{"id":"https://openalex.org/W4386476757","doi":"https://doi.org/10.1016/j.jtha.2023.08.033","title":"Mice possess a more limited natural antihuman factor VIII antibody repertoire than humans that is produced disproportionately by marginal zone B cells","display_name":"Mice possess a more limited natural antihuman factor VIII antibody repertoire than humans that is produced disproportionately by marginal zone B cells","publication_year":2023,"publication_date":"2023-09-06","ids":{"openalex":"https://openalex.org/W4386476757","doi":"https://doi.org/10.1016/j.jtha.2023.08.033","pmid":"https://pubmed.ncbi.nlm.nih.gov/37678547","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10872961"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtha.2023.08.033","doi":"https://doi.org/10.1016/j.jtha.2023.08.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtha.2023.08.033","pdf_url":"http://www.jthjournal.org/article/S1538783623006645/pdf","source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jthjournal.org/article/S1538783623006645/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020002310","display_name":"Matthew Cormier","orcid":"https://orcid.org/0000-0002-8101-7386","observed_orcids":["https://orcid.org/0000-0002-8101-7386"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Matthew Cormier","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address: Matt.cormier@queensu.ca","Department of Pathology and Molecular Medicine, Queen\u2019s University, Kingston, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8101-7386","affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address: Matt.cormier@queensu.ca","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen\u2019s University, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087122197","display_name":"Erin Burnett","orcid":"https://orcid.org/0000-0002-5361-3631","observed_orcids":["https://orcid.org/0000-0002-5361-3631"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Erin Burnett","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5361-3631","affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005599318","display_name":"Aomei Mo","orcid":"https://orcid.org/0000-0001-6164-6823","observed_orcids":["https://orcid.org/0000-0001-6164-6823"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aomei Mo","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6164-6823","affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034805317","display_name":"Colleen R. P. Notley","orcid":"https://orcid.org/0000-0001-6833-5307","observed_orcids":["https://orcid.org/0000-0001-6833-5307"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Colleen Notley","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0001-6833-5307","affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021613599","display_name":"Nathalie Tijet","orcid":"https://orcid.org/0009-0005-8285-7597","observed_orcids":["https://orcid.org/0009-0005-8285-7597"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nathalie Tijet","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada"],"raw_orcid":"https://orcid.org/0009-0005-8285-7597","affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076335321","display_name":"Natasha Christie-Holmes","orcid":"https://orcid.org/0000-0001-7051-8663","observed_orcids":["https://orcid.org/0000-0001-7051-8663"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Natasha Christie-Holmes","raw_affiliation_strings":["Emerging & Pandemic Infections Consortium, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0001-7051-8663","affiliations":[{"raw_affiliation_string":"Emerging & Pandemic Infections Consortium, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008809031","display_name":"Christine A. Hough","orcid":"https://orcid.org/0000-0001-5663-4801","observed_orcids":["https://orcid.org/0000-0001-5663-4801"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christine Hough","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0001-5663-4801","affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061703162","display_name":"David Lillicrap","orcid":"https://orcid.org/0000-0003-2410-6312","observed_orcids":["https://orcid.org/0000-0003-2410-6312"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"David Lillicrap","raw_affiliation_strings":["Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address: david.lillicrap@queensu.ca","Department of Pathology and Molecular Medicine, Queen\u2019s University, Kingston, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0003-2410-6312","affiliations":[{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address: david.lillicrap@queensu.ca","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen\u2019s University, Kingston, Ontario, Canada","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020002310","https://openalex.org/A5061703162"],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.1875,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.444296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"22","issue":"1","first_page":"76","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.8450000286102295},{"id":"https://openalex.org/keywords/natural-antibodies","display_name":"natural antibodies","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hemophilia-a","display_name":"hemophilia A","score":0.824999988079071},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.8360000252723694},{"id":"https://openalex.org/keywords/marginal-zone-b-cells","display_name":"marginal zone B cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.48100000619888306},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.6769999861717224},{"id":"https://openalex.org/keywords/iga","display_name":"IgA","score":0.8980000019073486},{"id":"https://openalex.org/keywords/b-domain","display_name":"B domain","score":0.4860000014305115},{"id":"https://openalex.org/keywords/antibody-repertoire","display_name":"antibody repertoire","score":0.6290000081062317},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.8130000233650208},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7837666273117065},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5684859752655029},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5615421533584595},{"id":"https://openalex.org/C2910693471","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody Repertoire","level":3,"score":0.4691140949726105},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4131152629852295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3862806558609009},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.38449859619140625}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006467","descriptor_name":"Hemophilia A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jtha.2023.08.033","doi":"https://doi.org/10.1016/j.jtha.2023.08.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtha.2023.08.033","pdf_url":"http://www.jthjournal.org/article/S1538783623006645/pdf","source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:37678547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37678547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thrombosis and haemostasis : JTH","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10872961","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10872961","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10872961/pdf/nihms-1930423.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Thromb Haemost","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jtha.2023.08.033","doi":"https://doi.org/10.1016/j.jtha.2023.08.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtha.2023.08.033","pdf_url":"http://www.jthjournal.org/article/S1538783623006645/pdf","source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4111268097","display_name":"Molecular and cellular mechanisms of the FVIII immune response","funder_award_id":"U54HL142012","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6947608973","display_name":null,"funder_award_id":"154285","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320322015","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386476757.pdf","grobid_xml":"https://content.openalex.org/works/W4386476757.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1572191362","https://openalex.org/W1575105525","https://openalex.org/W1792313494","https://openalex.org/W1940564482","https://openalex.org/W1964975805","https://openalex.org/W1965272893","https://openalex.org/W1967850547","https://openalex.org/W1977004360","https://openalex.org/W1977971077","https://openalex.org/W1979187662","https://openalex.org/W1983347503","https://openalex.org/W1991305546","https://openalex.org/W1998611493","https://openalex.org/W2002697968","https://openalex.org/W2003230234","https://openalex.org/W2003603592","https://openalex.org/W2004914260","https://openalex.org/W2008996942","https://openalex.org/W2010778973","https://openalex.org/W2013310889","https://openalex.org/W2016190951","https://openalex.org/W2018955424","https://openalex.org/W2037201482","https://openalex.org/W2038030714","https://openalex.org/W2057670418","https://openalex.org/W2063229662","https://openalex.org/W2073872022","https://openalex.org/W2078547612","https://openalex.org/W2091721067","https://openalex.org/W2098426068","https://openalex.org/W2102771576","https://openalex.org/W2129806278","https://openalex.org/W2131261387","https://openalex.org/W2136590857","https://openalex.org/W2156049613","https://openalex.org/W2158547214","https://openalex.org/W2162928156","https://openalex.org/W2168962377","https://openalex.org/W2280935809","https://openalex.org/W2335855130","https://openalex.org/W2401865216","https://openalex.org/W2463594392","https://openalex.org/W2557185850","https://openalex.org/W2562603171","https://openalex.org/W2601286611","https://openalex.org/W2759383150","https://openalex.org/W2762460052","https://openalex.org/W2785170117","https://openalex.org/W2845051690","https://openalex.org/W2875193073","https://openalex.org/W2895648255","https://openalex.org/W2912154925","https://openalex.org/W2924878231","https://openalex.org/W2966726206","https://openalex.org/W3007287792","https://openalex.org/W3021323304","https://openalex.org/W3034325807","https://openalex.org/W3035839621","https://openalex.org/W3047325596","https://openalex.org/W3084272827"],"related_works":["https://openalex.org/W4409913838","https://openalex.org/W2410247943","https://openalex.org/W4403904954","https://openalex.org/W2091721067","https://openalex.org/W2046322158","https://openalex.org/W2010778973","https://openalex.org/W69001209","https://openalex.org/W157872429","https://openalex.org/W4385686908","https://openalex.org/W4280573922"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-07T00:00:00"}