{"id":"https://openalex.org/W4386530920","doi":"https://doi.org/10.1002/jbm.a.37606","title":"Nano\u2212/micro\u2010scaled hydroxyapatite ceramic construction and the regulation of immune\u2010associated osteogenic differentiation","display_name":"Nano\u2212/micro\u2010scaled hydroxyapatite ceramic construction and the regulation of immune\u2010associated osteogenic differentiation","publication_year":2023,"publication_date":"2023-09-08","ids":{"openalex":"https://openalex.org/W4386530920","doi":"https://doi.org/10.1002/jbm.a.37606","pmid":"https://pubmed.ncbi.nlm.nih.gov/37680167"},"language":"en","primary_location":{"id":"doi:10.1002/jbm.a.37606","doi":"https://doi.org/10.1002/jbm.a.37606","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.37606","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003243051","display_name":"Shijia Fu","orcid":"https://orcid.org/0009-0006-6606-0278","observed_orcids":["https://orcid.org/0009-0006-6606-0278"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijia Fu","raw_affiliation_strings":["School of Life Sciences, Northwestern Polytechnical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101832124","display_name":"Huishan Li","orcid":"https://orcid.org/0009-0008-3472-4097","observed_orcids":["https://orcid.org/0009-0008-3472-4097"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huishan Li","raw_affiliation_strings":["School of Life Sciences, Northwestern Polytechnical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101758302","display_name":"Yue Wu","orcid":"https://orcid.org/0000-0003-1061-4607","observed_orcids":["https://orcid.org/0000-0003-1061-4607"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Wu","raw_affiliation_strings":["School of Life Sciences, Northwestern Polytechnical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020774364","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0001-5647-529X","observed_orcids":["https://orcid.org/0000-0001-5647-529X"]},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Wang","raw_affiliation_strings":["School of Life Sciences, Northwestern Polytechnical University, Xi'an, China"],"raw_orcid":"https://orcid.org/0000-0001-5647-529X","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University, Xi'an, China","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020774364"],"corresponding_institution_ids":["https://openalex.org/I17145004"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":0.4237,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.48966277,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"112","issue":"2","first_page":"193","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoscale-topography","display_name":"nanoscale topography","score":0.972000002861023},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/osteoinductivity","display_name":"osteoinductivity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cytokine-cytokine-receptor-interaction","display_name":"cytokine-cytokine receptor interaction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/surface-roughness","display_name":"surface roughness","score":0.6679999828338623},{"id":"https://openalex.org/keywords/wettability","display_name":"wettability","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6456919312477112},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6328513622283936},{"id":"https://openalex.org/C2781460891","wikidata":"https://www.wikidata.org/wiki/Q422360","display_name":"Osteonectin","level":5,"score":0.5463992357254028},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5307276844978333},{"id":"https://openalex.org/C101414908","wikidata":"https://www.wikidata.org/wiki/Q1541818","display_name":"Osseointegration","level":3,"score":0.442840039730072},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4302656352519989},{"id":"https://openalex.org/C88001094","wikidata":"https://www.wikidata.org/wiki/Q7251453","display_name":"Protein adsorption","level":3,"score":0.42989373207092285},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4141552150249481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26097726821899414},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23264247179031372},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.18178844451904297},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.17811012268066406},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13857513666152954},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.12993600964546204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10846704244613647},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002516","descriptor_name":"Ceramics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017886","descriptor_name":"Durapatite","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbm.a.37606","doi":"https://doi.org/10.1002/jbm.a.37606","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbm.a.37606","pdf_url":null,"source":{"id":"https://openalex.org/S184573928","display_name":"Journal of Biomedical Materials Research Part A","issn_l":"1549-3296","issn":["1549-3296","1552-4965"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Materials Research Part A","raw_type":"journal-article"},{"id":"pmid:37680167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37680167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical materials research. Part A","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6816276310","display_name":null,"funder_award_id":"31900948","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1981549657","https://openalex.org/W1985838524","https://openalex.org/W1990446563","https://openalex.org/W2003292476","https://openalex.org/W2007184239","https://openalex.org/W2007200874","https://openalex.org/W2015614056","https://openalex.org/W2020330911","https://openalex.org/W2021053451","https://openalex.org/W2021261257","https://openalex.org/W2031876019","https://openalex.org/W2035904396","https://openalex.org/W2044314806","https://openalex.org/W2044783635","https://openalex.org/W2045383620","https://openalex.org/W2046576188","https://openalex.org/W2053441291","https://openalex.org/W2056539843","https://openalex.org/W2058384092","https://openalex.org/W2067025066","https://openalex.org/W2072067362","https://openalex.org/W2075926473","https://openalex.org/W2092731808","https://openalex.org/W2093162963","https://openalex.org/W2094199657","https://openalex.org/W2094979592","https://openalex.org/W2107735396","https://openalex.org/W2135004341","https://openalex.org/W2155961206","https://openalex.org/W2159103663","https://openalex.org/W2159695232","https://openalex.org/W2164551466","https://openalex.org/W2165395280","https://openalex.org/W2175670474","https://openalex.org/W2290282561","https://openalex.org/W2325678970","https://openalex.org/W2414671399","https://openalex.org/W2534527342","https://openalex.org/W2539305709","https://openalex.org/W2563342193","https://openalex.org/W2590271487","https://openalex.org/W2605976672","https://openalex.org/W2744274844","https://openalex.org/W2750418409","https://openalex.org/W2810834087","https://openalex.org/W2887248285","https://openalex.org/W2888554684","https://openalex.org/W2896325756","https://openalex.org/W2897285377","https://openalex.org/W2898444350","https://openalex.org/W2970678760","https://openalex.org/W2983821096","https://openalex.org/W3008592843","https://openalex.org/W3033225111","https://openalex.org/W3036098484","https://openalex.org/W3186364778","https://openalex.org/W4206233075","https://openalex.org/W4281973136","https://openalex.org/W4283793927","https://openalex.org/W7042495530"],"related_works":["https://openalex.org/W3010404517","https://openalex.org/W2294529321","https://openalex.org/W2801296264","https://openalex.org/W2972228367","https://openalex.org/W2325678970","https://openalex.org/W2887248285","https://openalex.org/W4200479285","https://openalex.org/W4200289342","https://openalex.org/W2076020557","https://openalex.org/W2012412040"],"abstract_inverted_index":{"Hydroxyapatite":[0],"(HA)":[1],"bioceramic":[2],"is":[3],"a":[4,62,66,97,160],"promising":[5],"substitute":[6],"for":[7],"bone":[8],"defects,":[9],"and":[10,20,33,52,69,72,96,118,130,134,149,155,173,177,196,207],"the":[11,42,47,54,82,113,164,185,192,208],"surface":[12,36,64,187],"properties":[13],"are":[14],"major":[15],"factors":[16],"that":[17,184],"influence":[18],"bioactivity":[19],"osteoinductivity.":[21],"In":[22],"this":[23],"study,":[24],"two":[25],"kinds":[26],"of":[27,49,84,100,103,153,189,194,204,210],"HA":[28,190],"bioceramics":[29],"with":[30,163],"nanoscale":[31,186],"(n-HA)":[32],"microscale":[34],"(m-HA)":[35],"topography":[37,188],"were":[38,126,138],"designed":[39],"to":[40,58,92,143],"mimic":[41],"natural":[43],"bone,":[44],"thus":[45],"enhancing":[46],"stimulation":[48],"osteogenic":[50,101],"differentiation":[51,102],"revealing":[53],"potential":[55],"mechanism.":[56],"Compared":[57],"m-HA,":[59,88],"n-HA":[60,79,117,141],"owned":[61],"larger":[63],"roughness,":[65],"stronger":[67,98],"wettability,":[68],"reduced":[70],"hardness":[71],"indentation":[73],"modulus.":[74],"Based":[75],"on":[76],"these":[77],"properties,":[78],"could":[80,197],"maintain":[81],"conformation":[83],"vitronectin":[85],"better":[86],"than":[87],"which":[89],"may":[90],"contribute":[91],"higher":[93],"cellular":[94],"activities":[95],"promotion":[99],"mesenchymal":[104],"stem":[105],"cells":[106],"(MSCs).":[107],"Further":[108],"RNA":[109],"sequencing":[110],"analysis":[111,148],"compared":[112,142],"molecular":[114],"expression":[115],"between":[116],"m-HA.":[119,144],"Six":[120],"hundred":[121],"twenty-seven":[122],"differentially":[123],"expressed":[124],"genes":[125,133,137,154],"identified":[127],"in":[128,167],"MSCs,":[129],"17":[131],"upregulated":[132,169],"610":[135],"downregulated":[136,178],"included":[139],"when":[140],"The":[145],"GO":[146],"cluster":[147],"enriched":[150],"Kyoto":[151],"encyclopedia":[152],"genome":[156],"signaling":[157,171],"pathways":[158,179],"revealed":[159],"close":[161],"correlation":[162],"immune":[165,205],"process":[166],"both":[168],"(chemokine":[170],"pathway":[172],"cytokine-cytokine":[174],"receptor":[175],"interaction)":[176],"(osteoclasts":[180],"differentiation).":[181],"It":[182],"suggested":[183],"enhanced":[191],"osteoinductivity":[193],"MSCs":[195],"not":[198],"be":[199],"separated":[200],"from":[201],"its":[202],"regulation":[203],"function":[206],"retention":[209],"adsorbed":[211],"protein":[212],"conformation.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-09T00:00:00"}