{"id":"https://openalex.org/W4386538883","doi":"https://doi.org/10.1093/neuonc/noad137.171","title":"P07.11.B A NOVEL CRISPR/CAS9 KNOCKOUT LIBRARY UNCOVERS PAN-ESSENTIAL MIRNAS IN HUMAN CANCER CELL LINES","display_name":"P07.11.B A NOVEL CRISPR/CAS9 KNOCKOUT LIBRARY UNCOVERS PAN-ESSENTIAL MIRNAS IN HUMAN CANCER CELL LINES","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386538883","doi":"https://doi.org/10.1093/neuonc/noad137.171"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noad137.171","doi":"https://doi.org/10.1093/neuonc/noad137.171","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad137.171","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_2/ii53/51442704/noad137.171.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_2/ii53/51442704/noad137.171.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D J Merk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D J Merk","raw_affiliation_strings":["Hertie Institute for clinical brain research , Tuebingen , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hertie Institute for clinical brain research , Tuebingen , Germany","institution_ids":["https://openalex.org/I4210141865"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Paul","raw_affiliation_strings":["Hertie Institute for clinical brain research , Tuebingen , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hertie Institute for clinical brain research , Tuebingen , Germany","institution_ids":["https://openalex.org/I4210141865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066976316","display_name":"Foteini Tsiami","orcid":"https://orcid.org/0009-0001-6070-0434","observed_orcids":["https://orcid.org/0009-0001-6070-0434"]},"institutions":[{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Tsiami","raw_affiliation_strings":["Hertie Institute for clinical brain research , Tuebingen , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hertie Institute for clinical brain research , Tuebingen , Germany","institution_ids":["https://openalex.org/I4210141865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092774759","display_name":"Helen Hohenthanner","orcid":"https://orcid.org/0009-0000-3761-4776","observed_orcids":["https://orcid.org/0009-0000-3761-4776"]},"institutions":[{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Hohenthanner","raw_affiliation_strings":["Hertie Institute for clinical brain research , Tuebingen , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hertie Institute for clinical brain research , Tuebingen , Germany","institution_ids":["https://openalex.org/I4210141865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092774760","display_name":"G Mohseni-Kouchesfahani","orcid":"https://orcid.org/0009-0001-3156-7929","observed_orcids":["https://orcid.org/0009-0001-3156-7929"]},"institutions":[{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Mohseni-Kouchesfahani","raw_affiliation_strings":["Hertie Institute for clinical brain research , Tuebingen , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hertie Institute for clinical brain research , Tuebingen , Germany","institution_ids":["https://openalex.org/I4210141865"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Walter","raw_affiliation_strings":["Hertie Institute for clinical brain research , Tuebingen , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hertie Institute for clinical brain research , Tuebingen , Germany","institution_ids":["https://openalex.org/I4210141865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021962600","display_name":"Lara Annina Haeusser","orcid":"https://orcid.org/0000-0002-3288-4280","observed_orcids":["https://orcid.org/0000-0002-3288-4280"]},"institutions":[{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L A Haeusser","raw_affiliation_strings":["Hertie Institute for clinical brain research , Tuebingen , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hertie Institute for clinical brain research , Tuebingen , Germany","institution_ids":["https://openalex.org/I4210141865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101447466","display_name":"Adam Brown","orcid":"https://orcid.org/0000-0002-9122-4960","observed_orcids":["https://orcid.org/0000-0002-9122-4960"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Brown","raw_affiliation_strings":["Broad Institute of MIT and Harvard , Cambridge, MA , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard , Cambridge, MA , United States","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051919461","display_name":"Nicole S. Persky","orcid":"https://orcid.org/0000-0002-9948-2761","observed_orcids":["https://orcid.org/0000-0002-9948-2761"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N S Persky","raw_affiliation_strings":["Broad Institute of MIT and Harvard , Cambridge, MA , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard , Cambridge, MA , United States","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086771961","display_name":"David E. Root","orcid":"https://orcid.org/0000-0001-5122-861X","observed_orcids":["https://orcid.org/0000-0001-5122-861X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D E Root","raw_affiliation_strings":["Broad Institute of MIT and Harvard , Cambridge, MA , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard , Cambridge, MA , United States","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091648075","display_name":"Ghazaleh Tabatabai","orcid":"https://orcid.org/0000-0002-3542-8782","observed_orcids":["https://orcid.org/0000-0002-3542-8782"]},"institutions":[{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Tabatabai","raw_affiliation_strings":["Hertie Institute for clinical brain research , Tuebingen , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hertie Institute for clinical brain research , Tuebingen , Germany","institution_ids":["https://openalex.org/I4210141865"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_2","first_page":"ii53","last_page":"ii53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.296099990606308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.48500001430511475},{"id":"https://openalex.org/keywords/human-cancer-cell-lines","display_name":"human cancer cell lines","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gene-essentiality","display_name":"gene essentiality","score":0.7390000224113464},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/off-target-effects","display_name":"off-target effects","score":0.7459999918937683},{"id":"https://openalex.org/keywords/pan-cancer-genomics","display_name":"pan-cancer genomics","score":0.4410000145435333},{"id":"https://openalex.org/keywords/network-analysis","display_name":"network analysis","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7042244672775269},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.6594393849372864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6461467146873474},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6390933394432068},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.612690806388855},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5323182940483093},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45536014437675476},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.4484432637691498},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4371689558029175},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.4335607886314392},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3960982859134674},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3733265995979309}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noad137.171","doi":"https://doi.org/10.1093/neuonc/noad137.171","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad137.171","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_2/ii53/51442704/noad137.171.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10489438","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10489438","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10489438/pdf/noad137.171.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noad137.171","doi":"https://doi.org/10.1093/neuonc/noad137.171","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad137.171","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_2/ii53/51442704/noad137.171.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386538883.pdf","grobid_xml":"https://content.openalex.org/works/W4386538883.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399743266","https://openalex.org/W6958292837","https://openalex.org/W2800218175","https://openalex.org/W2180291937","https://openalex.org/W2953212411","https://openalex.org/W2404451320","https://openalex.org/W2563414546","https://openalex.org/W2925675330","https://openalex.org/W2727479110","https://openalex.org/W2233359408"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND":[1],"MicroRNAs":[2],"(miRNAs)":[3],"are":[4,50,296,302],"post-transcriptional":[5],"regulators":[6],"of":[7,65,79,86,93,124,127,159,201,213,231,241,259,335,339,353,384,389,410],"gene":[8,131,138,248],"expression":[9],"that":[10,144,177,292,295,393],"play":[11],"an":[12,136],"important":[13],"role":[14],"during":[15],"cancer":[16,96,322],"initiation":[17],"and":[18,39,135,166,227,264,276,308,355],"progression.":[19,403],"Genome-wide":[20],"functional":[21,62,333,382],"screening":[22],"using":[23,156],"the":[24,122,160,167,205,228,242,257,407],"CRISPR/Cas9":[25,76,341],"system":[26],"is":[27],"a":[28,74,84,91,125,128,157,198,218,235,313,329,361,369,379,387],"powerful":[29],"tool":[30,363],"to":[31,109,190,364,377],"uncover":[32],"genetic":[33],"dependencies":[34],"for":[35,185,305,316,332],"distinct":[36,81],"tumor":[37,102],"entities,":[38,103],"has":[40,180],"revealed":[41,176,291],"novel":[42,75,330,362],"insights":[43],"into":[44],"pan-cancer":[45,390],"fitness":[46,112,219,247,269,280,300,391],"genes.":[47,113],"Current":[48],"libraries":[49,350],"focused":[51],"on":[52,121,221,256],"single":[53],"guide":[54],"RNAs":[55],"(sgRNAs)":[56],"targeting":[57,83],"protein-coding":[58,186,293],"genes,":[59],"thereby":[60],"limiting":[61],"genomics-based":[63],"investigations":[64],"miRNA":[66,111,142,357,366,415],"function.":[67],"MATERIAL":[68],"AND":[69],"METHODS":[70],"We":[71,326,372],"here":[72,327,373],"designed":[73],"knockout":[77,342],"library":[78,179,346,376,412],"8,107":[80],"sgRNAs":[82],"total":[85,92],"1,769":[87],"human":[88,95,206,321],"miRNAs.":[89],"Using":[90],"45":[94],"cell":[97,117,148,225,244,306,323,401],"lines,":[98,149,226],"representing":[99],"16":[100],"different":[101],"we":[104],"performed":[105],"negative":[106],"selection":[107],"screens":[108],"identify":[110],"Screen":[114],"hits":[115],"per":[116],"line":[118],"were":[119,154,283],"scored":[120,145],"basis":[123],"combination":[126,158],"supervised":[129],"Bayesian":[130],"essentiality":[132],"analysis":[133],"(BAGEL2)":[134],"unsupervised":[137],"ranking":[139],"algorithm":[140,165],"(MAGeCK).":[141],"genes":[143,187,233,281,294],"across":[146],"all":[147,214,278],"i.e.":[150],"potentially":[151],"pan-essential":[152],"miRNAs,":[153,274,385],"identified":[155,266,284],"Adaptive":[161],"Daisy":[162],"Model":[163],"(ADaM)":[164],"Fitness":[168],"Percentile":[169],"(FiPer)":[170],"method.":[171],"RESULTS":[172],"In":[173,208],"silico":[174],"analyses":[175,290],"our":[178],"significantly":[181,303],"lower":[182],"off-target":[183],"activity":[184],"as":[188,285,400],"compared":[189],"previously":[191,348],"described":[192],"miRNA-targeting":[193],"sgRNA":[194,345],"libraries,":[195],"while":[196],"providing":[197,312],"higher":[199],"coverage":[200],"miRNAs":[202,216,301,336,392],"present":[203],"in":[204,237,320,351,368,413,417],"genome.":[207],"total,":[209],"only":[210],"13%":[211],"(n=230)":[212],"targeted":[215],"induced":[217,234],"effect":[220],"one":[222],"or":[223,252,270],"more":[224],"majority":[229],"(83%)":[230],"these":[232],"dependency":[236,318],"less":[238],"than":[239],"50%":[240],"tested":[243],"lines.":[245,324],"Pan-cancer":[246],"detection":[249],"by":[250,298,337],"ADaM":[251,263],"FiPer":[253,265],"differed":[254],"solely":[255],"level":[258],"stringency.":[260],"As":[261],"such,":[262],"34":[267],"core":[268,279,299],"54":[271],"common":[272,286],"essential":[273,396],"respectively,":[275],"almost":[277],"(97%)":[282],"essential.":[287],"Preliminary":[288],"network":[289],"regulated":[297],"enriched":[304],"cycle":[307,402],"p53":[309],"signaling":[310],"networks,":[311],"first":[314],"rationale":[315],"their":[317],"profiles":[319],"CONCLUSION":[325],"established":[328,349],"method":[331],"investigation":[334],"means":[338],"genome-wide":[340,370,381],"screens.":[343],"Our":[344,404],"outperforms":[347],"terms":[352],"specificity":[354],"overall":[356],"coverage,":[358],"making":[359],"it":[360],"investigate":[365],"function":[367,416],"fashion.":[371],"use":[374],"this":[375,411],"define":[378],"first-of-its-kind":[380],"annotation":[383],"revealing":[386],"subset":[388],"might":[394],"regulate":[395],"cellular":[397],"processes":[398],"such":[399],"data":[405],"highlight":[406],"wide":[408],"potential":[409],"investigating":[414],"diverse":[418],"biological":[419],"settings.":[420]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-09-09T00:00:00"}