{"id":"https://openalex.org/W4386526324","doi":"https://doi.org/10.1158/2767-9764.24101066","title":"FIGURE 4 from A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer","display_name":"FIGURE 4 from A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer","publication_year":2023,"publication_date":"2023-09-07","ids":{"openalex":"https://openalex.org/W4386526324","doi":"https://doi.org/10.1158/2767-9764.24101066"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.24101066","doi":"https://doi.org/10.1158/2767-9764.24101066","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.24101066","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.24101066","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009806024","display_name":"Madeline A. Dorso","orcid":"https://orcid.org/0000-0002-4343-930X","observed_orcids":["https://orcid.org/0000-0002-4343-930X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Dorso","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4343-930X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048320845","display_name":"Payal T. Patel","orcid":"https://orcid.org/0000-0002-9623-7744","observed_orcids":["https://orcid.org/0000-0002-9623-7744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Payal T. Patel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9623-7744","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057054848","display_name":"Aleksandr Pankov","orcid":"https://orcid.org/0000-0003-1251-2911","observed_orcids":["https://orcid.org/0000-0003-1251-2911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aleksandr Pankov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1251-2911","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090143432","display_name":"Jacob A. Boyer","orcid":"https://orcid.org/0000-0001-5651-2337","observed_orcids":["https://orcid.org/0000-0001-5651-2337"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob A. Boyer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5651-2337","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079956746","display_name":"Rajesh Kumar Soni","orcid":"https://orcid.org/0000-0002-4556-4358","observed_orcids":["https://orcid.org/0000-0002-4556-4358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajesh K. Soni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4556-4358","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066892007","display_name":"Isabella S. Del Priore","orcid":"https://orcid.org/0000-0002-9665-1101","observed_orcids":["https://orcid.org/0000-0002-9665-1101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabella S. Del Priore","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9665-1101","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044403001","display_name":"Omar Hayatt","orcid":"https://orcid.org/0009-0007-7453-5621","observed_orcids":["https://orcid.org/0009-0007-7453-5621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omar Hayatt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-7453-5621","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016507930","display_name":"Amanda R. Kulick","orcid":"https://orcid.org/0000-0001-7365-4142","observed_orcids":["https://orcid.org/0000-0001-7365-4142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Kulick","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7365-4142","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070693180","display_name":"Connor J. Hagen","orcid":"https://orcid.org/0009-0000-2649-6284","observed_orcids":["https://orcid.org/0009-0000-2649-6284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Connor J. Hagen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-2649-6284","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004111432","display_name":"Elisa de Stanchina","orcid":"https://orcid.org/0000-0002-3873-315X","observed_orcids":["https://orcid.org/0000-0002-3873-315X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisa de Stanchina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3873-315X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040110214","display_name":"Melissa R. Junttila","orcid":"https://orcid.org/0000-0003-3538-1192","observed_orcids":["https://orcid.org/0000-0003-3538-1192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa R. Junttila","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3538-1192","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022839853","display_name":"Anneleen Daemen","orcid":"https://orcid.org/0000-0001-6287-7105","observed_orcids":["https://orcid.org/0000-0001-6287-7105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anneleen Daemen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6287-7105","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103054591","display_name":"Lori S. Friedman","orcid":"https://orcid.org/0000-0001-9127-9892","observed_orcids":["https://orcid.org/0000-0001-9127-9892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori S. Friedman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9127-9892","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012418100","display_name":"Ronald C. Hendrickson","orcid":"https://orcid.org/0000-0002-0851-903X","observed_orcids":["https://orcid.org/0000-0002-0851-903X","https://orcid.org/0000-0002-6899-7287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald C. Hendrickson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0851-903X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041961484","display_name":"Sarat Chandarlapaty","orcid":"https://orcid.org/0000-0003-4532-8053","observed_orcids":["https://orcid.org/0000-0003-4532-8053"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarat Chandarlapaty","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4532-8053","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxa1","display_name":"FOXA1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.878000020980835},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8149999976158142},{"id":"https://openalex.org/keywords/h441-cells","display_name":"H441 cells","score":0.7749999761581421},{"id":"https://openalex.org/keywords/glucocorticoid-response-element","display_name":"glucocorticoid response element","score":0.8809999823570251},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.6370512843132019},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.5326212048530579},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5115295648574829},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4780481457710266},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.45631182193756104},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4335940480232239},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41363051533699036},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36644336581230164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3147503137588501},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26898813247680664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2365644872188568},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06415596604347229}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.24101066","doi":"https://doi.org/10.1158/2767-9764.24101066","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.24101066","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.24101066","doi":"https://doi.org/10.1158/2767-9764.24101066","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.24101066","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2354241142","https://openalex.org/W3029340634","https://openalex.org/W1982434602","https://openalex.org/W2094844283","https://openalex.org/W2365729717","https://openalex.org/W1974494990","https://openalex.org/W1985998670","https://openalex.org/W2072481810","https://openalex.org/W2347992620","https://openalex.org/W4307860292"],"abstract_inverted_index":{"Growth":[0,242],"promoting":[1],"functions":[2],"of":[3,16,27,41,64,95,109,121,138,164,171,180,187,228,243],"GR":[4,18,23],"in":[5,33,73,77,125,129,148,173,217],"FOXA1/GR-dependent":[6],"NSCLC":[7],"can":[8],"be":[9],"inhibited":[10],"by":[11,68,208,236,267],"ORIC-101.":[12],"A,":[13],"Chemical":[14],"structures":[15],"steroidal":[17],"antagonist,":[19,24],"ORIC-101":[20,42,96,139,181,199],"and":[21,29,36,133,167,220],"non-steroidal":[22],"OP-4954.":[25,183],"Proliferation":[26],"H441":[28,126,174,188,244],"H3255":[30],"cells":[31,75,127,175,189,216],"cultured":[32,76,128],"normal":[34,130],"media":[35,132],"treated":[37,54,82,134,176,190,247],"with":[38,83,135,177,194,248],"indicated":[39,93,122],"concentrations":[40,94],"(B)":[43],"or":[44,88,97,141,182,196,200,202,251],"OP-4954":[45,98,142,205],"(C).":[46],"Datapoints":[47],"are":[48,103,224,260],"Resazurin":[49],"fluorescence":[50],"normalized":[51],"to":[52,151],"DMSO":[53,195,201],"cells,":[55],"means":[56,106,225,261],"\u00b1":[57,107,160,226,262],"SD,":[58],"n":[59],"=":[60,256],"6.":[61],"D,":[62],"Measurement":[63],"luciferase":[65],"activity":[66],"driven":[67],"glucocorticoid":[69],"response":[70],"element":[71],"promoter":[72],"293T":[74],"charcoal-stripped":[78],"media.":[79],"Cells":[80],"were":[81],"vehicle,":[84,249],"100":[85,89],"nmol/L":[86,90],"dexamethasone,":[87],"dexamethasone":[91],"plus":[92],"for":[99,191],"24":[100,192],"hours.":[101],"Data":[102,223],"shown":[104],"as":[105,206,214],"SD":[108,227],"three":[110,158,229],"biologically":[111],"independent":[112,230],"replicates.":[113],"E,":[114],"mRNA":[115],"levels":[116],"over":[117],"a":[118],"24-hour":[119],"period":[120],"FOXA1/GR":[123,165],"targets":[124,166,172],"serum-containing":[131],"10":[136,178,197,203],"\u03bcmol/L":[137,179,198,204],"(black)":[140],"(pink).":[143],"Values":[144],"represent":[145],"fold":[146],"change":[147],"expression":[149],"relative":[150],"0":[152],"hour.":[153],"(no":[154],"treatment)":[155],"condition":[156],"from":[157],"replicates":[159],"SEM.":[161,263],"F,":[162],"Immunoblots":[163],"signaling":[168],"pathways":[169],"downstream":[170],"G,":[184],"Cell-cycle":[185],"distribution":[186],"hours":[193],"measured":[207],"DNA":[209],"content":[210],"using":[211],"FACS,":[212],"plotted":[213],"%":[215],"G1,":[218],"S,":[219],"G2\u2013M":[221],"phases.":[222],"biological":[231],"repeats.":[232],"P":[233,264],"value":[234,265],"calculated":[235,266],"two-tailed":[237,268],"Student":[238,269],"t":[239,270],"test.":[240,271],"H,":[241],"xenograft":[245],"tumors":[246],"75":[250],"150":[252],"mg/kg":[253],"daily.":[254],"N":[255],"8":[257],"mice/group,":[258],"data":[259]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}