{"id":"https://openalex.org/W4386529620","doi":"https://doi.org/10.19852/j.cnki.jtcm.20220907.001","title":"Spinosin protects Neuro-2a/APP695 cells from oxidative stress damage by inactivating p38.","display_name":"Spinosin protects Neuro-2a/APP695 cells from oxidative stress damage by inactivating p38.","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4386529620","doi":"https://doi.org/10.19852/j.cnki.jtcm.20220907.001","pmid":"https://pubmed.ncbi.nlm.nih.gov/37679974","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10465843"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10465843","doi":"https://doi.org/10.19852/j.cnki.jtcm.20220907.001","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10465843","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10465843/pdf/JTCM-43-5-868.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Tradit Chin Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10465843/pdf/JTCM-43-5-868.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhang Xiaoying","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Xiaoying","raw_affiliation_strings":["School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wang Ruixuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Ruixuan","raw_affiliation_strings":["School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104011097","display_name":"Wang Yiqing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Yiqing","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101189545","display_name":"X U Fanxing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X U Fanxing","raw_affiliation_strings":["Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Tingxu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Tingxu","raw_affiliation_strings":["Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101800718","display_name":"Bo Wu","orcid":"https://orcid.org/0000-0003-4251-6972","observed_orcids":["https://orcid.org/0000-0003-4251-6972"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W U Bo","raw_affiliation_strings":["Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100751823","display_name":"Ming Zhang","orcid":"https://orcid.org/0000-0003-2956-4056","observed_orcids":["https://orcid.org/0000-0003-2956-4056","https://orcid.org/0009-0001-5829-9020"]},"institutions":[{"id":"https://openalex.org/I4405267619","display_name":"Shenyang Women and Infants Hospital","ror":"https://ror.org/03m116c06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405267619"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Ming","raw_affiliation_strings":["Gynecology Department, Shenyang Women's and Children's Hospital, Shenyang 110011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecology Department, Shenyang Women's and Children's Hospital, Shenyang 110011, China","institution_ids":["https://openalex.org/I4405267619"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091336311","display_name":"Ying Jia","orcid":"https://orcid.org/0000-0002-1289-4350","observed_orcids":["https://orcid.org/0000-0002-1289-4350"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Ying","raw_affiliation_strings":["Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China","institution_ids":["https://openalex.org/I103890011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0956,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.31492346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"43","issue":"5","first_page":"868","last_page":"875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinosin","display_name":"spinosin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8640000224113464},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9639999866485596},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8140000104904175},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/synaptic-dysfunction","display_name":"synaptic dysfunction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6927118301391602},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6570316553115845},{"id":"https://openalex.org/C2777209535","wikidata":"https://www.wikidata.org/wiki/Q14864388","display_name":"Synaptophysin","level":3,"score":0.5737084746360779},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5398982763290405},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.5156358480453491},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4519753158092499},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43403416872024536},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.4322672486305237},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.4276033043861389},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4180610775947571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3951660990715027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3116811513900757},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3076159358024597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2764524221420288},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2541572153568268},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.21331363916397095},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19156935811042786},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1791163980960846},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.17042440176010132},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.16102999448776245},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10465843","doi":"https://doi.org/10.19852/j.cnki.jtcm.20220907.001","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10465843","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10465843/pdf/JTCM-43-5-868.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Tradit Chin Med","raw_type":"Text"},{"id":"pmid:37679974","doi":"https://doi.org/10.19852/j.cnki.jtcm.20220907.001","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37679974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10465843","doi":"https://doi.org/10.19852/j.cnki.jtcm.20220907.001","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10465843","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10465843/pdf/JTCM-43-5-868.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Tradit Chin Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6195301145","display_name":null,"funder_award_id":"82003926","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8155808090","display_name":null,"funder_award_id":"XLYC2008029","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8943692757","display_name":null,"funder_award_id":"82173961","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386529620.pdf","grobid_xml":"https://content.openalex.org/works/W4386529620.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1964476920","https://openalex.org/W1972886222","https://openalex.org/W2029155091","https://openalex.org/W2061387301","https://openalex.org/W2071267504","https://openalex.org/W2088075448","https://openalex.org/W2111357727","https://openalex.org/W2112136536","https://openalex.org/W2193968315","https://openalex.org/W2414939357","https://openalex.org/W2531562496","https://openalex.org/W2566072918","https://openalex.org/W2588581682","https://openalex.org/W2615432724","https://openalex.org/W2795882273","https://openalex.org/W2809449805","https://openalex.org/W2882341351","https://openalex.org/W2900629169","https://openalex.org/W2943963095","https://openalex.org/W2947059421","https://openalex.org/W2975469258","https://openalex.org/W2986411193","https://openalex.org/W2992997106","https://openalex.org/W2993874908","https://openalex.org/W3025860373","https://openalex.org/W3036923546","https://openalex.org/W3037473414","https://openalex.org/W3042276809","https://openalex.org/W3044196334"],"related_works":["https://openalex.org/W3042276809","https://openalex.org/W2992997106","https://openalex.org/W2809449805","https://openalex.org/W2124263476","https://openalex.org/W7095920340","https://openalex.org/W2097243284","https://openalex.org/W2973070969","https://openalex.org/W2039173359","https://openalex.org/W2592886763","https://openalex.org/W2056122831"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"explore":[2],"the":[3,24,30,41,63,71,89,101,163,192],"protective":[4],"mechanism":[5],"of":[6,26,32,45,66,73,92,104,160,165],"spinosin":[7],"(SPI)":[8],"on":[9,29],"Alzheimer's":[10],"disease":[11],"(AD)":[12],"model":[13],"cells,":[14],"Neuro-2a/APP695":[15],"(N2a/APP695),":[16],"against":[17],"HO-induced":[18],"oxidative":[19,27,202],"stress":[20,28,203],"damage,":[21],"to":[22,35,55,136,149,173],"reflect":[23,137],"influence":[25],"development":[31,44],"AD,":[33],"and":[34,43,57,70,76,114,153,155,171],"provide":[36],"a":[37,157],"valuable":[38],"basis":[39],"for":[40,48],"research":[42],"therapeutic":[46],"drug":[47],"AD.":[49],"METHODS:":[50],"N2a/APP695":[51,147,199],"cells":[52,148,200],"were":[53,80,121],"exposed":[54],"HO":[56,145,182,207],"then":[58],"treated":[59],"with":[60,191],"spinosin.":[61],"Firstly,":[62],"secretion":[64],"level":[65],"amyloid":[67],"\u03b2":[68],"(A\u03b2)":[69],"production":[72],"malondialdehyde":[74],"(MDA)":[75],"lactate":[77],"dehydrogenase":[78],"(LDH)":[79],"detected":[81,122],"by":[82,96,123,181,183,189,206],"enzyme":[83],"linked":[84],"immunosorbent":[85],"assay":[86],"kits.":[87],"Secondly,":[88],"oligomerization":[90],"degree":[91],"A\u03b2":[93],"was":[94,131,187],"performed":[95],"Thioflavin":[97],"T":[98],"staining.":[99],"Thirdly,":[100],"expression":[102],"levels":[103],"p-Tau":[105],"(Ser199/202/396),":[106],"synaptophysin":[107],"(SYP),":[108],"postsynaptic":[109],"density":[110],"protein":[111,116,169],"95":[112],"(PSD95),":[113],"mitogen-activated":[115],"kinase":[117],"(MAPK)":[118],"family-related":[119],"proteins":[120],"Western":[124],"blot":[125],"analysis.":[126],"In":[127],"addition,":[128],"FITC-labeled":[129],"phalloidin":[130],"used":[132],"in":[133],"cytoskeleton":[134],"staining":[135],"synaptic":[138,174],"function.":[139],"RESULTS:":[140],"This":[141],"study":[142],"showed":[143],"that":[144],"stimulated":[146],"produce":[150],"excessive":[151],"MDA":[152],"LDH":[154],"secrete":[156],"large":[158],"amount":[159],"A\u03b2,":[161,166],"promoted":[162],"aggregation":[164],"induced":[167],"Tau":[168],"hyperphosphorylation,":[170],"led":[172],"dysfunction.":[175],"Spinosin":[176,197],"reversed":[177],"these":[178],"changes":[179],"caused":[180,205],"inactivating":[184,209],"p38,":[185],"which":[186],"verified":[188],"treatment":[190],"p38":[193],"inhibitor":[194],"BIRB796.":[195],"CONCLUSION:":[196],"protects":[198],"from":[201],"damage":[204],"through":[208],"p38.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-09T00:00:00"}