6902235353","https://openalex.org/W6977125759","https://openalex.org/W3021923338","https://openalex.org/W2390826163"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,78],"carcinogenesis":[2],"of":[3,19,44,105,279,287],"hepatocellular":[4,33,53,111,159,178,215,258,316,341],"carcinoma":[5,34,54,112,160,179,216,259,317,342],"is":[6,324],"complicated,":[7],"and":[8,52,93,110,158,200,237,308,357],"genetic":[9,115,263],"factor":[10],"may":[11],"have":[12,25],"the":[13,16,40,67,86,103,131,145,182,222,273,285,294,328],"role":[14],"in":[15,32,75,181,260,318],"malignant":[17],"transformation":[18],"liver":[20],"cells.":[21],"IL-10":[22,45,155,171,208,246,288,305,333,354],"gene":[23],"polymorphisms":[24,43,312],"been":[26],"investigated":[27],"for":[28,276,284,293],"their":[29],"potential":[30],"roles":[31],"This":[35,64],"study":[36,65],"aimed":[37],"to":[38,84,101,129],"investigate":[39],"relationship":[41],"between":[42,107,154],"(-1082":[46,156,172,306,355],"A/G,":[47],"-819":[48,299],"T/C,":[49],"-592":[50],"A/C),":[51,290],"by":[55,120],"performing":[56],"a":[57,149],"meta-analysis":[58],"with":[59,177,214,249,257,315,340,344,361],"eligible":[60],"individual":[61],"studies.":[62],"METHODS:":[63],"followed":[66],"PRISMA":[68],"2020":[69],"Checklist.":[70],"Relevant":[71],"studies":[72,87,138,352],"were":[73,82,99,142],"searched":[74],"health-related":[76],"databases.":[77],"Newcastle-Ottawa":[79],"Scale":[80],"criteria":[81],"used":[83,100],"evaluate":[85],"quality.":[88],"Pooled":[89],"odds":[90],"ratio":[91],"(OR)":[92],"its":[94],"95%":[95,164,189,197,205,226,234,242],"confidence":[96],"interval":[97],"(CI)":[98],"determine":[102,130],"strength":[104],"association":[106,152,256],"each":[108],"polymorphism":[109,336],"using":[113],"five":[114,262],"models.":[116],"Stratification":[117],"was":[118,127,174,211,253,281,331,337],"done":[119],"ethnic":[121],"groups.":[122],"Trial":[123],"sequential":[124],"analysis":[125,286],"(TSA)":[126],"performed":[128],"required":[132],"information":[133,274,346],"size.":[134,347],"RESULTS:":[135],"Fifteen":[136],"case-control":[137,351],"(n":[139],"=":[140],"8182)":[141],"identified.":[143],"Overall,":[144],"heterozygous":[146,194],"model":[147],"showed":[148],"marginal":[150],"significant":[151,255],"only":[153,218,283],"A/G)":[157,173],"risk":[161,180,217],"(OR:":[162,187,195,203,224,232,240],"0.82,":[163],"CI:":[165,190,198,206,227,235,243],"0.67-1.00,":[166],"9":[167],"studies).":[168],"On":[169],"stratification,":[170],"significantly":[175,212],"associated":[176,213,314,339],"non-Asian":[183],"population":[184],"under":[185,221],"dominant":[186,223],"0.62,":[188],"0.45-0.86,":[191],"4":[192],"studies),":[193,230],"0.60,":[196],"0.43-0.85)":[199],"allelic":[201],"models":[202,239,264],"0.79,":[204],"0.64-0.99).":[207],"(-819":[209],"T/C)":[210,311,360],"among":[219],"non-Asians":[220],"1.47,":[225],"1.02-2.13,":[228],"8":[229],"recessive":[231],"1.99,":[233],"1.03-3.86,":[236],"homozygous":[238],"2.18,":[241],"1.13-4.23).":[244],"For":[245],"(-592":[247,289,334],"A/C)":[248,335],"11":[250],"studies,":[251],"there":[252],"no":[254],"all":[261],"(P":[265],"values":[266],">":[267],"0.5).":[268],"TSA":[269],"plots":[270],"indicated":[271],"that":[272,304],"size":[275,330],"firm":[277],"evidence":[278,323],"effect":[280],"sufficient":[282,345],"but":[291],"not":[292,325,338],"-":[295,309,358],"1082":[296],"A/G":[297,307,356],"or":[298],"T/C.":[300],"CONCLUSIONS:":[301],"Findings":[302],"suggest":[303],"819":[310,359],"are":[313,364],"ethnic-specific":[319],"manner.":[320],"However,":[321],"this":[322],"conclusive":[326],"because":[327],"sample":[329],"insufficient.":[332],"albeit":[343],"Future":[348],"well-designed":[349],"large":[350],"on":[353],"different":[362],"ethnicities":[363],"recommended.":[365]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-09-09T00:00:00"}