{"id":"https://openalex.org/W4386538015","doi":"https://doi.org/10.1093/neuonc/noad137.029","title":"JS07.4.A REGIONAL B-CELL MEDIATED IMMUNOSUPPRESSION IDENTIFIED THROUGH SPATIAL AND SINGLE-CELL TRANSCRIPTOMIC ANALYSIS OF CHORDOMA","display_name":"JS07.4.A REGIONAL B-CELL MEDIATED IMMUNOSUPPRESSION IDENTIFIED THROUGH SPATIAL AND SINGLE-CELL TRANSCRIPTOMIC ANALYSIS OF CHORDOMA","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386538015","doi":"https://doi.org/10.1093/neuonc/noad137.029"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noad137.029","doi":"https://doi.org/10.1093/neuonc/noad137.029","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad137.029","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_2/ii11/51442510/noad137.029.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_2/ii11/51442510/noad137.029.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026407846","display_name":"Jasim Kada Benotmane","orcid":"https://orcid.org/0009-0005-2100-913X","observed_orcids":["https://orcid.org/0009-0005-2100-913X"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Kada Benotmane","raw_affiliation_strings":["Albert-Ludwigs University , Freiburg im Breisgau , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert-Ludwigs University , Freiburg im Breisgau , Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033949023","display_name":"Victor Andr\u00e9s Arrieta","orcid":"https://orcid.org/0000-0003-2738-9741","observed_orcids":["https://orcid.org/0000-0003-2738-9741","https://orcid.org/0000-0002-4319-6993"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V A Arrieta","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023153659","display_name":"Junfei Zhao","orcid":"https://orcid.org/0000-0002-4569-9797","observed_orcids":["https://orcid.org/0000-0002-4569-9797"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Zhao","raw_affiliation_strings":["Columbia University , New York, NY , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University , New York, NY , United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Hou","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Katz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Katz","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Pandey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Pandey","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092774541","display_name":"Meghan E. Cholak","orcid":"https://orcid.org/0009-0007-4100-4787","observed_orcids":["https://orcid.org/0009-0007-4100-4787"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Cholak","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060408739","display_name":"Adam M. Sonabend","orcid":"https://orcid.org/0000-0002-8347-1945","observed_orcids":["https://orcid.org/0000-0002-8347-1945"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Sonabend","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009670051","display_name":"Craig Horbinski","orcid":"https://orcid.org/0000-0001-8340-9992","observed_orcids":["https://orcid.org/0000-0001-8340-9992"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Horbinski","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074786388","display_name":"Jason M. Miska","orcid":"https://orcid.org/0000-0001-9608-2810","observed_orcids":["https://orcid.org/0000-0001-9608-2810"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Miska","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053052330","display_name":"Roger Stupp","orcid":"https://orcid.org/0000-0002-5483-3118","observed_orcids":["https://orcid.org/0000-0002-5483-3118"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Stupp","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053972433","display_name":"Maciej S. Lesniak","orcid":"https://orcid.org/0000-0002-0096-5107","observed_orcids":["https://orcid.org/0000-0002-0096-5107"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Lesniak","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065000331","display_name":"Dieter Henrik Heiland","orcid":"https://orcid.org/0000-0002-9258-3033","observed_orcids":["https://orcid.org/0000-0002-9258-3033"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D Heiland","raw_affiliation_strings":["Albert-Ludwigs University , Freiburg im Breisgau , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert-Ludwigs University , Freiburg im Breisgau , Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112091249","display_name":"Catherine K. Chang","orcid":"https://orcid.org/0009-0003-1568-9066","observed_orcids":["https://orcid.org/0009-0003-1568-9066","https://orcid.org/0000-0002-2804-4297"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Chang","raw_affiliation_strings":["Northwestern University , Chicago, IL , United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University , Chicago, IL , United States","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_2","first_page":"ii11","last_page":"ii11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chordoma","display_name":"chordoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/regulatory-b-cells","display_name":"regulatory B cells","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8240000009536743},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tcr-repertoire","display_name":"T cell receptor repertoire","score":0.5429999828338623},{"id":"https://openalex.org/keywords/b-cell-repertoire","display_name":"B cell receptor repertoire","score":0.8939999938011169},{"id":"https://openalex.org/keywords/m2-tumor-associated-macrophages","display_name":"M2 tumor-associated macrophages","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.6769999861717224},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.5799999833106995},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.642817497253418},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6011449694633484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.595686674118042},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5809506773948669},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.48710155487060547},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.486102819442749},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.48425933718681335},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.45893216133117676},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3313090205192566},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28546416759490967},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.26185888051986694},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19556227326393127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11755836009979248},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1074846088886261},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10161501169204712},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.08662289381027222},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noad137.029","doi":"https://doi.org/10.1093/neuonc/noad137.029","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad137.029","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_2/ii11/51442510/noad137.029.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10489262","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10489262","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10489262/pdf/noad137.029.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noad137.029","doi":"https://doi.org/10.1093/neuonc/noad137.029","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noad137.029","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/25/Supplement_2/ii11/51442510/noad137.029.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386538015.pdf","grobid_xml":"https://content.openalex.org/works/W4386538015.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388589725","https://openalex.org/W4220927656","https://openalex.org/W4392887458","https://openalex.org/W7125817137","https://openalex.org/W4392871310","https://openalex.org/W4416140388","https://openalex.org/W4414800107","https://openalex.org/W4391234982","https://openalex.org/W4387826446","https://openalex.org/W4409898719"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND":[1],"Chordomas,":[2],"rare":[3],"indolent":[4],"neoplasms,":[5],"mainly":[6],"occur":[7],"in":[8,164,187,222,246,333,356,375],"the":[9,44,61,65,79,179,223,226,258,263,272,304,334,350,357],"skull":[10],"base":[11],"or":[12],"lower":[13],"spine.":[14],"Therapies,":[15],"including":[16,340],"surgery":[17],"and":[18,51,54,60,83,94,105,117,121,154,160,183,195,200,218,253,283,291,310,344,368],"radiotherapy,":[19],"often":[20],"fail":[21],"to":[22,36,42,192,295,322,371],"impede":[23],"local":[24],"recurrence.":[25],"Though":[26],"checkpoint":[27],"inhibition":[28],"therapy":[29],"shows":[30],"promise,":[31],"recent":[32],"immunotherapy":[33],"trials":[34],"failed":[35],"reach":[37],"endpoints.":[38],"Here,":[39],"we":[40,111,136,177,211,240,278],"aim":[41],"investigate":[43],"immunological":[45,153],"landscape":[46,82],"of":[47,78,97,147,170,181,216,228,265,306,336,352],"chordomas":[48],"using":[49],"spatial":[50],"single-cell":[52,76,89,103],"transcriptomics,":[53],"TCR/BCR":[55],"profiling,":[56],"elucidating":[57],"cellular":[58],"interplay":[59],"intricate":[62],"mechanisms":[63,367],"governing":[64],"immunosuppressive":[66,315,366],"tumor":[67,95,193],"microenvironment.":[68],"MATERIAL":[69],"AND":[70],"METHODS":[71],"We":[72,157],"generated":[73],"a":[74,168,284],"comprehensive":[75],"atlas":[77],"chordoma":[80,358],"neoplastic":[81],"its":[84],"associated":[85],"microenvironment,":[86],"incorporating":[87],"paired":[88],"transcriptomic":[90],"samples":[91],"from":[92,132,190],"blood":[93,191],"cells":[96,186,221,231,299,309,313,355],"six":[98],"patients,":[99],"as":[100,102,296],"well":[101],"BCR":[104],"TCR":[106,128,208],"sequencing":[107],"data.":[108],"Utilizing":[109,174],"scGEN,":[110],"integrated":[112,207],"pre-annotated":[113],"gene":[114],"expression":[115],"datasets":[116],"identified":[118,241,279,332],"both":[119],"established":[120],"novel":[122,365],"antigen":[123],"binding":[124,242,251],"patterns":[125,243],"by":[126,144],"employing":[127],"Bidirectional":[129],"Encoder":[130],"Representations":[131],"Transformers":[133],"(BERT).":[134],"Moreover,":[135],"conducted":[137],"GeoMx":[138],"Digital":[139],"Spatial":[140,301],"Profiler":[141],"(DSP)":[142],"analysis":[143],"selecting":[145],"regions":[146],"interest":[148],"(ROIs)":[149],"that":[150],"encompass":[151],"critical":[152],"malignant":[155],"niches.":[156],"also":[158],"curated":[159],"quantified":[161],"cell":[162,202,249,286,325,373],"distributions":[163],"immunohistochemical":[165],"staining":[166],"for":[167,268],"total":[169],"107":[171],"chordomas.":[172],"RESULTS":[173],"pseudo-temporal":[175],"mapping,":[176],"delineated":[178],"trajectories":[180],"CD8":[182],"CD4":[184],"T":[185,201,220,230,248,312,324,372],"chordomas,":[188],"spanning":[189],"stroma":[194],"encompassing":[196],"na\u00efve,":[197],"memory,":[198],"cytotoxic,":[199],"exhaustion":[203,374],"profiles.":[204],"Through":[205],"an":[206,318],"profiling":[209,302],"methodology,":[210],"observed":[212],"extratumoral":[213],"clonal":[214],"expansion":[215],"cytotoxic":[217],"memory":[219],"blood,":[224],"whereas":[225],"majority":[227],"intratumoral":[229,276],"with":[232],"shared":[233,255],"motifs":[234,256],"exhibited":[235],"terminal":[236],"exhaustion.":[237,326],"Leveraging":[238],"TCR-BERT,":[239],"exclusively":[244],"enriched":[245],"exhausted":[247,311],"receptors'":[250],"sites":[252],"uncovered":[254],"within":[257,314],"reactive":[259],"tumor-infiltrating":[260],"compartment,":[261],"implying":[262],"existence":[264],"potential":[266],"reservoirs":[267],"anti-tumor":[269],"immunity.":[270],"Investigating":[271],"cell-cell":[273],"interactions":[274],"driving":[275],"exhaustion,":[277],"M2":[280],"tumor-associated":[281],"macrophages":[282],"plasma":[285],"phenotype-like":[287],"subset":[288],"upregulating":[289],"TGFB":[290],"IL10":[292],"expression,":[293],"referred":[294],"regulatory":[297,307,353],"B":[298,308,354],"(Bregs).":[300],"substantiated":[303],"proximity":[305],"niches,":[316],"suggesting":[317],"underexplored":[319],"mechanism":[320],"contributing":[321],"tumor-derived":[323],"CONCLUSION":[327],"Regulatory":[328],"B-cells":[329],"have":[330],"been":[331],"TME":[335],"various":[337],"solid":[338],"tumors,":[339],"colorectal,":[341],"breast,":[342],"cervical,":[343],"ovarian":[345],"carcinomas.":[346],"Our":[347],"study":[348],"emphasizes":[349],"role":[351],"immune":[359],"environment,":[360],"providing":[361],"crucial":[362],"insights":[363],"into":[364],"pathways":[369],"leading":[370],"chordoma.":[376]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-09-09T00:00:00"}
