{"id":"https://openalex.org/W4386485376","doi":"https://doi.org/10.1158/1535-7163.24089582","title":"Figure 4 from Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model","display_name":"Figure 4 from Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model","publication_year":2023,"publication_date":"2023-09-06","ids":{"openalex":"https://openalex.org/W4386485376","doi":"https://doi.org/10.1158/1535-7163.24089582"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.24089582","doi":"https://doi.org/10.1158/1535-7163.24089582","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.24089582","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.24089582","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069800885","display_name":"Rupali Sharma","orcid":"https://orcid.org/0000-0002-0370-675X","observed_orcids":["https://orcid.org/0000-0002-0370-675X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rupali Sharma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0370-675X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022252505","display_name":"Bhargav Earla","orcid":"https://orcid.org/0009-0000-4658-1945","observed_orcids":["https://orcid.org/0009-0000-4658-1945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhargav Earla","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-4658-1945","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018219579","display_name":"Kwamena E. Baidoo","orcid":"https://orcid.org/0009-0007-3726-1609","observed_orcids":["https://orcid.org/0009-0007-3726-1609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwamena E. Baidoo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-3726-1609","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025622172","display_name":"Martha A. Zeiger","orcid":"https://orcid.org/0000-0001-8998-0858","observed_orcids":["https://orcid.org/0000-0001-8998-0858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martha A. Zeiger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8998-0858","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014881195","display_name":"James P. Madigan","orcid":"https://orcid.org/0000-0002-0503-3704","observed_orcids":["https://orcid.org/0000-0002-0503-3704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James P. Madigan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0503-3704","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078610086","display_name":"Freddy E. Escorcia","orcid":"https://orcid.org/0000-0002-0727-3242","observed_orcids":["https://orcid.org/0000-0002-0727-3242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Freddy E. Escorcia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0727-3242","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050780818","display_name":"Samira Mercedes Sadowski","orcid":"https://orcid.org/0000-0002-7538-9431","observed_orcids":["https://orcid.org/0000-0002-7538-9431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samira M. Sadowski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7538-9431","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin-receptor-2","display_name":"somatostatin receptor 2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/177lu-dotatate","display_name":"177Lu-DOTATATE","score":0.9240000247955322},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.921999990940094},{"id":"https://openalex.org/keywords/ci-994","display_name":"CI-994","score":0.9670000076293945},{"id":"https://openalex.org/keywords/receptor-upregulation","display_name":"receptor up-regulation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/peptide-receptor-radionuclide-therapy","display_name":"peptide receptor radionuclide therapy","score":0.878000020980835}],"concepts":[{"id":"https://openalex.org/C150008808","wikidata":"https://www.wikidata.org/wiki/Q18031731","display_name":"Somatostatin receptor 2","level":4,"score":0.730303943157196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6692098379135132},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5824559926986694},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.48896992206573486},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.42226824164390564},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.4081597328186035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3809013068675995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3746829926967621}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.24089582","doi":"https://doi.org/10.1158/1535-7163.24089582","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.24089582","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.24089582","doi":"https://doi.org/10.1158/1535-7163.24089582","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.24089582","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386485051","https://openalex.org/W4386475082","https://openalex.org/W4386475078","https://openalex.org/W4293236675","https://openalex.org/W4402816920","https://openalex.org/W4385212580","https://openalex.org/W4385719496","https://openalex.org/W3120206025","https://openalex.org/W2474863315","https://openalex.org/W4386485150"],"abstract_inverted_index":{"HDACis":[0],"increase":[1,16,47,91,136],"SSTR2":[2,18,49,83],"surface":[3],"expression":[4,19,50,84],"and":[5,85],"177Lu-DOTATATE":[6,76,93,124],"uptake":[7,77,122],"in":[8,17,48,78,96,138],"QGP-1":[9,79],"xenograft":[10],"model.":[11],"A,":[12],"There":[13,44],"was":[14,32,45,63,94,131],"an":[15,46],"with":[20,51,101,133,141],"CI-994":[21,52,102,130,142,162],"(5":[22],"mg/kg)":[23,54,158,164],"after":[24,55,125],"10":[25,56,104,147],"days":[26,57,105,148],"of":[27,58,92,98,123],"treatment,":[28,59],"though":[29,60],"the":[30,61],"change":[31,62],"not":[33,64],"significant":[34,65,90,135],"(control":[35,66],"n":[36,40,67,71,113,117,153,159,165],"=":[37,41,68,72,110,114,118,150,154,160,166],"9,":[38,69,115],"treated":[39,70,100,116,140],"6).":[42],"B,":[43],"(10":[53],"11).":[73],"C,":[74],"Higher":[75],"tumors":[80,97],"indicates":[81],"increased":[82,86],"therapeutic":[87],"potential.":[88],"A":[89],"observed":[95,137],"mice":[99,139],"for":[103,146],"at":[106,143],"5":[107,157],"mg/kg":[108,145],"(P":[109,149],"0.0175,":[111],"control":[112,152],"12).":[119],"D,":[120],"Persistent":[121],"a":[126,134],"72-hour":[127],"interval":[128],"without":[129],"found,":[132],"7.5":[144],"0.0092,":[151],"6,":[155],"CI-994;":[156],"7,":[161],"(7.5":[163],"8.":[167],"Each":[168],"circle,":[169],"square,":[170],"or":[171],"triangle":[172],"represents":[173],"one":[174],"tumor.":[175],"Data":[176],"are":[177],"expressed":[178],"as":[179],"mean":[180],"\u00b1":[181],"SEM;":[182],"*,":[183],"P":[184,188],"<":[185,189],"0.05;":[186],"**,":[187],"0.01.":[190]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-09-07T00:00:00"}