{"id":"https://openalex.org/W4386537610","doi":"https://doi.org/10.1093/neuonc/noad137.199","title":"P10.01.A A PATIENT-DERIVEDEX VIVO ORGANOID MODEL ALLOWS EVALUATION OF TUMOR TREATING FIELDS (TTFIELDS) EFFECTS ON GLIOBLASTOMA, ANAPLASTIC EPENDYMOMA AND OLIGODENDROGLIOMA SAMPLES","display_name":"P10.01.A A PATIENT-DERIVEDEX VIVO ORGANOID MODEL ALLOWS EVALUATION OF TUMOR TREATING FIELDS (TTFIELDS) EFFECTS ON GLIOBLASTOMA, ANAPLASTIC EPENDYMOMA AND OLIGODENDROGLIOMA SAMPLES","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4386537610","doi":"https://doi.org/10.1093/neuonc/noad137.199"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noad137.199","doi":"https://doi.org/10.1093/neuonc/noad137.199","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noad137.199","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10489495/pdf/noad137.199.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057105239","display_name":"Vera Nickl","orcid":"https://orcid.org/0009-0002-0453-1135","observed_orcids":["https://orcid.org/0009-0002-0453-1135","https://orcid.org/0000-0003-4232-1673"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"V Nickl","raw_affiliation_strings":["University Hospital Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010981068","display_name":"E Schulz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Schulz","raw_affiliation_strings":["University Hospital Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034461088","display_name":"Ellaine Salvador","orcid":"https://orcid.org/0000-0003-2127-4548","observed_orcids":["https://orcid.org/0000-0003-2127-4548"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Salvador","raw_affiliation_strings":["University Hospital Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L Trautmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Trautmann","raw_affiliation_strings":["University Hospital Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031887908","display_name":"Leopold Diener","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Diener","raw_affiliation_strings":["University Hospital Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056787795","display_name":"Almuth Friederike Kessler","orcid":"https://orcid.org/0000-0002-0605-7791","observed_orcids":["https://orcid.org/0000-0002-0605-7791"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A F Kessler","raw_affiliation_strings":["University Hospital Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104594104","display_name":"Camelia Maria Monoranu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C M Monoranu","raw_affiliation_strings":["University of Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057149436","display_name":"Ralf\u2010Ingo Ernestus","orcid":"https://orcid.org/0000-0003-0780-8064","observed_orcids":["https://orcid.org/0000-0003-0780-8064"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Ernestus","raw_affiliation_strings":["University Hospital Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103088635","display_name":"Mario L\u00f6hr","orcid":"https://orcid.org/0000-0002-4081-1102","observed_orcids":["https://orcid.org/0000-0002-4081-1102"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M L\u00f6hr","raw_affiliation_strings":["University Hospital Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010337152","display_name":"Carsten Hagemann","orcid":"https://orcid.org/0000-0001-9759-8149","observed_orcids":["https://orcid.org/0000-0001-9759-8149"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Hagemann","raw_affiliation_strings":["University Hospital Wuerzburg , W\u00fcrzburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Wuerzburg , W\u00fcrzburg , Germany","institution_ids":["https://openalex.org/I4210126310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4612,"currency":"USD","value_usd":4612},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_2","first_page":"ii61","last_page":"ii61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-treating-fields","display_name":"tumor treating fields","score":0.953000009059906},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/anaplastic-ependymoma","display_name":"anaplastic ependymoma","score":1.0},{"id":"https://openalex.org/keywords/oligodendroglioma","display_name":"oligodendroglioma","score":1.0},{"id":"https://openalex.org/keywords/patient-derived-tumor-organoids","display_name":"patient-derived tumor organoids","score":0.8569999933242798},{"id":"https://openalex.org/keywords/organotypic-hippocampal-slice-cultures","display_name":"organotypic hippocampal slice cultures","score":0.9729999899864197},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.718999981880188},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2777931997","wikidata":"https://www.wikidata.org/wiki/Q1318384","display_name":"Oligodendroglioma","level":4,"score":0.8503259420394897},{"id":"https://openalex.org/C2781432949","wikidata":"https://www.wikidata.org/wiki/Q1346753","display_name":"Ependymoma","level":2,"score":0.7691894769668579},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.7410261034965515},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6125767230987549},{"id":"https://openalex.org/C16945437","wikidata":"https://www.wikidata.org/wiki/Q7924669","display_name":"Vibratome","level":3,"score":0.5811522006988525},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5151773691177368},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4977741539478302},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.43475469946861267},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4094313085079193},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.38730260729789734},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2848529815673828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17959165573120117},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.17195215821266174},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.13307619094848633},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0734437108039856},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noad137.199","doi":"https://doi.org/10.1093/neuonc/noad137.199","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/noad137.199","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10489495","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10489495","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10489495/pdf/noad137.199.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10489495","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10489495","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10489495/pdf/noad137.199.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386537610.pdf","grobid_xml":"https://content.openalex.org/works/W4386537610.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362594221","https://openalex.org/W4307327616","https://openalex.org/W2523123787","https://openalex.org/W2774497257","https://openalex.org/W4308976567","https://openalex.org/W6908434803","https://openalex.org/W6927229608","https://openalex.org/W2767833272","https://openalex.org/W4409627462","https://openalex.org/W2899765334"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND":[1],"The":[2,153,203,288],"use":[3],"of":[4,11,29,46,115,123,234,290,311,327],"TTFields,":[5],"which":[6],"are":[7],"alternating":[8],"electric":[9],"fields":[10],"low":[12],"intensity":[13],"(1-3":[14],"V/cm)":[15],"and":[16,83,97,129,148,162,177,183,213,285],"intermediate":[17],"frequency":[18],"(100-500":[19],"kHz),":[20],"has":[21],"shown":[22],"its":[23],"clinical":[24,258],"efficacy":[25],"in":[26,207,268],"the":[27,44,113,172,175,190,235,243,247,277,293],"treatment":[28,67,224],"newly":[30],"diagnosed":[31],"glioblastoma":[32],"(GBM)":[33],"patients":[34],"at":[35,102,180,225],"200":[36,103,181,226],"kHz.":[37,104],"Nevertheless,":[38,306],"more":[39],"knowledge":[40],"is":[41,309],"required":[42],"for":[43,65,132,157,186],"prediction":[45],"individual":[47],"tumors\u2019":[48],"responsiveness":[49],"to":[50,61,74,100,120,229,265,272,279,282,298,324],"treatment.":[51],"Recently,":[52],"we":[53,70,170,260,275],"developed":[54],"patient-derived":[55,283,316],"three-dimensional":[56],"GBM":[57,238],"tissue":[58,142,318],"culture":[59,319],"models":[60,73],"screen":[62],"patient":[63],"tumors":[64,76],"TTFields":[66,101,179,223,263,281,304,328],"susceptibility.":[68],"Here,":[69],"extended":[71],"these":[72],"brain":[75,331],"beyond":[77],"GBM,":[78,145,211],"namely":[79],"anaplastic":[80],"ependymoma":[81],"(AE)":[82],"oligodendroglioma.":[84],"We":[85,108,135,195],"cultured":[86,156],"tumor-organoids":[87],"as":[88,160,216,240,242],"microtumors":[89,217],"on":[90,257,292,329],"murine":[91],"organotypic":[92],"hippocampal":[93],"slice":[94],"cultures":[95],"(OHSCs)":[96],"subjected":[98],"them":[99,131],"MATERIAL":[105],"AND":[106],"METHODS":[107],"prepared":[109],"OHSCs":[110,176],"by":[111,199],"slicing":[112],"brains":[114],"mice":[116],"5-8":[117],"days":[118,159],"postpartum":[119],"a":[121,127,266],"thickness":[122],"350":[124],"\u00b5m":[125],"using":[126,189],"vibratome":[128],"culturing":[130],"14":[133,158],"days.":[134],"obtained":[136],"organoids":[137,154,173,209],"from":[138,143,210],"freshly":[139],"resected":[140],"tumor":[141,205,332],"three":[144,204,236],"one":[146,149],"AE,":[147],"oligodendroglioma":[150,248,286],"patient,":[151],"each.":[152],"were":[155,276],"well":[161,241],"then":[163],"stained":[164],"with":[165],"carboxyfluorescein":[166],"succinimidyl":[167],"ester.":[168],"Next,":[169],"placed":[171,220],"onto":[174,221],"administered":[178],"kHz":[182,227],"1.5":[184],"V/cm":[185],"72":[187],"h":[188],"inovitro\u2122":[191],"laboratory":[192],"research":[193],"system.":[194],"quantified":[196],"microtumor":[197,232,249,269],"growth":[198],"fluorescence":[200],"imaging.":[201],"RESULTS":[202],"entities,":[206],"particular":[208],"AE":[212,244,284],"oligodendroglioma,":[214],"grew":[215],"after":[218],"being":[219],"OHSCs.":[222],"led":[228],"significantly":[230,253],"decreased":[231],"size":[233,250],"analysed":[237],"samples":[239],"sample.":[245],"However,":[246,271],"was":[251],"not":[252],"reduced.":[254],"CONCLUSION":[255],"Based":[256],"experience,":[259],"expected":[261],"that":[262,313],"lead":[264],"reduction":[267],"size.":[270],"our":[273,307],"knowledge,":[274],"first":[278],"apply":[280],"samples.":[287],"lack":[289],"TTFields-effects":[291],"latter":[294],"might":[295],"be":[296,322],"due":[297],"different":[299,330],"inter-patient":[300],"sensitivity":[301],"or":[302],"suboptimal":[303],"frequency.":[305],"work":[308],"proof":[310],"principle":[312],"an":[314],"organoid-based":[315],"3D":[317],"model":[320],"could":[321],"used":[323],"evaluate":[325],"effects":[326],"entities.":[333]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-09-09T00:00:00"}