{"id":"https://openalex.org/W4386503052","doi":"https://doi.org/10.25122/jml-2022-0281","title":"Role of Iberin as an anti-apoptotic agent on renal ischemia-reperfusion injury in rats","display_name":"Role of Iberin as an anti-apoptotic agent on renal ischemia-reperfusion injury in rats","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4386503052","doi":"https://doi.org/10.25122/jml-2022-0281","pmid":"https://pubmed.ncbi.nlm.nih.gov/37675177","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10478648"},"language":"en","primary_location":{"id":"doi:10.25122/jml-2022-0281","doi":"https://doi.org/10.25122/jml-2022-0281","is_oa":true,"landing_page_url":"https://doi.org/10.25122/jml-2022-0281","pdf_url":"https://medandlife.org/wp-content/uploads/18.-JML-2022-0281.pdf","source":{"id":"https://openalex.org/S2755172410","display_name":"Journal of Medicine and Life","issn_l":"1844-122X","issn":["1844-122X","1844-3117"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320337","host_organization_name":"Carol Davila University of Medicine and Pharmacy Publishing House","host_organization_lineage":["https://openalex.org/P4310320337"],"host_organization_lineage_names":["Carol Davila University of Medicine and Pharmacy Publishing House"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicine and Life","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://medandlife.org/wp-content/uploads/18.-JML-2022-0281.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101909649","display_name":"Najah Rayish Hadi","orcid":"https://orcid.org/0000-0001-9084-591X","observed_orcids":["https://orcid.org/0000-0001-9084-591X"]},"institutions":[{"id":"https://openalex.org/I2799923299","display_name":"University of Alkafeel","ror":"https://ror.org/05qxq4371","country_code":"IQ","type":"education","lineage":["https://openalex.org/I2799923299"]},{"id":"https://openalex.org/I47229656","display_name":"University of Kufa","ror":"https://ror.org/02dwrdh81","country_code":"IQ","type":"education","lineage":["https://openalex.org/I47229656"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Najah Rayish Hadi","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Kufa, Iraq","Deptartment of Pharmacology, Faculty of Pharmacy, University of Alkafeel, Najaf, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Kufa, Iraq","institution_ids":["https://openalex.org/I47229656"]},{"raw_affiliation_string":"Deptartment of Pharmacology, Faculty of Pharmacy, University of Alkafeel, Najaf, Iraq","institution_ids":["https://openalex.org/I2799923299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003635702","display_name":"Yahiya Ibrahim Yahiya","orcid":"https://orcid.org/0000-0001-8678-0623","observed_orcids":["https://orcid.org/0000-0001-8678-0623"]},"institutions":[{"id":"https://openalex.org/I2799923299","display_name":"University of Alkafeel","ror":"https://ror.org/05qxq4371","country_code":"IQ","type":"education","lineage":["https://openalex.org/I2799923299"]},{"id":"https://openalex.org/I47229656","display_name":"University of Kufa","ror":"https://ror.org/02dwrdh81","country_code":"IQ","type":"education","lineage":["https://openalex.org/I47229656"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Yahiya Ibrahim Yahiya","raw_affiliation_strings":["Deptartment of Pharmacology, Faculty of Pharmacy, University of Alkafeel, Najaf, Iraq","Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Kufa, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptartment of Pharmacology, Faculty of Pharmacy, University of Alkafeel, Najaf, Iraq","institution_ids":["https://openalex.org/I2799923299"]},{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Kufa, Iraq","institution_ids":["https://openalex.org/I47229656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041174469","display_name":"Ahmed Rahmah Abu-Raghif","orcid":"https://orcid.org/0000-0003-4514-3892","observed_orcids":["https://orcid.org/0000-0003-4514-3892"]},"institutions":[{"id":"https://openalex.org/I56409017","display_name":"Nahrain University","ror":"https://ror.org/05v2p9075","country_code":"IQ","type":"education","lineage":["https://openalex.org/I56409017"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ahmed Abu Raghif","raw_affiliation_strings":["Deptartment of Pharmacology, College of Medicine, Al Nahrain University, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptartment of Pharmacology, College of Medicine, Al Nahrain University, Baghdad, Iraq","institution_ids":["https://openalex.org/I56409017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044801209","display_name":"Heider S Qassam","orcid":"https://orcid.org/0000-0002-1422-8677","observed_orcids":["https://orcid.org/0000-0002-1422-8677"]},"institutions":[{"id":"https://openalex.org/I2799923299","display_name":"University of Alkafeel","ror":"https://ror.org/05qxq4371","country_code":"IQ","type":"education","lineage":["https://openalex.org/I2799923299"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Heider Qassam","raw_affiliation_strings":["Deptartment of Pharmacology, Faculty of Pharmacy, University of Alkafeel, Najaf, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptartment of Pharmacology, Faculty of Pharmacy, University of Alkafeel, Najaf, Iraq","institution_ids":["https://openalex.org/I2799923299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085235085","display_name":"Noor Ghaffar Said AL Habooby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47229656","display_name":"University of Kufa","ror":"https://ror.org/02dwrdh81","country_code":"IQ","type":"education","lineage":["https://openalex.org/I47229656"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Noor Ghaffar Said AL Habooby","raw_affiliation_strings":["Medical College, University of Kufa, Kufa, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College, University of Kufa, Kufa, Iraq","institution_ids":["https://openalex.org/I47229656"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101909649"],"corresponding_institution_ids":["https://openalex.org/I2799923299","https://openalex.org/I47229656"],"apc_list":null,"apc_paid":null,"fwci":5.924,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.97063279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"16","issue":"6","first_page":"915","last_page":"919"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.9750000238418579},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.8130000233650208},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8309999704360962},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.593999981880188},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.906000018119812},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.8240000009536743},{"id":"https://openalex.org/keywords/ischemic-tolerance","display_name":"ischemic tolerance","score":0.7429999709129333},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.6474014520645142},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6223517060279846},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5871295928955078},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5463890433311462},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4746285676956177},{"id":"https://openalex.org/C2780721119","wikidata":"https://www.wikidata.org/wiki/Q7312492","display_name":"Renal ischemia","level":4,"score":0.41462963819503784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2565039396286011},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18800461292266846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09650999307632446}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017879","descriptor_name":"Isothiocyanates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.25122/jml-2022-0281","doi":"https://doi.org/10.25122/jml-2022-0281","is_oa":true,"landing_page_url":"https://doi.org/10.25122/jml-2022-0281","pdf_url":"https://medandlife.org/wp-content/uploads/18.-JML-2022-0281.pdf","source":{"id":"https://openalex.org/S2755172410","display_name":"Journal of Medicine and Life","issn_l":"1844-122X","issn":["1844-122X","1844-3117"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320337","host_organization_name":"Carol Davila University of Medicine and Pharmacy Publishing House","host_organization_lineage":["https://openalex.org/P4310320337"],"host_organization_lineage_names":["Carol Davila University of Medicine and Pharmacy Publishing House"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicine and Life","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10478648","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10478648","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10478648/pdf/JMedLife-16-915.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Life","raw_type":"Text"},{"id":"pmid:37675177","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37675177","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicine and life","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.25122/jml-2022-0281","doi":"https://doi.org/10.25122/jml-2022-0281","is_oa":true,"landing_page_url":"https://doi.org/10.25122/jml-2022-0281","pdf_url":"https://medandlife.org/wp-content/uploads/18.-JML-2022-0281.pdf","source":{"id":"https://openalex.org/S2755172410","display_name":"Journal of Medicine and Life","issn_l":"1844-122X","issn":["1844-122X","1844-3117"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320337","host_organization_name":"Carol Davila University of Medicine and Pharmacy Publishing House","host_organization_lineage":["https://openalex.org/P4310320337"],"host_organization_lineage_names":["Carol Davila University of Medicine and Pharmacy Publishing House"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicine and Life","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386503052.pdf","grobid_xml":"https://content.openalex.org/works/W4386503052.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W14616489","https://openalex.org/W204998232","https://openalex.org/W1492991941","https://openalex.org/W1720082734","https://openalex.org/W1968713494","https://openalex.org/W1976065095","https://openalex.org/W1985209496","https://openalex.org/W2005976688","https://openalex.org/W2017234408","https://openalex.org/W2019442978","https://openalex.org/W2021612256","https://openalex.org/W2022555554","https://openalex.org/W2025469226","https://openalex.org/W2054570690","https://openalex.org/W2067067767","https://openalex.org/W2085145831","https://openalex.org/W2095364552","https://openalex.org/W2096998441","https://openalex.org/W2105034272","https://openalex.org/W2123204783","https://openalex.org/W2135522110","https://openalex.org/W2160807970","https://openalex.org/W2183290946","https://openalex.org/W2326287677","https://openalex.org/W2405183840","https://openalex.org/W2407574550","https://openalex.org/W2782894548","https://openalex.org/W2802537586","https://openalex.org/W2912546084","https://openalex.org/W2916095365","https://openalex.org/W2985798375","https://openalex.org/W2997181391","https://openalex.org/W2997704767","https://openalex.org/W3032927695","https://openalex.org/W3042235131","https://openalex.org/W3133492956","https://openalex.org/W4288076435"],"related_works":["https://openalex.org/W4380291910","https://openalex.org/W2010409515","https://openalex.org/W3007497749","https://openalex.org/W2810324178","https://openalex.org/W2128377921","https://openalex.org/W4386631726","https://openalex.org/W4360991224","https://openalex.org/W4403358899","https://openalex.org/W3014244821","https://openalex.org/W3083061397"],"abstract_inverted_index":{"Ischemia-reperfusion":[0],"injury":[1,224],"(IRI)":[2],"is":[3],"a":[4,37,91,218],"major":[5],"contributor":[6],"to":[7,21,76,121,189,229,232],"acute":[8],"and":[9,15,33,97,109,123,137,155,174,186,192],"chronic":[10],"kidney":[11],"failure,":[12,14],"heart":[13],"ischemic":[16,199],"stroke.":[17],"This":[18],"study":[19],"aimed":[20],"investigate":[22],"the":[23,115,190,198,213],"therapeutic":[24],"potential":[25,214],"of":[26,40,83,93,101,107,150,182,201,215],"Iberin,":[27],"known":[28],"for":[29,73,221],"its":[30,230],"anti-inflammatory,":[31],"antioxidant,":[32],"antiapoptotic":[34],"properties,":[35],"in":[36],"rat":[38],"model":[39],"renal":[41,70,202,223],"IRI.":[42],"Twenty-four":[43],"adult":[44],"male":[45],"rats":[46],"were":[47,139],"randomly":[48],"divided":[49],"into":[50],"four":[51],"groups:":[52],"Group":[53,62,85,110],"I":[54],"(Sham":[55],"group)":[56,65,89,113],"underwent":[57,66,98],"laparotomy":[58,67],"without":[59],"IRI":[60],"induction;":[61],"II":[63],"(Control":[64],"followed":[68,79,103],"by":[69,80,104,226],"artery":[71],"clamping":[72],"30":[74,99],"minutes":[75,100],"induce":[77],"ischemia,":[78],"2":[81,105],"hours":[82,106],"reperfusion;":[84,108],"III":[86],"(Iberin":[87],"treatment":[88,146,196],"received":[90,114],"pre-injection":[92],"Iberin":[94,126,145,179,195,216],"(15":[95],"mg/kg)":[96],"ischemia":[102,122],"IV":[111],"(Vehicle-treated":[112],"vehicle":[116,193],"(ethanol)":[117],"1":[118],"hour":[119],"prior":[120],"reperfusion":[124],"induction.":[125],"was":[127],"diluted":[128],"with":[129,133],"ethanol.":[130],"Biomarkers":[131],"associated":[132],"inflammation,":[134],"oxidative":[135],"stress,":[136],"apoptosis":[138],"measured":[140],"using":[141],"enzyme-linked":[142],"immunosorbent":[143],"assay.":[144],"significantly":[147],"reduced":[148],"levels":[149,181],"inflammatory":[151,234],"cytokines":[152],"interleukin-1\u03b2":[153],"(IL-1\u03b2)":[154],"IL-6,":[156],"Bcl-2-associated":[157],"X":[158],"protein":[159,185],"(BAX),":[160],"tumor":[161],"necrosis":[162],"factor":[163,167],"\u03b1":[164],"(TNF-\u03b1),":[165],"nuclear":[166],"kappa":[168],"p56,":[169],"high":[170],"mobility":[171],"group":[172],"B1,":[173],"neutrophil":[175],"gelatinase-associated":[176],"lipocalin.":[177],"Moreover,":[178],"increased":[180],"heat":[183],"shock":[184],"Bcl2":[187],"compared":[188],"control":[191],"groups.":[194],"prolonged":[197],"tolerance":[200],"tissue,":[203],"potentially":[204],"preventing":[205],"or":[206],"delaying":[207],"irreversible":[208],"injuries.":[209],"These":[210],"findings":[211],"highlight":[212],"as":[217],"promising":[219],"candidate":[220],"mitigating":[222],"caused":[225],"ischemia-reperfusion,":[227],"due":[228],"ability":[231],"modulate":[233],"markers.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-09-08T00:00:00"}